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Role of glycolysis in inflammatory bowel disease and its associated colorectal cancer

FRONTIERS IN ENDOCRINOLOGY (2023)

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IDH2, a novel target of OGT, facilitates glucose uptake and cellular bioenergy production via NF-κB signaling to promote colorectal cancer progression

Xiaoli He et al.

Summary: The wild-type IDH2 is often associated with poor survival rates in CRC patients and can promote the growth of CRC cells and tumor progression. This IDH2 reprograms glucose metabolism and the TCA cycle, activates the NF-κB signaling pathway to enhance glucose uptake, and drives CRC development and progression. The interaction with OGT increases the stability of IDH2 protein, further promoting tumor progression.

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Article Oncology

METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression

Peng Xia et al.

Summary: This study reveals the role of METTL5 in glucose metabolic reprogramming, proliferation, and metastasis of HCC. The findings suggest a novel mechanism of CREB1/P300-METTL5-USP5-c-Myc axis in controlling abnormal glucose metabolism and promoting tumor growth.

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Article Biochemistry & Molecular Biology

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells

Yichao Hou et al.

Summary: In this study, the researchers found that METTL14 is activated by wild-type p53 and suppresses tumor growth in p53-wild-type CRC cells. METTL14 deletion promotes the growth of CRC in mouse models. Additionally, METTL14 inhibits aerobic glycolysis and tumor progression by repressing SLC2A3 and PGAM1 expression. Clinically, METTL14 is found to be a beneficial prognosis factor for p53-wild-type CRC patients. These findings suggest that the activation of METTL14 could be targeted for therapy in p53-wild-type CRC.

EMBO REPORTS (2023)

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Article Gastroenterology & Hepatology

Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019

Yichen Wang et al.

Summary: This study examined the worldwide burden of digestive diseases from 1990 to 2019. The incidence and prevalence of digestive diseases remained relatively stable during this period, with enteric infections being the primary cause. There was a significant disparity in the burden of digestive diseases among countries with different development levels.

GASTROENTEROLOGY (2023)

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Article Immunology

Dendritic cell-expressed IDO alleviates atherosclerosis by expanding CD4+CD25+Foxp3+Tregs through IDO-Kyn-AHR axis

Yuekang Xu et al.

Summary: A study showed that metabolic products from dendritic cells (DCs) play an important role in the development of atherosclerosis. Through experiments on pro-atherosclerotic mice, researchers found that DCs-produced IDO can induce the expansion of CD4+CD25+Foxp3+Treg in the aorta through the IDO-Kyn-AHR axis, thereby reducing atherosclerotic lesions.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Article Endocrinology & Metabolism

PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages

Maaike Schilperoort et al.

Summary: The study reveals that transient increase in glycolysis and lactate production are essential for continual efferocytosis, contrasting with prolonged glycolysis in pro-inflammatory macrophages. This unique metabolic process depends on the activation of PFKFB2 enzyme and promotes continual efferocytosis through lactate-mediated upregulation of MerTK and LRP1. Inhibiting this process may provide a potential therapeutic pathway in chronic inflammatory diseases.

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Article Oncology

Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance

Hannah N. Bell et al.

Summary: Microbial dysbiosis is associated with colorectal cancer and affects tumor growth and therapy response. Healthy microbial metabolites inhibit tumor growth, but this effect is reduced in colorectal cancer patients. Lactobacillus reuteri and its metabolite reuterin are downregulated in colorectal cancer and exert anti-tumor effects by altering redox balance, reducing proliferation, and inhibiting protein translation.

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Article Oncology

EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling

Xingkang Jiang et al.

Summary: This study reveals the important role of circARHGAP29 in docetaxel-resistant prostate cancer by promoting glycolytic metabolism. circARHGAP29 upregulation leads to docetaxel resistance and enhanced glycolytic metabolism, while silencing circARHGAP29 can reduce these effects.

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Article Oncology

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

Shuohui Dong et al.

Summary: This study describes the abnormality of glucose metabolism in 5-FU-resistant CRC, and shows that enhanced glycolysis and pentose phosphate pathway are associated with increased HIF-1 alpha expression. HIF-1 alpha-induced glucose metabolic reprogramming imparts 5-FU resistance in CRC. HIF-1 alpha is a potential biomarker for 5-FU-resistant CRC, and targeting HIF-1 alpha in combination with 5-FU may represent an effective therapeutic strategy in 5-FU-resistant CRC.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Article Plant Sciences

Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa

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Summary: Emodin exhibited a novel anti-tumor mechanism by decreasing the expression levels of sPLA2-IIa and NF-kappa B pathways, thus inhibiting the proliferation of KRAS mutant cell lines in non-small-cell lung cancer (NSCLC). This suggests that emodin could potentially serve as a therapeutic target in NSCLC.

