4.7 Article

Analysis of Urinary Glycosaminoglycans to Predict Outcome in COVID-19 and Community-Acquired Pneumonia-A Proof-of-Concept Study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Critical Care Medicine

Distinctive Biomarker Features in the Endotheliopathy of COVID-19 and Septic Syndromes

Sara Fernandez et al.

Summary: COVID-19 patients exhibit increased circulating biomarkers of endothelial damage, complement activation, and fibrinolytic dysregulation, associated with disease severity. COVID-19 endotheliopathy differs from sepsis syndrome, in which endothelial damage is also a critical feature of pathobiology.
Article Medicine, General & Internal

Relationship Between Endothelial and Angiogenesis Biomarkers Envisage Mortality in a Prospective Cohort of COVID-19 Patients Requiring Respiratory Support

Felipe Maldonado et al.

Summary: This study aimed to evaluate whether early detection of endothelial and angiogenic biomarkers predicts mortality and major cardiovascular events in COVID-19 patients. The results showed that certain biomarkers had significantly increased concentrations in COVID-19 patients and could predict mortality. Furthermore, serum samples from COVID-19 patients enhanced the migration ability of endothelial cells.

FRONTIERS IN MEDICINE (2022)

Article Peripheral Vascular Disease

Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study

Alexandros Rovas et al.

Summary: This study compares microvascular injury patterns and proteomic signatures in COVID-19 and bacterial sepsis patients, and finds substantial overlap between the two diseases. Disease severity is the main factor influencing data variation. The study also identifies two main coregulated plasma protein signatures in both diseases that are associated with microvascular dysfunction and markers of clinical severity.

ANGIOGENESIS (2022)

Article Peripheral Vascular Disease

Microvascular dysfunction in COVID-19: the MYSTIC study

Alexandros Rovas et al.

Summary: Our study found that COVID-19 patients have reduced microvascular density, slower red blood cell velocity, and glycocalyx damage. Elevated markers of endothelial dysfunction are associated with disease severity and can predict 60-day in-hospital mortality.

ANGIOGENESIS (2021)

Article Biochemistry & Molecular Biology

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19

Dong Zhang et al.

Summary: The study found that COVID-19 patients with high Syndecan-1 levels develop more serious endothelial damage and inflammatory reactions, leading to increased mortality. Syndecan-1 has potential as a marker for disease progression or severity in COVID-19, and protecting the glycocalyx may be a potential treatment for the disease.

MOLECULAR MEDICINE (2021)

Review Peripheral Vascular Disease

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

David M. Smadja et al.

Summary: COVID-19 caused by SARS-CoV-2 is a systemic disease associated with vascular inflammation and endothelial injury, which can lead to ARDS and hypercoagulation. Besides pro-inflammatory cytokines, endothelial dysfunction can also cause hypercoagulation, thrombosis and pathological angiogenesis.

ANGIOGENESIS (2021)

Article Multidisciplinary Sciences

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

Geraldine Nouailles et al.

Summary: The immune response is crucial in determining disease severity in COVID-19. Research has found that in the early stages of infection, monocyte-derived macrophages in the lungs exhibit the earliest and strongest transcriptional response to infection.

NATURE COMMUNICATIONS (2021)

Review Critical Care Medicine

The glycocalyx: a novel diagnostic and therapeutic target in sepsis

Ryo Uchimido et al.

CRITICAL CARE (2019)

Article Endocrinology & Metabolism

Glycosaminoglycans detection methods: Applications of mass spectrometry

Francyne Kubaski et al.

MOLECULAR GENETICS AND METABOLISM (2017)

Article Critical Care Medicine

Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome

Eric P. Schmidt et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

Article Biochemistry & Molecular Biology

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

Eric P. Schmidt et al.

NATURE MEDICINE (2012)

Article Obstetrics & Gynecology

Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women

Mary J. G. Zamboni et al.

INTERNATIONAL UROGYNECOLOGY JOURNAL (2009)

Article Urology & Nephrology

Urinary glycosaminoglycan excretion during the menstrual cycle in normal young women

MVO Maroclo et al.

JOURNAL OF UROLOGY (2005)

Article Infectious Diseases

CAPNETZ - Community-acquired pneumonia competence network

T Welte et al.

INFECTION (2004)