☆ 4.7 Review

Oxidative stress, the blood-brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

ACTA PHARMACEUTICA SINICA B (2023)

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Natural Products as Modulators of Nrf2 Signaling Pathway in Neuroprotection

Ignacio Moratilla-Rivera et al.

Summary: Neurodegenerative diseases (NDs) are common diseases affecting the West due to increased life expectancy. Cells accumulate oxidative damage, triggering neurodegeneration. The transcription factor Nrf2 regulates endogenous antioxidant systems and induces the transcription of genes containing ARE in response to prooxidant conditions. Natural products such as quercetin, curcumin, and terpenoids can positively modulate Nrf2, reducing oxidative damage to the nervous system. This review aims to update knowledge on the potential treatments for NDs by activating the Nrf2 pathway with secondary metabolites of health interest.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Advances in Neurodegenerative Diseases

Jeroen Van Schependom et al.

JOURNAL OF CLINICAL MEDICINE (2023)

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Article Neurosciences

Dietary antioxidants associated with slower progression of parkinsonian signs in older adults

Puja Agarwal et al.

Summary: This study investigated the relationship between dietary intake of antioxidant nutrients (carotenoids, vitamin E, and vitamin C) and the progression of parkinsonian signs in older adults. The findings suggest that a higher level of dietary antioxidant nutrients may slow the rate of parkinsonian sign progression in older adults.

NUTRITIONAL NEUROSCIENCE (2022)

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Review Biochemistry & Molecular Biology

Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?

Bindu D. Paul

Summary: In this study, we discuss the cytoprotective and neuroprotective properties of ET, which may be harnessed for combating neurodegeneration and decline during aging.

ANTIOXIDANTS & REDOX SIGNALING (2022)

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Review Medicine, Research & Experimental

Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

Md. Tanvir Kabir et al.

Summary: Neurodegenerative disorders (NDs) such as Alzheimer's disease and Parkinson's disease are characterized by oxidative stress (OS) and neuroinflammation. Carotenoids (CTs) have antioxidant and anti-inflammatory properties, which can help prevent and treat NDs.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Chemistry, Multidisciplinary

Quercetin alleviates styrene oxide-induced cytotoxicity in cortical neurons in vitro via modulation of oxidative stress and apoptosis

Sabrine Moujahed et al.

Summary: This study investigates the mechanisms of cytotoxicity of Styrene 7,8-oxide (SO) in cortical neurons and the neuroprotective potential of quercetin (QUER). The results suggest that SO decreases cell viability in a concentration-dependent manner, while QUER increases cell viability by reducing intracellular ROS, decreasing calcium overload, and restoring mitochondrial membrane depolarization. Furthermore, SO-induced cell death involves apoptotic, necrotic, and necroptotic pathways, and QUER exerts its neuroprotective effects mainly through its anti-apoptotic activity.

DRUG AND CHEMICAL TOXICOLOGY (2022)

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Article Neurosciences

Neuroprotective effects of curcumin on the cerebellum in a rotenone-induced Parkinson's Disease Model

Heba Fikry et al.

Summary: This study investigated the protective influence of curcumin on the cerebellum of rats with rotenone-induced Parkinson's disease. The results showed that curcumin could alleviate degenerative changes and neurotoxic effects in the cerebellum, as well as reduce oxidative stress. This suggests that dietary supplementation of curcumin may have neuroprotective effects against cerebellum-related Parkinson's disease symptoms.

CNS NEUROSCIENCE & THERAPEUTICS (2022)

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Review Food Science & Technology

Vitamin E in foodstuff: Nutritional, analytical, and food technology aspects

Farah Zaaboul et al.

Summary: Vitamin E is a group of isoprenoid chromanols known for their antioxidant activity, gene-regulation effects, and anti-inflammatory and nephroprotective properties. Animals can only obtain vitamin E through their diet, primarily from plant-based food. Processing can alter the vitamin E content and profile in food, making it important to identify and understand their levels in order to meet daily intake requirements.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2022)

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Article Biochemistry & Molecular Biology

Quercetin acts as a P-gp modulator via impeding signal transduction from nucleotide-binding domain to transmembrane domain

Ashutosh Singh et al.

Summary: The resistance of cancer cells to chemotherapy is a major challenge in drug discovery. P-glycoprotein (P-gp) overexpression is directly linked to multidrug resistance (MDR) in cancer cells. Quercetin has been reported to inhibit the activity of P-gp, but the underlying mechanism is not fully understood. This study reveals the mechanistic understanding of quercetin-induced modulation of P-gp using molecular docking and molecular dynamics simulation.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

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Article Biochemistry & Molecular Biology

Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer's disease

Hamieh Goshtasbi et al.

Summary: The brain is highly sensitive to oxidative stress, and maintaining a balance between oxidants and antioxidants is crucial for its normal function. Imbalance between reactive oxygen species (ROS) and cellular mechanisms can lead to neurodegenerative disorders. Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor that regulates the expression of antioxidant genes in response to oxidative stress. This review focuses on the mechanisms of generation of endogenous and exogenous oxidants and the role of antioxidants in neural cells through the NRF2-ARE signaling pathway.

NEUROCHEMISTRY INTERNATIONAL (2022)

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Review Cell Biology

Dietary Plant Polyphenols as the Potential Drugs in Neurodegenerative Diseases: Current Evidence, Advances, and Opportunities

Lu Yan et al.

Summary: Neurodegenerative diseases, characterized by neuronal degeneration, still have limited understanding of their mechanisms. Dietary plant polyphenols are believed to have neuroprotective effects, but their low bioavailability hinders clinical application. This review summarizes the mechanisms associated with neurodegenerative diseases and discusses the neuroprotective effects of dietary plant polyphenols, as well as the factors contributing to low bioavailability.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Article Food Science & Technology

Dietary flavonoids and human top-ranked diseases: The perspective of in vivo bioactivity and bioavailability

Di Zhou et al.

Summary: Dietary flavonoids have attracted attention for their protective and therapeutic effects on cancers, cardiovascular and cerebrovascular diseases, and NDs. Strategies to enhance the bioavailability of dietary flavonoids, such as using various nano-systems, have shown promising results in increasing their therapeutic index. This suggests the potential utility of dietary flavonoids as complementary therapies for these diseases.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2022)

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Article Instruments & Instrumentation

Quercetin-biapigenin nanoparticles are effective to penetrate the blood-brain barrier

Ana Isabel Oliveira et al.

