☆ 4.8 Article

The cellular response to extracellular vesicles is dependent on their cell source and dose

SCIENCE ADVANCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

HuMSC-EV induce monocyte/macrophage mobilization to orchestrate neovascularization in wound healing process following radiation injury

Celine Loinard et al.

Summary: This study investigates the mechanisms by which human mesenchymal stem cell-derived extracellular vesicles (HuMSC-EV) promote angiogenesis and neovascularization after radiation injury. The study found that HuMSC-EV improved neovascularization of irradiated tissue by stimulating angiogenesis, increasing capillary density, and producing proangiogenic factors. HuMSC-EV also promoted vasculogenesis by recruiting and differentiating bone marrow progenitors. Furthermore, HuMSC-EV enhanced arteriogenesis by mobilizing monocytes and promoting their recruitment to the injured site. These findings suggest that HuMSC-EV could be a potential alternative to stem cells for therapeutic neovascularization in tissue repair.

CELL DEATH DISCOVERY (2023)

添加到收藏夹

Article Hematology

Myeloid cells from Langerhans cell histiocytosis patients exhibit increased vesicle trafficking and an altered secretome capable of activating NK cells

Daniel W. Hagey et al.

Summary: This study compared monocyte-derived dendritic cells from LCH patients to those from healthy controls or patients with Crohn's disease. The findings showed that LCH cells exhibited increased endo- and exocytosis gene activity and the enrichment of pathological transcripts in extracellular vesicles. The study also indicated that the LCH secretome had a significant effect on lymphocyte activity.

HAEMATOLOGICA (2023)

添加到收藏夹

Article Engineering, Biomedical

Growth Media Conditions Influence the Secretion Route and Release Levels of Engineered Extracellular Vesicles

Jeremy P. Bost et al.

Summary: Extracellular vesicles (EVs) are nanosized cell-derived vesicles that facilitate intercellular communication via transmitting biological cargo. The production of EVs is influenced by various pathways and external factors in the cell media, with ceramide-dependent pathway being a major contributor to engineered EV production. The study provides insights into understanding and optimizing EV production in cell culture for developing advanced methods.

ADVANCED HEALTHCARE MATERIALS (2022)

添加到收藏夹

Article Biology

Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides

Jeremy P. Bost et al.

Summary: By interfering with the trafficking of SSOs to LAMP1-positive endosomal compartments, inducing endosomal membrane rupture and facilitating the escape of SSOs into the cytosol, these two novel endosomolytic compounds have shown increased delivery efficacy of splice-switching oligonucleotides.

COMMUNICATIONS BIOLOGY (2022)

添加到收藏夹

Article Cell Biology

Identification of storage conditions stabilizing extracellular vesicles preparations

Andre Gorgens et al.

Summary: This study aimed to address the issue of storage stability of extracellular vesicles (EVs) and compared the impact of different storage buffer formulations on EVs derived from different cellular sources. The results showed that adding human albumin and trehalose to PBS (PBS-HAT) significantly improved the short-term and long-term preservation of EVs and their recovery rates.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

Dosing extracellular vesicles

Dhanu Gupta et al.

Summary: This study analyzed 64 pre-clinical studies on EV-based therapeutics and found variations in dosing strategies regardless of EV purification method. Disease models influenced dose discrepancies, showing a need for qualitative consideration in EV dosing. Recommendations were made to focus on qualitative aspects like therapeutic cargo potency for better reliability and reproducibility in EV-based therapeutics.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Shedding Light on Extracellular Vesicle Biogenesis and Bioengineering

Fei Teng et al.

Summary: Extracellular vesicles (EVs) are nano-sized secreted vesicles containing various biomolecules, which have low immunogenicity and can functionally modify recipient cells by transferring bioactive constituents. Therefore, they are considered as an excellent candidate for the next generation drug delivery system.

ADVANCED SCIENCE (2021)

添加到收藏夹

Article Genetics & Heredity

MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cells

Manuel T. Albanese et al.

Summary: The study found that the miRNAs carried by extracellular vesicles (EVs) do not effectively facilitate cell-to-cell communication.

PLOS GENETICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Exosome Traceability and Cell Source Dependence on Composition and Cell-Cell Cross Talk

Rabab N. Hamzah et al.