PHYTOMEDICINE (2022)

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Article Pharmacology & Pharmacy

Albuca Bracteata Polysaccharides Attenuate AOM/DSS Induced Colon Tumorigenesis via Regulating Oxidative Stress, Inflammation and Gut Microbiota in Mice

Ziyan Qin et al.

Summary: Inflammation is a significant risk factor for the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Polysaccharides extracted from Albuca bracteata (ABP) have been shown to have anti-tumor and anti-inflammatory properties, making them a potential therapeutic agent for treating colorectal cancer.

FRONTIERS IN PHARMACOLOGY (2022)

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Targeting uPA-uPAR interaction to improve intestinal epithelial barrier integrity in inflammatory bowel disease

Yang Cheng et al.

Summary: This study reveals that the coordinated upregulation of uPA and uPAR in IBD mucosa is associated with the breakdown of the intestinal epithelial barrier. Inhibiting the interaction between uPA and uPAR through genetic and pharmacological approaches can protect the epithelial barrier. Additionally, uPAR deficiency enhances EGF/EGFR signaling, promoting epithelial homeostasis and repair.

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Expression of proteins associated with the Warburg-effect and survival in colorectal cancer

Kelly Offermans et al.

Summary: This study found that CRC patients with Warburg-high subtype had the poorest survival rates, especially for those with TNM stage III CRC and cancers located in the rectum. Further research is needed to confirm the findings and explore the potential clinical utility of Warburg subtypes in CRC.

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Review Immunology

Metabolic dynamics instruct CD8+ T-cell differentiation and functions

Alessio Bevilacqua et al.

Summary: This article reviews how metabolism affects the differentiation and function of CD8(+) T cells, as well as the principal metabolic dysregulation that leads to the exhausted phenotype. The article also summarizes recent strategies to reprogram impaired metabolic pathways to promote CD8(+) T cell effector function and survival.

EUROPEAN JOURNAL OF IMMUNOLOGY (2022)

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Article Oncology

TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivation

Giuseppina Bruno et al.

Summary: The study reveals the role of the TRAP1 gene in the adaptive response of human colorectal cancer cells to hypoxia. TRAP1 is involved in regulating HIF-1α stabilization, glycolytic metabolism, and gene expression reprogramming. It also affects glucose uptake, lactate production, and ribosome biogenesis through the mTOR pathway.

INTERNATIONAL JOURNAL OF ONCOLOGY (2022)

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Article Oncology

Downregulation of miRNA-14669 Reverses Vincristine Resistance in Colorectal Cancer Cells through PI3K/AKT Signaling Pathway

Weihua Dong et al.

Summary: This study identified a novel miRNA-14669 that can reverse vincristine resistance and sensitize drug-resistant colorectal cancer cells. MiRNA-14669 is involved in drug resistance mechanisms through affecting cell apoptosis, detoxification, and drug efflux.

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Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer

Huimin Jiang et al.

Summary: This study identifies a Zeb1-dependent mechanism that drives breast cancer progression by stimulating tumor-macrophage interplay, which could be a potential therapeutic target for the treatment of advanced cancers.

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Gut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate

Ruiqing Wang et al.

Summary: This study demonstrates that the gut microbiota is associated with AML progression. Dysbiosis of the gut microbiota induced by antibiotic treatment accelerates AML progression in mice, while fecal microbiota transplantation reverses this process. Decreased levels of butyrate, produced by the gut microbiota (especially Faecalibacterium), are found in the feces of AML patients. However, gavage with butyrate or Faecalibacterium postpones AML progression in mice. Additionally, the study reveals that AML mice have damaged intestinal barriers, leading to increased leakage of lipopolysaccharide (LPS) into the blood. The increased LPS exacerbates leukemia progression in vitro and in vivo. Butyrate can repair intestinal barrier damage and inhibit LPS absorption in AML mice.

NATURE COMMUNICATIONS (2022)

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Article Oncology

Cancer treatment and survivorship statistics, 2022

Kimberly D. Miller et al.

Summary: The number of cancer survivors in the United States is increasing due to population growth, aging, and improved detection and treatment. The most prevalent cancers are prostate, skin melanoma, and colon and rectum for males, and breast, uterine corpus, and thyroid for females. Treatment disparities exist, with Black patients being less likely to be diagnosed with early-stage cancer and having lower surgical receipt rates.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

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Article Veterinary Sciences

Eimeria tenella 14-kDa phosphohistidine phosphatase stimulates maturation of chicken dendritic cells and mediates DC-induced T cell priming in a Th1 cytokine interface

Shakeel Ahmed Lakho et al.