Summary: The study investigated the protective effect of nanoparticles on oxidative stress in brain cells, as well as their permeability through the blood-brain barrier. The nanoparticles were found to reduce toxicity effectively and have higher permeability than free compounds.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2022)

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Article Nutrition & Dietetics

Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer's Disease

Giuseppe Caruso et al.

Summary: Cognitive impairment is a significant public health problem associated with normal aging and neurodegenerative disorders. Dietary polyphenols, particularly phenolic acids, play an important role in healthy aging and the prevention of cognitive decline.

NUTRIENTS (2022)

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Article Nutrition & Dietetics

The Citrus Flavonoid Hesperetin Encounters Diabetes-Mediated Alzheimer-Type Neuropathologic Changes through Relieving Advanced Glycation End-Products Inducing Endoplasmic Reticulum Stress

Mei-Chou Lai et al.

Summary: The study found that hesperetin, a citrus flavonoid, can counteract the pathophysiological changes of Alzheimer's disease induced by advanced glycation end-products (AGEs). The underlying mechanisms include reducing oxidative stress and apoptosis, regulating protein expression, and decreasing endoplasmic reticulum stress.

NUTRIENTS (2022)

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Review Biochemistry & Molecular Biology

Novel Nutraceutical Compounds in Alzheimer Prevention

Ricardo Benjamin Maccioni et al.

Summary: The incidence of Alzheimer's disease is increasing worldwide. Prevention efforts, such as adopting a healthy lifestyle, using disease-modifying agents, and focusing on nutrition, can help mitigate symptoms or even prevent AD.

BIOMOLECULES (2022)

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Review Biochemistry & Molecular Biology

Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases

May Nasser Bin-Jumah et al.

Summary: Lycopene, a bioactive red pigment found in plants, has been shown to have positive effects on human health, including preventing chronic diseases such as diabetes and cardiovascular diseases. It acts as an antioxidant, lowers blood pressure, and improves lipid levels, thus protecting against coronary artery disease and hypertension.

ANTIOXIDANTS (2022)

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Article Oncology

Genistein mitigates oxidative stress and inflammation by regulating Nrf2/HO-1 and NF-κB signaling pathways in hypoxic-ischemic brain damage in neonatal mice

Yuan Li et al.

Summary: Genistein treatment effectively reduces cerebral infarction and attenuates neuronal injury and apoptosis in neonatal hypoxic-ischemic brain damage (HIBD). It also contributes to long-term recovery of neurological outcomes and reduces oxidative stress and neuroinflammation. Additionally, genistein increases cell viability, reverses neuronal injury, and decreases cell apoptosis after oxygen-glucose deprivation/reperfusion (OGD/R) injury. The neuroprotective effects of genistein are mediated through the Nrf2/HO-1 and NF-kappa B signaling pathways.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Article Biology

Vitamin E: Where Are We Now in Vascular Diseases?

Anahita Garg et al.

Summary: This review examines the role of dietary vitamin E as an antioxidant and bioactive molecule in promoting vascular health. While the antioxidant effect of vitamin E is well established, its capacity as a promising regulatory molecule in the control of the vascular system needs further research. The article also discusses foods rich in vitamin E and potential toxicological effects of excessive supplemental vitamin E.

LIFE-BASEL (2022)

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Article Nutrition & Dietetics

Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and a randomized, double-blind, placebo-controlled trial

Minju Sim et al.

Summary: Vitamin C status is positively related to mental vitality, and supplementation can enhance work motivation and attentional focus, leading to improved performance on cognitive tasks demanding sustained attention.

EUROPEAN JOURNAL OF NUTRITION (2022)

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Article Biochemistry & Molecular Biology

Oxidative stress and regeneration

Morana Jaganjac et al.

Summary: Regeneration is the process of replacing damaged cells/tissues/organs, which depends on various factors and involves different mechanisms. Oxidative stress, particularly involving 4-HNE, may play a significant role in neuroregeneration, highlighting its potential benefits.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Review Endocrinology & Metabolism

Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies

Jaydeep Roy et al.

Summary: In this review, the developmental trends and neuroprotective mechanisms of melatonin therapies for Alzheimer's disease (AD) are examined. Melatonin has been shown to alleviate various pathological processes in AD and beneficially affect behavior in animal models. Clinical studies demonstrate positive effects of melatonin on sleep, cognition, behavior, and psychiatric symptoms in AD patients.

FRONTIERS IN NEUROENDOCRINOLOGY (2022)

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Review Biochemistry & Molecular Biology

Nutraceuticals as Modulators of Autophagy: Relevance in Parkinson's Disease

Michal Rakowski et al.

Summary: This review focuses on the modulation of autophagy by selected vitamins and nutraceuticals, and their potential value in the treatment of neurodegenerative diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pharmacology & Pharmacy

Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications

Jin Feng et al.

Summary: Metformin is the oldest and most commonly used first-line antidiabetic drug due to its good clinical efficacy, safety, affordability, and accessibility. Recent studies have found that metformin may have potential as a therapeutic drug in various areas. This review article focuses on the main mechanism of metformin, particularly its impact on mitochondria. With the emerging evidence, mitochondria have been identified as central in the application of metformin. The article explores the role of mitochondria in the pharmacological and toxicological effects of metformin, providing insights for its repurposing and the treatment of human diseases.

PHARMACOLOGICAL RESEARCH (2022)

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Article Food Science & Technology

Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington's disease

Pradeep Singh et al.

Summary: Huntington's disease is a neurodegenerative disease that poses a major threat to the elderly population. It is caused by the expansion of repeats, triggering the formation of a mutant huntingtin protein that leads to neuronal death. Herbal nutraceuticals, enriched with antioxidants, are believed to have significant effects on Huntington's disease.

JOURNAL OF FUNCTIONAL FOODS (2022)

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Article Immunology

Silymarin constrains diacetyl-prompted oxidative stress and neuroinflammation in rats: involvements of Dyn/GDNF and MAPK signaling pathway

Manar Mohammed El Tabaa et al.

