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The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis

FRONTIERS IN ENDOCRINOLOGY (2023)

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Article Endocrinology & Metabolism

The association of diabetes status and bone mineral density among US adults: evidence from NHANES 2005-2018

Bo Liu et al.

Summary: This study aimed to explore the relationship between diabetes status and bone mineral density among adults with pre-diabetes and diabetes. The findings showed that both pre-diabetic and diabetic patients had increased bone mineral density in the hip, femoral neck, and lumbar spine. Subgroup analyses revealed that this trend was more prominent in whites, women, and those over 50 years old.

BMC ENDOCRINE DISORDERS (2023)

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Article Endocrinology & Metabolism

Visceral Adipose Tissue is Negatively Associated With Bone Mineral Density in NHANES 2011-2018

Rajesh K. Jain et al.

Summary: This study investigated the relationship between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with bone mineral density (BMD). The results showed a negative association between VAT and BMD, while the association between SAT and BMD was weaker. Further research is needed to understand the mechanisms and develop strategies for optimizing bone health in obese individuals.

JOURNAL OF THE ENDOCRINE SOCIETY (2023)

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Article Endocrinology & Metabolism

Relationships between Obesity and Incidence of Fractures in a Middle-Aged Population: A Study from the CARTaGENE Cohort

Anne-Frederique Turcotte et al.

Summary: The association between obesity and fracture risk is complex and may vary by definition of obesity, skeletal site, and sex. This study aimed to evaluate the relationships between obesity, defined using body mass index (BMI) or waist circumference (WC), and fracture incidence at any site and by skeletal site. The results showed a linear relationship between fracture incidence and WC, while cubic splines best fitted the relationship for BMI.

JBMR PLUS (2023)

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Article Geriatrics & Gerontology

Effect of Physical Activity Intervention on Gait Speed by Frailty Condition: A Randomized Clinical Trial

Carlo Custodero et al.

Journal of the American Medical Directors Association (2023)

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Review Pharmacology & Pharmacy

Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets

Yuki Yoshimoto et al.

Summary: Skeletal muscle contraction is essential for movement, and tendons and ligaments play a crucial role in connecting muscles to bones. Dysfunctions in these tissues due to disease can significantly impact quality of life. Skeletal muscle diseases like sarcopenia and chronic tendon dysfunction like tendinopathy remain difficult to treat.

PHARMACOLOGY & THERAPEUTICS (2023)

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Article Endocrinology & Metabolism

Association of Bone Turnover Markers with Type 2 Diabetes Mellitus and Microvascular Complications: A Matched Case-Control Study

Yilin Hou et al.

Summary: The aim of this study was to evaluate the association between bone turnover markers (BTMs) and type 2 diabetes mellitus (T2DM) and microvascular complications. The results showed a negative association between serum OC and P1NP levels and the risk of T2DM, especially the risk of diabetic retinopathy (DR).

DIABETES METABOLIC SYNDROME AND OBESITY (2023)

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Review Biochemistry & Molecular Biology

Role of Advanced Glycation End-Products and Oxidative Stress in Type-2-Diabetes-Induced Bone Fragility and Implications on Fracture Risk Stratification

Guido Cavati et al.

Summary: Type 2 diabetes and osteoporosis are often associated with each other, and diabetes-induced bone fragility is different from other forms of osteoporosis. The accumulation of advanced glycation end-products and oxidative stress are major mechanisms explaining bone fragility in diabetes. Improving fracture risk prediction in type 2 diabetes patients is challenging.

ANTIOXIDANTS (2023)

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Article Oncology

Role of Mel1/Prdm16 in bone differentiation and morphology

Kazuko Kaneda-Nakashima et al.

Summary: MEL1/Prdm16 gene plays an important role in acute myeloid leukemia and regulates fat metabolism. Mel1/Prdm16-deficient mice show embryonic lethality and skeletal abnormalities. In osteoblast and chondrocyte cells, Mel1/Prdm16 promotes chondrocyte differentiation and regulates osteoblast differentiation. Mel1/Prdm16 is crucial for the early repression of Runx2 expression during osteochondral differentiation.

