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Editorial Material
Public, Environmental & Occupational Health
Harold L. Mashauri
HEALTH SCIENCE REPORTS
(2023)
Article
Medicine, General & Internal
Emily R. Pfaff et al.
Summary: This study examined the heterogeneity in the adoption and use of the ICD-10-CM code for Post COVID-19 condition in the US. The findings showed demographic disparities among patients diagnosed with U09.9, as well as disparities in the diagnosis of long COVID. This work provides insights into potential subtypes of long COVID and highlights the need for further research and remedies for the existing disparities.
Review
Medicine, General & Internal
Vasiliki Tsampasian et al.
Summary: Post-COVID-19 condition (PCC) is a complex disorder that has affected millions of people globally. Identifying potential risk factors to understand who is at risk of developing PCC is important for early clinical support.
JAMA INTERNAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Daniel Pan et al.
Article
Health Care Sciences & Services
Tiffany J. Callahan et al.
Summary: Common data models address standardization challenges in EHR data, but fail to integrate all resources for deep phenotyping. OBO ontologies provide computable representations of biological knowledge, but mapping EHR data to OBO ontologies requires manual curation. OMOP2OBO is an algorithm that maps OMOP vocabularies to OBO ontologies, enabling deep phenotyping and identification of undiagnosed patients.
NPJ DIGITAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Juan Ignacio Moran Blanco et al.
Summary: In Yepes, Spain, 468 COVID-19 patients received early treatment with antihistamines, and the addition of azithromycin in some cases. The study found that early treatment with antihistamines may reduce the odds of hospitalization for COVID-19 patients.
Article
Biochemistry & Molecular Biology
Yapeng Su et al.
Summary: Post-acute sequelae of COVID-19 (PASC) is an emerging global crisis, and the quantifiable risk factors and biological associations are not well understood. In this study, a deep multi-omic investigation was conducted on 309 COVID-19 patients, and four PASC-anticipating risk factors were identified at the time of initial diagnosis. The study also observed changes in immune states during recovery from COVID-19.
Article
Pharmacology & Pharmacy
Manisha Thakur et al.
Summary: A meta-analysis of relevant studies has shown that the use of steroids in hospitalized COVID-19 patients can significantly reduce the risk of death.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biology
Pradeep Kumar Yadalam et al.
Summary: The study aimed to investigate the antiviral effects of melatonin and related drugs on SARS-CoV-2 infection through computational analysis. The results showed that melatonin, ramelteon, and agomelatine can strongly prevent viral entry into host cells by binding to the SARS-CoV-2 receptor binding site and ACE2, with ramelteon demonstrating the most superior antiviral properties.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Bevyn Jarrott et al.
Summary: Infection with SARS-CoV-2 can lead to COVID-19, with a range of symptoms from asymptomatic to severe. Some patients, diagnosed with LONG COVID, experience various symptoms even after 12 weeks. Longitudinal clinical studies suggest that a battery of cytokine markers can identify infected patients with persistent inflammation and troubling symptoms. There is a hypothesis that drugs activating NRF2 or the hormone melatonin may help alleviate symptoms in LONG COVID patients.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2022)
Article
Virology
Justin T. Reese et al.
Summary: This study found that the use of non-steroidal anti-inflammatory drugs (NSAIDs) is not associated with increased severity or other adverse outcomes in COVID-19 inpatients. The results confirm and extend the findings of previous observational studies and provide evidence against the initial concerns raised about the use of NSAIDs in COVID-19 patients.
Article
Multidisciplinary Sciences
Viet-Thi Tran et al.
Summary: About 10% of people infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experience post COVID-19 disease. This study analyzed data from a French disease cohort and found that among patients symptomatic after 2 months, 85% still reported symptoms one year after their symptom onset. Symptoms showed different trends over time, with some decreasing, some remaining stable, and some increasing in prevalence. The study provides important insights into the natural history of post COVID-19 disease.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Justin T. Reese et al.
News Item
Multidisciplinary Sciences
Heidi Ledford
Article
Biochemistry & Molecular Biology
Anuradhaa Subramanian et al.
Summary: A retrospective analysis of primary care records in the United Kingdom reveals individual symptoms associated with SARS-CoV-2 infections, which persisted for 12 weeks or more after infection, as well as risk factors associated with developing long COVID.
Review
Food Science & Technology
Alessia Catalano et al.
Summary: The importance of post-COVID syndrome has increased due to the reduction of severe cases and deaths from COVID-19. Nutraceutical products have attracted great interest in the prevention and/or treatment of COVID-19 disease and post-COVID syndrome.
Article
Medicine, General & Internal
Leah J. McGrath et al.
Summary: This retrospective cohort study found that patients of all ages in clinical practice in the US had a post-COVID-19 ICD-10-CM diagnosis code following the acute phase of COVID-19 disease. The use of the U09.9 code encompassed a wide range of conditions. It will be important to monitor how the use of this code changes as the pandemic continues to evolve.
