☆ 4.7 Review

Early Prediction of Asthma

JOURNAL OF CLINICAL MEDICINE (2023)

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Review Medicine, General & Internal

Asthma

Celeste Porsbjerg et al.

Summary: Asthma is a common chronic non-communicable disease characterized by variable airflow obstruction. Effective therapies have significantly improved asthma morbidity and mortality, but undertreatment remains an issue. Understanding when and how to adjust treatment is crucial. With the advent of biological therapies, management has shifted towards precision medicine and remission. This article provides a clinically focused overview of asthma in children and adults, including epidemiology, pathophysiology, diagnosis, and management.

LANCET (2023)

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Article Pediatrics

Impulse oscillometry in preschool children with persistent asthma can predict spirometry at school age

Alberto Vidal Grell et al.

Summary: This study aimed to investigate the relationship between some impulse oscillometry (IOS) parameters during preschool age and spirometry alterations at school age. The results showed that R5, R20, Fres, AX, and D5-20 during preschool age were associated with abnormal spirometry at school age. These parameters could be useful for predicting abnormal spirometry in schoolchildren.

PEDIATRIC PULMONOLOGY (2023)

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Review Nutrition & Dietetics

Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma

Jose Valverde-Molina et al.

Summary: The importance of the microbiome and the gut-lung axis in the development and persistence of asthma is currently being investigated. The colonization of microbes in the first three years of life, especially the first hundred days, plays a crucial role in determining health. Early microbial dysbiosis caused by factors such as cesarean delivery, artificial lactation, and antibiotic therapy have been associated with the later development of asthma in children.

NUTRIENTS (2023)

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Review Medical Informatics

Machine learning classification approach for asthma prediction models in children

Raphael Henshaw Ekpo et al.

Summary: Machine learning is an automated modeling method in data analysis that allows for the discovery of insights from large datasets without explicit programming. This study aims to explore machine learning strategies to address the weaknesses of existing asthma prediction models in children and summarize the current models. The results reveal that the existing models have limitations in decision support, clinical impact, and predictive accuracy. ANN and SVM algorithms perform best in the prediction of pediatric asthma.

HEALTH AND TECHNOLOGY (2023)

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Article Physiology

Baseline reticular basement membrane morphology is related to subsequent spirometry deterioration in pediatric chronic airway inflammation: a follow-up study

Vaclav Koucky et al.

Summary: This study investigated the relationship between baseline reticular basement membrane (RBM) morphology and follow-up spirometry in children with asthma, cystic fibrosis, and primary ciliary dyskinesia. It was found that RBM morphology and ventilation inhomogeneity can predict trends in subsequent spirometry.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2023)

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Article Critical Care Medicine

Bronchial Remodeling-based Latent Class Analysis Predicts Exacerbations in Severe Preschool Wheezers

Michael Fayon et al.

Summary: This study aimed to use bronchial remodeling to better characterize severe preschool wheezers. The findings suggest that assessing bronchial remodeling can help identify subgroups of severe preschool wheezers and predict their risk of subsequent exacerbations. This has important implications for clinical management.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

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Article Public, Environmental & Occupational Health

The influence of early-life animal exposure on the risk of childhood atopic dermatitis, asthma and allergic rhinoconjunctivitis: findings from the Danish National Birth Cohort

Angela Pinot De Moira et al.

Summary: This study explored factors that may modify associations of early-life animal exposure with asthma and allergic disease, and found that type of animal, source of exposure, parental history of asthma or allergy, and timing of exposure can modify these associations. It is important to consider these factors when assessing the risks associated with early-life animal exposure.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2023)

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Review Allergy

Personalized Treatment of Asthma: The Importance of Sex and Gender Differences

Christine R. Jenkins et al.

Summary: An individual's sex and gender have various influences on the clinical course and management of asthma, including physiological development, hormonal effects, exposure to triggers, prevalence of comorbidities, and interactions with healthcare professionals. Current healthcare practices often overlook gender differences, highlighting the need for further research to better understand the impact of gender differences on asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Article Allergy

Characterization of Asthma by Age of Onset: A Multi-Database Cohort Study

Esme J. Baan et al.