Summary: This study demonstrated that the 14-kDa phosphohistidine phosphatase (EtPHP14) from Eimeria tenella can promote the maturation of chicken dendritic cells (DCs) and initiate DC-induced T cell immunity. The presence of EtPHP14 on the surface of chicken DCs was confirmed. The expression of maturation markers and the activation of signaling pathways associated with immune response were observed in rEtPHP14-treated DCs. Additionally, co-culturing rEtPHP14-treated DCs with autologous T cells resulted in increased proliferation of T cells and differentiation of CD4+ cells. These findings highlight the importance of EtPHP14 as a potential candidate for coccidiosis vaccine development.

RESEARCH IN VETERINARY SCIENCE (2022)

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Article Pharmacology & Pharmacy

Disturbing effect of cepharanthine on valve interstitial cells calcification via regulating glycolytic metabolism pathways

Fei Xie et al.

Summary: This study investigated the effects and molecular mechanism of cepharanthine (CEP), a natural product, on inhibiting the osteogenic differentiation of valve interstitial cells (VICs). The results showed that CEP inhibited valve calcification by regulating the glycolytic pathway.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Gastroenterology & Hepatology

The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease

Xinwei Xu et al.

Summary: Inflammatory bowel disease (IBD) is a chronic gut immune dysregulation and dysbiosis condition that is rapidly increasing in global incidence. Changes in gut microbial composition and metabolites are closely associated with the pathogenesis of IBD. This study found that IBD patients exhibit severe perturbation in gut bacteria community composition, diversity, and metabolites, with specific metabolites showing high sensitivity and specificity in differentiating between IBD patients and healthy individuals. Additionally, affected metabolic pathways in IBD include primary bile acid biosynthesis, vitamin digestion and absorption, and carbohydrate metabolism. The combined evaluation of metabolites and fecal microbiome may serve as useful therapeutic and diagnostic targets for IBD.

GUT PATHOGENS (2022)

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Correction Cell Biology

HIF-1α Is a Metabolic Switch Between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma (vol 27, 226-237.e1-e4, 2019)

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CELL REPORTS (2022)

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Article Medicine, Research & Experimental

Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1α Pathway

Wen-bo Long et al.

Summary: Arginine ADP-ribosyltransferase 1 (ART1) plays a crucial role in glycolysis in colorectal cancer (CRC) cells and may regulate GLUT1-dependent glycolysis through the PI3K/AKT/HIF1alpha pathway.

CURRENT MEDICAL SCIENCE (2022)

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Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer

Hongyan Lin et al.

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INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Oncology

Tumor glycolysis, an essential sweet tooth of tumor cells

Sumana Paul et al.

Summary: Cancer cells undergo metabolic alterations to meet energy demands, with glycolysis playing a central role. Glycolysis is intertwined with other metabolic pathways, leading to diverse and heterogeneous cancer metabolism. Oncogenic signaling enhances glycolytic enzyme activity, promoting tumor growth and metastasis. This article discusses the interactions between tumor glycolysis and other metabolic pathways, the role and regulation of key enzymes, and the significance of lactate in tumor growth and metastasis.

SEMINARS IN CANCER BIOLOGY (2022)

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Review Gastroenterology & Hepatology

Neutrophil-Epithelial Crosstalk During Intestinal Inflammation

Le Kang et al.

Summary: Neutrophils play a multifaceted role in intestinal inflammation, contributing to the elimination of pathogens but also causing tissue damage. This article focuses on the interactions between neutrophils and epithelial cells in the intestine and highlights the molecular factors involved in neutrophil recruitment, migration, and detachment from the epithelium.

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Immune effects of PI3K/Akt/HIF-1α-regulated glycolysis in polymorphonuclear neutrophils during sepsis

Tingting Pan et al.

Summary: This study investigated the metabolic characteristics and immunomodulatory pathways of polymorphonuclear neutrophils (PMNs) during sepsis. The study found significant changes in glycolysis and the mTOR/HIF-1 alpha signaling pathway during sepsis. The Warburg effect was also altered in septic patients. Glycolysis was found to regulate PMNs' chemotaxis and phagocytosis functions, and lactate dehydrogenase A (LDHA) downregulation played a key role in inhibiting glycolysis in PMNs. The PI3K/Akt-HIF-1 alpha pathway was involved in LDHA expression and influenced PMNs' chemotaxis and phagocytosis functions.

CRITICAL CARE (2022)

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Article Gastroenterology & Hepatology

The four epidemiological stages in the global evolution of inflammatory bowel disease

Gilaad G. Kaplan et al.

