4.7 Article

Pharmacokinetics of single low dose primaquine in Ugandan and Congolese children with falciparum malaria

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Safety of age-dosed, single low-dose primaquine in children with glucose-6-phosphate dehydrogenase deficiency who are infected with Plasmodium falciparum in Uganda and the Democratic Republic of the Congo: a randomised, double- blind, placebo-controlled, non-inferiority trial

Walter R. Taylor et al.

Summary: This study aimed to investigate the safety of age-dosed, single low-dose primaquine in children from Uganda and the Democratic Republic of the Congo. The study found that single low-dose primaquine treatment is safe in children infected with Plasmodium falciparum and supports the broader implementation of this treatment in Africa.

LANCET INFECTIOUS DISEASES (2023)

Article Immunology

Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis

Kasia Stepniewska et al.

Summary: A meta-analysis of individual patients was conducted to assess the gametocytocidal and transmission-blocking activities of single-dose primaquine. The results showed that primaquine, when administered with artemisinin-based combination therapies, can effectively reduce the gametocyte carriage rate after 7 and 14 days, especially in patients with existing gametocytes at the start of treatment. Furthermore, the combination of primaquine and artemether-lumefantrine showed a faster decline in gametocyte carriage compared to the combination with dihydroartemisinin-piperaquine. Additionally, the addition of 0.25 mg/kg primaquine can nearly completely prevent transmission to mosquitoes.

JOURNAL OF INFECTIOUS DISEASES (2022)

Article Infectious Diseases

Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry

Warunee Hanpithakpong et al.

Summary: A simple and sensitive LC-MS/MS method was developed for simultaneous quantification of enantiomers and racemic forms of primaquine and carboxyprimaquine in human plasma. The methods were successfully validated and implemented in clinical drug analysis.

MALARIA JOURNAL (2022)

Article Biochemistry & Molecular Biology

Quantification of Tafenoquine and 5,6-Orthoquinone Tafenoquine by UHPLC-MS/MS in Blood, Plasma, and Urine, and Application to a Pharmacokinetic Study

Geoffrey W. Birrell et al.

Summary: Analytical methods have been validated for quantifying the antimalarial drug tafenoquine (TQ) and its metabolite 5,6-orthoquinone tafenoquine (5,6-OQTQ) in human blood, plasma, and urine. These methods involve sample extraction followed by ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). The calibration ranges and precision for TQ and 5,6-OQTQ in blood, plasma, and urine are reported, along with the correlation between TQ urine concentrations and parasite recrudescence times.

MOLECULES (2022)

Review Medicine, General & Internal

Safety of single-dose primaquine as a Plasmodium falciparum gametocytocide: a systematic review and meta-analysis of individual patient data

Kasia Stepniewska et al.

Summary: This study analyzed the side effects of primaquine for the treatment of falciparum malaria and found that the use of 0.25 mg/kg primaquine as a gametocytocide is safe and effective, even in individuals with G6PD deficiency.

BMC MEDICINE (2022)

Article Multidisciplinary Sciences

Antimalarial activity of primaquine operates via a two-step biochemical relay

Grazia Camarda et al.

NATURE COMMUNICATIONS (2019)

Article Microbiology

Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children

Bronner P. Goncalves et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

Review Pharmacology & Pharmacy

Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: Current state of the art

Sean R. Marcsisin et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Article Microbiology

Pharmacokinetic Interactions between Primaquine and Pyronaridine-Artesunate in Healthy Adult Thai Subjects

Podjanee Jittamala et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

Article Microbiology

Open-Label Crossover Study of Primaquine and Dihydroartemisinin-Piperaquine Pharmacokinetics in Healthy Adult Thai Subjects

Borimas Hanboonkunupakarn et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Article Microbiology

Pharmacokinetic Interactions between Primaquine and Chloroquine

Sasithon Pukrittayakamee et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Review Chemistry, Medicinal

A Pharmacokinetic Standard for Babies and Adults

Nick Holford et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

Letter Medicine, General & Internal

Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria

Jason W. Bennett et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)