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Management of Patients Treated with Direct Oral Anticoagulants in Clinical Practice and Challenging Scenarios

JOURNAL OF CLINICAL MEDICINE (2023)

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Summary: Patients with active cancer treated with DOACs for NVAF have similar risks of stroke, intracranial hemorrhage, and gastrointestinal bleeding compared to those treated with warfarin.

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Association of conflicting information from healthcare providers and poor shared decision making with suboptimal adherence in direct oral anticoagulant treatment: A cross-sectional study in patients with atrial fibrillation

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2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

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Steven Deitelzweig et al.

Summary: This study found that among patients with nonvalvular atrial fibrillation and concurrent cancer, apixaban was associated with lower risk of stroke/systemic embolism and major bleeding compared to warfarin, while dabigatran and rivaroxaban had similar risks. There were variations in risk among different NOACs, but consistent treatment effects were seen across different types of cancer.

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Jongmin Hwang et al.

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Summary: The study compared medication persistence and adherence between low molecular weight heparin (LMWH) and direct oral anticoagulants (DOACs) in cancer-associated thrombosis (CAT) patients. Results showed that patients remained on DOACs longer than LMWH, but medication adherence was similar at PDC >= 80%, while higher in LMWH users at PDC >= 95%. Additionally, prescription copayments were higher on average for LMWH compared to DOACs.

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Giuseppe Boriani et al.

Summary: This study analyzed the pharmacokinetics/pharmacodynamics and clinical outcomes of patients receiving different anticoagulant treatments at extremes of body weight. Edoxaban showed similar efficacy compared with warfarin, with the most favorable outcomes in terms of non-major bleeding and net clinical results in LBW patients.

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Stefan H. Hohnloser et al.

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Li Zhu et al.

Summary: The study found that patients' education background, place of residence, number of complications, CHADS2-VASc score, and HAS-BLED score are independent factors affecting the compliance of NVAF patients with NOACs, and there is a negative correlation between NOAC compliance and severity of ischemic stroke. Strengthening clinical supervision and management of patients with NVAF after NOACs can improve patient compliance, reduce the harm of ischemic stroke, and improve prognosis.

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Summary: This study found that higher copayments in commercial insurance for NOACs were associated with lower adherence and higher rates of discontinuation in the first year among newly initiating atrial fibrillation patients. Policies to lower or limit cost sharing of important medications may lead to improved adherence and better outcomes among patients receiving NOACs.

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Shahrzad Salmasi et al.

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Daniele Pastori et al.

Summary: This study investigated the impact of cancer on clinical outcomes in atrial fibrillation (AF) patients, as well as the performance of HAS-BLED and CHA(2)DS(2)-VASc scores. The results showed that cancer increased all-cause mortality, major bleeding, and intracranial hemorrhage risk in AF patients. The risk of ischemic stroke varied among different cancer types, with some showing higher bleeding risk compared to thromboembolic risk.

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Filip Ionescu et al.

Summary: A study comparing the hemorrhagic risk in hemodialysis patients receiving oral anticoagulants found that apixaban is associated with lower bleeding risk compared to warfarin, but the safety advantage may be negated when antiplatelets are used concurrently. Prospective trials are needed to further investigate the impact of antiplatelet use on apixaban safety.

EUROPEAN JOURNAL OF HAEMATOLOGY (2021)

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Patients' adherence to oral anticoagulants therapy: Comparison between vitamin K antagonists and direct oral anticoagulants

Doris Barcellona et al.

Summary: The study found that patients treated with Vitamin K Antagonists or Direct Oral Anticoagulants show good adherence and persistence to their oral anticoagulant therapy. Factors such as age over 75 years, male gender, having experienced a thrombotic episode, and taking Direct Oral Anticoagulants twice a day are significantly associated with a higher risk of forgetting to take the oral anticoagulant.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Current status of oral anticoagulant adherence in Japanese patients with atrial fibrillation: A claims database analysis

Naoharu Yagi et al.

Summary: In Japanese patients with NVAF, the adherence to DOACs remains relatively high at 3 years, with over 90% of patients showing high adherence based on PDC evaluation, regardless of the types of DOACs used.

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Long-term adherence to direct acting oral anticoagulants and the influence of health beliefs after switching from vitamin-K antagonists: Findings from the Switching Study

John K. Bartoli-Abdou et al.

Summary: While many patients who switched from VKAs to DOACs were adherent to therapy long-term, between 23 and 39% exhibited sub-optimal adherence. These patients can be identified through their modifiable health beliefs at the time of switching.

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Reasons for non-adherence to thromboprophylaxis prescribing guidelines in atrial fibrillation in Western Australia: A qualitative descriptive study of general practitioners' views

Eyob Alemayehu Gebreyohannes et al.

Summary: In Australia, a significant proportion of atrial fibrillation patients are not receiving guideline-adherent oral anticoagulant treatment, with reasons for non-adherence including GPs' decision-making process and patient refusal. Behavioral factors identified through mapping to the COM-B model include GPs' knowledge of AF guideline recommendations, access to cardiologists, and patients' refusal to take OACs.

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Effectiveness and Safety of Direct Oral Anticoagulants in Patients with Nonvalvular Atrial Fibrillation and Weighing ≥ 120 Kilograms versus 60-120 Kilograms

Eryne E. Wiethorn et al.

