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Anticancer Potential of the Cyclolinopeptides

CANCERS (2023)

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Review Health Care Sciences & Services

The Role of Flaxseed in Improving Human Health

Wioletta Nowak et al.

Summary: Flaxseed is considered a superfood due to its high content of biologically active components and numerous health benefits. Regular consumption of flaxseed can improve lipid profile, lower blood pressure and blood sugar, and reduce insulin resistance. It also possesses anticancer and antioxidant properties, and can alleviate symptoms associated with menopause, constipation, and mental fatigue, as well as improve skin condition and wound healing. However, flaxseed also contains antinutrients that may limit its health-promoting effects. Ground flaxseed is recommended for optimal bioavailability of its bioactive components.

HEALTHCARE (2023)

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Article Biochemistry & Molecular Biology

Anti-Melanogenesis Effects of a Cyclic Peptide Derived from Flaxseed via Inhibition of CREB Pathway

Ji Hye Yoon et al.

Summary: This study investigated the inhibitory effects of cyclic peptides Linosorbs (Los) from flaxseed oil on melanogenesis, and found that LOMIX and LO could suppress melanin synthesis by downregulating the CREB-dependent signaling pathways, suggesting their potential application in treating hyperpigmentation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Food Science & Technology

Uptake of Flaxseed Dietary Linusorbs Modulates Regulatory Genes Including Induction of Heat Shock Proteins and Apoptosis

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Summary: Flaxseed contains health-promoting peptides that suppress immunity, induce apoptosis, and modulate gene expression. These peptides can be taken up from the diet and may serve as delivery platforms for cancer therapy.

FOODS (2022)

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Article Nutrition & Dietetics

Identification and Characterization of the Stability of Hydrophobic Cyclolinopeptides From Flaxseed Oil

Adnan Fojnica et al.

Summary: This study analyzed CLPs in samples obtained from nine different flaxseed oil manufacturers using HPLC-MS. The concentration and composition of CLPs varied substantially among the different manufacturers, possibly due to differences in plant cultivars. Most CLPs gradually degraded over time, even at room temperature.

FRONTIERS IN NUTRITION (2022)

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Article Medicine, Research & Experimental

Clinical trials in Bosnia and Herzegovina: Challenges and future perspectives

Dragana Stanisic et al.

Summary: This study analyzed the registration process for clinical trials in Bosnia and Herzegovina compared to other Balkan countries. The results showed that Bosnia has the lowest number of clinical trials and the registration process is complex and time-consuming. Recommendations include establishing an ethical committee at the state level and enabling parallel submission to ethical committees and databases to improve the registration process.

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS (2022)

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Review Food Science & Technology

Novel trends and opportunities for microencapsulation of flaxseed oil in foods: A review

Kouadio Jean Eric-Parfait Kouame et al.

Summary: Flaxseed oil is associated with the prevention and reduction of several serious diseases, mainly due to its omega-3 fatty acid content. However, factors like pH, temperature, oxygen, and light can limit the incorporation of omega-3 fatty acids into various food products. The development of microencapsulation techniques has allowed for the design of flaxseed oil-enriched food products to overcome these limitations, ensuring better stability and bioavailability of active compounds.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Review Biochemistry & Molecular Biology

Signal pathways of melanoma and targeted therapy

Weinan Guo et al.

Summary: Melanoma, a lethal skin cancer, has limited therapeutic options. Innovations in targeting mutated driver genes and immune checkpoints have improved patient prognosis, but resistance and low response rates remain challenges in melanoma treatment.

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Methionine epimerization in cyclic peptides

Pramodkumar D. Jadhav et al.

Summary: Bioactive flax cyclic peptides containing single methionine (Met) and its oxidized forms were subjected to regio-selective epimerization under mild alkaline conditions. The developed d-amino isomers and Met alkylation strategy provide a novel approach to chemical functionalization of biomolecules. These d-amino analogs can serve as potential biomarkers in plant protein processing and biomedical applications.

RSC ADVANCES (2021)

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Article Plant Sciences

Resequencing 200 Flax Cultivated Accessions Identifies Candidate Genes Related to Seed Size and Weight and Reveals Signatures of Artificial Selection

Dongliang Guo et al.