Summary: This study reveals the protective and therapeutic effects of silymarin (Sily) on diacetyl (DA)-induced neuroinflammation. Sily is found to maintain cognitive and behavioral functions, alleviate brain antioxidant status, and inhibit microglial activation. It positively regulates cytokine levels and down-regulates the MAPK pathway, thus protecting neurons from inflammatory damage.

INFLAMMOPHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells

Caterina Peggion et al.

Summary: ALS is a fatal neurodegenerative disorder characterized by the loss of motor neurons in the brain and spinal cord. Mutations in the Cu/Zn superoxide dismutase (SOD1) gene have been found to be related to ALS, affecting non-neuronal cells, such as glial and skeletal muscle cells, and leading to alterations in redox balance and Ca2+ homeostasis. These effects contribute to the progression of ALS.

ANTIOXIDANTS (2022)

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Article Neurosciences

Factors influencing the blood-brain barrier permeability

Yibin Zhao et al.

Summary: The blood-brain barrier (BBB) is a dynamic structure that protects the brain and maintains a stable microenvironment. Various cellular components and structural elements contribute to the integrity of the BBB. Transporters and transcytosis regulate the movement of substances, and differences in localization and expression affect transport properties. Inflammation and other factors can alter BBB permeability by influencing structural components and barrier function. Understanding the factors influencing BBB permeability is important for identifying potential therapeutic targets for protecting the BBB and delivering drugs to the central nervous system.

BRAIN RESEARCH (2022)

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Article Biochemistry & Molecular Biology

Redox biology in neurodegenerative disorders

Andrey Y. Abramov

Summary: This Special Issue discusses the role of oxidative stress and alteration of redox signaling in the mechanism of neuronal loss in neurodegenerative diseases, as well as explores possible prevention strategies.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Plant Sciences

Ethnomedicinal plants used for the treatment of neurodegenerative diseases in Himachal Pradesh, India in Western Himalaya

Kiran Sharma et al.

Summary: This study focuses on the usage of different ethnomedicinal plants in the treatment of neurodegenerative diseases in different regions of Himachal Pradesh, India. The study reveals 73 ethnomedicinal plants used for various neurological disorders, with a particular emphasis on plants used for epilepsy. The study also highlights the importance of phytochemicals and their neuroprotective effects in traditional medicine.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Ergothioneine and central nervous system diseases

Noritaka Nakamichi et al.

Summary: This article discusses the association between Ergothioneine (ERGO) and central nervous system (CNS) diseases, highlighting the lower ERGO concentrations in patients with cognitive impairment, Parkinson's disease, and frailty compared to healthy individuals. ERGO exhibits a protective effect against neurotoxins and improves symptoms in animal models of cognitive impairment, depression, and epilepsy.

NEUROCHEMICAL RESEARCH (2022)

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Review Nutrition & Dietetics

Age-Associated Glia Remodeling and Mitochondrial Dysfunction in Neurodegeneration: Antioxidant Supplementation as a Possible Intervention

Anna Picca et al.

Summary: Aging leads to significant remodeling of glia, impairing their functions and exacerbating neuroinflammation and neurodegeneration. Antioxidant supplementation-based strategies may help alleviate these processes.

NUTRIENTS (2022)

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Article Biochemistry & Molecular Biology

Melatonin attenuates MPP+-induced apoptosis via heat shock protein in a Parkinson's disease model

Yu Jin Jung et al.

Summary: Heat shock proteins (HSPs) and melatonin play important roles in protecting dopamine neurons from the pathomechanisms of Parkinson's disease (PD). This study investigates the protective properties of melatonin in an in vitro PD model and demonstrates that melatonin can protect against neuronal toxicity by promoting anti-oxidative and anti-apoptotic properties through the HSF1/HSP70 pathway.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Article Plant Sciences

Advances in fucoxanthin chemistry and management of neurodegenerative diseases

Na Li et al.

Summary: This study explores the mechanisms and targets of fucoxanthin in the management of neurodegenerative diseases, highlighting the importance of communication between the brain and the gut, and presenting new insights for future therapeutic directions based on the application of artificial intelligence.

PHYTOMEDICINE (2022)

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Article Engineering, Biomedical

Brain-targeting, acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery

Shenqi Zhang et al.

Summary: Research has developed natural compound-derived nanoparticles that can be used both as a therapeutic agent for stroke treatment and as a carrier for efficient drug delivery to the brain, potentially improving stroke treatment.

BIOACTIVE MATERIALS (2022)

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Article Biochemistry & Molecular Biology

A microbial transporter of the dietary antioxidant ergothioneine

Daniel G. Dumitrescu et al.

Summary: This study identified a mechanism by which Helicobacter pylori acquires low-molecular-weight-thiols from the host environment and revealed a new mechanism of microbial redox regulation in the gut.

CELL (2022)

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Review Neurosciences

Effect of nutrition on neurodegenerative diseases. A systematic review

Vittorio Emanuele Bianchi et al.

Summary: Neurodegenerative diseases are characterized by the loss of neurons in the brain, and nutrition plays a crucial role in their pathogenesis and development. The Mediterranean diet, nutritional support, and calorie-controlled diets have a protective effect against cognitive decline and diseases like Alzheimer's and Parkinson's, while malnutrition and insulin resistance are significant risk factors.

NUTRITIONAL NEUROSCIENCE (2021)

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Article Neurosciences

Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR7/SNCA axis

Dong-Fang Shen et al.

Summary: In this study, astaxanthin was shown to protect against Parkinson's disease-induced neuron damage by targeting the miR-7/SNCA axis and suppressing ER stress. These findings suggest that astaxanthin may be a potential therapeutic agent for PD.

NEUROSCIENCE RESEARCH (2021)

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Article Neurosciences

Impaired intracellular trafficking of sodium-dependent vitamin C transporter 2 contributes to the redox imbalance in Huntington's disease

Adriana Covarrubias-Pinto et al.

Summary: Huntington's disease is a neurodegenerative disorder caused by a glutamine expansion in the huntingtin gene, associated with energy metabolism failure and oxidative damage. Ascorbic acid, a powerful antioxidant highly concentrated in the brain, modulates neuronal metabolism through the SVCT2 transporter. Alterations in SVCT2 trafficking to the plasma membrane in resting and active conditions in HD result in redox imbalance during early stages of the disease.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

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Review Chemistry, Multidisciplinary

New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease

Feng Zhang et al.

