☆ 4.7 Review

A comprehensive overview of exosome lncRNAs: emerging biomarkers and potential therapeutics in endometriosis

FRONTIERS IN ENDOCRINOLOGY (2023)

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Article Biochemistry & Molecular Biology

IGF2BP2 enhances LincRNA01116 stability via m6A: A potential biomarker and therapeutic target for patients with pre-eclampsia

Tingting Zhang et al.

Summary: This study discovered that linc01116 expression was significantly reduced in pre-eclampsia (PE) patients and was associated with poor uterine spiral artery remodeling. Knockdown of linc01116 decreased trophoblast cell angiogenesis both in vitro and in vivo. Mechanistically, IGF2BP2 regulated linc01116 RNA stability through m(6)A methylation. Further experiments revealed that linc01116 upregulated AAMP expression by adsorbing miR-210-3p in trophoblast cells. In conclusion, this study uncovered the crucial role of linc01116 in regulating trophoblast angiogenesis and provided new insights for detecting placental pathology in PE.

JOURNAL OF CELLULAR BIOCHEMISTRY (2023)

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Review Biochemical Research Methods

A review on comparative studies addressing exosome isolation methods from body fluids

Tania Soares Martins et al.

Summary: Exosomes are valuable sources of disease biomarkers and therapeutic tools. However, isolating extracellular vesicles with exosome-like characteristics from certain biofluids is still challenging due to the complexity and specific properties of each biofluid. This review summarizes and discusses comparative studies on different exosome isolation methods from human biofluids, including challenges, physical properties, and potential variation sources.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2023)

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Review Anatomy & Morphology

Exosomes and exosome-loaded scaffolds: Characterization and application in modern regenerative medicine

Fatemeh Khazaei et al.

Summary: Exosomes are extracellular vesicles derived from endosomes that have gained attention for their potential use in regenerative therapies and tissue repair. However, their poor bioavailability and lack of controlled-release mechanisms have been addressed by scaffolding them with biomaterials to create Exosomes-loaded scaffolds (ELS). These biomaterial-based scaffolds can be designed and functionalized to improve the bioavailability, biocompatibility, and controlled release of Exosomes.

TISSUE & CELL (2023)

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Review Materials Science, Biomaterials

Exosome-Based Smart Drug Delivery Tool for Cancer Theranostics

Rishav Kar et al.

Summary: Exosomes are phospholipid-membrane-bound subpopulation of extracellular vesicles derived from the plasma membrane. They play a crucial role in cellular communication and have significant implications in cancer, both as contributors to carcinogenesis and as potential theragnostics and drug delivery tools. The outer phospholipid membrane of exosomes improves drug targeting efficiency, and their biocompatibility, low toxicity, and low immunogenicity make them an exciting drug delivery system.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2023)

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Article Biochemistry & Molecular Biology

Comparative Analyses of Human Exosome Proteomes

Hao Yang et al.

Summary: This study applied proteomics and bioinformatics approaches to investigate the proteome of exosomes derived from human embryonic kidney cells and compared them to other exosome proteomes. The findings provide insight into exosome heterogeneity, biological function, and the molecular mechanisms of biogenesis, secretion, and uptake, which have potential clinical applications.

PROTEIN JOURNAL (2023)

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Article Medicine, General & Internal

Identification of lncRNA-miRNA-mRNA networks in circulating exosomes as potential biomarkers for systemic sclerosis

Xiaolin Sun et al.

Summary: This study aimed to identify potential biomarkers for systemic sclerosis (SSc) by analyzing lncRNA-miRNA-mRNA networks in circulating exosomes (cirexos). Differentially expressed mRNAs (DEmRNAs) and lncRNAs (DElncRNAs) in SSc cirexos were screened using high-throughput sequencing and validated with real-time quantitative PCR (RT-qPCR). The study identified the ENST00000313807-hsa-miR-29a-3p-COL1A1 network as a potential combined biomarker for the clinical diagnosis and treatment of SSc.

FRONTIERS IN MEDICINE (2023)

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Review Oncology

LncRNA MALAT1-related signaling pathways in osteosarcoma

Maryam Farzaneh et al.

Summary: Osteosarcoma (OS) is a common bone cancer that affects children and young adults. Recent studies have shown that long non-coding RNAs (lncRNAs), such as MALAT1, play important roles in the development and treatment of OS.

