相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors
Liudi Zhang et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2023)
De novo design of luciferases using deep learning
Andy Hsien-Wei Yeh et al.
NATURE (2023)
DrugEx v3: scaffold-constrained drug design with graph transformer-based reinforcement learning
Xuhan Liu et al.
JOURNAL OF CHEMINFORMATICS (2023)
GLOW: A Workflow Integrating Gaussian-Accelerated Molecular Dynamics and Deep Learning for Free Energy Profiling
Hung N. Do et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2022)
Scaffolding protein functional sites using deep learning
Jue Wang et al.
SCIENCE (2022)
Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
Stefanie Kampen et al.
ACS CHEMICAL BIOLOGY (2022)
De novo protein design by deep network hallucination
Ivan Anishchenko et al.
NATURE (2021)
Discovery of novel dual adenosine A(1)/A(2A) receptor antagonists using deep learning, pharmacophore modeling and molecular docking
Mukuo Wang et al.
PLOS COMPUTATIONAL BIOLOGY (2021)
Biased agonism at adenosine receptors
Samantha M. McNeill et al.
CELLULAR SIGNALLING (2021)
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
Christopher J. Draper-Joyce et al.
NATURE (2021)
Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening
Qingtong Zhou et al.
BIOMOLECULES (2021)
PBF-680, an oral A1 adenosine receptor antagonist, inhibits adenosine monophosphate (AMP) airway hyperresponsiveness (AHR) in mild-to-moderate asthma: a Phase-IIa proof-of-concept trial
David Ramos-Barbon et al.
EUROPEAN RESPIRATORY JOURNAL (2020)
PBF-680, an oral A1 adenosine receptor antagonist, inhibits the late allergic response (LAR) in mild-to-moderate atopic asthmatics: a Phase-IIa trial
David Ramos-Barbon et al.
EUROPEAN RESPIRATORY JOURNAL (2020)
Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development
Kenneth A. Jacobson et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2019)
Effect of Neladenoson Bialanate on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction A Randomized Clinical Trial
Sanjiv J. Shah et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)
Safety and efficacy of the partial adenosine A1 receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced ejection fraction: a phase IIb, randomized, double-blind, placebo-controlled trial
Adriaan A. Voors et al.
EUROPEAN JOURNAL OF HEART FAILURE (2019)
Discovery of a potential positive allosteric modulator of glucagon-like peptide 1 receptor through virtual screening and experimental study
Tejashree Redij et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2019)
Structural Modeling and in Silico Screening of Potential Small-Molecule Allosteric Agonists of a Glucagon-like Peptide 1 Receptor
Tejashree Redij et al.
ACS OMEGA (2019)
Generating Focused Molecule Libraries for Drug Discovery with Recurrent Neural Networks
Marwin H. S. Segler et al.
ACS CENTRAL SCIENCE (2018)
New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism
Elizabeth A. Vecchio et al.
BRITISH JOURNAL OF PHARMACOLOGY (2018)
Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor
Magdalena Korczynska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The Role of Adenosine Receptors in Psychostimulant Addiction
Inmaculada Ballesteros-Yanez et al.
FRONTIERS IN PHARMACOLOGY (2018)
Structure of the adenosine-bound human adenosine A(1) receptor-G(i) complex
Christopher J. Draper-Joyce et al.
NATURE (2018)
Structural insights into G-protein-coupled receptor allostery
David M. Thal et al.
NATURE (2018)
Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A1 Receptor
Yinglong Miao et al.
SCIENTIFIC REPORTS (2018)
Pharmacological targeting of adenosine receptor signaling
Maria Peleli et al.
MOLECULAR ASPECTS OF MEDICINE (2017)
Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity
Robert K. Y. Cheng et al.
STRUCTURE (2017)
Purinergic Signaling in Mast Cell Degranulation and Asthma
Zhan-Guo Gao et al.
FRONTIERS IN PHARMACOLOGY (2017)
Adenosine A1 receptor-operated calcium entry in renal afferent arterioles is dependent on postnatal maturation of TRPC3 channels
Hitesh Soni et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2017)
Allosteric modulation as a unifying mechanism for receptor function and regulation
Jean-Pierre Changeux et al.
