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Review
Respiratory System
Laura Martino et al.
Summary: There is increasing evidence that children can develop Long Covid, but there are no specific reviews providing a clear description of reported respiratory symptoms and potential diagnostics.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Pediatrics
Iris Shachar-Lavie et al.
Summary: A new study finds that individuals infected with SARS-CoV-2 may experience long-term symptoms, known as long COVID (LC) or post COVID-19 condition. This study focuses on the consequences of LC on children's mental health. The findings show that children with LC exhibit more memory difficulties, but no significant differences in other aspects of mental health compared to a control group. Exposure to COVID-19-related stressors and parental worries about their children's functioning and economic difficulties at home are significant predictors of emotional-behavioral problems among children.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Karolina Dolezalova et al.
Summary: This multicentre study in Czech Republic focused on children with long-term respiratory issues after COVID-19, finding that exertional dyspnoea and chronic cough were the dominant symptoms, with a relatively mild impact and favorable prognosis observed in the cohort.
Editorial Material
Allergy
John O. Warner et al.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Allergy
Deepika Narayanan et al.
Summary: Respiratory syncytial virus (RSV) and rhinovirus (RV) infections are associated with an increased risk of post-viral airway disease and atopy. However, the mechanisms linking these viruses to the development of these diseases appear to be different, suggesting the need for specific treatments targeted at the viral etiology.
Article
Pediatrics
Luise Borch et al.
Summary: The study aimed to evaluate symptoms and duration of 'long COVID' in children. It found that most children recovered from symptoms within 1-5 months, suggesting that long COVID in children is rare and mainly of short duration.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Carlo Cervia et al.
Summary: By studying the immunoglobulin signature of COVID-19 patients and combining it with factors such as age, history of asthma, and symptoms during the primary infection, the risk of post-acute COVID-19 syndrome (PACS) can be predicted independently of the timepoint of blood sampling.
NATURE COMMUNICATIONS
(2022)
Review
Allergy
Philip A. Palmon et al.
Summary: There is no convincing evidence that asthma is a risk factor for severe COVID-19, possibly due to reduced receptor expression in the respiratory tract of asthmatic patients. Vaccination is recommended for asthma patients, and unnecessary use of systemic corticosteroids should be avoided.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Pediatrics
Terence Stephenson et al.
Summary: The objective of this study was to establish a research definition for 'Long COVID (post-COVID-19 condition)' in children and young people (CYP) to enable comparison of research studies. A three-phase online Delphi process and a consensus meeting were conducted. The research definition proposed includes a minimum duration of 12 weeks of persisting physical symptoms after initial testing, impacting everyday functioning and not explained by an alternative diagnosis, in young people with a history of confirmed SARS-CoV-2 infection. This is the first research definition of Long COVID in CYP and aligns with the clinical case definition proposed by the WHO.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Pediatrics
Leona Knoke et al.
Summary: This study aimed to investigate the long-term effects of symptomatic and asymptomatic SARS-CoV-2 infections on pulmonary function in children and adolescents. The results showed that pulmonary function is rarely impaired in this age group after SARS-CoV-2 infection, except for those with severe infection.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Sabrina Palacios et al.
Summary: This study is the largest to date on long-term pulmonary sequelae in pediatric patients after COVID-19. Identified clinical phenotypes and risk factors require further study and treatment.
PEDIATRIC PULMONOLOGY
(2022)
Article
Pediatrics
Selina Kikkenborg Berg et al.
Summary: This study investigated the prevalence of long-lasting symptoms in children aged 0-14 years infected with SARS-CoV-2, finding that the infected group had longer symptom duration and better quality of life scores related to emotional and social functioning in certain age groups.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Review
Respiratory System
Jong Hyuk Lee et al.
Summary: The prevalence of pulmonary sequelae of COVID-19, such as impaired diffusion capacity and pulmonary fibrosis, remains significant even after 1 year of recovery. The severity of the initial COVID-19 infection is associated with the development of these sequelae. Close respiratory follow-up is necessary for patients who recover from severe COVID-19.
RESPIRATORY RESEARCH
(2022)
Article
Pediatrics
Amanda K. Morrow et al.
Summary: This review discusses emerging understandings of adolescent long COVID or post-COVID-19 conditions, including clinical definitions, common symptoms, epidemiology, overlaps with other diseases, and preliminary guidance on management. The recent World Health Organization clinical case definition of post-COVID-19 conditions requires a history of SARS-CoV-2 infection, with symptoms starting within 3 months of COVID-19 onset. Common symptoms of the condition include fatigue, shortness of breath, and cognitive dysfunction, which may overlap with ME/CFS and have an impact on everyday functioning.
CURRENT PEDIATRICS REPORTS
(2022)
Review
Virology
Xiaojian Cui et al.
Summary: This study provides a comprehensive analysis of demographic characteristics, clinical symptoms, laboratory findings, and imaging features of COVID-19 in pediatric patients. It revealed that children with COVID-19 tend to have mild illness with typical manifestations of fever and cough, normal white blood cell counts, and common imaging features of normal or ground-glass opacity. However, the high incidence of critical cases and vomiting symptoms in children under 1 year old should be given attention.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Respiratory System
Wei Qin et al.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Pediatrics
Marlos Melo Martins et al.
Summary: Despite the global spread of SARS-CoV-2 infection, limited knowledge exists regarding the clinical presentations, transmission ways, severity, and prognosis in children and adolescents. Recent reports provide new insights on the infection in this age group, emphasizing the need for understanding and identifying the various aspects of the disease to effectively manage and prevent its spread.
PAEDIATRICS AND INTERNATIONAL CHILD HEALTH
(2021)
Article
Immunology
Liat Ashkenazi-Hoffnung et al.
Summary: This study on pediatric long COVID found that around 60% of children experienced symptoms associated with functional impairment 1-7 months after infection. A structured evaluation revealed mild abnormal findings in approximately half of the patients, mainly in the respiratory aspect.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Medicine, General & Internal
Harry Crook et al.
Summary: The long-term effects of covid-19 can affect multiple systems in the body, leading to persistent symptoms that impact patients of varying severity. These symptoms include fatigue, dyspnea, and cognitive impairment, among others. Studies discuss risk factors for acute and long covid, as well as potential therapeutic options.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Letter
Pediatrics
Daniela Say et al.
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Review
Infectious Diseases
Thi Loi Dao et al.
Summary: This meta-analysis revealed that the proportion of influenza virus co-infection in SARS-CoV-2 positive patients was 0.7%, with most cases being due to influenza A virus. Children had a significantly higher co-infection rate with influenza viruses compared to adults, and critically ill patients tended to have a slightly higher co-infection rate than overall patients.
JOURNAL OF CLINICAL VIROLOGY PLUS
(2021)
Article
Respiratory System
Pinelopi Anagnostopoulou et al.
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Critical Care Medicine
Brian L. Graham et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Respiratory System
Allan L. Coates et al.
EUROPEAN RESPIRATORY JOURNAL
(2017)
Article
Respiratory System
Paul D. Robinson et al.
EUROPEAN RESPIRATORY JOURNAL
(2013)
Article
Critical Care Medicine
Raed A. Dweik et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2011)
Article
Respiratory System
J Wanger et al.
EUROPEAN RESPIRATORY JOURNAL
(2005)
Article
Respiratory System
G Izbicki et al.
EUROPEAN RESPIRATORY JOURNAL
(2001)