Summary: The global burden of inflammatory bowel disease is evolving into four epidemiological stages: Emergence, Acceleration in Incidence, Compounding Prevalence, and Prevalence Equilibrium. Developing countries, newly industrialized countries, and Western regions are in different stages of disease evolution.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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YAP promotes ocular neovascularization by modifying PFKFB3-driven endothelial glycolysis

Yifan Feng et al.

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ANGIOGENESIS (2021)

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Article Oncology

Anlotinib Overcomes Multiple Drug Resistant Colorectal Cancer Cells via Inac-tivating PI3K/AKT Pathway

Weilan Lan et al.

Summary: Anlotinib inhibited the proliferation, migration, invasion, and induced apoptosis of HCT-8/5-FU cells by inactivating the PI3K/AKT pathway, overcoming multidrug resistance in colorectal cancer cells.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

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Article Oncology

MiR-4310 regulates hepatocellular carcinoma growth and metastasis through lipid synthesis

Huayue Li et al.

Summary: The study demonstrates that miR-4310 inhibits lipid synthesis by targeting FASN and SCD1, leading to suppressed HCC cell proliferation, migration, and invasion. Low expression of miR-4310 is associated with poor prognosis in HCC patients, highlighting its potential role as a therapeutic target for HCC treatment.

CANCER LETTERS (2021)

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Review Biochemistry & Molecular Biology

The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms

Sofia Frigerio et al.

Summary: Patients with IBD have an increased risk of CRC, which develops in a background of chronic inflammation and pro-inflammatory immune cells. The role of the immunosuppressive microenvironment in these cancers is not well understood, but it has gained more attention in recent years.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression

Xiao-Hong Wang et al.

Summary: FOXO4 downregulation in gastric cancer is associated with poor prognosis. Restoring FOXO4 expression decreases glycolysis rate in GC cells, while silencing it increases glycolysis rate. FOXO4 is a transcriptional target of HIF-1 alpha and plays a key role in regulating glycolysis in GC.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer

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Summary: In this study, a potential drug candidate 29e for treating CRC was designed to inhibit tumor growth by targeting PKM2 kinase, demonstrating significant antiproliferative effects in cell experiments and animal models.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Review Oncology

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Yang Liu et al.

Summary: Macrophages are key regulators of tissue homeostasis, involved in tissue development, repair, and defense against pathogens. TAMs play a crucial role in the tumor microenvironment, impacting tumor initiation, growth, invasion, and metastasis. The metabolic characteristics of macrophages influence their phenotype and function, with pro-inflammatory M1 macrophages relying on glycolysis and anti-inflammatory M2 macrophages more dependent on mitochondrial OXPHOS.

BIOMARKER RESEARCH (2021)

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Review Immunology

Dendritic Cell Regulation of T Helper Cells

Xiangyun Yin et al.

Summary: Dendritic cells play a crucial role in sensing the microenvironment and shaping the adaptive immune response. They consist of several subsets that regulate T lymphocyte differentiation and determine distinct CD4(+) T helper cell differentiation outcomes. The intrinsic properties of DC subsets, local tissue microenvironments, and interactions with other immune cells contribute to Th cell differentiation during homeostasis and inflammation.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

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Article Biochemistry & Molecular Biology

CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer

Tao Jiang et al.

Summary: The study demonstrates that upregulation of circIL4R in CRC plays an oncogenic role by promoting CRC cell proliferation, migration, and invasion through activation of the PI3K/AKT signaling pathway. Targeting circIL4R may serve as a potential diagnostic and prognostic biomarker for CRC detection and treatment.

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Review Medicine, General & Internal

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Leah H. Biller et al.

Summary: Colorectal cancer is the third most common cause of cancer mortality worldwide. For patients diagnosed with metastatic colorectal cancer, approximately 70% to 75% can survive beyond 1 year. Tailoring treatments based on the molecular and pathologic features of the tumor has shown to improve overall survival rates.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Global colorectal cancer burden in 2020 and projections to 2040

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Summary: Colorectal cancer is a major global public health challenge with higher incidence rates in developed countries and increasing trends in middle- and low-income countries. The rise of early-onset colorectal cancer is also seen. Increasing awareness, promoting healthy lifestyle choices, and implementing global screening programs are crucial in reducing the morbidity and mortality of colorectal cancer in the future.

TRANSLATIONAL ONCOLOGY (2021)

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Article Endocrinology & Metabolism

Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1α/HO-1 Pathway in db/db Mice

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Summary: The study found that ferroptosis aggravated diabetic nephropathy and damaged renal tubules in db/db mice through the HIF-1 alpha/HO-1 pathway.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Oncology

Cyclosporine modulates neutrophil functions via the SIRT6-HIF-1α-glycolysis axis to alleviate severe ulcerative colitis

Huiying Lu et al.

