☆ 4.8 Article

Three-dimensional histological electrophoresis enables fast automatic distinguishment of cancer margins and lymph node metastases

SCIENCE ADVANCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Multidisciplinary Sciences

A genetic engineering strategy for editing near-infrared-II fluorophores

Rui Tian et al.

Summary: The authors propose a strategy to modify protein coatings with biofunctional molecules, resulting in long-wavelength fluorophores for in vivo imaging. These modified albumin variants protect inserted dyes, enhance their brightness, and can be genetically edited to develop size-tunable complexes with precise pharmacokinetics. This approach widens the clinical application prospects for NIR-II fluorophores.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

PI3K drives the de novo synthesis of coenzyme A from vitamin B5

Christian C. Dibble et al.

Summary: In response to hormones and growth factors, the PI3K signalling network plays a crucial role in regulating metabolism and growth by controlling cellular nutrient uptake, energy generation, cofactor production, and macromolecule biosynthesis. This study reveals that PI3K signalling stimulates the de novo synthesis of coenzyme A (CoA), a key metabolic cofactor, and identifies PANK2 and PANK4 as substrates of the PI3K effector kinase AKT. Furthermore, the study shows that PANK4 acts as a suppressor of CoA synthesis and phosphorylation by AKT relieves this suppression. Ultimately, the PI3K-PANK4 axis regulates important processes such as lipid metabolism and proliferation by controlling the abundance of acetyl-CoA and other acyl-CoAs.

NATURE (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Ultrabright Renal-Clearable Cyanine-Protein Nanoprobes for High- Quality NIR-II Angiography and Lymphography

Jiajun Xu et al.

Summary: This study develops a cyanine-protein composite strategy to produce a bright and stable NIR-I/II fluorophore with excellent biocompatibility and renal excretion. The probe enables noninvasive and precise visualization of the physiological and pathological conditions of the vascular and lymphatic drainage system, facilitating surgery guidance and postoperative monitoring.

NANO LETTERS (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging

Lang Bai et al.

Summary: This study investigates the interaction mechanism of dye@albumin complexes and identifies key parameters that govern their binding. The study finds that chloride-containing cyanine dyes with specific chemical structures can bind more efficiently to albumin, resulting in a stable fluorescent probe. This finding addresses the issue of photobleaching in clinically-available cyanine dyes and expands the probe library for NIR-II bioimaging and imaging-guided surgery.

THERANOSTICS (2022)

添加到收藏夹

Review Cell Biology

Progression of Metastasis through Lymphatic System

Hengbo Zhou et al.

Summary: The review focuses on the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes, and further spread to other distant organs. It discusses emerging molecular targets and potential strategies to inhibit lymph node metastasis.

CELLS (2021)

添加到收藏夹

Review Chemistry, Multidisciplinary

Hows and Whys of Tumor-Seeking Dyes

Syed Muhammad Usama et al.

Summary: The text discusses the application and advantages of active targeting in the medical field, as well as the important role of tumor-seeking dyes in overcoming tumor heterogeneity.

ACCOUNTS OF CHEMICAL RESEARCH (2021)

添加到收藏夹

Article Biochemical Research Methods

Role of Albumin in Accumulation and Persistence of Tumor-Seeking Cyanine Dyes

Syed Muhammad Usama et al.

BIOCONJUGATE CHEMISTRY (2020)

添加到收藏夹

Article Oncology

Automated deep-learning system for Gleason grading of prostate cancer using biopsies: a diagnostic study

Wouter Bulten et al.

LANCET ONCOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

3D projection electrophoresis for single-cell immunoblotting

Samantha M. Grist et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Review Oncology

Vessel co-option in cancer

Elizabeth A. Kuczynski et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

QuatCy: A Heptamethine Cyanine Modification With Improved Characteristics

Sopida Thavornpradit et al.

THERANOSTICS (2019)

添加到收藏夹

Article Chemistry, Organic

Site- specific near- infrared fluorescent labelling of proteins on cysteine residues with meso- chlorosubstituted heptamethine cyanine dyes

Coline Canovas et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2018)

添加到收藏夹

Article Medicine, General & Internal

Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer

Babak Ehteshami Bejnordi et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2017)

添加到收藏夹

Article Cell Biology

Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system

Jialing Zhang et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

添加到收藏夹

Article Chemistry, Analytical

Joule Heating-Induced Dispersion in Open Microfluidic Electrophoretic Cytometry

Julea Vlassakis et al.

ANALYTICAL CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Hydrogel Pore-Size Modulation for Enhanced Single-Cell Western Blotting

Todd A. Duncombe et al.