CLINICAL & TRANSLATIONAL ONCOLOGY (2023)

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Review Cell Biology

Exosome: A novel neurotransmission modulator or non-canonical neurotransmitter?

Xiaohuan Xia et al.

Summary: This article reviews the role of exosomes in regulating neurotransmission. Exosomes can modulate synaptic activity and neural plasticity by transferring biomolecules. The article also proposes exosomes as novel neurotransmitters and discusses future directions in neurotransmission research.

AGEING RESEARCH REVIEWS (2022)

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Review Obstetrics & Gynecology

Effects of ovarian endometrioma aspiration on in vitro fertilization-intracytoplasmic sperm injection and embryo transfer outcomes: a systematic review and meta-analysis

Xinyan Gao et al.

Summary: The study found that compared with surgical treatment or no intervention treatment, ovarian endometrioma aspiration has less effect on ovarian response, ovarian reserve, and pregnancy outcomes.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

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Review Neurosciences

Placental mediated mechanisms of perinatal brain injury: Evolving inflammation and exosomes

Alexander R. Gall et al.

Summary: Pregnancy is regulated by the placenta through inflammation, while exosomes play a crucial role in propagating inflammation and brain injury.

EXPERIMENTAL NEUROLOGY (2022)

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Article Biochemistry & Molecular Biology

Getting to the bottom of lncRNA mechanism: structure-function relationships

Karissa Sanbonmatsu

Summary: Long non-coding RNAs play critical roles in diseases and development, yet there is a lack of structural studies for this important class of RNAs, emphasizing the need for high-resolution 3-D structural studies. Utilizing techniques such as chemical probing and nuclear magnetic resonance, structural studies of other RNA classes can be conducted, and a better understanding of the structure-function relationships of long non-coding RNAs is crucial for further elucidation.

MAMMALIAN GENOME (2022)

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Review Cell Biology

Non-coding RNAs and their cross-talks impacting reproductive health of women

Neha Jain et al.

Summary: Non-coding RNAs play crucial roles in women's health, impacting normal physiology and reproductive health. Understanding the functions and mode of actions of ncRNAs is vital for developing effective prognostic and therapeutic strategies.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2022)

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Review Pathology

microRNAs as novel diagnostic biomarkers in endometriosis patients: a systematic review and meta-analysis

Narges Zafari et al.

Summary: The research investigated the effectiveness of using miRNAs as noninvasive biomarkers to differentiate endometriosis patients from non-endometriosis women. Results showed high sensitivity and specificity of miRNAs in distinguishing between the two groups, indicating their potential as noninvasive biomarkers.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2022)

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Review Cell Biology

The implications of exosomes in pregnancy: emerging as new diagnostic markers and therapeutics targets

Mehri Ghafourian et al.

Summary: Extracellular vehicles (EVs) are a diverse group of cell and membranous particles involved in fetal-maternal communications and various functions during pregnancy.

CELL COMMUNICATION AND SIGNALING (2022)

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Review Biochemistry & Molecular Biology

Emerging Functions of lncRNA Loci beyond the Transcript Itself

Hober Nelson Nunez-Martinez et al.

Summary: Thousands of long noncoding RNAs (lncRNAs) in mammalian genomes play important regulatory functions, and their functional mechanisms can be achieved through RNA-based or RNA-independent ways, further expanding the understanding of their significance in genome biology.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Endocrinology & Metabolism

Progesterone Receptor Status of Epithelial Cells as a Predictive Marker for Postoperative Recurrence of Endometriosis

Yosuke Tarumi et al.

Summary: This study investigates the association between progesterone receptor (PR) expression levels in ovarian endometrioma and the recurrence of endometriosis. The results suggest that low PR expression levels in ovarian endometrioma epithelial cells may predict the recurrence of endometriosis.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Review Oncology

LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond

Wanxu Huang et al.

Summary: DNA methylation is a crucial epigenetic mechanism that regulates gene expression, and aberrant patterns of DNA methylation are associated with human diseases such as cancer. This review provides an overview of the current understanding of long non-coding RNA (lncRNA)-mediated DNA methylation, with a focus on its roles in cancer. The potential clinical applications of this mechanism in RNA-targeting drug development are also discussed.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Medicine, General & Internal

Exosome as a target for cancer treatment

Samira Nafar et al.