Summary: As the population ages, Alzheimer's disease will impose social and economic burdens globally. Current drugs for AD only provide symptomatic relief with limited impact on disease progression. Therefore, early diagnosis and multi-target interventions are crucial for promising outcomes in AD treatment.

ACTA PHARMACOLOGICA SINICA (2021)

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Article Cell Biology

Involvement of α7nAChR in the Protective Effects of Genistein Against β-Amyloid-Induced Oxidative Stress in Neurons via a PI3K/Akt/Nrf2 Pathway-Related Mechanism

Jianbin Guo et al.

Summary: Genistein, a phytoestrogen, shows significant neuroprotective effects against Aβ-induced oxidative stress by modulating α7nAChR signaling and activating the PI3K/Akt/Nrf2 pathway. This study reveals the molecular mechanism underlying the protective effects of Genistein on Aβ-induced oxidative injury.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

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Review Chemistry, Medicinal

Oxidative stress mitigation by antioxidants - An overview on their chemistry and influences on health status

Aurelia Magdalena Pisoschi et al.

Summary: This review paper examines the chemistry of oxidative stress mitigation by antioxidants, highlighting the crucial role of balancing pro-oxidant and antioxidant species. It discusses the association between oxidative stress and various diseases, elucidating the types, mechanisms, and defense strategies of antioxidants.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Developmental Biology

Gallic acid protects cerebral cortex, hippocampus, and striatum against oxidative damage and cholinergic dysfunction in an experimental model of manic-like behavior: Comparison with lithium effects

Vania Machado Recart et al.

Summary: The study found that gallic acid can alleviate hyperlocomotion and brain oxidative damage induced by ketamine in a manic model, as well as prevent cholinergic signaling dysfunction.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2021)

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Review Clinical Neurology

Dietary Insights in Neurological Diseases

Sergio A. Ramirez-Salazar et al.

Summary: Dietary interventions can play a role in the pathophysiology of common neurological disorders, with plant-based, low-fat, high-fiber diets potentially reducing the burden of these diseases. Common neurological disorders share similar pathophysiological mechanisms, and dietary interventions can influence these processes to improve clinical outcomes.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2021)

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Review Endocrinology & Metabolism

Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis

Alicia Aliena-Valero et al.

Summary: This systematic review found that uric acid has neuroprotective effects in animal models of ischemic stroke, significantly reducing infarct size, improving blood-brain barrier integrity, and ameliorating neurofunctional deficits. Despite some heterogeneity and publication bias, the study suggests the potential therapeutic benefits of uric acid in ischemic stroke.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

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Article Pharmacology & Pharmacy

The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis

Edward J. Calabrese et al.

Summary: Sulforaphane (SFN) induces hormetic dose responses through Nrf2 activation, reducing human-related pathologies and enhancing stem cell proliferation. SFN shows potential utility in cancer treatment and plays a role in limiting age-related damage and disease progression.

PHARMACOLOGICAL RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Unusual Bioactive Compounds with Antioxidant Properties in Adjuvant Therapy Supporting Cognition Impairment in Age-Related Neurodegenerative Disorders

Natalia Cichon et al.

Summary: Age-related cognitive decline can be improved through proper diet, comprehensive nutrition, and a healthy lifestyle. The effectiveness in preventing dementia is particularly important before symptoms appear, and the impact of diet and nutrition on cognitive function can be continuously observed.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress

Anamaria Jurcau

Summary: With an aging population, the incidence of neurodegenerative diseases is on the rise, and current treatments primarily focus on symptom relief. Preventative measures such as a healthy lifestyle and avoidance of oxidative stress are recommended.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Impact of Innovative Technologies on the Content of Vitamin C and Its Bioavailability from Processed Fruit and Vegetable Products

Monika Mieszczakowska-Frac et al.

Summary: Thermal treatments are commonly used to extend the shelf-life of vegetable and fruit products by inactivating microorganisms and enzymes, but they can also lead to negative changes in the product quality. In response, the food industry is exploring non-thermal processing technologies as alternatives. These technologies, such as minimal processing, high-pressure processing, high-pressure homogenization, ultrasounds, and pulsed electric fields, offer gentler alternatives to thermal treatments.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators

Eliana Jardim Fernandes et al.

Summary: The study showed that lutein-loaded nanoparticles protected against locomotor damage and neurotoxicity induced by Parkinson's disease model in fruit flies, restored dopamine levels and oxidative stress markers.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Review Biochemistry & Molecular Biology

Signaling mechanisms underlying inhibition of neuroinflammation by resveratrol in neurodegenerative diseases

Juan Huang et al.

Summary: Neurodegenerative diseases, such as Alzheimer's and Parkinson's, involve progressive loss of neurons and are common in the elderly. Excessive microglial activation leading to neuroinflammation is closely linked to the onset and progression of these diseases. Natural products like resveratrol show therapeutic potential in modulating microglial polarization and controlling neuroinflammation in the treatment of NDs.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Review Pharmacology & Pharmacy

Melatonin as a promising modulator of aging related neurodegenerative disorders: Role of microRNAs

Arezoo Fathalizadeh Alamdari et al.

Summary: Melatonin (MLT) plays a crucial role in regulating various biological processes and possesses antioxidant, anti-inflammatory, and anti-cancer properties. The microRNAs family also contributes to promoting the advantageous effects of MLT. The joint impact of MLT and miRNAs in anti-aging has garnered significant attention recently.

PHARMACOLOGICAL RESEARCH (2021)

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Article Food Science & Technology

Lycopene can modulate the LRP1 and RAGE transporters expression at the choroid plexus in Alzheimer's disease rat

Rui Wang et al.

Summary: The study showed that lycopene administration can reduce A beta accumulation, increase LRP1 levels, and decrease RAGE levels in the CSF or CP of AD rats. Additionally, lycopene administration enhances antioxidant enzyme systems, suppresses the NF-kappa B signaling pathway, and inhibits the production of pro-inflammatory cytokines in the CP of AD rats.

JOURNAL OF FUNCTIONAL FOODS (2021)

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Review Cell Biology

The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy

Christian Grinan-Ferre et al.

