4.8 Article

Transcriptional regulation by the NSL complex enables diversification of IFT functions in ciliated versus nonciliated cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Physiology

The Role of Parietal Epithelial Cells in the Pathogenesis of Podocytopathy

Zhi-Hang Li et al.

Summary: Podocytopathy is a common feature of glomerular disorder characterized by excessive proteinuria caused by podocyte injury or dysfunction, leading to glomerulosclerosis and renal function loss. The self-renewal ability of podocytes is limited, and mild podocyte depletion triggers replacement and repair processes driven by stem cells or PECs. Activated PECs contribute to the establishment of glomerular lesions when podocyte recovery fails.

FRONTIERS IN PHYSIOLOGY (2022)

Article Cell Biology

Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest

Johannes Wichmann et al.

Summary: Histone acetylation is crucial for chromatin conformation and gene transcription, and TIP60 is a key enzyme involved in this process. Loss of TIP60 leads to cell growth arrest and abnormal chromosome alignment during mitosis. However, cell survival is not affected. TIP60 is essential for the acetylation of H2AZ at lysine 7 and plays a role in the activation of transcription for thousands of genes, including those involved in metabolism.

CELL DEATH & DISEASE (2022)

Article Multidisciplinary Sciences

A slit-diaphragm-associated protein network for dynamic control of renal filtration

Maciej K. Kocylowski et al.

Summary: The slit-diaphragm is a crucial cellular junction for blood filtration in the kidney. Researchers have found that it is composed of a protein network that dynamically controls filtration. Disturbance to this network leads to severe filtration defects. The study highlights the importance of the multi-component system and its context-dependent dynamics in the slit-diaphragm's role in kidney function.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis

Aliaksandra Radzisheuskaya et al.

Summary: KAT8 displays complex-dependent catalytic activity, catalyzing different histone modifications within the NSL and MSL complexes. The NSL complex is essential for cell survival and transcription initiation, while the MSL complex proteins and H4K16ac are not required for cell proliferation and chromatin accessibility.

MOLECULAR CELL (2021)

Article Biochemistry & Molecular Biology

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome

Edward L. Huttlin et al.

Summary: This study explores thousands of interactions between proteins, creating two essential cell-line specific interaction networks that help researchers understand the principles of proteome organization and unknown protein characteristics. Comparing different cell lines revealed extensive customization, linking core complexes with essential proteins and rewiring subnetworks to produce each cell's phenotype.
Article Urology & Nephrology

Tripartite Separation of Glomerular Cell Types and Proteomes from Reporter-Free Mice

Favian A. Hatje et al.

Summary: timMEP method successfully isolated mesangial cells, endothelial cells, and podocytes from mice, enabling protein-biochemical analyses without the need for reporters. The method revealed cell type-specific proteome differences between mouse strains and variations based on sex, age, and transgene, as well as highlighted a protein-based mechanism of podocyte injury in a specific animal model, showing the potential for comprehensive characterization of glomerular cell biology.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Article Multidisciplinary Sciences

Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells

Cecilia Pessoa Rodrigues et al.

Summary: The levels of histone acetyltransferase MOF and its modification H4K16ac vary among hematopoietic stem cells (HSCs) and influence their proliferation capacities. CD93(+) HSC subpopulation exhibits both transcriptional features of quiescent HSCs and functional features of active HSCs. Low MOF and high CD93 levels are associated with poor survival and increased proliferation capacity in leukemia.

SCIENCE ADVANCES (2021)

Article Biochemistry & Molecular Biology

The HOPS complex subunit VPS39 controls ciliogenesis through autophagy

Daniela Iaconis et al.

HUMAN MOLECULAR GENETICS (2020)

Article Medicine, Research & Experimental

Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability

Lin Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Multidisciplinary Sciences

KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion

Peter O. Oladimeji et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

PLCE1 regulates the migration, proliferation, and differentiation of podocytes

Seyoung Yu et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Article Multidisciplinary Sciences

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

Aline Gaub et al.

NATURE COMMUNICATIONS (2020)

Review Food Science & Technology

Uremia-Associated Ageing of the Thymus and Adaptive Immune Responses

Michiel G. H. Betjes

TOXINS (2020)

Article Multidisciplinary Sciences

Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate

Cecilia Pessoa Rodrigues et al.

SCIENCE ADVANCES (2020)

Article Multidisciplinary Sciences

Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury

Sandrine Ettou et al.

SCIENCE ADVANCES (2020)

Article Urology & Nephrology

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury

Jun-Jae Chung et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

Article Multidisciplinary Sciences

An image J plugin for the high throughput image analysis ofin vitroscratch wound healing assays

Alejandra Suarez-Arnedo et al.

PLOS ONE (2020)

Article Biochemistry & Molecular Biology

Transcriptome analysis of primary podocytes reveals novel calcium regulated regulatory networks

Thaddaeus Struk et al.

FASEB JOURNAL (2020)

Article Medicine, Research & Experimental

Podocyte histone deacetylase activity regulates murine and human glomerular diseases

Kazunori Inoue et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Article Multidisciplinary Sciences

Parathyroid hormone and premature thymus ageing in patients with chronic kidney disease

Kenichiro Iio et al.

SCIENTIFIC REPORTS (2019)

Article Biochemical Research Methods

snakePipes: facilitating flexible, scalable and integrative epigenomic analysis

Vivek Bhardwaj et al.

BIOINFORMATICS (2019)

Article Biochemistry & Molecular Biology

Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion

Marie Alice Dupont et al.

HUMAN MOLECULAR GENETICS (2019)

Article Cell Biology

The NSL complex maintains nuclear architecture stability via lamin A/C acetylation

Adam Karoutas et al.