Article
Biochemical Research Methods
Luca Cappelletti et al.
Summary: CRRs play a central role in regulating transcription under physiological and pathological conditions. Accurately identifying CRRs and their tissue-specific activity status using machine learning methods is essential for studying the impact of genetic variants on human diseases.
BMC BIOINFORMATICS
(2022)
Article
Immunology
Susan A. Olender et al.
Summary: In a comparative analysis, remdesivir was found to be associated with significantly higher recovery rates and a 62% reduced mortality rate compared to standard-of-care treatment by day 14 in patients with severe COVID-19.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Leah R. Reznikov et al.
Summary: The urgency to identify therapies that prevent SARS-CoV-2 infection and enhance COVID-19 outcomes is emphasized. The study identified potential repurposed antihistamine drugs with in vitro antiviral activity against SARS-CoV-2 through mining electronic health records. Clinical studies are recommended to evaluate the effectiveness of these antihistamines for disease prevention and treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Carole H. Sudre et al.
Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.
Article
Medicine, General & Internal
Rachel R. Deer et al.
Article
Biochemistry & Molecular Biology
Alberto Utrero-Rico et al.
Summary: Patients with persistent symptoms after acute SARS-CoV-2 infection showed perturbed distribution of circulating mononuclear cell populations and a pro-inflammatory phenotype. Corticosteroid treatment led to immune alterations reverting to normal, correlating with clinical improvement.
Article
Multidisciplinary Sciences
Ziyad Al-Aly et al.
Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.
Review
Biochemistry & Molecular Biology
Ani Nalbandian et al.
Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.
Article
Infectious Diseases
James B. O'Keefe et al.
Summary: This study assessed the use of medications and perceived effectiveness in treating COVID-19 symptoms, finding that longitudinal follow-up providers used specific therapies more often than episodic providers in managing certain symptoms. Providers reported that medications commonly used for other respiratory infections were effective for mild COVID-19, but specific symptoms remained challenging to manage.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Miguel Alejandro Pinzon et al.
Summary: The study compared the clinical outcomes and laboratory results of hospitalized patients with severe SARS-CoV2 pneumonia treated with 6 mg dexamethasone versus high-dose methylprednisolone. The high-dose methylprednisolone treatment significantly decreased recovery time, need for ICU transfer, and levels of inflammatory markers CRP, D-dimer, and LDH compared to 6 mg dexamethasone treatment. Randomized controlled trials are needed to further confirm the effectiveness of methylprednisolone in COVID-19 treatment.
Review
Microbiology
Amy D. Proal et al.
Summary: The novel coronavirus SARS-CoV-2 has led to a pandemic of COVID-19, with some patients developing persistent symptoms known as Long COVID or PASC. These patients may have different underlying biological factors driving their symptoms, such as organ damage, persistent viral reservoirs, re-activation of pathogens, and immune dysregulation. Therapeutic approaches may need to be individualized to effectively manage care for specific patients with PASC.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Tellen D. Bennett et al.
Summary: The study evaluated COVID-19 severity and risk factors in over 1.9 million US adults, finding that machine learning models can accurately predict clinical severity. It also observed a decrease in COVID-19 mortality over time in 2020 and identified associations between patient demographic characteristics and comorbidities with higher clinical severity.
Article
Endocrinology & Metabolism
A. V. Raveendran et al.
Summary: Long COVID refers to the persistence of symptoms in individuals who have recovered from SARS-CoV-2 infection, possibly related to organ damage, post viral syndrome, etc. Clinical evaluation should focus on identifying the pathophysiology and appropriate remedial measures.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Computer Science, Information Systems
Carlos Saez et al.
Summary: The lack of representative COVID-19 data poses a challenge for reliable machine learning, and variability in data sources can lead to biases and increase the risk of overfitting in models. It is important to systematically assess and report data source variability and quality to ensure reliable and generalizable machine learning in COVID-19 research.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Computer Science, Information Systems
Melissa A. Haendel et al.
Summary: N3C is an open science community focused on analyzing patient-level data from multiple centers to address the challenges posed by COVID-19. By overcoming technical, regulatory, policy, and governance barriers, N3C has successfully established a secure data enclave for efficient, transparent, and reproducible collaborative analytics.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Letter
Medicine, General & Internal
Chong Tang et al.
Article
Medicine, General & Internal
Yeming Wang et al.
Article
Medicine, General & Internal
Lei Zha et al.
MEDICAL JOURNAL OF AUSTRALIA
(2020)
Article
Medicine, General & Internal
John H. Beigel et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Review
Medicine, Research & Experimental
Rui Zhang et al.
Article
Hematology
Henny H. Billett et al.
THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Computer Science, Artificial Intelligence
Scott M. Lundberg et al.
NATURE MACHINE INTELLIGENCE
(2020)