Summary: This study compared the safety and efficacy of DOACs in patients with NVAF weighing >= 120 kg with those weighing < 120 kg. The results suggest that apixaban, dabigatran, or rivaroxaban may be well-tolerated and effective anticoagulant options in patients with NVAF weighing >= 120 kg.

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Long-Term Medication Adherence Trajectories to Direct Oral Anticoagulants and Clinical Outcomes in Patients With Atrial Fibrillation

Jaejin An et al.

Summary: A study in a large US integrated health care system found three adherence trajectories to DOAC therapy in nonvalvular atrial fibrillation patients: consistently adherent, early discontinuation, and gradually declining adherence. Early discontinuation was associated with a higher risk of thromboembolic events, while gradually declining adherence was associated with lower risk.

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Direct-Acting Oral Anticoagulant Choice for Stroke Prevention in Obese Patients With Atrial Fibrillation

Tanveer Brar et al.

Summary: For obese patients with atrial fibrillation, direct-acting oral anticoagulants (DOACs) are more effective than warfarin, with evidence supporting their use in this population. In patients with higher BMIs, consideration may need to be given to using alternative DOACs or continuing warfarin therapy.

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Jeffrey S. Berger et al.

Summary: This study demonstrated that rivaroxaban is an effective and safe treatment option for NVAF patients with obesity in a commercially-insured US population, with a 26% lower risk of stroke/SE compared to warfarin at 36 months post-treatment initiation. The risk of major bleeding was similar between rivaroxaban-initiated patients and warfarin-initiated patients.

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2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation

Jan Steffel et al.

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Effectiveness and Safety of DOACs vs. VKAs in AF Patients With Cancer: Evidence From Randomized Clinical Trials and Observational Studies

Fuwei Liu et al.

Summary: DOACs showed significant reductions in the risks of stroke or systemic embolism, venous thromboembolism, intracranial bleeding, and gastrointestinal bleeding compared to VKAs in patients with AF and cancer. There were no significant differences in other outcomes between the two groups.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Ischemic Stroke Risk Factors in Patients with Atrial Fibrillation Treated with New Oral Anticoagulants

Pawel Wankowicz et al.

Summary: For the prevention of ischemic stroke in atrial fibrillation patients, the most commonly used therapeutic option is oral anticoagulants, with new-generation oral anticoagulants being as effective as old-generation ones but with reduced risk of hemorrhage. However, solely relying on these medications may not be sufficient to protect this group of patients from the risk of ischemic stroke.

JOURNAL OF CLINICAL MEDICINE (2021)

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Letter Cardiac & Cardiovascular Systems

2021 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: comment-Authors' reply

Michihiro Suwa et al.

EUROPACE (2021)

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Review Cardiac & Cardiovascular Systems

2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)

Michael Glikson et al.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Meta-Analysis of Reversal Agents for Severe Bleeding Associated With Direct Oral Anticoagulants

Antonio Gomez-Outes et al.

Summary: This study investigated the clinical outcomes associated with the use of different reversal agents for severe DOAC-related bleeding, finding a high rate of effective hemostasis but a significant association between failure to achieve effective hemostasis and mortality risk. Thromboembolism rates were particularly high with andexanet.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Oncology

Mortality associated with the use of non-vitamin K antagonist oral anticoagulants in cancer patients: Dabigatran versus rivaroxaban

Yu-Sheng Lin et al.

Summary: Dabigatran may be associated with a lower risk of cancer-related death and all-cause mortality compared with rivaroxaban, as well as lower risks of major bleeding and GI bleeding.

CANCER MEDICINE (2021)

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Review Medicine, General & Internal

Anticoagulation in Atrial Fibrillation Cardioversion: What Is Crucial to Take into Account

Fabiana Luca et al.

Summary: The therapeutic dilemma between rhythm and rate control remains unresolved in the management of AF, with electrical or pharmacological cardioversion often being useful. Anticoagulation should be based on individual thromboembolic risk, with NOACs representing a significant advancement. Emergency ECV is necessary for hemodynamically unstable patients, with anticoagulation administered prior to CV.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Medicine, General & Internal

Direct Oral Anticoagulants in Patients with Obesity and Atrial Fibrillation: Position Paper of Italian National Association of Hospital Cardiologists (ANMCO)

David Mocini et al.

Summary: DOACs, including dabigatran, rivaroxaban, apixaban, and edoxaban, offer major advantages over VKAs, but concerns remain regarding potential undertreatment in obese patients without specific RCTs comparing the two. Despite limitations, the Italian Association of Hospital Cardiologists has proposed recommendations for the use of DOACs in obese patients based on existing evidence.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Health Care Sciences & Services

Antithrombotic therapy in patients with liver disease: population-based insights on variations in prescribing trends, adherence, persistence and impact on stroke and bleeding

Wai Hoong Chang et al.

Summary: The study investigated the prescribing prevalence, adherence, persistence, and impact of adherence on bleeding and stroke risk in patients with and without liver disease taking anticoagulants and antiplatelets. Patients with liver disease had lower prescribing prevalence but higher adherence rates compared to those without liver disease. Non-adherence rates were higher in liver disease patients, especially after stopping medication.