Summary: Exosomes are small vesicles produced by various cell types that can transfer cellular components to target cells and affect cell signaling. Recent research suggests that the outcomes of exosome communication depend on the cell type and host cell environment. Key questions remain in cancer research regarding the selectivity of exosome uptake, methods for tracing uptake selectivity, and the impact of donor cell growth environment on cell interaction.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Cell Biology

Extracellular vesicles are the primary source of blood-borne tumour-derived mutant KRAS DNA early in pancreatic cancer

Daniel W. Hagey et al.

Summary: This study focused on extracellular vesicles as an important source of tumor-derived DNA in liquid biopsies, and conducted experiments by collecting blood samples from 17 pancreatic cancer patients. The results showed that tumor-derived DNA was mainly present in LEVs and SEVs in the early stage of disease progression, and in SEVs and SP in the late stage of disease progression.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Democratising deep learning for microscopy with ZeroCostDL4Mic

Lucas von Chamier et al.

Summary: ZeroCostDL4Mic is an entry-level platform that simplifies access to deep learning by leveraging the free, cloud-based computational resources of Google Colab. Researchers can train and apply key deep learning networks for various microscopy tasks without coding expertise. The platform provides quantitative tools for model evaluation and optimization.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Adherence to minimal experimental requirements for defining extracellular vesicles and their functions

Rodolphe Poupardin et al.

Summary: Research shows a significant improvement in EV characterization in recent years, with papers using more methods and markers being more frequently cited. Papers citing MISEV criteria tend to use a higher number of characterization methods, indicating a positive impact of the guidelines on EV research quality.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Article Engineering, Biomedical

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

Dhanu Gupta et al.

Summary: This study optimized the loading of two different therapeutic protein receptors onto extracellular vesicles through genetic engineering and protein moiety screening, leading to alleviation of inflammation-related diseases.

NATURE BIOMEDICAL ENGINEERING (2021)

添加到收藏夹

Article Cell & Tissue Engineering

Low dose of extracellular vesicles identified that promote recovery after ischemic stroke

Laura Otero-Ortega et al.

STEM CELL RESEARCH & THERAPY (2020)

添加到收藏夹

Article Immunology

Assessment of faithful interleukin-3 production by novel bicistronic interleukin-3 reporter mice

Tracy L. Deem et al.

IMMUNOLOGY LETTERS (2020)

添加到收藏夹

Review Cell Biology

RNA delivery by extracellular vesicles in mammalian cells and its applications

Killian O'Brien et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

CYCLIN-B1/2 and-D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment

Daniel W. Hagey et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature

Antonietta Rosa Silini et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells

Maria Sancho-Albero et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools

Huaiyu Mi et al.

NUCLEIC ACIDS RESEARCH (2019)

添加到收藏夹

Article Clinical Neurology

Application of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Stroke: Biodistribution and MicroRNA Study

Gyeong Joon Moon et al.

TRANSLATIONAL STROKE RESEARCH (2019)

添加到收藏夹

Article Immunology

Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures

Oscar P. B. Wiklander et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome

Helena Sork et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

Nicholas Schaum et al.

NATURE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Distinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells

Daniel W. Hagey et al.

GENOME RESEARCH (2016)

添加到收藏夹

Article Cell Biology

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

Wolf Heusermann et al.

JOURNAL OF CELL BIOLOGY (2016)

添加到收藏夹

Article Oncology

Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers

Stephanie N. Hurwitz et al.

ONCOTARGET (2016)

添加到收藏夹

Article Cell Biology

Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

Oscar P. B. Wiklander et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

添加到收藏夹

Article Biochemical Research Methods

ThunderSTORM: a comprehensive ImageJ plug-in for PALM and STORM data analysis and super-resolution imaging

Martin Ovesny et al.

BIOINFORMATICS (2014)

添加到收藏夹

Article Genetics & Heredity

Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model

Suyan Bian et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2014)

添加到收藏夹

Article Biochemical Research Methods

Full-length RNA-seq from single cells using Smart-seq2

Simone Picelli et al.

NATURE PROTOCOLS (2014)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

添加到收藏夹

Article Cell Biology

Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons

Mathilde Chivet et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Amedeo Avogadro's cry: What is 1 μg of exosomes?

Eugene D. Sverdlov

BIOESSAYS (2012)

添加到收藏夹

Article Nanoscience & Nanotechnology

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

Rebecca A. Dragovic et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

添加到收藏夹

Article Cell Biology

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Johan Skog et al.

NATURE CELL BIOLOGY (2008)

添加到收藏夹

Article Cell Biology

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi et al.

NATURE CELL BIOLOGY (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.