FRONTIERS IN PLANT SCIENCE (2020)

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Article Food Science & Technology

Orbitides isolated from flaxseed induce apoptosis against SGC-7901 adenocarcinoma cells

Xian-Guo Zou et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2020)

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Article Biochemistry & Molecular Biology

The Anti-Cancer Effect of Linusorb B3 from Flaxseed Oil through the Promotion of Apoptosis, Inhibition of Actin Polymerization, and Suppression of Src Activity in Glioblastoma Cells

Nak Yoon Sung et al.

MOLECULES (2020)

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Article Chemistry, Medicinal

Cyclolinopeptide F, a cyclic peptide from flaxseed inhibited RANKL-induced osteoclastogenesis via downergulation of RANK expression

Toshio Kaneda et al.

JOURNAL OF NATURAL MEDICINES (2019)

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Review Nutrition & Dietetics

Dietary Flaxseed as a Strategy for Improving Human Health

Mihir Parikh et al.

NUTRIENTS (2019)

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Article Biochemistry & Molecular Biology

Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer

Rashmi Deshpande et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2019)

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Anti-tumor Effects of Cyclolinopeptide on Giant-cell Tumor of the Bone

Yuta Taniguchi et al.

ANTICANCER RESEARCH (2019)

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Review Food Science & Technology

Orbitides from flaxseed (Linum usitatissimum L.): A comprehensive review

Youn Young Shim et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2019)

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[1-9-NαC]-linusorb B2 and [1-9-NαC]-linusorb B3 isolated from flaxseed induce G1 cell cycle arrest on SGC-7901 cells by modulating the AKT/JNK signaling pathway

Xian-Guo Zou et al.

JOURNAL OF FUNCTIONAL FOODS (2019)

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Article Public, Environmental & Occupational Health

Use of complementary and alternative medicine in Europe: Health-related and sociodemographic determinants

Laura M. Kemppainen et al.

SCANDINAVIAN JOURNAL OF PUBLIC HEALTH (2018)

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Mechanisms of invasion and motility of high-grade gliomas in the brain

Devin B. Mair et al.

MOLECULAR BIOLOGY OF THE CELL (2018)

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Review Medicine, General & Internal

Breast cancer

Nadia Harbeck et al.

LANCET (2017)

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Article Chemistry, Medicinal

Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity

Toshio Kaneda et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

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Article Oncology

Chemomodulatory Potential of Flaxseed Oil Against DMBA/Croton Oil-Induced Skin Carcinogenesis in Mice

Jyoti Sharma et al.

INTEGRATIVE CANCER THERAPIES (2016)

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Proposed Systematic Nomenclature for Orbitides

Youn Young Shim et al.

JOURNAL OF NATURAL PRODUCTS (2015)

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Tissue invasion and metastasis: Molecular, biological and clinical perspectives

W. G. Jiang et al.

SEMINARS IN CANCER BIOLOGY (2015)

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RANK pathway in giant cell tumor of bone: pathogenesis and therapeutic aspects

Pan-Feng Wu et al.

TUMOR BIOLOGY (2015)

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Evaluating the cytotoxicity of flaxseed orbitides for potential cancer treatment

Denis P. Okinyo-Owiti et al.

TOXICOLOGY REPORTS (2015)

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Flax and flaxseed oil: an ancient medicine & modern functional food

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JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2014)

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Article Agriculture, Multidisciplinary

Identification and Quantification of Cyclolinopeptides in Five Flaxseed Cultivars

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

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Review Chemistry, Organic

BIOACTIVE CYCLIC PEPTIDES FROM HIGHER PLANTS

Hiroshi Morita et al.

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Article Biotechnology & Applied Microbiology

Biomolecular Interaction Study of Cyclolinopeptide A with Human Serum Albumin

Ben Rempel et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)

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Article Biochemistry & Molecular Biology

Switching Akt: from survival signaling to deadly response

Marek Los et al.

BIOESSAYS (2009)

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Article Oncology

Effects of Dietary Flaxseed on Intestinal Tumorigenesis in ApcMin Mouse

Ajay Bommareddy et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2009)

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Review Surgery

Molecular pathobiology of gastric cancer

W. Yasui et al.

SCANDINAVIAN JOURNAL OF SURGERY (2006)

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Article Chemistry, Organic

Conformational analysis of cyclolinopeptides A and B

T Matsumoto et al.

TETRAHEDRON (2002)

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Article Immunology

Cyclolinopeptide:: A novel immunosuppressive agent with potential anti-lipemic activity

A Górski et al.

TRANSPLANTATION PROCEEDINGS (2001)

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Article Surgery

Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia

AP Ireland et al.

ANNALS OF SURGERY (2000)

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