LANCET REGIONAL HEALTH-EUROPE (2021)

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Article Health Care Sciences & Services

Association between Cerebral Infarction Risk and Medication Adherence in Atrial Fibrillation Patients Taking Direct Oral Anticoagulants

Yuuki Akagi et al.

Summary: DOACs are beneficial for nonvalvular atrial fibrillation patients due to the lack of regular anticoagulation monitoring required. However, low medication adherence has been identified as a risk factor for cerebral infarction in patients taking DOACs. Pharmacists should focus on maintaining ≥80% adherence to DOAC therapy to prevent cerebral infarction.

HEALTHCARE (2021)

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Article Cardiac & Cardiovascular Systems

Outcomes of Direct Oral Anticoagulants in Atrial Fibrillation Patients Across Different Body Mass Index Categories

Amr F. Barakat et al.

Summary: In patients with atrial fibrillation, direct oral anticoagulants (DOACs) are associated with better safety and effectiveness compared to warfarin across all body mass index (BMI) categories, including BMI <18.5 and >= 40 kg/m(2).

JACC-CLINICAL ELECTROPHYSIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Anticoagulation in patients with atrial fibrillation and active cancer: an international survey on patient management

Giuseppe Boriani et al.

Summary: The survey highlights the challenges in managing anticoagulation in patients with AF and active cancer, with substantial heterogeneity in therapeutic choices. Despite the emerging role of DOACs, the substantial use of LMWH continues, despite the lack of long-term data on thromboprophylaxis in AF.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Outcomes of uninterrupted vs interrupted Periprocedural direct oral Anticoagulants in atrial Fibrillation ablation: A meta-analysis

Indranill Basu-Ray et al.

Summary: This meta-analysis compared interrupted and uninterrupted direct oral anticoagulation during catheter ablation of atrial fibrillation and found that uninterrupted anticoagulation was similar to interrupted anticoagulation in terms of bleeding event rates, procedural times, and mean activated clotting times, but had fewer silent cerebral events.

JOURNAL OF ARRHYTHMIA (2021)

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Article Medicine, General & Internal

A prospective survey of the persistence of warfarin or NOAC in nonvalvular atrial fibrillation: a COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation (CODE-AF)

Hyeongsoo Kim et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2020)

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Article Peripheral Vascular Disease

Direct Anticoagulants and Risk of Myocardial Infarction, a Multiple Treatment Network Meta-Analysis

Peter Kupo et al.

ANGIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Revisiting the effects of omitting aspirin in combined antithrombotic therapies for atrial fibrillation and acute coronary syndromes or percutaneous coronary interventions: meta-analysis of pooled data from the PIONEER AF-PCI, RE-DUAL PCI, and AUGUSTUS trials

Tatjana S. Potpara et al.

EUROPACE (2020)

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Article Cardiac & Cardiovascular Systems

The optimal drug adherence to maximize the efficacy and safety of non-vitamin K antagonist oral anticoagulant in real-world atrial fibrillation patients

Daehoon Kim et al.

EUROPACE (2020)

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Article Cardiac & Cardiovascular Systems

Adherence and persistence to direct oral anticoagulants in atrial fibrillation: a population-based study

Amitava Banerjee et al.

HEART (2020)

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Article Cardiac & Cardiovascular Systems

Medication adherence to rivaroxaban and dabigatran in patients with non-valvular atrial fibrillation: a meta-analysis

Ashley Prentice et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2020)

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Article Hematology

Rivaroxaban versus apixaban in non-valvular atrial fibrillation patients with end-stage renal disease or receiving dialysis

Benjamin Miao et al.

EUROPEAN JOURNAL OF HAEMATOLOGY (2020)

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Review Cardiac & Cardiovascular Systems

Emerging clinical setting of direct oral anticoagulants: atherothrombotic events prevention

Stefania A. Di Fusco et al.

JOURNAL OF CARDIOVASCULAR MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Clinical characteristics, management and outcomes of patients with acute coronary syndrome and atrial fibrillation: real-world data from two nationwide registries in Italy

Fabiana Luca et al.

JOURNAL OF CARDIOVASCULAR MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Examining Adherence to Medication in Patients With Atrial Fibrillation The Role of Medication Beliefs, Attitudes, and Depression

Elaina Charlotte Taylor et al.

JOURNAL OF CARDIOVASCULAR NURSING (2020)

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Review Cardiac & Cardiovascular Systems

Ultrasound guidance for femoral venous access in electrophysiology procedures-systematic review and meta-analysis

Peter Kupo et al.

JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY (2020)

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Article Pharmacology & Pharmacy

Oral Anticoagulant Prescription Trends, Profile Use, and Determinants of Adherence in Patients with Atrial Fibrillation

Sylvie Perreault et al.

PHARMACOTHERAPY (2020)

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Article Cardiac & Cardiovascular Systems

Adherence to oral anticoagulant treatment and risk factor assessment six months after DC-conversion of atrial fibrillation

V. H. R. Kjekshus et al.

SCANDINAVIAN CARDIOVASCULAR JOURNAL (2020)

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Editorial Material Hematology

The Compelling Issue of Nonvitamin K Antagonist Oral Anticoagulant Adherence in Atrial Fibrillation Patients: A Systematic Need for New Strategies

Marco Proietti et al.

