A convenient synthetic protocol for the construction of spiro[indoline-3,3'-quinoline]-2,5'-dione motifs was successfully developed by base promoted one-pot three-component reaction. The reaction conditions were mild and the yields were high.
A convenient synthetic protocol for the construction of spiro[indoline-3,3'-quinoline]-2,5'-dione motifs was successfully developed by base promoted one-pot three-component reaction. In the presence of piperidine, three-component reaction of ammonium acetate, aromatic aldehydes and the in situ generated 3-isatyl 1,4-dicarbonyl compounds, which were derived from base mediated addition of dimedone to 3-meth- yleneoxindoles, resulted in two diastereoisomers of spiro[indoline-3,3'-quinoline]-2,5'-dione derivatives in good yields and with good diastereoselectivity. The stereochemistry of the reaction was clearly elucidated by isolation of two diastereomers and determination of several single crystal structures.
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