Summary: Exosomes are small vesicles that play a role in the physiological and pathological environments of target cells by transferring different molecules. They contain proteins, lipids, and nucleic acids, and can participate in various diseases. Biomarkers in exosomes isolated from body fluids provide a more accurate diagnostic method. Exosomes can be used in treatment and diagnosis, and play a significant role in different stages of cancer.

JOURNAL OF INVESTIGATIVE MEDICINE (2022)

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Article Genetics & Heredity

Long Intergenic Non-Protein Coding RNA 02381 Promotes the Proliferation and Invasion of Ovarian Endometrial Stromal Cells through the miR-27b-3p/CTNNB1 Axis

Xiaoqing Wang et al.

Summary: This study investigated the interaction mechanism between LINC02381 and CTNNB1 in endometriosis, revealing that LINC02381 upregulates CTNNB1 by adsorbing miR-27b-3p to promote proliferation and invasion of ESCs. The findings suggest a potential new therapeutic target for endometriosis.

GENES (2022)

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Review Immunology

Exosome-based vaccines and their position in next generation vaccines

Manica Negahdaripour et al.

Summary: Exosome-based vaccines have emerged as promising tools for delivering a wide range of antigens and immunomodulatory properties. Studies have shown their potential in tackling infectious diseases and cancers both in vitro and in vivo.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Endocrinology & Metabolism

Plasma Exosomal miRNAs Associated With Metabolism as Early Predictor of Gestational Diabetes Mellitus

Zhixin Ye et al.

Summary: This study identified differentially expressed miRNAs in plasma exosomes of pregnant women with gestational diabetes mellitus (GDM) using high-throughput small-RNA sequencing and validation. The upregulation of exosomal miR-423-5p and downregulation of miR-122-5p, miR-148a-3p, miR-192-5p, and miR-99a-5p were observed in women with GDM. These dysregulated exosomal miRNAs could potentially impact insulin and AMPK signaling pathways and contribute to the early prediction of GDM.

DIABETES (2022)

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Review Medicine, General & Internal

Pathophysiology, diagnosis, and management of endometriosis

Andrew W. Home et al.

Summary: Endometriosis is a chronic, inflammatory gynecologic disease that affects many women, leading to painful symptoms and risks of infertility. There are common issues such as diagnostic delay and symptom recurrence despite treatment. Treatment strategies include surgical, pharmacologic, and non-pharmacologic approaches, with emphasis on personalized and interdisciplinary care.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Review Biochemistry & Molecular Biology

Integrated lncRNA function upon genomic and epigenomic regulation

Allison B. Herman et al.

Summary: In the past 25 years, numerous long noncoding RNAs (lncRNAs) with diverse sequences, structures, and functions have been discovered through high-throughput and sensitive technologies. lncRNAs create an additional regulatory dimension by interacting with proteins and nucleic acids, helping to establish robust, nimble, and specific transcriptional and posttranscriptional control over gene expression.

MOLECULAR CELL (2022)

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Review Medicine, Research & Experimental

Exosomes and exosomal non-coding RNAs throughout human gestation (Review)

Ioanna Maligianni et al.

Summary: In recent years, intensive research on exosomes and their content has revealed their important role in cell-to-cell communication and their association with various physiological processes and diseases. The placenta has been established as an important source of circulating exosomes during pregnancy, which orchestrates maternal-fetal crosstalk and adaptations. Altered patterns of exosomal non-coding RNAs have been observed in pregnancy complications, highlighting exosomes as promising candidate biomarkers for diagnosis and treatment. This review provides insight into the role of exosomes in normal and pathological pregnancies.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Article Chemistry, Analytical

Electrochemical Resistive-Pulse Sensing of Extracellular Vesicles

Rui Jia et al.

Summary: Extracellular vesicles have potential applications in cancer diagnostics and cell signaling. Electrochemical resistive-pulse sensing allows for direct detection and analysis of these vesicles, as well as monitoring the effects of therapeutic agents.

ANALYTICAL CHEMISTRY (2022)

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Correction Cell Biology

Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics (vol 23, pg 389, 2022)

Takayuki Nojima et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Article Biochemical Research Methods

DeepWalk based method to predict lncRNA-miRNA associations via lncRNA-miRNA-disease-protein-drug graph

Long Yang et al.

Summary: In this study, a method called DWLMI is proposed to infer potential associations between lncRNAs and miRNAs by representing them as vectors and combining multiple information for prediction. Experimental results show that this method can effectively predict potential lncRNA-miRNA associations.