THROMBOSIS AND HAEMOSTASIS (2020)

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Review Pharmacology & Pharmacy

Drug-Drug Interactions with Direct Oral Anticoagulants

Kathrin I. Foerster et al.

CLINICAL PHARMACOKINETICS (2020)

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Review Cardiac & Cardiovascular Systems

The Combination of Oral Anticoagulant and Antiplatelet Therapies: Stay One Step Ahead

Fabiana Luca et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2020)

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Review Cardiac & Cardiovascular Systems

Select Drug-Drug Interactions With Direct Oral Anticoagulants JACC Review Topic of the Week

Barbara S. Wiggins et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Review Medicine, General & Internal

Adherence to oral anticoagulants among patients with atrial fibrillation: a systematic review and meta-analysis of observational studies

Shahrzad Salmasi et al.

BMJ OPEN (2020)

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Article Medicine, General & Internal

Real-world adherence to oral anticoagulants in atrial fibrillation

Simonyi Gabor et al.

ORVOSI HETILAP (2020)

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Article Medicine, General & Internal

Effectiveness and Safety of Oral Anticoagulants among NVAF Patients with Obesity: Insights from the ARISTOPHANES Study

Steve Deitelzweig et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Cardiac & Cardiovascular Systems

Direct Oral Anticoagulant Use: A Practical Guide to Common Clinical Challenges

Ashley Chen et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Review Cardiac & Cardiovascular Systems

Safety and Efficacy of Double Antithrombotic Therapy With Non-Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis

Davide Capodanno et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Hematology

Predictors of preprocedural direct oral anticoagulant levels in patients having an elective surgery or procedure

Joseph R. Shaw et al.

BLOOD ADVANCES (2020)

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Review Cardiac & Cardiovascular Systems

Continued versus interrupted direct oral anticoagulation for cardiac electronic device implantation: A systematic review

Pablo A. Mendoza et al.

PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2020)

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Article Medicine, General & Internal

Antithrombotic management of patients with acute coronary syndrome and atrial fibrillation undergoing coronary stenting: a prospective, observational, nationwide study

Leonardo De Luca et al.

BMJ OPEN (2020)

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Article Health Care Sciences & Services

Medication adherence for atrial fibrillation patients: triangulating measures from a smart pill bottle, e-prescribing software, and patient communication through the electronic health record

Tammy Toscos et al.

JAMIA OPEN (2020)

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Article Cardiac & Cardiovascular Systems

The Japanese Catheter Ablation Registry (J-AB): A prospective nationwide multicenter registry in Japan. Annual report in 2018

Kengo Kusano et al.

JOURNAL OF ARRHYTHMIA (2020)

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Article Hematology

Self-reported therapy adherence and predictors for nonadherence in patients who switched from vitamin K antagonists to direct oral anticoagulants

Myrthe M. A. Toorop et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

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Article Oncology

Novel Oral Anticoagulant versus Warfarin in Cancer Patients with Atrial Fibrillation: An 8-Year Population-Based Cohort Study

Victor Chien-Chia Wu et al.

JOURNAL OF CANCER (2020)

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Article Hematology

Persistence of oral anticoagulant treatment for atrial fibrillation in the Netherlands: A surveillance study

Gilda Denise Zielinski et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

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Article Nursing

Discrepancy Among Self-Reported Adherence, Prescription Refills, and Actual Anticoagulant Control

Pai-En Chiu et al.

JOURNAL OF NURSING RESEARCH (2020)

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Article Pharmacology & Pharmacy

Evaluation of risk factors and drug adherence in the occurrence of stroke in patients with atrial fibrillation

Maya El-Hajj et al.

PHARMACY PRACTICE-GRANADA (2020)

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Review Oncology

Direct Oral Anticoagulants in Patients With Active Cancer A Systematic Review and Meta-Analysis

Jolanda Sabatino et al.

JACC: CARDIOONCOLOGY (2020)

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Review Pharmacology & Pharmacy

Patient Adherence to Novel Oral Anticoagulants (NOACs) for the Treatment of Atrial Fibrillation and Occurrence of Associated Bleeding Events: A Systematic Review and Meta-analysis

Abdulla Shehab et al.

CURRENT VASCULAR PHARMACOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

2018 Joint European consensus document on the management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous cardiovascular interventions: a joint consensus document of the European Heart Rhythm Association (EHRA), European Society of Cardiology Working Group on Thrombosis, European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Association of Acute Cardiac Care (ACCA) endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), Latin America Heart Rhythm Society (LAHRS), and Cardiac Arrhythmia Society of Southern Africa (CASSA)

Gregory Y. H. Lip et al.

EUROPACE (2019)

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Article Cardiac & Cardiovascular Systems

2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration With the Society of Thoracic Surgeons

Craig T. January et al.

CIRCULATION (2019)

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Review Cardiac & Cardiovascular Systems

Anticoagulation Strategies in Patients With Cancer JACC Review Topic of the Week

Ramya C. Mosarla et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Medicine, General & Internal

Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation

Renato D. Lopes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Medicine, General & Internal

Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors

S. J. Connolly et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Cardiac & Cardiovascular Systems

Anticoagulation in chronic kidney disease: from guidelines to clinical practice

Viviana Aursulesei et al.