Summary: This study reveals the differences in characteristics among patients with childhood, adult, and late-onset asthma. Compared to childhood asthma, adult-onset asthma patients are more likely to be overweight/obese, while late-onset asthma patients are more likely to have nasal polyposis, overweight/obesity, gastroesophageal reflux disease, and diabetes. There is a significant association between late-onset asthma and uncontrolled asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

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Review Pediatrics

New Directions in Understanding Atopic March Starting from Atopic Dermatitis

Nunzia Maiello et al.

Summary: Recent evidence suggests that the linear progression of the atopic march does not capture the heterogeneity of allergic phenotypes. Atopic dermatitis often serves as the first manifestation of the atopic march. Improved understanding of the pathogenesis of atopic dermatitis could be crucial in preventing the progression of atopic march.

CHILDREN-BASEL (2022)

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Review Allergy

Epigenetic regulation of immune function in asthma

Sunita Sharma et al.

Summary: This review examines the relationship between asthma and three key epigenetic processes: DNA methylation, modification of histone tails, and noncoding RNAs. Epigenetic marks play an important role in the pathogenesis of asthma and can serve as therapeutic targets and biomarkers. There are future directions for studying immune regulation in asthma and investigating epigenetics in allergic airway disease.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

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Article Allergy

Cord blood IgE predicts allergic sensitization, elevation of exhaled nitric oxide, and asthma in schoolchildren

Hsin-Ju Lee et al.

Summary: This study found a positive correlation between cord blood IgE levels and allergic sensitization, FeNO elevation, and asthma in Asian schoolchildren. Cord blood IgE could be a useful indicator for identifying newborns at risk for subsequent allergic sensitization and allergic airway inflammation.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2022)

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Article Pediatrics

The external validation of the asthma prediction tool in the French ELFE cohort

Sadia Khan et al.

Summary: This study validates the effectiveness of a non-invasive asthma prediction tool in different populations, providing encouragement for its application by general practitioners.

PEDIATRIC PULMONOLOGY (2022)

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Review Allergy

Application of Machine Learning Algorithms for Asthma Management with mHealth: A Clinical Review

Kevin C. H. Tsang et al.

Summary: Applying machine learning to asthma mHealth data has great potential, but current research is limited. Most studies use traditional machine learning techniques, with only a few exploring deep learning algorithms. Future research should focus on data collection and validation to improve the generalizability of the studies.

JOURNAL OF ASTHMA AND ALLERGY (2022)

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Review Cell Biology

Current Understanding of Asthma Pathogenesis and Biomarkers

Nazia Habib et al.

Summary: Asthma is a heterogeneous lung disease with different phenotypes and endotypes. Th2 inflammation is the most important pathological process, although non-Th2 cytokines can also mediate asthma. Inflammation-independent processes contribute to asthma pathogenesis. Targeting newly identified molecules and practical biomarkers can improve the diagnosis, classification, and treatment of asthma.

CELLS (2022)

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Review Medicine, General & Internal

Critical evaluation of asthma biomarkers in clinical practice

Giuseppe Guida et al.

Summary: The development of personalized medicine has revolutionized asthma management and is crucial for future advancements. Biomarkers play a vital role in diagnosing different asthma phenotypes and predicting disease progression and treatment response. However, the currently used biomarkers have limitations in accurately segregating different asthma phenotypes, especially in severe asthma and cases with low type-2 biomarkers. Sputum inflammatory cell analysis, considered the gold standard, also has limitations in clinical applicability due to various factors. This review critically examines the role of routinely used biomarkers in asthma and provides an overview of recent evidence.

FRONTIERS IN MEDICINE (2022)

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Review Allergy

Recent miRNA Research in Asthma

Rinku Sharma et al.

Summary: The study of microRNA in asthma has revealed a new level of gene regulation underlying asthma pathology. miRNAs have been shown to be important in asthma, influencing various biological mechanisms. They have also been proposed as biomarkers of asthma status, severity, and treatment response.