NATURE CELL BIOLOGY (2019)

Review Genetics & Heredity

The many lives of KATs - detectors, integrators and modulators of the cellular environment

Bilal N. Sheikh et al.

NATURE REVIEWS GENETICS (2019)

Article Medicine, Research & Experimental

Sonic hedgehog connects podocyte injury to mesangial activation and glomerulosclerosis

Dong Zhou et al.

JCI INSIGHT (2019)

Article Biochemistry & Molecular Biology

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

Brian T. Weinert et al.

Article Developmental Biology

Ift25 is not a cystic kidney disease gene but is required for early steps of kidney development

Paurav B. Desai et al.

MECHANISMS OF DEVELOPMENT (2018)

Article Cell Biology

ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier

Christoph Schell et al.

DEVELOPMENTAL CELL (2018)

Article Biology

RELACS nuclei barcoding enables high-throughput ChIP-seq

Laura Arrigoni et al.

COMMUNICATIONS BIOLOGY (2018)

Article Cell Biology

Primary Cilia and Mammalian Hedgehog Signaling

Fiona Bangs et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Review Urology & Nephrology

The Evolving Complexity of the Podocyte Cytoskeleton

Christoph Schell et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Review Cell Biology

Genes and molecular pathways underpinning ciliopathies

Jeremy F. Reiter et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Developmental Biology

The Role of Hedgehog Signalling in the Formation of the Ventricular Septum

Antonia Wiegering et al.

JOURNAL OF DEVELOPMENTAL BIOLOGY (2017)

Article Physiology

A small molecule screening to detect potential therapeutic targets in human podocytes

Eugen Widmeier et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)

Article Biochemistry & Molecular Biology

The Koolen-de Vries syndrome: a phenotypic comparison of patients with a 17q21.31 microdeletion versus a KANSL1 sequence variant

David A. Koolen et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2016)

Article Biochemistry & Molecular Biology

MOF maintains transcriptional programs regulating cellular stress response

B. N. Sheikh et al.

ONCOGENE (2016)

Article Biochemistry & Molecular Biology

MOF Acetyl Transferase Regulates Transcription and Respiration in Mitochondria

Aindrila Chatterjee et al.

Review Endocrinology & Metabolism

Podocytes: the Weakest Link in Diabetic Kidney Disease?

Jamie S. Lin et al.

CURRENT DIABETES REPORTS (2016)

Article Biochemistry & Molecular Biology

Global and Specific Responses of the Histone Acetylome to Systematic Perturbation

Christian Feller et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis

Sylvain Meunier et al.

NATURE COMMUNICATIONS (2015)

Review Endocrinology & Metabolism

Podocytes ... What's under yours? (Podocytes and foot processes and how they change in nephropathy)

Chris R. Neal

FRONTIERS IN ENDOCRINOLOGY (2015)

Article Urology & Nephrology

MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype

Leonie Kietzmann et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2015)

Article Urology & Nephrology

A Homozygous Missense Mutation in the Ciliary Gene TTC21B Causes Familial FSGS

Evelyne Huynh Cong et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)

Article Biochemistry & Molecular Biology

deepTools: a flexible platform for exploring deep-sequencing data

Fidel Ramirez et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Differences in Specificity and Selectivity Between CBP and p300 Acetylation of Histone H3 and H3/H4

Ryan A. Henry et al.

BIOCHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Birt-Hogg-Dube syndrome is a novel ciliopathy

Monique N. H. Luijten et al.

HUMAN MOLECULAR GENETICS (2013)

Article Urology & Nephrology

N-WASP Is Required for Stabilization of Podocyte Foot Processes

Christoph Schell et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)

Article Multidisciplinary Sciences

Primary cilia are specialized calcium signalling organelles

Markus Delling et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset

Christian Feller et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

Article Genetics & Heredity

The NSL Complex Regulates Housekeeping Genes in Drosophila

Kin Chung Lam et al.

PLOS GENETICS (2012)

Article Multidisciplinary Sciences

Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice

Rakesh Kumar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Physiology

Marker expression, behaviors, and responses vary in different lines of conditionally immortalized cultured podocytes

Seetharamaiah Chittiprol et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2011)

Article Cell Biology

Primary cilia disappear in rat podocytes during glomerular development

Koichiro Ichimura et al.

CELL AND TISSUE RESEARCH (2010)

Article Cell Biology

Intraflagellar transport molecules in ciliary and nonciliary cells of the retina

Tina Sedmak et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Drosophila MCRS2 Associates with RNA Polymerase II Complexes To Regulate Transcription

Ditte Skovaa Andersen et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

The Nonspecific Lethal Complex Is a Transcriptional Regulator in Drosophila

Sunil Jayaramaiah Raja et al.

MOLECULAR CELL (2010)

Article Urology & Nephrology

Regeneration of Glomerular Podocytes by Human Renal Progenitors

Elisa Ronconi et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Urology & Nephrology

Slit Diaphragms Contain Tight Junction Proteins

Hirotaka Fukasawa et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2009)

Article Biochemistry & Molecular Biology

The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development

Sebastian Guelman et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis

Arun Gupta et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Review Urology & Nephrology

Podocytes in culture: past, present, and future

S. J. Shankland et al.

KIDNEY INTERNATIONAL (2007)

Article Biochemistry & Molecular Biology

HMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells

M Taipale et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Genetics & Heredity

Genetic heterogeneity in Rubinstein-Taybi syndrome:: Mutations in both the CBP and EP300 genes cause disease

JH Roelfsema et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2005)

Article Developmental Biology

Podocyte-specific expression of Cre recombinase in transgenic mice

MJ Moeller et al.

GENESIS (2003)

Article Physiology

Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton

HP Yuan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2002)

Review Biochemistry & Molecular Biology

Histone acetylation and disease

S Timmermann et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2001)