CLINICAL CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Uninterrupted edoxaban vs. vitamin K antagonists for ablation of atrial fibrillation: the ELIMINATE-AF trial

Stefan H. Hohnloser et al.

EUROPEAN HEART JOURNAL (2019)

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Article Cardiac & Cardiovascular Systems

Defining High Bleeding Risk in Patients Undergoing Percutaneous Coronary Intervention A Consensus Document From the Academic Research Consortium for High Bleeding Risk

Philip Urban et al.

CIRCULATION (2019)

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Review Cardiac & Cardiovascular Systems

Management of Antithrombotic Therapy in Atrial Fibrillation Patients Undergoing PCI JACC State-of-the-Art Review

Davide Capodanno et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Hematology

Improved Population-Based Clinical Outcomes of Patients with Atrial Fibrillation by Compliance with the Simple ABC (Atrial Fibrillation Better Care) Pathway for Integrated Care Management: A Nationwide Cohort Study

Minjae Yoon et al.

THROMBOSIS AND HAEMOSTASIS (2019)

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Article Hematology

Differences between patient-driven adherence to vitamin K antagonists and direct oral anticoagulants. Do few missed doses matter? ACO-MEMS Study

Itziar Solla-Ruiz et al.

THROMBOSIS RESEARCH (2019)

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Review Cardiac & Cardiovascular Systems

Non Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Cancer and Atrial Fibrillation: A Systematic Review and Meta-Analysis

Yuqing Deng et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2019)

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Review Pharmacology & Pharmacy

Clinical Management of Pharmacokinetic Drug Interactions with Direct Oral Anticoagulants (DOACs)

Megan C. Herink et al.

DRUGS (2019)

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Article Medicine, General & Internal

Edoxaban-based versus vitamin K antagonist-based antithrombotic regimen after successful coronary stenting in patients with atrial fibrillation (ENTRUST-AF PCI): a randomised, open-label, phase 3b trial

Pascal Vranckx et al.

LANCET (2019)

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Article Medicine, General & Internal

Anticoagulation adherence and its associated factors in patients with atrial fibrillation: a cross-sectional study

Pei-Ti Chen et al.

BMJ OPEN (2019)

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Article Medicine, General & Internal

Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant

James D. Douketis et al.

JAMA INTERNAL MEDICINE (2019)

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Editorial Material Cardiac & Cardiovascular Systems

Specific Antidotes for Direct Oral Anticoagulant Reversal Case Closed or Cold Case?

Anne Godier et al.

CIRCULATION (2019)

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Review Cardiac & Cardiovascular Systems

Safety and efficacy outcomes of double vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review and meta-analysis of non-vitamin K antagonist oral anticoagulant-based randomized clinical trials

Giuseppe Gargiulo et al.

EUROPEAN HEART JOURNAL (2019)

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Review Pharmacology & Pharmacy

Bleeding after antiplatelet therapy for the treatment of acute coronary syndromes: a review of the evidence and evolving paradigms

Sergio Buccheri et al.

EXPERT OPINION ON DRUG SAFETY (2019)

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Review Cardiac & Cardiovascular Systems

Anticoagulation in Concomitant Chronic Kidney Disease and Atrial Fibrillation JACC Review Topic of the Week

Shankar Kumar et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

First report of a comparative patient-oriented perspective on the use of non-vitamin-K oral anticoagulants or vitamin-K antagonists in atrial fibrillation: patients' experiences, side-effects and practical problems leading to non-adherence

N. Bennaghmouch et al.

NETHERLANDS HEART JOURNAL (2019)

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Article Neurosciences

Adequate Adherence to Direct Oral Anticoagulant is Associated with Reduced Ischemic Stroke Severity in Patients with Atrial Fibrillation

Kazuo Yamashiro et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2019)

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Review Health Care Sciences & Services

Pharmacogenomics of Novel Direct Oral Anticoagulants: Newly Identified Genes and Genetic Variants

Sri H. Kanuri et al.

JOURNAL OF PERSONALIZED MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF

Leo Ungar et al.

CARDIOLOGY AND THERAPY (2019)

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Article Cardiac & Cardiovascular Systems

Efficacy and safety of rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation and a history of cancer: observations from ROCKETAF

Sean T. Chen et al.

EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES (2019)

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Article Cardiac & Cardiovascular Systems

2017 EACTS Guidelines on perioperative medication in adult cardiac surgery

Miguel Sousa-Uva et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2018)

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Article Medicine, General & Internal

From a direct oral anticoagulant to warfarin: reasons why patients switch

Aisling Barrett et al.

IRISH JOURNAL OF MEDICAL SCIENCE (2018)

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Review Medicine, Research & Experimental

Patients with atrial fibrillation and coronary artery disease - Double trouble

Ewelina Michniewicz et al.

ADVANCES IN MEDICAL SCIENCES (2018)

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Article Medicine, General & Internal

Clinical Outcomes and History of Fall in Patients with Atrial Fibrillation Treated with Oral Anticoagulation: Insights From the ARISTOTLE Trial

Meena P. Rao et al.