CURRENT ALLERGY AND ASTHMA REPORTS (2022)

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Article Immunology

Downregulation of miRNA-451a Promotes the Differentiation of CD4+T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma

Tianyue Wang et al.

Summary: In children with asthma, downregulation of miRNA-451a and upregulation of ETS1 in CD4+ T cells may contribute to enhanced Th2 cell differentiation, exacerbating asthma symptoms.

JOURNAL OF INNATE IMMUNITY (2021)

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Review Biochemistry & Molecular Biology

Roles of microRNAs in chronic pediatric diseases and their use as potential biomarkers: A review

Sujay Paul et al.

Summary: MiRNAs are small non-coding RNA molecules that play a crucial role in chronic pediatric diseases such as bronchial asthma, congenital heart diseases, cystic fibrosis, type 1 diabetes mellitus, and epilepsy, serving as potential novel biomarkers for diagnosis and prognosis.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2021)

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Review Biochemistry & Molecular Biology

Genetics and Epigenetics in Asthma

Polyxeni Ntontsi et al.

Summary: Asthma, a common respiratory disease worldwide, has been associated with various genes and different phenotypes. Research efforts are now focusing on epigenetics, particularly DNA methylation, in understanding asthma susceptibility.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Allergy

Prevalence and early-life risk factors of school-age allergic multimorbidity: The EuroPrevall-iFAAM birth cohort

Sigurveig T. Sigurdardottir et al.

Summary: Allergic multimorbidity should be considered an important chronic childhood disease in Europe. Some early-life factors associated with it are modifiable and could be considered for prevention strategies.

ALLERGY (2021)

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Review Physiology

Pathogenesis of Children's Allergic Diseases: Refocusing the Role of the Gut Microbiota

Tingting Hu et al.

Summary: The gut microbiota plays a crucial role in allergic diseases, with dysbiosis potentially leading to immune system imbalances. A stable gut microbiota is beneficial for the immune response of the host.

FRONTIERS IN PHYSIOLOGY (2021)

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Article Respiratory System

Sex and gender in asthma

Nowrin U. Chowdhury et al.

Summary: Asthma is a heterogeneous disease with significant differences in prevalence and severity between males and females. Factors such as sex hormones, genetics, and environmental factors play important roles in the differences observed in asthma incidence and severity. Fluctuations in sex hormone levels, gene expression, epigenetic modifications, and responses to environmental factors all contribute to the varying manifestations of asthma between genders.

EUROPEAN RESPIRATORY REVIEW (2021)

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Review Allergy

Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review

Hans Jacob L. Koefoed et al.

Summary: This systematic review found that factors such as asthma, wheezing, bronchial hyper-responsiveness, and early-life allergic sensitization can impact the development of large and small airway lung function in early childhood, potentially leading to lower levels of lung function growth. However, in later childhood, even with the presence of asthma or wheezing, lung function development continues at a lower level but largely tracks parallel to individuals without these conditions.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2021)

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Article Allergy

Decision tree-based rules outperform risk scores for childhood asthma prognosis

Arthur H. Owora et al.

Summary: This study compared and contrasted the prognostic performance of conditional inference decision tree-based rules and the pediatric asthma risk score for predicting childhood asthma at 7 years. The results showed that conditional inference decision tree-based rules had higher prognostic performance than the pediatric asthma risk score in predicting childhood asthma.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2021)

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Review Oncology

A review of epigenetic changes in asthma: methylation and acetylation

Mojgan Sheikhpour et al.

Summary: Epigenetic modifications can influence childhood and adulthood asthma and its symptoms, with DNA methylation and histone modifications being the most common alterations. Studies suggest that these changes can lead to asthma phenotypes and features through immune pathways regulation, but there is still a lack of research in this area.

CLINICAL EPIGENETICS (2021)

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Review Immunology

The Hygiene Hypothesis and New Perspectives-Current Challenges Meeting an Old Postulate

Holger Garn et al.

