期刊
JOURNAL OF CLINICAL MEDICINE
卷 12, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/jcm12196167
关键词
blood pressure variability; antihypertensive treatment; cardiovascular disease; cardiovascular risk; ambulatory blood pressure monitoring
Blood pressure variability (BPV) has attracted scientific interest and is associated with poor cardiovascular outcomes. Calcium channel blockers, particularly amlodipine, may be more effective in reducing BPV compared to other antihypertensive drugs.
Blood pressure oscillations during different time scales, known as blood pressure variability (BPV), have become a focus of growing scientific interest. BPV can be measured at long-term (seasonal variability or visit-to-visit), at mid-term (differences in consecutive days or weeks) or at short-term (day-night differences or changes induced by other daily activities and conditions). An increased BPV, either at long, mid or short-term is associated with a poor cardiovascular prognosis independently of the amount of blood pressure elevation. There is scarce evidence on the effect of different antihypertensive treatments on BPV, but some observational and interventional studies suggest that calcium channel blockers in general, and particularly amlodipine, either in monotherapy or combined with renin-angiotensin system blockers, can reduce BPV more efficiently than other antihypertensive drugs or combinations. Nevertheless, there are several aspects of the relationship between BPV, antihypertensive treatment, and clinical outcomes that are still unknown, and more work should be performed before considering BPV as a therapeutical target in clinical practice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据