EXPERIMENTAL CELL RESEARCH (2022)

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Review Endocrinology & Metabolism

The dietary inflammatory index, obesity, type 2 diabetes, and cardiovascular risk factors and diseases

Rohit Hariharan et al.

Summary: Research suggests that an unhealthy diet is associated with an increased risk of obesity, T2DM, and CVD, but there is limited research on the association between dietary inflammation and T2DM and its risk factors, as well as a lack of interventional studies designed to change the inflammatory potential of diets and study its effect on cardiometabolic risk factors and diseases. Interventions studies are recommended to assess whether changes in DII can independently modulate cardiometabolic risk factors and diseases.

OBESITY REVIEWS (2022)

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Article Genetics & Heredity

Wnt Pathway Extracellular Components and Their Essential Roles in Bone Homeostasis

Nuria Martinez-Gil et al.

Summary: This article reviews the extracellular modulators of the Wnt pathway and their impact on bone homeostasis. By studying these factors, potential therapeutic targets for bone diseases can be identified.

GENES (2022)

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Article Orthopedics

Dysregulation of Wnt signaling in bone of type 2 diabetes mellitus and diabetic Charcot arthropathy

Laurens Christian Gassel et al.

Summary: For the first time, this study demonstrates the downregulation of members of the Wnt-signaling pathway in the bone of diabetic patients with and without Charcot arthropathy, suggesting a potential therapeutic target for this severe disease.

BMC MUSCULOSKELETAL DISORDERS (2022)

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Review Pharmacology & Pharmacy

PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes

Na Jiang et al.

Summary: This review summarizes the evidence of PRDM16 involvement in the progression of obesity and diabetes and suggests that PRDM16 may be a promising therapy for these diseases.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Pharmacology & Pharmacy

Bone-Targeted Nanoparticle Drug Delivery System: An Emerging Strategy for Bone-Related Disease

Yulin Chen et al.

Summary: Targeted delivery of therapeutics to the bone can improve the treatment of bone metabolism diseases, and nanotechnology offers a more effective approach with reduced side effects.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Endocrinology & Metabolism

Bone fragility in diabetes: novel concepts and clinical implications

Lorenz C. Hofbauer et al.

Summary: Increased fracture risk is a serious complication of diabetes, leading to prolonged immobility and hospitalizations that can result in significant morbidity and mortality. In type 1 diabetes, bone mass and strength are reduced, leading to a five-fold increased risk of lifelong fractures. In type 2 diabetes, fracture risk is increased despite normal bone mass. The fragility of bones in diabetes can be attributed to cellular abnormalities, matrix interactions, immune and vascular changes, and musculoskeletal maladaptation to chronic hyperglycemia.

LANCET DIABETES & ENDOCRINOLOGY (2022)

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Article Engineering, Biomedical

A bone-targeted engineered exosome platform delivering siRNA to treat osteoporosis

Yongzhi Cui et al.

Summary: The complex pathogenesis of osteoporosis makes it difficult to treat with conventional therapies. Researchers have developed an exosome delivery system based on exosomes secreted by mesenchymal stem cells derived from induced pluripotent stem cells. By modifying a bone-targeting peptide, the system can specifically deliver siRNA to osteoblasts and enhance therapeutic effects.

BIOACTIVE MATERIALS (2022)

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Article Endocrinology & Metabolism

Fat, adipokines, bone structure and bone regulatory factors associations in obesity

T. Vilaca et al.

Summary: Obese individuals have higher bone mineral density and more favorable bone microarchitecture. Subcutaneous adipose tissue is strongly associated with bone density and bone turnover. Leptin may play a crucial role in mediating the effects of subcutaneous adipose tissue on the skeleton.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2022)

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Review Food Science & Technology

Role of Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation

Esther Ramirez-Moreno et al.

