☆ 4.7 Article

Investigating the Prognostic Role of Peripheral Inflammatory Markers in Mild Cognitive Impairment

JOURNAL OF CLINICAL MEDICINE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Cell Biology

Lymphatic vasculature in the central nervous system

Sara Gonzalez-Hernandez et al.

Summary: The central nervous system is considered an immune privilege organ due to its limited capacity for an immune response. While recent discoveries have challenged this view by identifying lymphatic-like vessels in the eye and meninges, the presence of lymphatic vessels in the CNS parenchyma has not been reported. This article discusses the potential reasons for the dearth of lymphatic vessels specifically in the CNS parenchyma.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2023)

添加到收藏夹

Article Clinical Neurology

Association of peripheral immunity with cognition, neuroimaging, and Alzheimer's pathology

Jia-Hui Hou et al.

Summary: This study found that peripheral immune cells and the ratio of these cells were associated with cognitive function, neuroimaging, and AD pathology. These associations may be mediated by beta-amyloid and tau pathology.

ALZHEIMERS RESEARCH & THERAPY (2022)

添加到收藏夹

Article Public, Environmental & Occupational Health

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease 2019

Emma Nichols et al.

Summary: With projected trends in population ageing and growth, the number of people with dementia is expected to increase. Understanding the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritization, with a focus on potentially modifiable risk factors.

LANCET PUBLIC HEALTH (2022)

添加到收藏夹

Article Neurosciences

High neutrophil-to-lymphocyte ratio predicts short survival in multiple system atrophy

LingYu Zhang et al.

Summary: The neutrophil-to-lymphocyte ratio (NLR) is associated with poor prognosis in patients with multiple system atrophy (MSA), particularly in those with MSA-C subtype and in men.

NPJ PARKINSONS DISEASE (2022)

添加到收藏夹

Article Clinical Neurology

Investigation of the peripheral inflammation (neutrophil-lymphocyte ratio) in two neurodegenerative diseases of the central nervous system

Sonat Pinar Kara et al.

Summary: The NLR levels in patients with IPD were significantly higher compared to both the control and AD groups. Chronic inflammation plays an important role in the development and progression of neurodegenerative diseases, with peripheral inflammation being more significant in IPD than in AD.

NEUROLOGICAL SCIENCES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Systemic immune-inflammation index is associated with white matter hyperintensity volume

Ki-Woong Nam et al.

Summary: This study evaluated the association between the systemic immune-inflammation index (SII) and cerebral small vessel disease (cSVD). The results showed a significant correlation between high SII and white matter hyperintensity (WMH) volume, but no significant correlation with lacunes or cerebral microbleeds (CMBs). Subgroup analysis by age revealed that SII was only significantly associated with WMH volume in participants aged ≥ 60 years.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Article Clinical Neurology

Correlation between neutrophil/lymphocyte ratio and cognitive impairment in cerebral small vessel disease patients: A retrospective study

Lan Hou et al.

Summary: The blood neutrophil/lymphocyte ratio (NLR) is associated with an increased risk of mild cognitive impairment (CI) in patients with cerebral small vessel disease (CSVD). This study found that higher NLR in CSVD patients might be associated with an increased risk of CI.

FRONTIERS IN NEUROLOGY (2022)

添加到收藏夹

Editorial Material Medicine, General & Internal

From Biomarkers to Precision Medicine in Neurodegenerative Diseases: Where Are We?

Giacomo Tondo et al.

JOURNAL OF CLINICAL MEDICINE (2022)

添加到收藏夹

Article Psychology, Multidisciplinary

Effects of Concomitant Benzodiazepines and Antidepressants Long-Term Use on Social Decision-Making: Results From the Ultimatum Game

Carina Fernandes et al.

Summary: Long-term use of benzodiazepines and antidepressants may increase sensitivity to unfairness, resulting in higher rejection rates in disadvantageous situations.

FRONTIERS IN PSYCHOLOGY (2022)

添加到收藏夹

Article Neurosciences

Systemic immune-inflammation index (SII) but not platelet-albumin-bilirubin (PALBI) grade is associated with severity of acute ischemic stroke (AIS)

Duanlu Hou et al.

Summary: This study found that SII, but not PALBI, both of which are markers of inflammation, was independently associated with stroke severity.

INTERNATIONAL JOURNAL OF NEUROSCIENCE (2021)

添加到收藏夹

Letter Health Care Sciences & Services

Changes in Mortality in Top 10 Causes of Death from 2011 to 2018

Jamal S. Rana et al.