AMERICAN JOURNAL OF MEDICINE (2018)

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Article Cardiac & Cardiovascular Systems

Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis

Bianca Rocca et al.

EUROPEAN HEART JOURNAL (2018)

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Article Cardiac & Cardiovascular Systems

Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation

Paulus Kirchhof et al.

EUROPEAN HEART JOURNAL (2018)

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Article Cardiac & Cardiovascular Systems

The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation

Jan Steffel et al.

EUROPEAN HEART JOURNAL (2018)

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Article Cardiac & Cardiovascular Systems

Continued vs. interrupted direct oral anticoagulants at the time of device surgery, in patients with moderate to high risk of arterial thrombo-embolic events (BRUISE CONTROL-2)

David H. Birnie et al.

EUROPEAN HEART JOURNAL (2018)

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Article Medicine, General & Internal

Variations in clinical management of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation according to different equations for estimating renal function: Post hoc analysis of a prospective cohort

Vincenzo Livio Malavasi et al.

INTERNAL AND EMERGENCY MEDICINE (2018)

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Article Cardiac & Cardiovascular Systems

Major bleeding with old and novel oral anticoagulants: How tomanage it. Focus on general measures

Stefania Angela Di Fusco et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Major bleeding with old and novel oral anticoagulants: How to manage it. Focus on reversal agents

Stefania Angela Di Fusco et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

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Article Nursing

Adherence, knowledge, and perception about oral anticoagulants in patients with atrial fibrillation at high risk for thromboembolic events after radiofrequency ablation

Lily Smet et al.

JOURNAL OF ADVANCED NURSING (2018)

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Article Cardiac & Cardiovascular Systems

Adherence to Oral Anticoagulants in Atrial Fibrillation: An Australian Survey

Kehinde O. Obamiro et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2018)

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Review Neurosciences

Direct Oral Anticoagulant Agents: Pharmacologic Profile, Indications, Coagulation Monitoring, and Reversal Agents

Deborah K. Rose et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2018)

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Review Cardiac & Cardiovascular Systems

Oral Anticoagulation in Patients With Liver Disease

Arman Qamar et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Predictors of self-reported adherence to direct oral anticoagulation in a population of elderly men and women with non-valvular atrial fibrillation

Andrea P. Rossi et al.

JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2018)

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Article Hematology

Exploration of adherence and patient experiences with DOACs one year after switching from vitamin-K antagonists-insights from the switching study

John K. Bartoli-Abdou et al.

THROMBOSIS RESEARCH (2018)

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Article Medicine, General & Internal

Real-life experience of quality of life, treatment satisfaction, and adherence in patients receiving oral anticoagulants for atrial fibrillation

Michael Benzimra et al.

PATIENT PREFERENCE AND ADHERENCE (2018)

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Article Medicine, General & Internal

Comparison of claims vs patient-reported adherence measures and associated outcomes among patients with nonvalvular atrial fibrillation using oral anticoagulant therapy

Judith J. Stephenson et al.

PATIENT PREFERENCE AND ADHERENCE (2018)

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Review Cardiac & Cardiovascular Systems

Evidence Gaps in the Era of Non-Vitamin K Oral Anticoagulants

Konstantinos N. Aronis et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2018)

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Review Neurosciences

Direct Oral Anticoagulant Agents: Pharmacologic Profile, Indications, Coagulation Monitoring, and Reversal Agents

Deborah K. Rose et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2018)

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Article Health Care Sciences & Services

Type and doses of oral anticoagulants and adherence to anticoagulant treatment in elderly patients with atrial fibrillation: the ESPARTA study

Jose Maria Mostaza et al.

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH (2018)

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Article Critical Care Medicine

Antithrombotic Therapy for Atrial Fibrillation CHEST Guideline and Expert Panel Report

Gregory Y. H. Lip et al.

CHEST (2018)

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Review Hematology

Drug-drug interactions in an era of multiple anticoagulants: a focus on clinically relevant drug interactions

Sara R. Vazquez

BLOOD (2018)

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Review Cardiac & Cardiovascular Systems

ACC/AHA Versus ESC Guidelines on Dual Antiplatelet Therapy JACC Guideline Comparison

Davide Capodanno et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Asymptomatic Cerebral Infarction During Catheter Ablation for Atrial Fibrillation Comparing Uninterrupted Rivaroxaban and Warfarin (ASCERTAIN)

Takehiro Kimura et al.

JACC-CLINICAL ELECTROPHYSIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

A Prospective Randomized Trial of Apixaban Dosing During Atrial Fibrillation Ablation The AEIOU Trial

Matthew R. Reynolds et al.

JACC-CLINICAL ELECTROPHYSIOLOGY (2018)

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Article Hematology

Comparative effectiveness of direct oral anticoagulants and warfarin in patients with cancer and atrial fibrillation

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BLOOD ADVANCES (2018)

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Article Medicine, General & Internal

Real world adherence to oral anticoagulant in non-valvular atrial fibrillation patients in China

Xiao Xiang et al.