Summary: Obesity is a disease characterized by inflammation in adipose tissue, caused by immune cell infiltration, increased proinflammatory molecule secretion, and decreased anti-inflammatory molecule secretion. It also increases the risk of cardiovascular diseases, diabetes, and cancer. Natural products such as polyphenols and fiber have potential anti-inflammatory effects and play an important role in the prevention and treatment of obesity and other non-communicable diseases.

FOODS (2022)

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Review Endocrinology & Metabolism

Type 2 diabetes and bone fragility in children and adults

Maria Felicia Faienza et al.

Summary: Type 2 diabetes (T2D) is a global epidemic disease that is increasingly prevalent in adolescents and young adults. The mechanisms leading to T2D in young people are similar to those in older patients, but the severity of onset and specific characteristics may differ. T2D is associated with complications including bone fragility, which is explained by altered bone quality and reduced turnover. Researchers have identified several pathways involved in bone fragility in T2D, such as microvascular disease, advanced glycation end products, the senescence pathway, the Wnt/beta-catenin pathway, and others. Understanding these mechanisms is important for preventing poor bone quality in T2D and developing targeted interventions.

WORLD JOURNAL OF DIABETES (2022)

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Article Endocrinology & Metabolism

Baseline Testosterone Predicts Body Composition and Metabolic Response to Testosterone Therapy

F. N. U. Deepika et al.

Summary: Male hypogonadism negatively affects body composition, bone mineral density, and metabolic health. This study found that men with a baseline testosterone level of <264 ng/dl showed greater improvement in fat-free mass with testosterone therapy, while men with a testosterone level of >=264 ng/dl showed better improvement in metabolic profile.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Endocrinology & Metabolism

Circulating osteogenic progenitors and osteoclast precursors are associated with long-term glycemic control, sex steroids, and visceral adipose tissue in men with type 2 diabetes mellitus

Elliot Ballato et al.

Summary: This study aimed to investigate the impact of glycemic control on circulating osteogenic progenitor (COP) cells and osteoclast precursors (OCP), as well as identify other potential factors. The results showed that individuals with poor long-term glycemic control had a significantly higher percentage of COP, which was positively correlated with visceral adipose tissue volume and negatively correlated with free testosterone and osteocalcin levels.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Article Endocrinology & Metabolism

Impact of testosterone therapy on bone turnover markers in obese males with type 2 diabetes and functional hypogonadism

Kristina Groti Antonic

Summary: This study conducted a 2-year, double-blind placebo-controlled trial on obese males with type 2 diabetes and hypogonadism. The results showed decreased levels of CTX and PINP, as well as increased lumbar spine bone mineral density after 2 years of testosterone treatment.

AGING MALE (2022)

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Article Endocrinology & Metabolism

One-Year Mean A1c of > 7% is Associated with Poor Bone Microarchitecture and Strength in Men with Type 2 Diabetes Mellitus

Elliot Ballato et al.

Summary: This study found that poor glycemic control in men with T2DM is associated with poorer bone quality and reduced bone turnover, while good glycemic control appears to attenuate the impairment in bone quality.

CALCIFIED TISSUE INTERNATIONAL (2022)

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Article Endocrinology & Metabolism

Low serum levels of bone turnover markers are associated with the presence and severity of diabetic retinopathy in patients with type 2 diabetes mellitus

Yaxin An et al.

Summary: This study demonstrates that in patients with type 2 diabetes mellitus, those with diabetic retinopathy have lower levels of bone formation and resorption markers, with more significant associations in those with severe retinopathy. The findings suggest a potential link between the progression of diabetic retinopathy and deficits in bone metabolism induced by T2DM, calling for further research to validate these associations and explore underlying mechanisms.

JOURNAL OF DIABETES (2021)

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Article Medicine, General & Internal

Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus

Mahriani Sylvawani et al.

Summary: This study found that serum levels of sclerostin were significantly higher in premenopausal women with type 2 diabetes mellitus compared to those without diabetes, while there was no significant difference in IGF-1 levels between the two groups.

JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES (2021)

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Article Endocrinology & Metabolism

Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT

Mark Ng Tang Fui et al.