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CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Review Gastroenterology & Hepatology

Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation

Broc Drury et al.

Summary: Neutrophil extracellular traps (NETs) play a crucial role in inflammatory bowel diseases by acting as a defense mechanism to inhibit pathogens while also potentially exacerbating and perpetuating gut inflammation.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Oncology

The hexosamine biosynthetic pathway and cancer: Current knowledge and future therapeutic strategies

Christine Lam et al.

Summary: The hexosamine biosynthetic pathway (HBP) is a glucose metabolism pathway that results in the synthesis of UDP-GlcNAc, which can be used for post-translational modification of intracellular proteins. Activation of HBP has been implicated in cancer pathophysiology, and inhibition of HBP enzymes may serve as a novel strategy for cancer treatment by suppressing tumor growth and modulating immune response. Targeting HBP could potentially enhance sensitivity of tumor cells to conventional cancer therapy.

CANCER LETTERS (2021)

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Article Biochemistry & Molecular Biology

Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production

Kunlun Yin et al.

Summary: Research has shown that the mitochondria protein PINK1 suppresses colon tumor growth by metabolic reprogramming and reducing acetyl-CoA production. PINK1 overexpression promotes mitophagy, decreases glycolysis, and increases mitochondrial respiration, while PINK1 deletion leads to decreased apoptosis, increased glycolysis, and reduced mitochondrial respiration.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Immunology

Pro-Resolving Factors Released by Macrophages After Efferocytosis Promote Mucosal Wound Healing in Inflammatory Bowel Disease

Omayra Martin-Rodriguez et al.

Summary: The study focuses on evaluating the efficacy of pro-resolving factors produced by macrophages after efferocytosis in treating IBD. Reintroduction of these factors was shown to reduce inflammation in colitis models and promote tissue repair, with TGF-beta, IGF-I and VEGF identified as key factors. The administration of these pro-resolving factors released by efferocytic macrophages represents an innovative treatment approach for IBD.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish

Chi-Yu Lai et al.

Summary: miR-21 plays a crucial role in the development of CRC/CAC through the PI3K/AKT, STAT3, and PDCD4/TNF-alpha signaling networks, and may serve as a novel therapeutic target for the treatment of CRC/CAC.

CANCERS (2021)

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Article Environmental Sciences

Beta-Alanine Supplementation and Sport Climbing Performance

Krzysztof Sas-Nowosielski et al.

Summary: The study found that supplementation of beta-alanine (BA) can significantly improve specific performance of climbers, including the total number of slaps in campus board exercise and in easy traverse, as well as the time to failure in easy traverse. However, BA supplementation did not significantly enhance climbing performance of shorter duration.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Immunology

Tiliroside Ameliorates Ulcerative Colitis by Restoring the M1/M2 Macrophage Balance via the HIF-1α/glycolysis Pathway

Hongda Zhuang et al.

Summary: The study demonstrates that tiliroside can alleviate symptoms of colitis by modulating the balance between M1 and M2 macrophages, and has an impact on the metabolic level of macrophages.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Lactic Acid Fermentation Is Required for NLRP3 Inflammasome Activation

Hsin-Chung Lin et al.

Summary: The study found that lactic acid fermentation is essential for NLRP3 inflammasome activation, while pyruvate oxidation is dispensable. Inhibiting lactic acid fermentation can reduce inflammasome activation, while inhibiting pyruvate oxidation enhances inflammasome activation.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Microbiology

Gut microbiota-derived inosine from dietary barley leaf supplementation attenuates colitis through PPARγ signaling activation

Daotong Li et al.

Summary: Our study demonstrates that the gut microbiota-inosine-A(2A)R/PPAR gamma axis is crucial in maintaining intestinal homeostasis and may offer a novel approach for preventing colitis through manipulation of gut microbial purine metabolite. Additionally, dietary supplementation of barley leaf improves intestinal mucosal barrier functions and induces metabolic reprogramming in colonic tissues by enhancing the glycolysis process. Furthermore, the enrichment of microbiota-derived purine metabolite inosine from BL supplementation activates PPAR gamma signaling in human colon epithelial cells.

MICROBIOME (2021)

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Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

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EBIOMEDICINE (2021)

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Article Hematology

BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway

Miriam Butler et al.

Summary: Utilizing a CRISPR/Cas9-based screen, actionable signaling intermediates were identified to improve the response to ASNase by inhibiting the amino acid response pathway. Genetic inactivation of Bruton's tyrosine kinase (BTK) and pharmacological inhibition by the BTK inhibitor ibrutinib strongly synergize with ASNase. The synthetic lethal interaction between BTK and ASNase was observed in 90% of patient-derived xenografts, and ibrutinib substantially improved ASNase treatment response in a murine PDX model.