CURRENT MEDICAL RESEARCH AND OPINION (2018)

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Article Cardiac & Cardiovascular Systems

Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation

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EUROPACE (2017)

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Article Cardiac & Cardiovascular Systems

2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation

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HEART RHYTHM (2017)

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Article Cardiac & Cardiovascular Systems

Persistence With Dabigatran Therapy at 2 Years in Patients With Atrial Fibrillation

Miney Paquette et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)

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Article Hematology

Comparative effectiveness of venous thromboembolism prophylaxis options for the patient undergoing total hip and knee replacement: a network meta-analysis

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JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)

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Article Hematology

Association of body weight with efficacy and safety outcomes in phase III randomized controlled trials of direct oral anticoagulants: a systematic review and meta-analysis

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JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2017)

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Article Medicine, Research & Experimental

New digital adherence devices could prevent millions of strokes from atrial fibrillation by the end of the next century

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MEDICAL HYPOTHESES (2017)

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Letter Medicine, General & Internal

Uninterrupted Dabigatran versus Warfarin for Ablation in Atrial Fibrillation

Bo Lofgren et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation

Christopher P. Cannon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Idarucizumab for Dabigatran Reversal - Full Cohort Analysis

Charles V. Pollack et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Hematology

Adherence to oral anticoagulant therapy in patients with atrial fibrillation Focus on non-vitamin K antagonist oral anticoagulants

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THROMBOSIS AND HAEMOSTASIS (2017)

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Article Medicine, General & Internal

Assessment of quality of life, satisfaction with anticoagulation therapy, and adherence to treatment in patients receiving long-course vitamin K antagonists or direct oral anticoagulants for venous thromboembolism

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PATIENT PREFERENCE AND ADHERENCE (2017)

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Article Multidisciplinary Sciences

Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence

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SCIENTIFIC REPORTS (2017)

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Article Medicine, General & Internal

Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial

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AMERICAN JOURNAL OF MEDICINE (2017)

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Article Emergency Medicine

Idarucizumab for the Reversal of Dabigatran

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ANNALS OF EMERGENCY MEDICINE (2017)

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Article Cardiac & Cardiovascular Systems

Polypharmacy and major adverse events in atrial fibrillation: observations from the AFFIRM trial

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CLINICAL RESEARCH IN CARDIOLOGY (2016)

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Article Immunology

Comparison of subjective and objective adherence measures for preexposure prophylaxis against HIV infection among serodiscordant couples in East Africa

Nicholas Musinguzi et al.

AIDS (2016)

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Article Hematology

Evaluation of a Heparin-Calibrated Antifactor Xa Assay for Measuring the Anticoagulant Effect of Oral Direct Xa Inhibitors

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CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2016)

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Article Cardiac & Cardiovascular Systems

Does sinus rhythm conversion after cardiac surgery affect postoperative health- related quality of life?

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Article Cardiac & Cardiovascular Systems

Apixaban versus Warfarin for the Prevention of Periprocedural Cerebral Thromboembolism in Atrial Fibrillation Ablation: Multicenter Prospective Randomized Study

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Article Cardiac & Cardiovascular Systems

Assessing the Impact of Medication Adherence on Long-Term Cardiovascular Outcomes

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Article Cardiac & Cardiovascular Systems

Edoxaban Versus Warfarin in Atrial Fibrillation Patients at Risk of Falling ENGAGE AF-TIMI 48 Analysis

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Article Cardiac & Cardiovascular Systems

Clinically Significant Pocket Hematoma Increases Long-Term Risk of Device Infection BRUISE CONTROL INFECTION Study

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JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)

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Article Hematology

When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH

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Article Hematology

Use of the direct oral anticoagulants in obese patients: guidance from the SSC of the ISTH

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Article Cardiac & Cardiovascular Systems

Guidance for the practical management of the direct oral anticoagulants (DOACs) in VTE treatment

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Article Medicine, General & Internal

Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI

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NEW ENGLAND JOURNAL OF MEDICINE (2016)

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Article Medical Laboratory Technology

Diluted thrombin time reliably measures low to intermediate plasma dabigatran concentrations

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ANNALS OF CLINICAL BIOCHEMISTRY (2016)

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Letter Cardiac & Cardiovascular Systems

Study-Randomized Evaluation of Dabigatran Etexilate Compared to Warfarin in Pulmonary Vein Ablation: Assessment of an Uninterrupted Periprocedural Anticoagulation Strategy

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AMERICAN JOURNAL OF CARDIOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Chronic kidney disease in patients with cardiac rhythm disturbances or implantable electrical devices: clinical significance and implications for decision making-a position paper of the European Heart Rhythm Association endorsed by the Heart Rhythm Society and the Asia Pacific Heart Rhythm Society

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EUROPACE (2015)

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Article Cardiac & Cardiovascular Systems

Uninterrupted rivaroxaban vs. uninterrupted vitamin K antagonists for catheter ablation in non-valvular atrial fibrillation

Riccardo Cappato et al.