Summary: In men aged 50 and above, testosterone treatment for 2 years increased volumetric bone density, primarily through effects on cortical bone. The effects on trabecular bone architecture were minor.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Endocrinology & Metabolism

In Men With Obesity, T2DM Is Associated With Poor Trabecular Microarchitecture and Bone Strength and Low Bone Turnover

Francesca Vigevano et al.

Summary: In men, the combination of obesity and T2D is associated with reduced bone turnover and poorer trabecular bone microarchitecture and bone strength compared to those who are obese but without T2D, suggesting worse bone disease.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Article Pharmacology & Pharmacy

Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis Via Activation of β-Catenin Signaling in Growth Plate Chondrocytes

Rui Xu et al.

Summary: The study demonstrates that n-butanol extract of Shen-sui-tong-zhi formula (SSTZF-NB) prevents bone loss mainly via activation of beta-catenin signaling, providing a promising alternative therapeutic option for osteoporosis.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Endocrinology & Metabolism

Type 2 Diabetes Is Causally Associated With Reduced Serum Osteocalcin: A Genomewide Association and Mendelian Randomization Study

Hailuan Zeng et al.

Summary: The study found significant associations between circulating OCN and higher DBP and HDL-C, as well as decreased TG, blood glucose level, insulin resistance, liver fat content, bone mineral density, BMI, and a favorable body fat distribution pattern. MR analysis suggested a causal effect of T2DM on lower circulating OCN concentration.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

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Article Endocrinology & Metabolism

Testosterone Therapy Effects on Bone Mass and Turnover in Hypogonadal Men with Type 2 Diabetes

Georgia Colleluori et al.

Summary: The study found that hypogonadal men with T2D showed significant improvements in bone mass and density after 18 months of testosterone therapy, while those without T2D did not show significant changes.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2021)

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Review Endocrinology & Metabolism

Vitamin D and Obesity: Current Evidence and Controversies

Irene Karampela et al.

Summary: Obesity is linked to low vitamin D levels, but weight loss and vitamin D supplementation do not have significant effects on improving this. Studies on vitamin D status post-bariatric surgery have conflicting results, and the relationship between vitamin D and obesity remains controversial due to limitations and confounding factors. Further research is needed to understand the complicated interaction between vitamin D and adiposity.

CURRENT OBESITY REPORTS (2021)

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Article Endocrinology & Metabolism

Runt-related transcription factor-2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice

Xin Qin et al.

Summary: The study revealed the crucial role of Runx2 in the expression of major bone matrix protein genes and Tnfsf11 after commitment into osteoblasts in mice, and its deficiency may lead to dwarfism and reduced bone mass in mice.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

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Review Cell Biology

The complex role of Wnt ligands in type 2 diabetes mellitus and related complications

Xiaobo Nie et al.

Summary: Type 2 diabetes mellitus is a major chronic disease with increasing global prevalence, and the Wnt signalling pathways play crucial roles in its occurrence and progression. However, our understanding of the exact roles of Wnts in these diseases is still rudimentary due to the complexity of the pathways and the conflicting effects of different family members.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Review Multidisciplinary Sciences

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

Anne-Frederique Turcotte et al.

Summary: The association between obesity and fracture risk may vary depending on skeletal site and sex, with inconsistent results among studies. While several studies have reported higher bone mineral density in patients with obesity, altered bone quality could be a major determinant of bone fragility in this population.

PLOS ONE (2021)

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Article Physiology

Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis

Sandrine Verpoorten et al.

ACTA PHYSIOLOGICA (2020)

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Review Biochemistry & Molecular Biology

Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges

Fen He et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Divergent effects of myogenic differentiation and diabetes on the capacity for muscle precursor cell adipogenic differentiation in a fibrin matrix

Francisca M. Acosta et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Review Endocrinology & Metabolism

Prospect of Stem Cell Therapy and Regenerative Medicine in Osteoporosis

Babak Arjmand et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Article Endocrinology & Metabolism

Risk of fragility fractures in obesity and diabetes: a retrospective analysis on a nation-wide cohort

G. Adami et al.

OSTEOPOROSIS INTERNATIONAL (2020)

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Review Endocrinology & Metabolism

Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments

Mina Wang et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Critical Care Medicine

Obesity in the critically ill: a narrative review

Miet Schetz et al.