ADVANCED MATERIALS (2016)

添加到收藏夹

Article Biochemical Research Methods

Single cell-resolution western blotting

Chi-Chih Kang et al.

NATURE PROTOCOLS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

In vivo Real-Time Mass Spectrometry for Guided Surgery Application

Benoit Fatou et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Oncology

A framework for a personalized surgical approach to ovarian cancer

Alpa M. Nick et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

添加到收藏夹

Article Cell Biology

Personalized genomic analyses for cancer mutation discovery and interpretation

Sian Jones et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

添加到收藏夹

Article Oncology

Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stage I and II Invasive Breast Cancer: American Society of Clinical Oncology Endorsement of the Society of Surgical Oncology/American Society for Radiation Oncology Consensus Guideline

Thomas A. Buchholz et al.

JOURNAL OF CLINICAL ONCOLOGY (2014)

添加到收藏夹

Article Cell Biology

Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry

Julia Balog et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

添加到收藏夹

Review Oncology

Fluorescence-guided surgery with live molecular navigation - a new cutting edge

Quyen T. Nguyen et al.

NATURE REVIEWS CANCER (2013)

添加到收藏夹

Article Oncology

Sentinel Lymph Node Biopsy for Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Joint Clinical Practice Guideline

Sandra L. Wong et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Sequence analysis of mutations and translocations across breast cancer subtypes

Shantanu Banerji et al.

NATURE (2012)

添加到收藏夹

Article Chemistry, Analytical

In Situ, Real-Time Identification of Biological Tissues by Ultraviolet and Infrared Laser Desorption Ionization Mass Spectrometry

Karl-Christian Schaefer et al.

ANALYTICAL CHEMISTRY (2011)

添加到收藏夹

Article Biochemical Research Methods

Targeted, Activatable, In Vivo Fluorescence Imaging of Prostate-Specific Membrane Antigen (PSMA) Positive Tumors Using the Quenched Humanized J591 Antibody-Indocyanine Green (ICG) Conjugate

Takahito Nakajima et al.

BIOCONJUGATE CHEMISTRY (2011)

添加到收藏夹

Article Biochemical Research Methods

Layered electrophoretic transfer - A method for pre-analytic processing of histological sections

Liang Zhu et al.

PROTEOMICS (2011)

添加到收藏夹

Article Oncology

A Novel, Highly Sensitive Antibody Allows for the Routine Detection of ALK-Rearranged Lung Adenocarcinomas by Standard Immunohistochemistry

Mari Mino-Kenudson et al.

CLINICAL CANCER RESEARCH (2010)

添加到收藏夹

Article Chemistry, Multidisciplinary

In Vivo, In Situ Tissue Analysis Using Rapid Evaporative Ionization Mass Spectrometry

Karl-Christian Schaefer et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

添加到收藏夹

Review Oncology

What is the role for the circumferential margin in the modern treatment of rectal cancer?

Iris D. Nagtegaal et al.

JOURNAL OF CLINICAL ONCOLOGY (2008)

添加到收藏夹

Review Clinical Neurology

Glioma extent of resection and its impact on patient outcome

Nader Sanai et al.

NEUROSURGERY (2008)

添加到收藏夹

Article Surgery

Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation

Michele McElroy et al.

WORLD JOURNAL OF SURGERY (2008)

添加到收藏夹

Article Urology & Nephrology

Positive surgical margins in soft tissue following radical cystectomy for bladder cancer and cancer specific survival

Zohar A. Dotan et al.

JOURNAL OF UROLOGY (2007)

添加到收藏夹

Article Oncology

Real-time imaging of lymphogenic metastasis in orthotopic human breast cancer

Maya Dadiani et al.

CANCER RESEARCH (2006)

添加到收藏夹

Article Gastroenterology & Hepatology

Analysis of long-term survivors after surgical resection for pancreatic cancer

Sung-Sik Han et al.

PANCREAS (2006)

添加到收藏夹

Article Otorhinolaryngology

Surgical margins and survival after head and neck cancer surgery

Reina Haque et al.

BMC EAR NOSE AND THROAT DISORDERS (2006)

添加到收藏夹

Article Pathology

Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation

SJ Maygarden et al.

MODERN PATHOLOGY (2004)

添加到收藏夹

Article Biochemical Research Methods

Effect of Joule heating on efficiency and performance for microchip-based and capillary-based electrophoretic separation systems: A closer look

NJ Petersen et al.

ELECTROPHORESIS (2004)

添加到收藏夹

Article Oncology

Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy

F Meric et al.

CANCER (2003)

添加到收藏夹

Article Surgery

Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy

SE Singletary

AMERICAN JOURNAL OF SURGERY (2002)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Prognostic implications of a positive bronchial resection margin

G Massard et al.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.