JOURNAL OF GENERAL INTERNAL MEDICINE (2021)

添加到收藏夹

Article Clinical Neurology

Immunity and amyloid beta, total tau and neurofilament light chain: Findings from a community-based cohort study

Lana Fani et al.

Summary: Immunity markers levels are associated with levels of Aβ in plasma, and participants with higher genetic predisposition to AD have higher immunity markers, with these effects mainly driven by APOEε4.

ALZHEIMERS & DEMENTIA (2021)

添加到收藏夹

Article Clinical Neurology

Biomarker-based stability in limbic-predominant amnestic mild cognitive impairment

Giacomo Tondo et al.

Summary: In a large cohort of aMCI subjects, using in vivo biomarkers such as cerebrospinal fluid measures and [F-18]fluorodeoxyglucose (FDG)-positron emission tomography (PET) imaging can accurately predict the prognosis of patients. The specific [F-18]FDG-PET limbic-predominant hypometabolism pattern is associated with clinical stability and low likelihood of progression to Alzheimer's disease, providing important implications for prognosis and clinical trial planning.

EUROPEAN JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia

Miguel German Borda et al.

Summary: The study aimed to investigate the effects of benzodiazepines and antidepressants prescription on cognitive and functional decline in older adults with AD and LBD. The results showed that the combination of benzodiazepines and antidepressants was associated with faster functional decline in LBD patients, while BZD and BZD-ADep prescription was linked to greater functional deterioration in AD patients. ADep alone did not have significant positive or negative associations with the outcomes.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2021)

添加到收藏夹

Article Neurosciences

Current and Future Prevalence Estimates of Mild Cognitive Impairment, Dementia, and Its Subtypes in a Population-Based Sample of People 70 Years and Older in Norway: The HUNT Study

Linda Gjora et al.

Summary: A large population-based study in Norway found a higher prevalence of dementia and MCI than previous studies. The standardized prevalence of dementia and MCI in individuals aged 70 and above were 14.6% and 35.3% respectively, with dementia being more prevalent in women and MCI more prevalent in men. The most common subtype of dementia identified was Alzheimer's disease. The study projected a significant increase in the number of individuals with dementia in Norway by 2050 and 2100.

JOURNAL OF ALZHEIMERS DISEASE (2021)

添加到收藏夹

Article Neurosciences

Brain Metabolism and Microglia Activation in Mild Cognitive Impairment: A Combined [18F]FDG and [11C]-(R)-PK11195 PET Study

Giacomo Tondo et al.

Summary: This study used PET imaging techniques to investigate the presence of microglial activation in MCI patients, showing an inverse correlation with brain glucose metabolism, suggesting a possible contribution to neurodegeneration.

JOURNAL OF ALZHEIMERS DISEASE (2021)

添加到收藏夹

Article Geriatrics & Gerontology

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study

Jaime Ramos-Cejudo et al.

Summary: The study found that higher NLR in older adults is independently associated with a greater risk of subsequent dementia, indicating the need for further evaluation of the role of neutrophil-mediated inflammation in AD progression.

FRONTIERS IN AGING NEUROSCIENCE (2021)

添加到收藏夹

Review Clinical Neurology

Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Stroke: A Systematic Review and Meta-Analysis

Wenxia Li et al.

Summary: This meta-analysis found that elevated neutrophil-to-lymphocyte ratio (NLR) is significantly associated with poor prognosis of stroke patients, with a 1.1- to 1.3-fold increased risk of poor outcomes in acute ischemic stroke (AIS) and acute hemorrhagic stroke (AHS) patients. Additionally, elevated NLR is also linked to an increased incidence of hemorrhagic transformation (HT) in AIS patients. This suggests NLR could serve as a potential prognostic biomarker for guiding clinical decision making in stroke patients.

FRONTIERS IN NEUROLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews

Marta Perez-Gomez Moreta et al.

Summary: The study confirmed a low efficacy of AChEI in improving cognitive symptoms of patients with mild to moderate AD, especially in cognitive aspects. However, AChEI showed better effects in improving the global state, with donepezil being the most effective treatment. Nonetheless, there was no evidence of improvement in behavioral disturbances with the use of AChEI.

BIOMEDICINES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis

Seok-Jin Choi et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Article Clinical Neurology

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer's disease

Giacomo Tondo et al.

ALZHEIMERS RESEARCH & THERAPY (2020)

添加到收藏夹

Review Cell Biology

Neutrophil activation in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis of protein markers in blood and cerebrospinal fluid

Che-Yuan Wu et al.

AGEING RESEARCH REVIEWS (2020)

添加到收藏夹

Review Medicine, General & Internal

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

Gill Livingston et al.