INTENSIVE CARE MEDICINE (2019)

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Article Orthopedics

High-fat and high-glucose microenvironment decreases Runx2 and TAZ expression and inhibits bone regeneration in the mouse

Xuan Wu et al.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2019)

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Article Cell & Tissue Engineering

Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial

Woo-Suk Lee et al.

STEM CELLS TRANSLATIONAL MEDICINE (2019)

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Review Endocrinology & Metabolism

Bone Marrow Adiposity: Basic and Clinical Implications

Zachary L. Sebo et al.

ENDOCRINE REVIEWS (2019)

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Article Cell Biology

Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility

Michaela Tencerova et al.

CELL REPORTS (2019)

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Review Geriatrics & Gerontology

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis

Suey S. Y. Yeung et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2019)

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Article Medicine, General & Internal

Inhibition of Osteoclastogenesis by Thioredoxin-Interacting Protein-Derived Peptide (TN13)

Mi Jeong Kim et al.

JOURNAL OF CLINICAL MEDICINE (2019)

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Article Biochemistry & Molecular Biology

Petunidin, a B-ring 5-O-Methylated Derivative of Delphinidin, Stimulates Osteoblastogenesis and Reduces sRANKL-Induced Bone Loss

Masahiro Nagaoka et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Endocrinology & Metabolism

Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus

Richard H. Lee et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2019)

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Article Endocrinology & Metabolism

The effect of PPARγ inhibition on bone marrow adipose tissue and bone in C3H/HeJ mice

Kerensa M. Beekman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

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Review Endocrinology & Metabolism

Obesity and cancer risk: Emerging biological mechanisms and perspectives

Konstantinos Avgerinos et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

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Article Endocrinology & Metabolism

Increase in Osteocalcin Following Testosterone Therapy in Men With Type 2 Diabetes and Subnormal Free Testosterone

Husam Ghanim et al.

JOURNAL OF THE ENDOCRINE SOCIETY (2019)

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Article Endocrinology & Metabolism

Bone and body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 gene

Lina E. Aguirre et al.

ENDOCRINE (2019)

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Article Biochemistry & Molecular Biology

PPARγ Controls Ectopic Adipogenesis and Cross-Talks with Myogenesis During Skeletal Muscle Regeneration

Gabriele Dammone et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Biochemistry & Molecular Biology

Evaluation of osteoblast differentiation and function when cultured on mesoporous bioactive glass adsorbed with testosterone

Kai Gao et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

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Article Endocrinology & Metabolism

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society* Clinical Practice Guideline

Shalender Bhasin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

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Article Biochemistry & Molecular Biology

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

Sarah Weske et al.

NATURE MEDICINE (2018)

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Review Endocrinology & Metabolism

Insight into the development of obesity: functional alterations of adipose-derived mesenchymal stem cells

F. Louwen et al.

OBESITY REVIEWS (2018)

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Article Cell & Tissue Engineering

Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

Yang Song et al.

REGENERATIVE MEDICINE (2018)

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Article Nutrition & Dietetics

Spirulina maxima Extract Reduces Obesity through Suppression of Adipogenesis and Activation of Browning in 3T3-L1 Cells and High-Fat Diet-Induced Obese Mice

Young-Jin Seo et al.

NUTRIENTS (2018)

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Article Multidisciplinary Sciences

Effect of testosterone treatment on bone remodelling markers and mineral density in obese dieting men in a randomized clinical trial

Mark Ng Tang Fui et al.

SCIENTIFIC REPORTS (2018)

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Article Biochemistry & Molecular Biology

Ectopic BAT mUCP-1 overexpression in SKM by delivering a BMP7/PRDM16/PGC-1a gene cocktail or single PRMD16 using non-viral UTMD gene therapy

Shuyuan Chen et al.