Summary: The Hygiene Hypothesis has proven to be adaptive and continuously evolving over its 30-year history, adjusting to new scientific developments. This review discusses the impact of recent discoveries on the hypothesis, including new classes of immune cells, allergy/asthma phenotypes with diverse underlying mechanisms, and insights from epigenetic studies. Additionally, it explores potential expansion of the Hygiene Hypothesis to other disease areas like psychiatric disorders and cancer.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pediatrics

The asthma predictive index as a surrogate diagnostic tool in preschoolers: Analysis of a longitudinal birth cohort

Jose A. Castro-Rodriguez et al.

Summary: This study suggests that the asthma predictive index (API) can be used as a diagnostic tool for asthma in toddlers and preschoolers with high accuracy. Factors such as maternal body mass index, maternal education, birth weight, placenta weight, age of daycare, gastroesophageal reflux disease, acute otitis media, and respiratory infections were associated with API positivity. Using API for asthma diagnosis showed a sensitivity of 48% and specificity of 92%, with an adjusted odds for asthma of 11.4, indicating its potential as a diagnostic tool for respiratory illnesses in young children.

PEDIATRIC PULMONOLOGY (2021)

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Article Allergy

Performance of Three Asthma Predictive Tools in a Cohort of Infants Hospitalized With Severe Bronchiolitis

Ronaldo C. Fabiano Filho et al.

Summary: Predicting asthma in children with severe bronchiolitis using different asthma prediction indices showed sub-optimal performance, highlighting the need for more accurate tools for asthma prediction in this high-risk population.

FRONTIERS IN ALLERGY (2021)

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Article Medicine, General & Internal

Serum potential biomarkers according to sputum inflammatory cell profiles in adult asthmatics

Gyu-Young Hur et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2020)

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Editorial Material Allergy

The doctor will see you now: How machine learning and artificial intelligence can extend our understanding and treatment of asthma

Amanda I. Messinger et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Respiratory System

Age-specific incidence of allergic and non-allergic asthma

Johanna Pakkasela et al.

BMC PULMONARY MEDICINE (2020)

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Review Respiratory System

Artificial intelligence techniques in asthma: a systematic review and critical appraisal of the existing literature

Konstantinos P. Exarchos et al.

EUROPEAN RESPIRATORY JOURNAL (2020)

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Review Immunology

Role of Host and Pathogen-Derived MicroRNAs in Immune Regulation During Infectious and Inflammatory Diseases

Kumari Chandan et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Allergy

Prediction models for childhood asthma: A systematic review

Dilini M. Kothalawala et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2020)

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Article Immunology

MiRNA-451a inhibits airway remodeling by targeting Cadherin 11 in an allergic asthma model of neonatal mice

Tianyue Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Health Care Sciences & Services

Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk

Sunita Sharma et al.

HEALTHCARE (2020)

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Review Respiratory System

Epigenetic Changes in Asthma: Role of DNA CpG Methylation

Da-Jeong Bae et al.

TUBERCULOSIS AND RESPIRATORY DISEASES (2020)

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Review Allergy

Allergy and atopy from infancy to adulthood Messages from the German birth cohort MAS

Susanne Lau et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2019)

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Article Allergy

The Pediatric Asthma Risk Score (PARS) Predicts Atopic and Non-atopic Asthma Better than the Asthma Predictive Index

Eric M. Schauberger et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Prediction of premature all-cause mortality: A prospective general population cohort study comparing machine-learning and standard epidemiological approaches

Stephen F. Weng et al.

PLOS ONE (2019)

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Review Pediatrics

Asthma Across Age: Insights From Primary Care

Alan Kaplan et al.

FRONTIERS IN PEDIATRICS (2019)

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Article Cardiac & Cardiovascular Systems

Age- and gender-specific incidence of new asthma diagnosis from childhood to late adulthood

Jasmin Honkamaki et al.

RESPIRATORY MEDICINE (2019)

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Review Pediatrics

Predicting Asthma Using Clinical Indexes

Jose A. Castro-Rodriguez et al.