Summary: As the elderly population grows, so does the prevalence of neurodegenerative diseases. Lifestyle factors, including nutrition, exercise, and education, play a crucial role in influencing the aging process. Resveratrol, a dietary polyphenol, has antioxidant properties and can protect the nervous system from age-related decline and diseases like Alzheimer's and Parkinson's.

AGEING RESEARCH REVIEWS (2021)

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Article Neurosciences

Genistein Prevents Hypoxia-Induced Cognitive Dysfunctions by Ameliorating Oxidative Stress and Inflammation in the Hippocampus

Mohammad Rumman et al.

Summary: The study demonstrated that GE can ameliorate hypoxia-induced cognitive dysfunction in mice by reducing oxidative stress, suppressing neuroinflammation, and enhancing the expression of neuroprotective genes in the hippocampus.

NEUROTOXICITY RESEARCH (2021)

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Review Food Science & Technology

Protective effects of anthocyanins on neurodegenerative diseases

Ping Li et al.

Summary: Anthocyanins, a group of phytochemicals, have shown potential in ameliorating neurodegenerative diseases by protecting neurons, glial cells, and hippocampal nerve cells against damage. Additionally, they also reduce oxidative stress, suppress inflammation, and inhibit apoptosis in nerve cells, making them a potential dietary supplement to prevent against neurodegenerative diseases.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS

Elena Obrador et al.

Summary: Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease characterized by motor neuron degeneration leading to muscle weakness and paralysis. Mitochondrial dysfunction plays a significant role in ALS pathophysiology, affecting disease progression. Research indicates that targeting mitochondrial biology may offer potential therapeutic approaches to slow down ALS progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Current Trends in Neurodegeneration: Cross Talks between Oxidative Stress, Cell Death, and Inflammation

Tapan Behl et al.

Summary: The human body is complex and comprises various living cells and extracellular material forming tissues, organs, and organ systems. While most human cells turnover regularly, postmitotic nerve cells have the exceptional ability to regenerate and sustain throughout an individual's life to safeguard the central nervous system's functioning. Neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, result from factors like oxidative stress, cell death, and neuroinflammation, causing neuronal degradation and impacting the quality of life for millions worldwide.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Neurosciences

A Review of Oxidative Stress Products and Related Genes in Early Alzheimer's Disease

Federica Cioffi et al.

Summary: Oxidative stress is closely associated with the progression of Alzheimer's disease, leading to modifications in lipids, DNA, RNA, and proteins in the brain. Various biomarkers have been developed to identify oxidative stress levels in AD, but they may not differentiate well from other neurodegenerative disorders. Redox proteomics approaches provide specificity in identifying oxidative stress-associated biomarkers specific to AD pathology.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Article Biochemistry & Molecular Biology

Analysis of silymarin-modulating effects against acrylamide-induced cerebellar damage in male rats: Biochemical and pathological markers

Hany Elsawy et al.

Summary: The study demonstrated that silymarin has a protective effect against acrylamide-induced cerebellar neurotoxicity in rats, alleviating oxidative stress and apoptosis. This provides new evidence for the potential applications of silymarin in preventing neurologic damage.

JOURNAL OF CHEMICAL NEUROANATOMY (2021)

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Article Endocrinology & Metabolism

Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway

Xia Zhu et al.

Summary: This study demonstrates that hesperetin has anxiolytic and antidepressant effects in diabetic rats, potentially through activation of the Nrf2/ARE pathway. Furthermore, activation of Nrf2/ARE pathway by hesperetin is facilitated by increased nuclear Nrf2 phosphorylation through PKC activation and GSK-3 beta inhibition.

METABOLIC BRAIN DISEASE (2021)

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Review Endocrinology & Metabolism

Glial Metabolic Reprogramming in Amyotrophic Lateral Sclerosis

Patricia Cassina et al.

Summary: ALS is a human neurodegenerative disorder that leads to progressive muscle paralysis with no current cure. Recent studies suggest that changes in glial cell mitochondrial function are closely linked to disease progression in ALS, offering potential new therapeutic strategies.

NEUROIMMUNOMODULATION (2021)

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Review Cell Biology

Redox Homeostasis and Prospects for Therapeutic Targeting in Neurodegenerative Disorders

Musbau Adewumi Akanji et al.

Summary: Reactive species in cellular metabolism impact signaling processes and cellular stability, with redox imbalance potentially leading to oxidative damage. In neurodegenerative diseases, redox imbalance plays a significant role in disease progression, offering opportunities for new therapeutic strategies.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Biochemistry & Molecular Biology

Phenolic compounds that cross the blood-brain barrier exert positive health effects as central nervous system antioxidants

Dafne Velasquez-Jimenez et al.

Summary: The blood-brain barrier is a vital structure that regulates the access of compounds to the central nervous system. Despite being non-essential xenobiotics, some phenolic compounds are able to cross the barrier and accumulate in the brain, where they can have positive effects on brain health.

FOOD & FUNCTION (2021)

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Article Nutrition & Dietetics

Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants

Xiaoran Liu et al.

Summary: This study suggests that higher levels of alpha-carotene in the blood are associated with higher global cognition scores in a US population at risk for cognitive decline. The higher alpha-carotene levels in the blood reflect greater intakes of fruits and other types of vegetables, and lower intakes of butter, margarine, and meat. Higher circulating levels of lutein and zeaxanthin reflect a dietary pattern with high intakes of fruits, green leafy vegetables, and cheese, and low consumption of fried foods. Objective nutrient markers in the blood may help in implementing tailored dietary interventions for the prevention of cognitive decline.

JOURNAL OF NUTRITIONAL SCIENCE (2021)

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Article Pharmacology & Pharmacy

Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation

Sha Xiong et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Clinical Neurology

Uric Acid Treatment After Stroke Prevents Long-Term Middle Cerebral Artery Remodelling and Attenuates Brain Damage in Spontaneously Hypertensive Rats

Elena Jimenez-Xarrie et al.

TRANSLATIONAL STROKE RESEARCH (2020)

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Review Pharmacology & Pharmacy

The blood-brain barrier: Physiology and strategies for drug delivery

Rucha Pandit et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Medicine, Research & Experimental

Pathophysiology and Therapeutic Perspectives of Oxidative Stress and Neurodegenerative Diseases: A Narrative Review

Martina Rekatsina et al.