EUROPEAN HEART JOURNAL (2015)

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Article Hematology

Perioperative bridging anticoagulation during dabigatran or warfarin interruption among patients who had an elective surgery or procedure Substudy of the RE-LY trial

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THROMBOSIS AND HAEMOSTASIS (2015)

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Article Education, Scientific Disciplines

Coagulopathy in liver disease: a balancing act

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Desirability and feasibility of wireless electronic monitoring of medications in clinical trials

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Article Health Care Sciences & Services

Polypharmacy is Associated with an Increased Risk of Bleeding in Elderly Patients with Venous Thromboembolism

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Article Pharmacology & Pharmacy

Use of automated medication adherence monitoring in bipolar disorder research: pitfalls, pragmatics, and possibilities

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THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Periprocedural Stroke and Bleeding Complications in Patients Undergoing Catheter Ablation of Atrial Fibrillation With Different Anticoagulation Management Results From the Role of Coumadin in Preventing Thromboembolism in Atrial Fibrillation (AF) Patients Undergoing Catheter Ablation (COMPARE) Randomized Trial

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Article Cardiac & Cardiovascular Systems

Management of Antiplatelet and Anticoagulant Therapy in Patients With Atrial Fibrillation in the Setting of Acute Coronary Syndromes or Percutaneous Coronary Interventions

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Article Medicine, General & Internal

Non-compliance and inertia in hypertensive Spaniards at high cardiovascular risk: CUMPLE study

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CURRENT MEDICAL RESEARCH AND OPINION (2014)

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Article Cardiac & Cardiovascular Systems

Rivaroxaban vs. vitamin K antagonists for cardioversion in atrial fibrillation

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Article Medicine, General & Internal

Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials

Christian T. Ruff et al.

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Article Cardiac & Cardiovascular Systems

Guideline adherence in antithrombotic treatment after concomitant ablation surgery in atrial fibrillation patients

Henrica N. A. M. van Breugel et al.

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Article Pharmacology & Pharmacy

Co-administration of rivaroxaban with drugs that share its elimination pathways: pharmacokinetic effects in healthy subjects

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Article Gastroenterology & Hepatology

Coagulation in Liver Disease: A Guide for the Clinician

Patrick G. Northup et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2013)

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Review Pharmacology & Pharmacy

Anticoagulant Therapy with the Oral Direct Factor Xa Inhibitors Rivaroxaban, Apixaban and Edoxaban and the Thrombin Inhibitor Dabigatran Etexilate in Patients with Hepatic Impairment

Jochen Graff et al.

CLINICAL PHARMACOKINETICS (2013)

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Article Cardiac & Cardiovascular Systems

European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation

Hein Heidbuchel et al.

EUROPACE (2013)

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Article Medicine, General & Internal

Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial

Willem J. M. Dewilde et al.

LANCET (2013)

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Article Medicine, General & Internal

Edoxaban versus Warfarin in Patients with Atrial Fibrillation

Robert P. Giugliano et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Article Cardiac & Cardiovascular Systems

A randomised study of dabigatran in elective percutaneous coronary intervention in stable coronary artery disease patients

Pascal Vranckx et al.

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Article Urology & Nephrology

Chronic Kidney Disease and End-Stage Renal Disease Predict Higher Risk of Mortality in Patients with Primary Upper Gastrointestinal Bleeding

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AMERICAN JOURNAL OF NEPHROLOGY (2012)

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Article Cardiac & Cardiovascular Systems

Myocardial Ischemic Events in Patients With Atrial Fibrillation Treated With Dabigatran or Warfarin in the RE-LY (Randomized Evaluation of Long-Term Anticoagulation Therapy) Trial

Stefan H. Hohnloser et al.

CIRCULATION (2012)

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Review Cardiac & Cardiovascular Systems

Treatment of lone atrial fibrillation: a look at the past, a view of the present and a glance at the future

Sandro Gelsomino et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2012)

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Article Cardiac & Cardiovascular Systems

Risk of Bleeding With 2 Doses of Dabigatran Compared With Warfarin in Older and Younger Patients With Atrial Fibrillation An Analysis of the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) Trial

John W. Eikelboom et al.

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Article Medicine, General & Internal

Association between clusters of diseases and polypharmacy in hospitalized elderly patients: Results from the REPOSI study

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Article Cardiac & Cardiovascular Systems

Incidence and predictors of major complications from contemporary catheter ablation to treat cardiac arrhythmias

Marius Bohnen et al.

HEART RHYTHM (2011)

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Article Medicine, General & Internal

Apixaban versus Warfarin in Patients with Atrial Fibrillation

Christopher B. Granger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

Manesh R. Patel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Critical Care Medicine

Coagulopathy Does Not Protect Against Venous Thromboembolism in Hospitalized Patients With Chronic Liver Disease

Ousama Dabbagh et al.

CHEST (2010)

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Article Medicine, General & Internal

Dabigatran versus Warfarin in Patients with Atrial Fibrillation.

Stuart J. Connolly et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Article Cardiac & Cardiovascular Systems

Chronic atrial fibrillation:: Incidence, prevalence, and prediction of stroke using the Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack (CHADS2) risk stratification scheme

Stephan Rietbrock et al.

AMERICAN HEART JOURNAL (2008)

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Article Urology & Nephrology

Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: A cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA)

Christopher Keller et al.

BMC Nephrology (2008)

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Article Gastroenterology & Hepatology

Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism

PG Northup et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2006)

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Article Hematology

Ecarin chromogenic assay - A new method for quantitative determination of direct thrombin inhibitors like hirudin

U Lange et al.

PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS (2003)

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Review Gastroenterology & Hepatology

Coagulation disorders in liver disease

L Amitrano et al.

SEMINARS IN LIVER DISEASE (2002)

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