BLOOD (2021)

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Review Biochemistry & Molecular Biology

Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease

Angela Saez et al.

Summary: Inflammatory bowel disease (IBD) is a complex condition involving chronic intestinal inflammation and is associated with genetics, environment, immune system, and intestinal barrier function. Recent studies have shown that innate lymphoid cells (ILCs) play crucial roles in intestinal homeostasis and IBD.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Cell Biology

TKT maintains intestinal ATP production and inhibits apoptosis-induced colitis

Na Tian et al.

Summary: Depletion of TKT in intestinal epithelial cells leads to growth retardation and spontaneous colitis in mice, along with extensive mucosal erosion, aberrant tight junctions, impaired barrier function, and increased inflammatory cell infiltration in the intestine. This is due to the accumulation of PPP metabolites and reduction of glycolytic metabolites, resulting in decreased ATP production, excessive apoptosis, and defective intestinal barrier. Thus, TKT plays a crucial role in maintaining intestinal integrity and barrier function, suggesting it could be a potential therapeutic target for intestinal disorders.

CELL DEATH & DISEASE (2021)

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Article Biochemistry & Molecular Biology

The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis

Min Liu et al.

Summary: The study revealed that SETD2 regulates oxidative stress to attenuate colonic inflammation and tumorigenesis in mice. Depletion of Setd2 leads to excess ROS production, disrupting barrier integrity and causing inflammatory damage. These findings highlight the important role of SETD2 in maintaining intestinal epithelial homeostasis.

REDOX BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Melatonin and hyperbaric oxygen therapies suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms

Yi-Chen Li et al.

Summary: Melatonin and HBO therapies have been shown to suppress colorectal carcinogenesis through pleiotropic effects and multifaceted mechanisms, demonstrating effective anti-cancer activity in cell and animal models and offering potential as novel CRC treatment strategies.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Oncology

Cancer metabolism: looking forward

Inmaculada Martinez-Reyes et al.

Summary: This Perspective discusses the main themes in cancer metabolism research, focusing on the relationship between tumour initiation and progression with metabolic reprogramming, as well as the importance of tumor microenvironment and metabolic regulation.

NATURE REVIEWS CANCER (2021)

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Review Public, Environmental & Occupational Health

A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration

P. Tavakoli et al.

Summary: This review highlights the complexity of inflammatory bowel diseases (IBDs) and the comprehensive research on influencing factors, focusing on genetics, environment, microbiome, immune system, psychological factors, and gut nervous system. By understanding the interrelationships between these factors, novel diagnostic, interventions, and therapeutic strategies may be identified for better disease management and patient outcomes.

PUBLIC HEALTH REVIEWS (2021)

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Article Gastroenterology & Hepatology

Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling

Pim J. Koelink et al.

GUT (2020)

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Article Nutrition & Dietetics

Glycolysis/gluconeogenesis- and tricarboxylic acid cycle–related metabolites, Mediterranean diet, and type 2 diabetes

Marta Guasch-Ferré et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2020)

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Article Cell Biology

Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

Juliette Le Douce et al.

CELL METABOLISM (2020)

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Article Allergy

The microbiome and inflammatory bowel disease

Kerri L. Glassner et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Article Oncology

Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer

Xinyi Wang et al.

MOLECULAR ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance

Hoon Choi et al.

FASEB JOURNAL (2020)

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Article Multidisciplinary Sciences

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Mei-lin Weng et al.

NATURE COMMUNICATIONS (2020)

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Review Cell & Tissue Engineering

The Achievements and Challenges of Mesenchymal Stem Cell-Based Therapy in Inflammatory Bowel Disease and Its Associated Colorectal Cancer

Dickson Kofi Wiredu Ocansey et al.

STEM CELLS INTERNATIONAL (2020)

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Article Pharmacology & Pharmacy

Atractylenolide I Induces Apoptosis and Suppresses Glycolysis by Blocking the JAK2/STAT3 Signaling Pathway in Colorectal Cancer Cells

Yanxi Li et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

m6A-dependent glycolysis enhances colorectal cancer progression

Chaoqin Shen et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Redox regulation by SOD2 modulates colorectal cancer tumorigenesis through AMPK-mediated energy metabolism

Chen Zhou et al.

MOLECULAR CARCINOGENESIS (2020)

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Article Cell Biology

AMPK activation overcomes anti-EGFR antibody resistance induced by KRAS mutation in colorectal cancer

Hua Ye et al.