ADVANCES IN THERAPY (2020)

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Article Neurosciences

Comparing the Neuroprotective Effects of Caffeic Acid in Rat Cortical Slices and Caenorhabditis elegans: Involvement of Nrf2 and SKN-1 Signaling Pathways

Aline Colonnello et al.

NEUROTOXICITY RESEARCH (2020)

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Review Developmental Biology

Postnatal development of cerebrovascular structure and the neurogliovascular unit

Vanessa Coelho-Santos et al.

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2020)

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Review Engineering, Biomedical

Microphysiological systems for recapitulating physiology and function of blood-brain barrier

Suyeong Seo et al.

BIOMATERIALS (2020)

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Review Agriculture, Multidisciplinary

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

Bingren Tian et al.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2020)

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Review Clinical Neurology

The global burden of neurological disorders: translating evidence into policy

Valery L. Feigin et al.

LANCET NEUROLOGY (2020)

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Article Chemistry, Medicinal

Haematococcus pluvialis-Derived Astaxanthin Is a Potential Neuroprotective Agent against Optic Nerve Ischemia

Wei-Ning Lin et al.

MARINE DRUGS (2020)

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Article Neurosciences

Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice

Miren Ettcheto et al.

MOLECULAR NEUROBIOLOGY (2020)

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Article Neurosciences

Epigallocatechin Gallate Mitigates the Methamphetamine-Induced Striatal Dopamine Terminal Toxicity by Preventing Oxidative Stress in the Mouse Brain

Allen L. Pan et al.

NEUROTOXICITY RESEARCH (2020)

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Review Pharmacology & Pharmacy

Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives

Ramesh Kumar Saini et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Nutrition & Dietetics

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

Anna Winiarska-Mieczan et al.

NUTRIENTS (2020)

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Review Biochemistry & Molecular Biology

Neuroprotective Effects of Quercetin in Alzheimer's Disease

Haroon Khan et al.

BIOMOLECULES (2020)

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Review Biochemistry & Molecular Biology

The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders

Francesca Oppedisano et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Vitamin C controls neuronal necroptosis under oxidative stress

Luciano Ferrada et al.

REDOX BIOLOGY (2020)

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Review Nutrition & Dietetics

Dietary Factors and Neurodegenerative Disorders: An Umbrella Review of Meta-Analyses of Prospective Studies

Janett Barbaresko et al.

ADVANCES IN NUTRITION (2020)

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Review Environmental Sciences

Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Javad Sharifi-Rad et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

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Review Biochemistry & Molecular Biology

Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection

Ekta Singh et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Article Cell Biology

Quercetin mitigates monosodium glutamate-induced excitotoxicity of the spinal cord motoneurons in aged rats via p38 MAPK inhibition

Alaa El-Din L. Firgany et al.

ACTA HISTOCHEMICA (2020)

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Review Pharmacology & Pharmacy

Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders

Eva Gil-Martins et al.

PHARMACOLOGY & THERAPEUTICS (2020)

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Review Medicine, Research & Experimental

The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway

Tahereh Farkhondeh et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Review Pharmacology & Pharmacy

Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration

Md Sahab Uddin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Carotenoids and Chlorophylls as Antioxidants

Antonio Perez-Galvez et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

Dietary Antioxidants and Parkinson's Disease

Han-A Park et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

Antioxidant and Anti-Inflammatory Effects ofCitrusFlavonoid Hesperetin: Special Focus on Neurological Disorders

Amjad Khan et al.

ANTIOXIDANTS (2020)

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Article Clinical Neurology

Dietary Antioxidants and Risk of Parkinson's Disease in the Singapore Chinese Health Study

Ariel Fangting Ying et al.

MOVEMENT DISORDERS (2020)

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Article Pharmacology & Pharmacy

Neuronal degeneration and oxidative stress in the SNc of 6-OHDA intoxicated rats; improving role of silymarin long-term treatment

Rasool Haddadi et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Neuroprotective Effect of Antioxidants in the Brain

Kyung Hee Lee et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Neurosciences

Long-term oral melatonin alleviates memory deficits, reduces amyloid-β deposition associated with downregulation of BACE1 and mitophagy in APP/PS1 transgenic mice

Cuimei Sun et al.

NEUROSCIENCE LETTERS (2020)

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Article Nutrition & Dietetics

Low anthocyanin plum nectar does not impact cognition, blood pressure and gut microbiota in healthy older adults: A randomized crossover trial

Ezinne O. Igwe et al.

NUTRITION RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis

Elena Obrador et al.

ANTIOXIDANTS (2020)

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Review Biochemistry & Molecular Biology

A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

Nur Zuliani Ramli et al.

ANTIOXIDANTS (2020)

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Article Food Science & Technology

Aluminum chloride-induced amyloid β accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin

Kitipong Promyo et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

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Review Biochemistry & Molecular Biology

Efficacy of Sulforaphane in Neurodegenerative Diseases

Giovanni Schepici et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Melatonin Rescues the Dendrite Collapse Induced by the Pro-Oxidant Toxin Okadaic Acid in Organotypic Cultures of Rat Hilar Hippocampus

Hector Solis-Chagoyan et al.

MOLECULES (2020)

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Article Nutrition & Dietetics

Association of Antioxidant Vitamins A, C, E and Carotenoids with Cognitive Performance over Time: A Cohort Study of Middle-Aged Adults

May A. Beydoun et al.

NUTRIENTS (2020)

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Review Pharmacology & Pharmacy

Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease

Md. Habibur Rahman et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Lycopene Exerts Neuroprotective Effects After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the Nuclear Factor Erythroid-2 Related Factor 2/Nuclear Factor-κ-Gene Binding Pathway

Changchang Fu et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Neurosciences

A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity

Hossam Kadry et al.

FLUIDS AND BARRIERS OF THE CNS (2020)

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Article Neurosciences

Effects of Ferulic Acid and Angelica archangelica Extract (Feru-guard®) on Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Prospective Trial

Chiaki Kudoh et al.

JOURNAL OF ALZHEIMERS DISEASE REPORTS (2020)

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Review Food Science & Technology

Reactive Oxygen Species and Antioxidants in Postharvest Vegetables and Fruits

Karlia Meitha et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCE (2020)

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Review Chemistry, Medicinal

Emerging Proof of Protein Misfolding and Interactions in Multifactorial Alzheimer's Disease

Md Sahab Uddin et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Lipid Peroxidation and Antioxidant Supplementation in Neurodegenerative Diseases: A Review of Human Studies

Snjezana Petrovic et al.

