Osteoporosis and dermatoporosis: a review on the role of vitamin D

Osteoporosis (OP) and Dermatoporosis (DP) are expressions of the aging process at the skin and bone levels, respectively. Both conditions are associated with increased morbidity for elderly people, and this requires necessary interventions. They share many common risk factors; among these, vitamin D (VD) deficiency appears to have a role. VD is involved in either disease with many mechanisms, among which immunomodulation. VD deficiency has been linked to OP because it inhibits the body's capacity to absorb calcium and maintain optimal bone health. Available evidence suggests that proper vitaminosis D also appears to be vital in preventing skin age-related issues. DP is often seen in elderly individuals, particularly those with long-term sun exposure and a history of chronic sun damage. VD deficiency can be linked to DP, since its involvement in collagen production, epidermal barrier function, inflammation regulation, wound healing, and sun protection. Aim of this review is to summarize the most updated existing evidence on the role of VD in the development of fragility syndromes such as DP and OP and the possible benefits of VD supplementation as a simple and harmful weapon against aging.

Automated summary

Osteoporosis (OP) and Dermatoporosis (DP) are age-related conditions affecting the bones and skin. Both conditions are associated with increased morbidity in elderly individuals, and vitamin D deficiency plays a role in their development. Vitamin D is involved in various mechanisms related to these diseases, including immunomodulation. Deficiency of vitamin D inhibits calcium absorption and optimal bone health, leading to OP. Proper vitamin D is also important in preventing age-related skin issues like DP, as it affects collagen production, epidermal barrier function, inflammation regulation, wound healing, and sun protection.