BMC BIOINFORMATICS (2022)

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Article Endocrinology & Metabolism

Determination of PD-1 expression in peripheral blood cells in patients with endometriosis

Bugra Oksasoglu et al.

Summary: Elevated levels of PD-1 and gene expression in patients with endometriosis suggest that immunotherapy may be a potential treatment option for this condition.

GYNECOLOGICAL ENDOCRINOLOGY (2021)

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Review Developmental Biology

The role of hypoxia in the development and progression of endometriosis

Wan-Ning Li et al.

Summary: Endometriosis is a benign gynecological disease affecting approximately 10% of women of reproductive age, leading to symptoms such as dysmenorrhea, dyspareunia, and infertility. Hypoxia plays a critical role in the disease phenotypes of endometriosis, influencing factors such as adhesion ability, estrogen biosynthesis, proinflammatory cytokines, angiogenic ability, and immune functions. Targeting HIF and downstream effectors may offer potential therapeutic options for endometriosis treatment.

REPRODUCTION (2021)

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Review Oncology

Immunologic factors involved in the malignant transformation of endometriosis to endometriosis-associated ovarian carcinoma

S. Leenen et al.

Summary: Endometriosis is a risk factor for certain types of ovarian carcinoma, and immunological factors play a key role in the clinical outcome of both conditions. Chronic inflammation in endometriosis may drive carcinogenesis in endometriosis-associated ovarian carcinoma, but the exact immunological pathways and cellular processes involved remain unknown and require further investigation.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Review Cell Biology

LNCcation: lncRNA localization and function

Mary Catherine Bridges et al.

Summary: This review summarizes the current knowledge of subcellular localization of long noncoding RNAs (lncRNAs), factors controlling their localization, emerging themes, and discusses the implications of lncRNA localization on their function and cellular behavior, as well as opportunities for future research.

JOURNAL OF CELL BIOLOGY (2021)

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Article Neurosciences

VEGF Modulates the Neural Dynamics of Hippocampal Subregions in Chronic Global Cerebral Ischemia Rats

Ling Wang et al.

Summary: Theta and gamma rhythms in hippocampus play a crucial role in cognitive function and synaptic plasticity. This study found that VEGF treatment improved the power of theta and gamma rhythms in CA1 region and alleviated the decreased coupling strength between CA3 and CA1 in ischemic rats. The findings suggest that VEGF may enhance information transmission within the hippocampus and potentially improve cognitive function.

NEUROMOLECULAR MEDICINE (2021)

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Review Oncology

Potential roles of exosome non-coding RNAs in cancer chemoresistance

Yueyue Wang et al.

Summary: Chemoresistance is a common issue in various types of tumors, leading to cancer relapse. Non-coding RNAs, especially those carried by exosomes, play crucial roles in mediating chemoresistance and cell-to-cell communication in cancer.

ONCOLOGY REPORTS (2021)

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Review Biochemistry & Molecular Biology

The Role of Long Non-Coding RNAs in Endometriosis

Quanah J. Hudson et al.

Summary: Studies have shown that lncRNAs play an important role in the pathogenesis of endometriosis, with SNPs and genome-wide transcriptomic studies confirming this.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Zinc chloride affects chondrogenesis via VEGF signaling

Sarah Hozain et al.

Summary: The study found that Zinc Chloride induces the expression of chondrogenic genes and genes associated with VEGF-mediated signal transduction, with a more significant impact compared to insulin. The VEGFR antagonist Axitinib can attenuate the pro-chondrogenic effects of both insulin and Zinc Chloride, with a more profound reduction observed in cells treated with Zinc Chloride. This suggests an important role of VEGF-mediated signal transduction pathways in the positive effects of zinc-based compounds on chondrogenesis-mediated fracture healing.

EXPERIMENTAL CELL RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Role of Constitutive STAR in Leydig Cells

Melanie Galano et al.

Summary: Leydig cells contain STAR which plays a role in transporting cholesterol into mitochondria for steroidogenesis, while the function of constitutive STAR in Leydig cells is unclear. Studies have shown that constitutive STAR is involved in accumulating diacylglycerol (DAG) in lipid droplets in addition to cholesterol transport. This may impact cell functions mediated by DAG signaling.STAR KO cells fail to produce progesterone in response to certain hormones and TSPO ligands, but show increased cholesteryl ester, phosphatidylcholine, and diacylglycerol contents in their lipid droplets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Gastroenterology & Hepatology

Emerging role and therapeutic application of exosome in hepatitis virus infection and associated diseases

Ying Shi et al.