ANTIOXIDANTS (2020)

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Article Cell Biology

Possible mechanisms of lycopene amelioration of learning and memory impairment in rats with vascular dementia

Ning-Wei Zhu et al.

NEURAL REGENERATION RESEARCH (2020)

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Article Chemistry, Medicinal

Fucoxanthin Attenuates Behavior Deficits and Neuroinflammatory Response in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Parkinson's Disease in Mice

Guoqing Sun et al.

PHARMACOGNOSY MAGAZINE (2020)

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Article Nutrition & Dietetics

Blood-brain barrier transport and neuroprotective potential of blackberry-digested polyphenols: an in vitro study

Ines Figueira et al.

EUROPEAN JOURNAL OF NUTRITION (2019)

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Article Neurosciences

Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3 Signaling in LPS-Treated Adult Mice

Muhammad Sohail Khan et al.

MOLECULAR NEUROBIOLOGY (2019)

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Review Medicine, Research & Experimental

A review for the pharmacological effect of lycopene in central nervous system disorders

Dongjian Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Neurosciences

The Association between Mushroom Consumption and Mild Cognitive Impairment: A Community-Based Cross-Sectional Study in Singapore

Lei Feng et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

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Article Neurosciences

Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model

Muhammad Ikram et al.

MOLECULAR NEUROBIOLOGY (2019)

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Review Biochemistry & Molecular Biology

Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence

Marziyeh Hajialyani et al.

MOLECULES (2019)

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Article Neurosciences

The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats

Xiaolin Deng et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Nutrition & Dietetics

Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

Tahir Muhammad et al.

NUTRIENTS (2019)

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Article Multidisciplinary Sciences

Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance

Rui-Yuan Pan et al.

SCIENCE ADVANCES (2019)

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Article Geriatrics & Gerontology

Astaxanthin supplementation modulates cognitive function and synaptic plasticity in young and aged mice

Bethany Grimmig et al.

GEROSCIENCE (2019)

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Article Chemistry, Multidisciplinary

Increased BBB permeability contributes to EGCG-caused cognitive function improvement in natural aging rats: pharmacokinetic and distribution analyses

Bin-bin Wei et al.

ACTA PHARMACOLOGICA SINICA (2019)

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Article Biochemistry & Molecular Biology

Curcumin analogues attenuate Aβ25-35-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways

Jialin Xu et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2019)

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Review Biochemistry & Molecular Biology

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

Justine Renaud et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Biochemistry & Molecular Biology

Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases

Fabrice Collin

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Chemistry, Multidisciplinary

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model

Amanda Cano et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Endocrinology & Metabolism

Cortico-hippocampal memory enhancing activity of hesperetin on scopolamine-induced amnesia in mice: role of antioxidant defense system, cholinergic neurotransmission and expression of BDNF

Ismail O. Ishola et al.

METABOLIC BRAIN DISEASE (2019)

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Article Biochemistry & Molecular Biology

Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway

Cuiqin Huang et al.

MOLECULAR BIOLOGY REPORTS (2019)

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Review Biochemistry & Molecular Biology

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

Anju Singh et al.

MOLECULES (2019)

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Article Biotechnology & Applied Microbiology

Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson's Disease Model

Bharti Gaba et al.

BIOMED RESEARCH INTERNATIONAL (2019)

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Review Food Science & Technology

Current evidence on cognitive improvement and neuroprotection promoted by anthocyanins

Nathalia Medina dos Santos et al.

CURRENT OPINION IN FOOD SCIENCE (2019)

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Review Cell Biology

Development and Cell Biology of the Blood-Brain Barrier

Urs H. Langen et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35 (2019)

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Article Pharmacology & Pharmacy

Uric acid treatment after stroke modulates the Kruppel-like factor 2-VEGF-A axis to protect brain endothelial cell functions: Impact of hypertension

Elisabet Vila et al.

BIOCHEMICAL PHARMACOLOGY (2019)

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Article Nutrition & Dietetics

Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer's Disease Patients

Marta Cosin-Tomas et al.

NUTRIENTS (2019)

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Review Pharmacology & Pharmacy

Composition and Potential Health Benefits of Pomegranate: A Review

Vesna Vucic et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

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Article Biochemistry & Molecular Biology

Complex of EGCG with Cu(II) Suppresses Amyloid Aggregation and Cu(II)-Induced Cytotoxicity of α-Synuclein

Yilong Teng et al.

MOLECULES (2019)

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Article Biochemistry & Molecular Biology

β-Carotene: A Natural Compound Improves Cognitive Impairment and Oxidative Stress in a Mouse Model of Streptozotocin-Induced Alzheimer's Disease

Sundas Hira et al.

BIOMOLECULES (2019)

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Article Psychiatry

Coffee intake and decreased amyloid pathology in human brain

Jee Wook Kim et al.

TRANSLATIONAL PSYCHIATRY (2019)

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Review Biochemistry & Molecular Biology

Vitamin E: Mechanism of transport and regulation in the CNS

Paris Lee et al.

IUBMB LIFE (2019)

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Review Neurosciences

Protective Effects of Antioxidants in Huntington's Disease: an Extensive Review

Musthafa Mohamed Essa et al.

NEUROTOXICITY RESEARCH (2019)

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Review Physiology

BLOOD-BRAIN BARRIER: FROM PHYSIOLOGY TO DISEASE AND BACK

Melanie D. Sweeney et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Nutrition & Dietetics

Lutein across the Lifespan: From Childhood Cognitive Performance to the Aging Eye and Brain

James M. Stringham et al.

CURRENT DEVELOPMENTS IN NUTRITION (2019)

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Review Nutrition & Dietetics

Lycopene and cognitive function

Kristi M. Crowe-White et al.

JOURNAL OF NUTRITIONAL SCIENCE (2019)

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Article Neurosciences

β-carotene provides neuro protection after experimental traumatic brain injury via the Nrf2-ARE pathway

Peiqing Chen et al.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2019)

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Review Public, Environmental & Occupational Health

Diet and risk of diabetic retinopathy: a systematic review

Courtney Dow et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Vitamin C prevents hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats: A stereological study

Elnaz Khordad et al.