GENE THERAPY (2018)

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Review Endocrinology & Metabolism

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

John A. Batsis et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

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Article Cell Biology

MiR-499/PRDM16 axis modulates the adipogenic differentiation of mouse skeletal muscle satellite cells

Juan Jiang et al.

HUMAN CELL (2018)

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Article Endocrinology & Metabolism

Obesity-Associated miR-199a/214 Cluster Inhibits Adipose Browning via PRDM16-PGC-1 Transcriptional Network

Linyun He et al.

DIABETES (2018)

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Article Endocrinology & Metabolism

Sarcopenic Obesity and Its Temporal Associations With Changes in Bone Mineral Density, Incident Falls, and Fractures in Older Men: The Concord Health and Ageing in Men Project

David Scott et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

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Article Endocrinology & Metabolism

Total and Visceral Adiposity Are Associated With Prevalent Vertebral Fracture in Women but Not Men at Age 62 Years: The Newcastle Thousand Families Study

Karen Hind et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

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Article Endocrinology & Metabolism

Exercise Decreases Marrow Adipose Tissue Through β-Oxidation in Obese Running Mice

Maya Styner et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2017)

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Article Endocrinology & Metabolism

Bone Turnover Is Suppressed in Insulin Resistance, Independent of Adiposity

Katherine T. Tonks et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

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Letter Medicine, General & Internal

Romosozumab Treatment in Postmenopausal Osteoporosis

Rajeev Sharma et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults

Dennis T. Villareal et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Endocrinology & Metabolism

A systems perspective on brown adipogenesis and metabolic activation

R. N. Pradhan et al.

OBESITY REVIEWS (2017)

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Article Endocrinology & Metabolism

Low bone turnover in premenopausal women with type 2 diabetes mellitus as an early process of diabetes-associated bone alterations: a cross-sectional study

Dyah Purnamasari et al.

BMC ENDOCRINE DISORDERS (2017)

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Review Endocrinology & Metabolism

The impact of type 2 diabetes on bone metabolism

Claudia Pinheiro Sanches et al.

DIABETOLOGY & METABOLIC SYNDROME (2017)

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Article Medicine, General & Internal

Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone A Controlled Clinical Trial

Peter J. Snyder et al.

JAMA INTERNAL MEDICINE (2017)

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Article Multidisciplinary Sciences

A potential regulatory network underlying distinct fate commitment of myogenic and adipogenic cells in skeletal muscle

Wenjuan Sun et al.

SCIENTIFIC REPORTS (2017)

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Article Endocrinology & Metabolism

Hypogonadal Men with Higher Body Mass Index have Higher Bone Density and Better Bone Quality but Reduced Muscle Density

Lina E. Aguirre et al.

CALCIFIED TISSUE INTERNATIONAL (2017)

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Article Endocrinology & Metabolism

Hypogonadal men with type 2 diabetes mellitus have smaller bone size and lower bone turnover

Georgia Colleluori et al.

BONE (2017)

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Article Geriatrics & Gerontology

Type 2 diabetes and risk of low-energy fractures in postmenopausal women: meta-analysis of observational studies

Joanna Dytfeld et al.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2017)

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Review Endocrinology & Metabolism

Obesity, Type 2 Diabetes and Bone in Adults

Jennifer S. Walsh et al.

CALCIFIED TISSUE INTERNATIONAL (2017)

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Article Physiology

Transcriptional Regulation of Adipogenesis

Paula Mota de Sa et al.

COMPREHENSIVE PHYSIOLOGY (2017)

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Review Geriatrics & Gerontology

Physical activity and exercise as countermeasures to physical frailty and sarcopenia

Emanuele Marzetti et al.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2017)

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Review Endocrinology & Metabolism

Epidemiology of fractures in type 2 diabetes

Ann V. Schwartz

BONE (2016)

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Review Endocrinology & Metabolism

Influence of body weight on bone mass, architecture and turnover

Urszula T. Iwaniec et al.

JOURNAL OF ENDOCRINOLOGY (2016)

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Article Biochemistry & Molecular Biology

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Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes - a meta-analysis

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Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: Cross-sectional and interventional studies

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