CELL COMMUNICATION AND SIGNALING (2020)

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Article Public, Environmental & Occupational Health

Trends in the incidence of diabetes mellitus: results from the Global Burden of Disease Study 2017 and implications for diabetes mellitus prevention

Jinli Liu et al.

BMC PUBLIC HEALTH (2020)

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Review Biochemistry & Molecular Biology

Metabolism

Ayesha Judge et al.

UNDERSTANDING BIOCHEMISTRY 6 (2020)

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Article Oncology

Effects and mechanisms of fatty acid metabolism-mediated glycolysis regulated by betulinic acid-loaded nanoliposomes in colorectal cancer

Gang Wang et al.

ONCOLOGY REPORTS (2020)

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Article Oncology

MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis

Zhenqiang Sun et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation

Liang-Yan Chen et al.

MOLECULAR CANCER (2020)

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Article Gastroenterology & Hepatology

Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice

Lingyan Ma et al.

GUT MICROBES (2020)

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Article Oncology

TM4SF1 promotes EMT and cancer stemness via the Wnt/β-catenin/SOX2 pathway in colorectal cancer

Qiang Tang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth

Yang Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Cell Biology

Mammalian Target of Rapamycin 2 (MTOR2) and C-MYC Modulate Glucosamine-6-Phosphate Synthesis in Glioblastoma (GBM) Cells Through Glutamine: Fructose-6-Phosphate Aminotransferase 1 (GFAT1) (Publication with Expression of Concern. See vol. 39, pg. 1067, 2019)

Bo Liu et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2019)

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Review Gastroenterology & Hepatology

Immunotherapy in colorectal cancer: rationale, challenges and potential

Karuna Ganesh et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Immunology

Beneficial effects of dual TORC1/2 inhibition on chronic experimental colitis

Shurong Hu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Review Pharmacology & Pharmacy

PI3K/Akt/mTOR Pathway as a Therapeutic Target for Colorectal Cancer: A Review of Preclinical and Clinical Evidence

Arunaksharan Narayanankutty

CURRENT DRUG TARGETS (2019)

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Review Gastroenterology & Hepatology

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

Yi Rang Na et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Article Multidisciplinary Sciences

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Elizabeth Haythorne et al.

NATURE COMMUNICATIONS (2019)

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Review Immunology

Metabolic Control of Dendritic Cell Functions: Digesting Information

Stefanie K. Wculek et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Medicine, Research & Experimental

Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases

Rong Cai et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Cell Biology

Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity

Lucien P. Garo et al.

CELL REPORTS (2019)

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Review Immunology

Metabolic Insight of Neutrophils in Health and Disease

Sachin Kumar et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Immunology

Subsets of mononuclear phagocytes are enriched in the inflamed colons of patients with IBD

Hong Liu et al.

BMC IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Metabolic regulation of gene expression by histone lactylation

Di Zhang et al.

NATURE (2019)

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Article Multidisciplinary Sciences

LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc

Jiayin Tang et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

Yuan Fang et al.

NATURE COMMUNICATIONS (2019)

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Review Biochemistry & Molecular Biology

IL-23 in inflammatory bowel diseases and colon cancer

Markus F. Neurath

CYTOKINE & GROWTH FACTOR REVIEWS (2019)

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Article Microbiology

Gut microbiome structure and metabolic activity in inflammatory bowel disease

Eric A. Franzosa et al.

NATURE MICROBIOLOGY (2019)

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Review Immunology

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Daniela Parada Venegas et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Medicine, Research & Experimental

Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis

Karl Katholnig et al.

JCI INSIGHT (2019)

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Article Gastroenterology & Hepatology

CD177+ neutrophils as functionally activated neutrophils negatively regulate IBD

Guangxi Zhou et al.

GUT (2018)

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Article Cell Biology

T Helper Cell Differentiation, Heterogeneity, and Plasticity

Jinfang Zhu

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2018)

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Article Clinical Neurology

Evidence for brain glucose dysregulation in Alzheimer's disease

Yang An et al.

ALZHEIMERS & DEMENTIA (2018)

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Article Medical Laboratory Technology

Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indices

Ahmed A. Almousa et al.

CLINICAL BIOCHEMISTRY (2018)

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Article Medicine, Research & Experimental

Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation

Ming Zhao et al.

EMBO MOLECULAR MEDICINE (2018)

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Article Oncology

STK25-induced inhibition of aerobic glycolysis via GOLPH3-mTOR pathway suppresses cell proliferation in colorectal cancer

Fan Wu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Multidisciplinary Sciences

PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis

Qiuhua Yang et al.

NATURE COMMUNICATIONS (2018)

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Review Microbiology

Formation of propionate and butyrate by the human colonic microbiota

Petra Louis et al.