DIABETES OBESITY & METABOLISM (2017)
Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity
Alisa Glukhova et al.
CELL (2017)
Partial adenosine A1 receptor agonism: a potential new therapeutic strategy for heart failure
Stephen J. Greene et al.
HEART FAILURE REVIEWS (2016)
Adenosine regulation of the immune response initiated by ischemia reperfusion injury
D. Boros et al.
PERFUSION-UK (2016)
Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor
Yinglong Miao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?
Pier Andrea Borea et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity
Anh T. N. Nguyen et al.
MOLECULAR PHARMACOLOGY (2016)
Current status of A(1) adenosine receptor allosteric enhancers
Romeo Romagnoli et al.
FUTURE MEDICINAL CHEMISTRY (2015)
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
Xi-Ping Huang et al.
NATURE (2015)
Tissue-based map of the human proteome
Mathias Uhlen et al.
SCIENCE (2015)
A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model
Wendy L. Imlach et al.
MOLECULAR PHARMACOLOGY (2015)
Synthesis and biological evaluation of novel 2-amino-3-aroyl-4-neopentyl-5-substituted thiophene derivatives as allosteric enhancers of the A1 adenosine receptor
Romeo Romagnoli et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4′-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene
Romeo Romagnoli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist
Celine Valant et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The Second Extracellular Loop of the Adenosine A1 Receptor Mediates Activity of Allosteric Enhancers
Dylan P. Kennedy et al.
MOLECULAR PHARMACOLOGY (2014)
The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29
James D. Young et al.
MOLECULAR ASPECTS OF MEDICINE (2013)
Emerging paradigms in GPCR allostery: implications for drug discovery
Denise Wootten et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Adenosine receptors as drug targets - what are the challenges?
Jiang-Fan Chen et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Cardiovascular adenosine receptors: Expression, actions and interactions
John P. Headrick et al.
PHARMACOLOGY & THERAPEUTICS (2013)
Adenosine and its receptors as therapeutic targets: An overview
Sakshi Sachdeva et al.
SAUDI PHARMACEUTICAL JOURNAL (2013)
An Allosteric Modulator of the Adenosine A1 Receptor Improves Cardiac Function Following Ischaemia in Murine Isolated Hearts
Anna Butcher et al.
PHARMACEUTICALS (2013)
The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation
M. C. Peeters et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Synthesis and Biological Evaluation of 2-Amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-Modification on Allosteric Enhancer Activity at the A1 Adenosine Receptor
Romeo Romagnoli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Synthesis and Characterization of Novel 2-Amino-3-benzoylthiophene Derivatives as Biased Allosteric Agonists and Modulators of the Adenosine A1 Receptor
Celine Valant et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor
Luigi Aurelio et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Effects of the Adenosine A1 Receptor Antagonist Rolofylline on Renal Function in Patients With Acute Heart Failure and Renal Dysfunction Results From PROTECT (Placebo-Controlled Randomized Study of the Selective A1 Adenosine Receptor Antagonist Rolofylline for Patients Hospitalized With Acute Decompensated Heart Failure and Volume Overload to Assess Treatment Effect on Congestion and Renal Function)
Adriaan A. Voors et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)
Effects of Conformational Restriction of 2-Amino-3-benzoylthiophenes on A1 Adenosine Receptor Modulation
Luigi Aurelio et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Delineating the Mode of Action of Adenosine A1 Receptor Allosteric Modulators
Celine Valant et al.
MOLECULAR PHARMACOLOGY (2010)
3-and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists
Luigi Aurelio et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease
Riccardo Polosa et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Adenosine kinase and ribokinase - the RK family of proteins
J. Park et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
The Role of Cytokines in Sleep Regulation
James M. Krueger
CURRENT PHARMACEUTICAL DESIGN (2008)
2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists
Gemma N. Ferguson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor
Romeo Romagnoli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins
J. D. Young et al.
XENOBIOTICA (2008)
Intense exercise increases adenosine concentrations in rat brain:: Implications for a homeostatic sleep drive
M. Dworak et al.
NEUROSCIENCE (2007)
A1 receptor deficiency causes increased insulin and glucagon secretion in mice
Stina M. Johansson et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection
Derek J. Hausenloy et al.