JOURNAL OF CHEMICAL NEUROANATOMY (2018)

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Article Neurosciences

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer's Disease

Tahir Ali et al.

MOLECULAR NEUROBIOLOGY (2018)

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Review Medicine, Research & Experimental

Endogenous non-enzymatic antioxidants in the human body

Iwona Mironczuk-Chodakowska et al.

ADVANCES IN MEDICAL SCIENCES (2018)

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Article Geriatrics & Gerontology

Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

Gary W. Small et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2018)

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Article Biochemical Research Methods

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood - Brain Barrier

Carlos Fernandes et al.

BIOCONJUGATE CHEMISTRY (2018)

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Article Medicine, Research & Experimental

Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease

Elham Kheradmand et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Biochemistry & Molecular Biology

Dietary astaxanthin can accumulate in the brain of rats

Yuki Manabe et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Soy isoflavone genistein attenuates lipopolysaccharide-induced cognitive impairments in the rat via exerting anti-oxidative and anti-inflammatory effects

Seyed-Mohamad-Sadegh Mirahmadi et al.

CYTOKINE (2018)

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Article Integrative & Complementary Medicine

Effect of Chlorogenic Acid Intake on Cognitive Function in the Elderly: A Pilot Study

Morimasa Kato et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

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Article Biochemistry & Molecular Biology

Ergothioneine - a diet-derived antioxidant with therapeutic potential

Barry Halliwell et al.

FEBS LETTERS (2018)

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Review Biochemistry & Molecular Biology

Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

Panchanan Maiti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Agriculture, Multidisciplinary

Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease

Fabiana Morroni et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Review Neurosciences

Protective Effects of Indian Spice Curcumin Against Amyloid-beta in Alzheimer's Disease

P. Hemachandra Reddy et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Review Neurosciences

The neuroprotective role of melatonin in neurological disorders

B. S. Alghamdi

JOURNAL OF NEUROSCIENCE RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic dementia of Alzheimer's type

Simone Muniz Pacheco et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress

Jia Wang et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018)

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Article Neurosciences

Treatment with Uric Acid Reduces Infarct and Improves Neurologic Function in Female Mice After Transient Cerebral Ischemia

Nirav Dhanesha et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2018)

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Review Biochemistry & Molecular Biology

The Role of Catechins in Cellular Responses to Oxidative Stress

Jurga Bernatoniene et al.

MOLECULES (2018)

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Review Cell Biology

Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases

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Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons

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Lycopene attenuates Aβ1-42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease

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Ferulic acid pretreatment mitigates MPTP-induced motor impairment and histopathological alterations in C57BL/6 mice

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Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation

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Supplementation of Adult Rats with Moderate Amounts of β-Carotene Modulates the Redox Status in Plasma without Exerting Pro-Oxidant Effects in the Brain: A Safer Alternative to Food Fortification with Vitamin A?

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NEUROTOXICOLOGY (2013)

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Article Multidisciplinary Sciences

A Randomised Placebo-Controlled Trial to Differentiate the Acute Cognitive and Mood Effects of Chlorogenic Acid from Decaffeinated Coffee

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PLOS ONE (2013)

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A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice

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NATURE COMMUNICATIONS (2013)

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Experimental Neurobiology (2013)

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A Potential Commercial Source of Fucoxanthin Extracted from the Microalga Phaeodactylum tricornutum

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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2012)

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Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway

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Astaxanthin protects against MPP+-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis

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BMC NEUROSCIENCE (2012)

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Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease

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Ergothioneine protects against neuronal injury induced by β-amyloid in mice

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Dietary Intakes of Vitamin E, Vitamin C, and beta-Carotene and Risk of Alzheimer's Disease: A Meta-Analysis

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JOURNAL OF ALZHEIMERS DISEASE (2012)

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JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2012)

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Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines

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Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment

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Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

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Protocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cells

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Astaxanthin protects against MPTP/MPP plus -induced mitochondrial dysfunction and ROS production in vivo and in vitro

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Curcumin and its nano-formulation: The kinetics of tissue distribution and blood-brain barrier penetration

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2011)

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Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial (SELECT)

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

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Apricot Carotenoids Possess Potent Anti-amyloidogenic Activity in Vitro

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Green Tea Epigallocatechin-3-Gallate (EGCG) and Other Flavonoids Reduce Alzheimer's Amyloid-Induced Mitochondrial Dysfunction

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Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells

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Resveratrol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats

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Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson's Disease

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Silibinin: A novel inhibitor of Aβ aggregation

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Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice

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Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson's disease

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The unusual amino acid L-ergothioneine is a physiologic cytoprotectant

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Editorial [Hot topic: Melatonin and Brain (Guest Editor: Dun-Xian Tan)]

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Current Neuropharmacology (2010)

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Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo

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Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by β-amyloid peptides 25-35 in PC12 cells

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Neuroprotection induced by vitamin E against oxidative stress in hippocampal neurons: Involvement of TRPV1 channels

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MOLECULAR NUTRITION & FOOD RESEARCH (2010)

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In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma

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MOLECULAR NUTRITION & FOOD RESEARCH (2010)

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Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

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PHARMACEUTICAL RESEARCH (2010)

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Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials

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BMJ-BRITISH MEDICAL JOURNAL (2010)

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Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

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CURRENT NEUROPHARMACOLOGY (2009)

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High Fruit and Vegetable Intake is Positively Correlated with Antioxidant Status and Cognitive Performance in Healthy Subjects

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Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental

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Multipotent natural agents to combat Alzheimer's disease. Functional spectrum and structural features

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Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo

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NEUROSCIENCE LETTERS (2006)

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Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study

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Protective effect of protocatechuic acid from Alpinia oxyphylla on hydrogen peroxide-induced oxidative PC12 cell death

S Guan et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2006)

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Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

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Tryptophan metabolism and oxidative stress in patients with Huntington's disease

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Natural antioxidants for neurodegenerative diseases

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Early Vitamin E supplementation in young but not aged mice reduces A beta levels and amyloid deposition in a transgenic model of Alzheimer's disease

S Sung et al.

FASEB JOURNAL (2003)

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Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women - A randomized controlled trial

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)

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Mass spectrometric determination of genistein tissue distribution in diet-exposed Sprague-Dawley rats

HC Chang et al.

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