ENVIRONMENTAL MICROBIOLOGY (2017)

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Article Immunology

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

Madhav Kishore et al.

IMMUNITY (2017)

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Review Immunology

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

Joseph M. Pickard et al.

IMMUNOLOGICAL REVIEWS (2017)

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Article Cell Biology

Up-regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine-resistant pancreatic cancer cells

Hengqiang Zhao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2017)

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Article Biochemistry & Molecular Biology

α-enolase promotes tumorigenesis and metastasis via regulating AMPK/mTOR pathway in colorectal cancer

Panpan Zhan et al.

MOLECULAR CARCINOGENESIS (2017)

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Article Genetics & Heredity

Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis

Oliver G. McDonald et al.

NATURE GENETICS (2017)

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Review Gastroenterology & Hepatology

Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD

Sophie Van Welden et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Cell Biology

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

Fang Wang et al.

CELL REPORTS (2017)

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Article Endocrinology & Metabolism

Temporal Transcriptomic and Proteomic Landscapes of Deteriorating Pancreatic Islets in Type 2 Diabetic Rats

Junjie Hou et al.

DIABETES (2017)

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Article Immunology

Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis

K. Flueck et al.

MUCOSAL IMMUNOLOGY (2016)

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Article Oncology

RPS7 inhibits colorectal cancer growth via decreasing HIF-1a-mediated glycolysis

Wen Zhang et al.

ONCOTARGET (2016)

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Review Cell Biology

The Emerging Hallmarks of Cancer Metabolism

Natalya N. Pavlova et al.

CELL METABOLISM (2016)

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Article Immunology

Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice

Elena Talero et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

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Article Immunology

The pentacyclic triterpene Lupeol switches M1 macrophages to M2 and ameliorates experimental inflammatory bowel disease

Yeshan Zhu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

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Editorial Material Biology

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

James Cantley et al.

BMC BIOLOGY (2015)

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Article Oncology

NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth

Xiaojun Zha et al.

CANCER LETTERS (2015)

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Article Cell Biology

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Eva M. Palsson-McDermott et al.

CELL METABOLISM (2015)

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Review Medicine, Research & Experimental

mTOR: a pharmacologic target for autophagy regulation

Young Chul Kim et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

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Article Oncology

Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor

Libin Wei et al.

ONCOTARGET (2015)

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Article Biochemistry & Molecular Biology

Terazosin activates Pgk1 and Hsp90 to promote stress resistance

Xinping Chen et al.

NATURE CHEMICAL BIOLOGY (2015)

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Article Gastroenterology & Hepatology

A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis

Kathleen Machiels et al.

GUT (2014)

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Article Immunology

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKε supports the anabolic demands of dendritic cell activation

Bart Everts et al.

NATURE IMMUNOLOGY (2014)

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Article Multidisciplinary Sciences

Islet β cell mass in diabetes and how it relates to function, birth, and death

Gordon C. Weir et al.

YEAR IN DIABETES AND OBESITY (2013)

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Article Biochemistry & Molecular Biology

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

I. Paul et al.

ONCOGENE (2013)

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Article Cell Biology

Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells

C-Y Huang et al.

CELL DEATH & DISEASE (2013)

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Review Gastroenterology & Hepatology

The gut microbiota in IBD

Chaysavanh Manichanh et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2012)

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Review Gastroenterology & Hepatology

Intestinal barrier function in health and gastrointestinal disease

M. Camilleri et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2012)

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Article Gastroenterology & Hepatology

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

Warren Strober et al.

GASTROENTEROLOGY (2011)

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Article Hematology

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

Connie M. Krawczyk et al.

BLOOD (2010)

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Review Biochemistry & Molecular Biology

The Protein Family of Glucose Transport Facilitators: It's Not Only About Glucose After All

Robert Augustin

IUBMB LIFE (2010)

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Article Oncology

KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer

F. Loupakis et al.

BRITISH JOURNAL OF CANCER (2009)

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Article Immunology

Exaggerated inflammatory response of primary human myeloid dendritic cells to lipopolysaccharide in patients with inflammatory bowel disease

D. C. Baumgart et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)

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Review Microbiology

Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

Petra Louis et al.

FEMS MICROBIOLOGY LETTERS (2009)

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Review Biochemistry & Molecular Biology

CD4 T-cell differentiation and inflammatory bowel disease

Lauren A. Zenewicz et al.

TRENDS IN MOLECULAR MEDICINE (2009)

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Article Cell Biology

P53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

Keiko Kawauchi et al.

NATURE CELL BIOLOGY (2008)

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Review Multidisciplinary Sciences

Inflammation in atherosclerosis

P Libby

NATURE (2002)

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