Summary: Exosomes play a crucial role in the infection and progression of hepatitis viruses by mediating viral replication and modulating host immune responses. The characteristics of host exosomes significantly change after infection with hepatitis viruses, as they can act as a subterfuge for viral transportation and immune escape. Immune cell-derived exosomes contribute to antiviral immune defense and virus eradication, while exosomal biomarkers show potential for predicting disease progress and therapeutic outcomes.

JOURNAL OF GASTROENTEROLOGY (2021)

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Article Medicine, General & Internal

Endometriosis is a chronic systemic disease: clinical challenges and novel innovations

Hugh S Taylor et al.

LANCET (2021)

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Review Geriatrics & Gerontology

Molecular Insight Into the Therapeutic Potential of Long Non-coding RNA-Associated Competing Endogenous RNA Axes in Alzheimer's Disease: A Systematic Scoping Review

Hani Sabaie et al.

Summary: Alzheimer's disease is a heterogeneous degenerative brain disorder with increasing prevalence globally, characterized by amyloid plaques and neurofibrillary tangles. Long non-coding RNAs have regulatory functions in gene expressions by modulating microRNAs through the ceRNA mechanism. Investigating the ceRNA interaction networks can provide new insights into the etiology of AD and potential therapeutic targets.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Article Physiology

Possible therapeutic effect of royal jelly on endometriotic lesion size, pain sensitivity, and neurotrophic factors in a rat model of endometriosis

Zahra K. Farahani et al.

Summary: Endometriosis pain may be related to neurotrophic factors in the nervous system. Royal jelly treatment could significantly decrease the size of endometriosis lesions and pain scores. These findings may provide insights into other complementary and alternative remedies for endometriosis.

PHYSIOLOGICAL REPORTS (2021)

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Review Neurosciences

Microglial Exosomes in Neurodegenerative Disease

Min Guo et al.

Summary: Microglia play a crucial role in neurodegenerative diseases, impacting pathological changes, neurogenesis, neuronal cell death, and synaptic interactions. Additionally, microglial exosomes have been found to contribute significantly to CNS diseases, serving as potential biomarkers for disease monitoring and as drug delivery vehicles for treating disorders.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

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Review Physiology

Recent Advances of MicroRNAs, Long Non-coding RNAs, and Circular RNAs in Preeclampsia

Ailing Chen et al.

Summary: Preeclampsia is a clinical syndrome characterized by multiple-organ dysfunction in pregnant women after 20 weeks of gestation, with termination of pregnancy being the only current prevention method. Non-coding RNAs play important roles in regulating physiological functions and may impact the pathogenesis of preeclampsia.

FRONTIERS IN PHYSIOLOGY (2021)

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Review Biochemical Research Methods

The evolutionary acquisition and mode of functions of promoter-associated non-coding RNAs (pancRNAs) for mammalian development

Boyang An et al.

Summary: Increasing evidence suggests that long non-coding RNAs play important roles in gene regulation, with promoter-associated non-coding RNAs being crucial in regulating cellular specificity.

NON-CODING GENOME (2021)

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Article Oncology

Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes

Angiolo Gadducci et al.

Summary: Clear cell carcinoma of the ovary is a rare and distinct histotype of epithelial ovarian carcinomas, with endometriosis considered a main risk factor for its development. Different molecular pathways and mutations, including ARID1A and PIK3CA, have been identified in this type of cancer, and treatment strategies resemble those for high-grade serous carcinoma.

GYNECOLOGIC ONCOLOGY (2021)

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Review Medicine, General & Internal

The value of long noncoding RNAs for predicting the recurrence of endometriosis A protocol for meta-analysis and bioinformatics analysis

Yihong Chen et al.

Summary: This study explored the value of lncRNAs as a predictor for the recurrence of EM through meta-analysis and bioinformatics analysis, providing high-quality evidence support. Additionally, bioinformatics technology was used to predict and analyze the biological effects of lncRNAs, laying a theoretical foundation for further experimental verification.

MEDICINE (2021)

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Article Oncology

Protective effects of the knockdown of lncRNA AK139328 against oxygen glucose deprivation/reoxygenation-induced injury in PC12 cells

Liyan Liu et al.

