MCP-1-Loaded Poly(l-lactide-co-caprolactone) Fibrous Films Modulate Macrophage Polarization toward an Anti-inflammatory Phenotype and Improve Angiogenesis

Tissueengineering approaches such as the electrospinning techniquecan fabricate nanofibrous scaffolds which are widely used for small-diametervascular grafting. However, foreign body reaction (FBR) and lack ofendothelial coverage are still the main cause of graft failure afterthe implantation of nanofibrous scaffolds. Macrophage-targeting therapeuticstrategies have the potential to address these issues. Here, we fabricatea monocyte chemotactic protein-1 (MCP-1)-loaded coaxial fibrous filmwith poly(l-lactide-co-& epsilon;-caprolactone)(PLCL/MCP-1). The PLCL/MCP-1 fibrous film can polarize macrophagestoward anti-inflammatory M2 macrophages through the sustained releaseof MCP-1. Meanwhile, these specific functional polarization macrophagescan mitigate FBR and promote angiogenesis during the remodeling ofimplanted fibrous films. These studies indicate that MCP-1-loadedPLCL fibers have a higher potential to modulate macrophage polarity,which provides a new strategy for small-diameter vascular graft designing.

Automated summary

Researchers have developed a polymer fiber film loaded with monocyte chemotactic protein-1 (MCP-1), which can regulate macrophage polarization through sustained release of MCP-1, thereby reducing foreign body reaction and promoting angiogenesis.