4.7 Article

Tirbanibulin 1% Ointment Significantly Reduces the Actinic Keratosis Area and Severity Index in Patients with Actinic Keratosis: Results from a Real-World Study

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Comparative Efficacy and Safety of Tirbanibulin for Actinic Keratosis of the Face and Scalp in Europe: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

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Summary: This systematic review examined key treatments for actinic keratosis (AK) of the face and scalp, finding that tirbanibulin 1% ointment offers a novel treatment option with a short treatment period, favorable safety profile, and efficacy comparable to existing topical treatments available in Europe.

JOURNAL OF CLINICAL MEDICINE (2022)

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Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis

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Summary: Tirbanibulin, a tubulin polymerization and Src kinase inhibitor, was more effective than placebo ointment in clearing actinic keratoses on the face and scalp at 2 months. However, recurrence of lesions occurred in 47% of patients at 1 year, with adverse events related to local irritation.

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