期刊
FRONTIERS IN ENDOCRINOLOGY
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2023.1216817
关键词
PA; Wnt signaling pathway; Wnt pathway inhibitors; targeted drugs; non-coding RNA; TME
This article reviews the pathogenesis of pituitary adenoma and the role of the Wnt signaling pathway. It discusses the potential of combining Wnt pathway inhibitors with immunotherapy for the treatment of pituitary adenoma.
Pituitary adenoma (PA) is the third most common central nervous system tumor originating from the anterior pituitary, but its pathogenesis remains unclear. The Wnt signaling pathway is a conserved pathway involved in cell proliferation, Self-renewal of stem cells, and cell differentiation. It is related to the occurrence of various tumors, including PA. This article reviews the latest developments in Wnt pathway inhibitors and pathway-targeted drugs. It discusses the possibility of combining Wnt pathway inhibitors with immunotherapy to provide a theoretical basis for the combined treatment of PA.
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