FRONTIERS IN PEDIATRICS (2019)

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Review Pediatrics

Early Lung Function and Future Asthma

Manuel Sanchez-Solis

FRONTIERS IN PEDIATRICS (2019)

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Article Allergy

Indoor bacterial microbiota and development of asthma by 10.5 years of age

Anne M. Karvonen et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Review Genetics & Heredity

Cell-Specific DNA Methylation Signatures in Asthma

Andree-Anne Hudon Thibeault et al.

GENES (2019)

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Review Allergy

Validation of childhood asthma predictive tools: A systematic review

Silvia Colicino et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2019)

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Article Allergy

Individual risk assessment tool for school-age asthma prediction in UK birth cohort

Ran Wang et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2019)

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Article Allergy

Remission of persistent childhood asthma: Early predictors of adult outcomes

Alberta L. Wang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Health Care Sciences & Services

Machine learning in medicine: a practical introduction

Jenni A. M. Sidey-Gibbons et al.

BMC MEDICAL RESEARCH METHODOLOGY (2019)

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Article Allergy

Serum periostin is not related to asthma predictive index

J. A. Castro-Rodriguez et al.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA (2018)

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Editorial Material Allergy

The neonatal window of opportunity-early priming for life

Harald Renz et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Allergy

Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts

Lavinia Paternoster et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Review Pediatrics

The relationship between inflammation and remodeling in childhood asthma: A systematic review

Jose A. Castro-Rodriguez et al.

PEDIATRIC PULMONOLOGY (2018)

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Review Respiratory System

Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis

Helen L. Petsky et al.

THORAX (2018)

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Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Article Emergency Medicine

A Machine Learning Approach to Predicting Need for Hospitalization for Pediatric Asthma Exacerbation at the Time of Emergency Department Triage

Shilpa J. Patel et al.

ACADEMIC EMERGENCY MEDICINE (2018)

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Review Allergy

Recent developments and highlights in biomarkers in allergic diseases and asthma

Ibon Eguiluz-Gracia et al.

ALLERGY (2018)

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Review Pediatrics

Asthma: Differential Diagnosis and Comorbidities

Nicola Ullmann et al.

FRONTIERS IN PEDIATRICS (2018)

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Article Respiratory System

Sex differences in respiratory function

Antonella LoMauro et al.

BREATHE (2018)

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Article Critical Care Medicine

Obesity and Airway Dysanapsis in Children with and without Asthma

Erick Forno et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Article Allergy

Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies

Shatha A. Alduraywish et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2017)

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Article Allergy

Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers

Avery DeVries et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Allergy

Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development

Halie M. Anderson et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Allergy

Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision

Jan L. Brozek et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Genetics & Heredity

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Manuel A. Ferreira et al.

NATURE GENETICS (2017)

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Article Pediatrics

Sensitization predicts asthma development among wheezing toddlers in secondary healthcare

Nienke A. Boersma et al.

PEDIATRIC PULMONOLOGY (2017)

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Article Allergy

Serum periostin relates to type-2 inflammation and lung function in asthma: Data from the large population-based cohort Swedish GA(2)LEN

A. James et al.

ALLERGY (2017)

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Article Allergy

A new framework for the interpretation of IgE sensitization tests

G. Roberts et al.

ALLERGY (2016)

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Article Environmental Sciences

Urban Dust Microbiome: Impact on Later Atopy and Wheezing

Christina Tischer et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2016)

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Article Respiratory System

Epigenetic Mechanisms in Asthma

Avery DeVries et al.

ANNALS OF THE AMERICAN THORACIC SOCIETY (2016)

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Article Critical Care Medicine

Exhaled Biomarkers and Gene Expression at Preschool Age Improve Asthma Prediction at 6 Years of Age

Ester M. M. Klaassen et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Review Medical Informatics

A systematic review of predictive models for asthma development in children

Gang Luo et al.

BMC MEDICAL INFORMATICS AND DECISION MAKING (2015)

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Review Allergy

Biomarkers to predict asthma in wheezing preschool children

M. A. G. E. Bannier et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2015)

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Review Genetics & Heredity

Epigenome-modifying tools in asthma

Peter O. Brook et al.

