Copeptin analysis in endocrine disorders

Copeptin is cleaved from the same precursor as arginine vasopressin and is released in equimolar amounts with arginine vasopressin from the posterior pituitary in response to the same stimuli. Its level of stability in the blood, quick and simple analysis, and ease of automation make it much easier to analyze than arginine vasopressin, thereby offering a suitable alternative to measuring arginine vasopressin in endocrine disorders. Research has demonstrated the suitability of copeptin in adults for the differentiation of arginine vasopressin resistance and arginine vasopressin deficiency from primary polydipsia, in addition to the early identification of arginine vasopressin deficiency following pituitary surgery; however, further research is still required in the Syndrome of Inappropriate Antidiuretic Hormone (SIADH) and the pediatric population.

Automated summary

Copeptin, as an alternative to arginine vasopressin measurement, has advantages of high stability, simple analysis, and ease of automation. Research has shown its suitability for differentiating arginine vasopressin resistance and deficiency as well as primary polydipsia in adults, but further studies are needed in Syndrome of Inappropriate Antidiuretic Hormone (SIADH) and the pediatric population.