4.7 Article

Progressive Multifocal Leukoencephalopathy in Systemic Lupus Erythematosus: A Consequence of Patient-Intrinsic or -Extrinsic Factors?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Rheumatology

Progressive multifocal leukoencephalopathy in a patient with systemic lupus erythematosus and autoimmune hepatitis

Saranya Gomathy et al.

Summary: This is a case report on a rare demyelinating central nervous system disease called progressive multifocal leukoencephalopathy (PML). The case involves a 54-year-old female with systemic lupus erythematosus and coexisting autoimmune hepatitis, presenting with progressive cognitive decline, right hemiparesis, and ataxia. PML was diagnosed, along with severe CD4 lymphopenia. Low-dose prednisolone and plasma exchange were administered, resulting in significant clinical improvement.

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES (2022)

Article Clinical Neurology

Progressive multifocal leukoencephalopathy genetic risk variants for pharmacovigilance of immunosuppressant therapies

Eli Hatchwell et al.

Summary: PML is a rare and dangerous brain disease caused by JC virus infection, with immunosuppressed patients being more susceptible. Research has identified four genetic variants in immune system genes that are associated with PML risk.

FRONTIERS IN NEUROLOGY (2022)

Article Clinical Neurology

Progressive Multifocal Leukoencephalopathy Misdiagnosed as Neuropsychiatric Systemic Lupus Erythematosus With a Catastrophic Outcome

Hussein Algahtani et al.

Summary: The case report highlights the importance of considering progressive multifocal leukoencephalopathy (PML) in immunosuppressed patients with autoimmune disorders who present with cognitive impairment and seizures. Delay in diagnosis and misdiagnosis can lead to catastrophic outcomes. Multidisciplinary care involving a neurologist, infectious diseases consultant, neuroradiologist, and rheumatologist is crucial in the management of suspected neuropsychiatric systemic lupus erythematosus (SLE) cases.

NEUROLOGIST (2022)

Review Clinical Neurology

Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease

Irene Cortese et al.

Summary: The Review provides an overview of progressive multifocal leukoencephalopathy and diseases caused by JC virus, discussing emerging immunotherapeutic approaches for increased survival. It highlights the need to reassess PML pathophysiology and clinical course, and the challenges of reversing underlying immunosuppression in the absence of antiviral therapies. Emerging treatments show promise but caution is advised to manage potential complications such as immune reconstitution inflammatory syndrome and long-term neurological effects.

NATURE REVIEWS NEUROLOGY (2021)

Review Rheumatology

Progressive multifocal leukoencephalopathy in systemic lupus erythematosus managed with pembrolizumab: A case report with literature review

Ting-Yuan Lan et al.

Summary: Progressive multifocal leukoencephalopathy (PML) is a rare but lethal infectious complication in patients with SLE, with immune checkpoint inhibitors (ICI) showing potential as a treatment option. Case experiences suggest that high disease burden, JC viral load, and immunosuppression status may predict the response to ICI treatment.
Review Hematology

Progressive multifocal leukoencephalopathy in patients treated with rituximab: a 20-year review from the Southern Network on Adverse Reactions

Charles L. Bennett et al.

Summary: Progressive multifocal leukoencephalopathy (PML) is a serious CNS infection caused by the John Cunningham virus, with CD4+ and CD8+ T-cell lymphopenia being primary risk factors. The use of the immunomodulatory anti-CD20 monoclonal antibody, rituximab, has been associated with an increased risk of PML infection. Reassuringly, pharmacovigilance efforts have shown rituximab-associated PML to be a rare clinical event with specific causal factors after 20 years of monitoring.

LANCET HAEMATOLOGY (2021)

Article Medicine, General & Internal

Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

Irene Cortese et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Rheumatology

The Risk of Progressive Multifocal Leukoencephalopathy in the Biologic Era Prevention and Management

Eamonn S. Molloy et al.

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2017)

Review Infectious Diseases

Progressive Multifocal Leukoencephalopathy in HIV-Uninfected Individuals

Deanna Saylor et al.

CURRENT INFECTIOUS DISEASE REPORTS (2016)

Review Biochemistry & Molecular Biology

CHARGE syndrome: a review of the immunological aspects

Monica T. Y. Wong et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2015)

Review Immunology

B cells and progressive multifocal leukoencephalopathy: search for the missing link

Deniz Durali et al.

FRONTIERS IN IMMUNOLOGY (2015)

Article Clinical Neurology

Low frequencies of central memory CD4 T cells in progressive multifocal leukoencephalopathy

Evelyn Dubois et al.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2015)

Review Allergy

Systemic Lupus Erythematosus, Progressive Multifocal Leukoencephalopathy, and T-CD4+Lymphopenia

Mariana Brandao et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2012)

Review Clinical Neurology

Progressive multifocal leukoencephalopathy: a review of the neuroimaging features and differential diagnosis

M. A. Sahraian et al.

EUROPEAN JOURNAL OF NEUROLOGY (2012)

Article Genetics & Heredity

CHARGE syndrome:: the phenotypic spectrum of mutations in the CHD7 gene

MCJ Jongmans et al.

JOURNAL OF MEDICAL GENETICS (2006)