EPIGENOMICS (2015)

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Article Multidisciplinary Sciences

Associations of Pet Ownership with Wheezing and Lung Function in Childhood: Findings from a UK Birth Cohort

Simon M. Collin et al.

PLOS ONE (2015)

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Article Physiology

Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects

Rebecca C. Fry et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Airway Smooth Muscle Hyperproliferation Is Regulated by MicroRNA-221 in Severe Asthma

Mark M. Perry et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2014)

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Article Biochemistry & Molecular Biology

Fetal lung and placental methylation is associated with in utero nicotine exposure

Divya Chhabra et al.

EPIGENETICS (2014)

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Article Allergy

A simple asthma prediction tool for preschool children with wheeze or cough

Anina M. Pescatore et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Allergy

MicroRNA-155 is essential for TH2-mediated allergen-induced eosinophilic inflammation in the lung

Carina Malmhall et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Immunology

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility

Gregory Seumois et al.

NATURE IMMUNOLOGY (2014)

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Article Multidisciplinary Sciences

Correction: Relation of DNA Methylation of 5′-CpG Island of ACSL3 to Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Childhood Asthma

Frederica Perera et al.

PLoS One (2014)

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Article Pediatrics

Differential DNA Methylation Profiles of Infants Exposed to Maternal Asthma During Pregnancy

Lakshitha P. Gunawardhana et al.

PEDIATRIC PULMONOLOGY (2014)

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Article Pediatrics

Correlation Between Nitrites in Induced Sputum and Asthma Symptoms in Asthmatic Schoolchildren

Jose A. Castro-Rodriguez et al.

PEDIATRIC PULMONOLOGY (2014)

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Article Multidisciplinary Sciences

Profiling of Volatile Organic Compounds in Exhaled Breath As a Strategy to Find Early Predictive Signatures of Asthma in Children

Agnieszka Smolinska et al.

PLOS ONE (2014)

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Review Cardiac & Cardiovascular Systems

Current evidence and future research needs for FeNO measurement in respiratory diseases

Leif Bjermer et al.

RESPIRATORY MEDICINE (2014)

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Article Medicine, General & Internal

Developmental Profiles of Eczema, Wheeze, and Rhinitis: Two Population-Based Birth Cohort Studies

Danielle C. M. Belgrave et al.

PLOS MEDICINE (2014)

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Article Critical Care Medicine

Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study

Mariona Pinart et al.

LANCET RESPIRATORY MEDICINE (2014)

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Article Allergy

Optimum Predictors of Childhood Asthma: Persistent Wheeze or the Asthma Predictive Index?

Priyal Amin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2014)

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Article Allergy

Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma

F. Singer et al.

ALLERGY (2013)

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Article Allergy

Exhaled nitric oxide predicts persistence of wheezing, exacerbations, and decline in lung function in wheezy infants and toddlers

M. Elliott et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2013)

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Article Respiratory System

Exhaled breath profiling in diagnosing wheezy preschool children

Kim D. G. van de Kant et al.

EUROPEAN RESPIRATORY JOURNAL (2013)

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Article Immunology

Roles of repressive epigenetic machinery in lineage decision of T cells

Taku Naito et al.

IMMUNOLOGY (2013)

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Article Allergy

Young Infants with Recurrent Wheezing and Positive Asthma Predictive Index Have Higher Levels of Exhaled Nitric Oxide

Jose A. Castro-Rodriguez et al.

JOURNAL OF ASTHMA (2013)

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Article Pediatrics

Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children

Mi-Ae Oh et al.

PEDIATRIC PULMONOLOGY (2013)

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Article Allergy

Evaluation of the Modified Asthma Predictive Index in High-Risk Preschool Children

Timothy S. Chang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2013)

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Article Critical Care Medicine

Interaction between Asthma and Lung Function Growth in Early Life

Hans Bisgaard et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2012)

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Article Allergy

Childhood wheezing phenotypes and FeNO in atopic children at age 8

R. J. P. van der Valk et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2012)

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Article Veterinary Sciences

Environmental Epigenetics and Its Implication on Disease Risk and Health Outcomes

Shuk-Mei Ho et al.