Summary: Cerebral ischemic stroke is a major cause of morbidity and mortality worldwide. This study found that AK139328 expression levels were upregulated in patients with cerebral ischemic stroke, and knockdown of AK139328 may protect against ischemic injury by regulating inflammatory responses, oxidative stress, and cell apoptosis. These findings suggest AK139328 as a potential therapeutic target for the diagnosis and treatment of cerebral ischemic stroke.

MOLECULAR MEDICINE REPORTS (2021)

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Review Cell Biology

Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine

Mangesh D. Hade et al.

Summary: Exosomes are extracellular vesicles secreted by almost all cell types to aid in various cellular functions, including intercellular communication and immune signaling. They carry a multitude of signaling moieties, making them potential candidates for tissue engineering and regenerative medicine. The review highlights the emerging roles and potential applications of exosomes in regenerative medicine, particularly in brain injuries, cardiovascular disease, and COVID-19.

CELLS (2021)

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Review Biochemistry & Molecular Biology

Endometriosis: Etiology, pathobiology, and therapeutic prospects

Philippa T. K. Saunders et al.

Summary: Endometriosis is a common condition associated with infertility that causes chronic pain in women. The exact cause and natural history are still uncertain, but hormonal, neurological, and immunological factors are believed to play a role in the development of symptoms. Current interventions have limited efficacy with high rates of symptom recurrence.

CELL (2021)

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Article Medicine, Research & Experimental

The AMPK-mTOR axis requires increased MALAT1 expression for promoting granulosa cell proliferation in endometriosis

Xuejie Liu et al.

Summary: The study revealed that MALAT1 in granulosa cells of endometriosis plays a role in promoting cell proliferation, inhibiting apoptosis, and enhancing autophagy, possibly through regulating the AMPK-mTOR signaling pathway.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Oncology

RNA in cancer

Gregory J. Goodall et al.

Summary: Recent findings have shown that RNA processing is systematically altered in cancer, with mutations in RNA splicing factor genes and the shortening of 3' untranslated regions widely observed. Additionally, evidence suggests that other types of RNAs, including circular RNAs, can contribute to tumorigenesis.

NATURE REVIEWS CANCER (2021)

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Article Chemistry, Multidisciplinary

The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation

Ding-wen Cao et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Review Pathology

The Origin and Pathogenesis of Endometriosis

Yeh Wang et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020 (2020)

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Review Oncology

Endometriosis-associated ovarian cancer occurs early during follow-up of endometrial cysts

Kosuke Murakami et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2020)

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Review Obstetrics & Gynecology

Endometriosis and risk of ovarian cancer: what do we know?

Milena Kralickova et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2020)

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Article Oncology

Endometriosis-associated ovarian cancer is not a distinct clinical entity among young patients: A 12-year cohort study

Yan Cai et al.

EJSO (2020)

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Article Biochemistry & Molecular Biology

Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer

Yanmei Shi et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

SNP rs710886A>G in long noncoding RNA PCAT1 is associated with the risk of endometriosis by modulating expression of multiple stemness-related genes via microRNA-145 signaling pathway

Liming Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2020)

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Article Obstetrics & Gynecology

Posttraumatic stress, anxiety and depression following miscarriage and ectopic pregnancy: a multicenter, prospective, cohort study

Jessica Farren et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2020)

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Review Obstetrics & Gynecology

Endometriosis Fertility Index for predicting non-assisted reproductive technology pregnancy after endometriosis surgery: a systematic review and meta-analysis

S. Vesali et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis

Lu Zhang et al.

DISEASE MARKERS (2020)

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Article Oncology

Extracellular vesicle-mediated transfer of the lncRNA-TC0101441 promotes endometriosis migration/invasion

Jun-jun Qiu et al.

EXPERIMENTAL CELL RESEARCH (2020)

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Article Genetics & Heredity

Suppression of long noncoding RNA NEAT1 attenuates hypoxia-induced cardiomyocytes injury by targeting miR-378a-3p

Jiali Zhao et al.

GENE (2020)

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Review Oncology

Long non-coding RNAs in development and disease: conservation to mechanisms

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JOURNAL OF PATHOLOGY (2020)

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Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Pan Wu et al.

MOLECULAR CANCER (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Public, Environmental & Occupational Health

Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls

Ali-Akbar Delbandi et al.

BMC WOMENS HEALTH (2020)

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Article Immunology

Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases

Naganari Ohkura et al.