HEART FAILURE REVIEWS (2007)
A novel mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice
Armin Just et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
Katie Leach et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
Eliminating the antilipolytic adenosine A1 receptor does not lead to compensatory changes in the antilipolytic actions of PGE2 and nicotinic acid
S. M. Johansson et al.
ACTA PHYSIOLOGICA (2007)
On the stability of 2-aminoselenophene-3-carboxylates:: potential dual-acting selenium-containing allosteric enhancers of A1 adenosine receptor binding
Kylee M. Aumann et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2007)
Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A1 receptor
Romeo Romagnoli et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers
G Nikolakopoulos et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2006)
Adenosine receptors as therapeutic targets
KA Jacobson et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II)
AM Ross et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)
Allosteric modulation of the adenosine family of receptors
ZG Gao et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2005)
Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors.: Lack of effect of 2-aminothiazoles as allosteric enhancers
A Göblyös et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Actions of adenosine at its receptors in the CNS: Insights from knockouts and drugs
BB Fredholm et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2005)
The equilibrative nucleoside transporter family, SLC29
SA Baldwin et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors
AMCH van den Nieuwendijk et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Potassium channels and pain:: present realities and future opportunities
M Ocaña et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor
PG Baraldi et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2004)
Allosteric enhancers of A1 adenosine receptors increase receptor-G protein coupling and counteract guanine nucleotide effects on agonist binding
H Figler et al.
MOLECULAR PHARMACOLOGY (2003)
Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry
BP Zambrowicz et al.
CURRENT OPINION IN PHARMACOLOGY (2003)
A randomized, double-blinded, placebo-controlled, dose-ranging study measuring the effect of an adenosine agonist on infarct size reduction in patients undergoing primary percutaneous,transluminal under coronary angioplasty: The ADMIRE (AmP579 Delivery for Myocardial Infarction REduction) study
SL Kopecky et al.
AMERICAN HEART JOURNAL (2003)
2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding:: New 3, 4-, and 5-modifications
H Lütjens et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
N-[3-(R)-tetrahydrofuranyl]-6-aminopurine riboside, an A1 adenosine receptor agonist, antagonizes catecholamine-induced lipolysis without cardiovascular effects in awake rats
H Fraser et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor
PG Baraldi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A1 and A3 adenosine receptors
ZG Gao et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Role of direct RhoA-phospholipase D interaction in mediating adenosine-induced protection from cardiac ischemia
S Mozzicato et al.
FASEB JOURNAL (2003)
2-aminothiazoles:: A new class of agonist allosteric enhancers of A1 adenosine receptors
MD Chordia et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain
XH Li et al.
PAIN (2002)
BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy
SS Gottlieb et al.
CIRCULATION (2002)
2-amino-3-aroyl-4,5-alkylthiophenes:: Agonist allosteric enhancers at human A1 adenosine receptors
CE Tranberg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Cardiac overexpression of A(1)-adenosine receptor protects intact mice against myocardial infarction
ZQ Yang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2002)
Adenosine in the central nervous system: release mechanisms and extracellular concentrations
S Latini et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Mediation of tubuloglomerular feedback by adenosine: Evidence from mice lacking adenosine 1 receptors
DQ Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Allosteric adenosine modulation to reduce allodynia
HL Pan et al.
ANESTHESIOLOGY (2001)
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor
B Johansson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors
AB Fawzi et al.
MOLECULAR PHARMACOLOGY (2001)
The role and regulation of adenosine in the central nervous system
TV Dunwiddie et al.
ANNUAL REVIEW OF NEUROSCIENCE (2001)
Functions of neuronal adenosine receptors
HL Haas et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2000)
Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor
PG Baraldi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Structure and function of S-adenosylhomocysteine hydrolase
MA Turner et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2000)
Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A(1) and A(3) receptors
HT Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2000)
分享论文