ILAR JOURNAL (2012)

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Review Allergy

Diagnosis and management of early asthma in preschool-aged children

Leonard B. Bacharier et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Allergy

Airway epithelial cells from asthmatic children differentially express proremodeling factors

Jesus M. Lopez-Guisa et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Allergy

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

Guiquan Jia et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Review Genetics & Heredity

Functions of DNA methylation: islands, start sites, gene bodies and beyond

Peter A. Jones

NATURE REVIEWS GENETICS (2012)

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Article Biochemical Research Methods

Profiling allergic asthma volatile metabolic patterns using a headspace-solid phase microextraction/gas chromatography based methodology

M. Caldeira et al.

JOURNAL OF CHROMATOGRAPHY A (2011)

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Article Immunology

MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-γ Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity

Thomas X. Lu et al.

JOURNAL OF IMMUNOLOGY (2011)

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Article Allergy

Ambient air pollution impairs regulatory T-cell function in asthma

Kari Nadeau et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Allergy

Eosinophil activity in infants hospitalized for wheezing and risk of persistent childhood asthma

Mari K. Hyvarinen et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2010)

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Article Respiratory System

Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE

Daan Caudri et al.

THORAX (2010)

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Letter Allergy

Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic children

Ruey-Chyi Su et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Article Allergy

Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age

Daan Caudri et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Article Allergy

Lack of eosinophilia can predict remission in wheezy infants?

J. Just et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2008)

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Article Allergy

IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells

K. Chibana et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2008)

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Article Allergy

Epigenetic regulation of established human type 1 versus type 2 cytokine responses

Ruey-Chyi Su et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

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Article Allergy

Nitrites in induced sputum as a simple and cheap non-invasive marker of airway inflammation for asthmatic schoolchildren

Arturo Recabarren et al.

PEDIATRIC ALLERGY AND IMMUNOLOGY (2008)

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Article Critical Care Medicine

Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers

Sejal Saglani et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2007)

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Article Biochemistry & Molecular Biology

Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells

Vinod Suresh et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2007)

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Review Cardiac & Cardiovascular Systems

Eosinophil cationic protein: Is it useful in asthma? A systematic review

Gerald C. -H. Koh et al.

RESPIRATORY MEDICINE (2007)

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Article Medicine, General & Internal

Reduced lung function at birth and the risk of asthma at 10 years of age

Geir Haland et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

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Article Immunology

Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells

GC Chan et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Critical Care Medicine

Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction

S Saglani et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2005)

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Article Pediatrics

Sputum induction in children with difficult asthma: Safety, feasibility, and inflammatory cell pattern

C Lex et al.

PEDIATRIC PULMONOLOGY (2005)

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Article Critical Care Medicine

The relationship between infant airway function, childhood airway responsiveness, and asthma

SW Turner et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

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Review Medical Laboratory Technology

Diagnostic potential of breath analysis - focus on volatile organic compounds

W Miekisch et al.

CLINICA CHIMICA ACTA (2004)

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Article Critical Care Medicine

Airway inflammation in childhood asthma

A Barbato et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

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Article Respiratory System

Exhaled nitric oxide rather than lung function distinguishes preschool children with probable asthma

LP Malmberg et al.

THORAX (2003)

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Article Critical Care Medicine

Early thickening of the reticular basement membrane in children with difficult asthma

DNR Payne et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

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Article Respiratory System

Predicting persistent disease among children who wheeze during early life

RJ Kurukulaaratchy et al.

EUROPEAN RESPIRATORY JOURNAL (2003)

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Article Medicine, General & Internal

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial

RH Green et al.

LANCET (2002)

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Article Allergy

The association between persistent eosinophilia and asthma in childhood is independent of atopic status

F Karakoc et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2002)

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Article Critical Care Medicine

Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years

LA Castro-Rodríguez et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2001)

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Article Critical Care Medicine

A clinical index to define risk of asthma in young children with recurrent wheezing

JA Castro-Rodríguez et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2000)

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