IMMUNITY (2020)

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Article Obstetrics & Gynecology

LncRNA H19 Overexpression in Endometriosis and its Utility as a Novel Biomarker for Predicting Recurrence

Songping Liu et al.

REPRODUCTIVE SCIENCES (2020)

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Article Genetics & Heredity

Analysis of exosomal lncRNA, miRNA and mRNA expression profiles and ceRNA network construction in endometriosis

Jingni Wu et al.

EPIGENOMICS (2020)

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Article Cell Biology

LncRNA MEG3-210 regulates endometrial stromal cells migration, invasion and apoptosis through p38 MAPK and PKA/SERCA2 signalling via interaction with Galectin-1 in endometriosis

Yang Liu et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)

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Article Oncology

Effects of human umbilical cord mesenchymal stem cells derived from exosomes on migration ability of endometrial glandular epithelial cells

Ying Feng et al.

MOLECULAR MEDICINE REPORTS (2020)

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Review Medicine, General & Internal

Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis

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MicroRNA-202 inhibits endometrial stromal cell migration and invasion by suppressing the K-Ras/Raf1/MEK/ERK signaling pathway

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Circ_0007331 knock-down suppresses the progression of endometriosis via miR-200c-3p/HiF-1α axis

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Endometriosis Associated Infertility: A Critical Review and Analysis on Etiopathogenesis and Therapeutic Approaches

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Betulinic Acid Inhibits Endometriosis Through Suppression of Estrogen Receptor β Signaling Pathway

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Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis

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The Exosomal Long Noncoding RNA aHIF is Upregulated in Serum From Patients With Endometriosis and Promotes Angiogenesis in Endometriosis

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LncRNA-H19 regulates cell proliferation and invasion of ectopic endometrium by targeting ITGB3 via modulating miR-124-3p

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Downregulation of lncrna uca1 as a diagnostic and prognostic biomarker for ovarian endometriosis

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Long non-coding RNA AFAP1-AS1 promoting epithelial-mesenchymal transition of endometriosis is correlated with transcription factor ZEB1

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Knockdown of long noncoding RNA CCDC144NL-AS1 attenuates migration and invasion phenotypes in endometrial stromal cells from endometriosis

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Conventional and modern markers of endometrial receptivity: a systematic review and meta-analysis

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Long non-coding RNA MALAT1 mediates hypoxia-induced pro-survival autophagy of endometrial stromal cells in endometriosis

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LINC01541 overexpression attenuates the 17β-Estradiol-induced migration and invasion capabilities of endometrial stromal cells

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The Long Non-coding RNA NRIR Drives IFN-Response in Monocytes: Implication for Systemic Sclerosis

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The estrogen-regulated lncRNA H19/miR-216a-5p axis alters stromal cell invasion and migration via ACTA2 in endometriosis

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Down-regulation of long non-coding RNA MALAT1 inhibits granulosa cell proliferation in endometriosis by up-regulating P21 via activation of the ERK/MAPK pathway

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Aberrant Expression of lncRNA (HOXA11-AS1) and Homeobox A (HOXA9, HOXA10, HOXA11, and HOXA13) Genes in Infertile Women With Endometriosis

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Functional Classification and Experimental Dissection of Long Noncoding RNAs

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Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function

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Expression signatures of exosomal long non-coding RNAs in urine serve as novel non-invasive biomarkers for diagnosis and recurrence prediction of bladder cancer

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Identification of LINC01279 as a cell cycle-associated long non-coding RNA in endometriosis with GBA analysis

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LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation

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miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo

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LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway

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Mechanisms of long noncoding RNA function in development and disease

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A prospective cohort study of endometriosis and subsequent risk of infertility

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Genome-wide Long Non-coding RNA Analysis Identified Circulating LncRNAs as Novel Non-invasive Diagnostic Biomarkers for Gynecological Disease

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Genome-Wide Microarray Analysis of Long Non-Coding RNAs in Eutopic Secretory Endometrium with Endometriosis

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H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis

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The Landscape of long noncoding RNA classification

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Regulation of Transcription by Long Noncoding RNAs

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ANNUAL REVIEW OF GENETICS, VOL 48 (2014)

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Genome-wide profiling of long noncoding ribonucleic acid expression patterns in ovarian endometriosis by microarray

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FERTILITY AND STERILITY (2014)

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Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion

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Contribution of proteomics to understanding the role of tumor-derived exosomes in cancer progression: State of the art and new perspectives

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The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

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