LANCET (2020)

添加到收藏夹

Review Immunology

The neutrophil-to-lymphocyte ratio in Alzheimer's disease: Current understanding and potential applications

Ahmed Sayed et al.

JOURNAL OF NEUROIMMUNOLOGY (2020)

添加到收藏夹

Article Clinical Neurology

MCI-to-normal reversion using neuropsychological criteria in the Alzheimer's Disease Neuroimaging Initiative

Kelsey R. Thomas et al.

ALZHEIMERS & DEMENTIA (2019)

添加到收藏夹

Article Clinical Neurology

Association of Neutrophil-Lymphocyte Ratio with Mild Cognitive Impairment in Elderly Chinese Adults: A Case-control Study

Peilin An et al.

CURRENT ALZHEIMER RESEARCH (2019)

添加到收藏夹

Review Cell Biology

Neuroinflammation in mild cognitive impairment and Alzheimer's disease: A meta-analysis

Steven Bradburn et al.

AGEING RESEARCH REVIEWS (2019)

添加到收藏夹

Article Geriatrics & Gerontology

Predictive Value of Routine Peripheral Blood Biomarkers in Alzheimer's Disease

Xiaoyu Dong et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

添加到收藏夹

Article Clinical Neurology

Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology

Ronald C. Petersen et al.

NEUROLOGY (2018)

添加到收藏夹

Article Clinical Neurology

Chronic obstructive pulmonary disease may complicate Alzheimer's disease: a comorbidity problem

Giacomo Tondo et al.

NEUROLOGICAL SCIENCES (2018)

添加到收藏夹

Review Medicine, Research & Experimental

CNS inflammation and neurodegeneration

Tanuja Chitnis et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

添加到收藏夹

Editorial Material Medicine, General & Internal

Prevention and management of dementia: a priority for public health

Helen Frankish et al.

LANCET (2017)

添加到收藏夹

Editorial Material Cell Biology

Insights into the protective role of immunity in neurodegenerative disease

Cristoforo Comi et al.

NEURAL REGENERATION RESEARCH (2017)

添加到收藏夹

Review Clinical Neurology

Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium

Ian G. McKeith et al.

NEUROLOGY (2017)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Neutrophil and platelet to lymphocyte ratios in people with subjective, mild cognitive impairment and early Alzheimer's disease

Tevfik Kalelioglu et al.

PSYCHOGERIATRICS (2017)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Neutrophil and platelet to lymphocyte ratios in people with subjective, mild cognitive impairment and early Alzheimer's disease

Tevfik Kalelioglu et al.

PSYCHOGERIATRICS (2017)

添加到收藏夹

Article Clinical Neurology

Mild cognitive impairment with suspected nonamyloid pathology (SNAP) Prediction of progression

Anna Caroli et al.

NEUROLOGY (2015)

添加到收藏夹

Article Medical Laboratory Technology

Neutrophil-to-Lymphocyte Ratio Positively Correlates to Age in Healthy Population

Jian Li et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2015)

添加到收藏夹

Article Medicine, General & Internal

Mild cognitive impairment: a concept in evolution

R. C. Petersen et al.

JOURNAL OF INTERNAL MEDICINE (2014)

添加到收藏夹

Article Neurosciences

A Longitudinal Follow-Up of 550 Mild Cognitive Impairment Patients: Evidence for Large Conversion to Dementia Rates and Detection of Major Risk Factors Involved

Ana Espinosa et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

添加到收藏夹

Article Neurosciences

Peripheral markers of Alzheimer's disease: Surveillance of white blood cells

Kaneez Fatima Shad et al.

SYNAPSE (2013)

添加到收藏夹

Article Geriatrics & Gerontology

The Evaluation of Neutrophil-Lymphocyte Ratio in Alzheimer's Disease

Mehmet Emin Kuyumcu et al.

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS (2012)

添加到收藏夹

Article Geriatrics & Gerontology

Occurrence of medical co-morbidity in mild cognitive impairment: implications for generalisation of MCI research

Blossom C. M. Stephan et al.

AGE AND AGEING (2011)

添加到收藏夹

Article Clinical Neurology

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Guy M. McKhann et al.

ALZHEIMERS & DEMENTIA (2011)

添加到收藏夹

Article Clinical Neurology

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

Katya Rascovsky et al.

BRAIN (2011)

添加到收藏夹

Article Clinical Neurology

Effects of Hypertension and Hypercholesterolemia on Cognitive Functioning in Patients With Alzheimer Disease

Felicia C. Goldstein et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.