4.7 Article

miR-135a-5p overexpression in peripheral blood-derived exosomes mediates vascular injury in type 2 diabetes patients

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Circulating miRNA expression in long-standing type 1 diabetes mellitus

Paula Morales-Sanchez et al.

Summary: This study aimed to analyze the circulating miRNA expression profile of patients with type 1 diabetes and no other associated pathology. The expression of hsa-miR-1-3p was found to be significantly increased in patients with type 1 diabetes and positively correlated with glycated haemoglobin levels. Changes in hsa-miR-1-3p were also found to directly affect genes involved in vascular development and cardiovascular pathologies. Circulating hsa-miR-1-3p, along with glycemic control, could be used as prognostic biomarkers in type 1 diabetes to prevent the development of vascular complications in these patients.

SCIENTIFIC REPORTS (2023)

Article Medicine, General & Internal

Long non-coding RNA LINC00299 knockdown inhibits ox-LDL-induced T/G HA-VSMC injury by regulating miR-135a-5p/XBP1 axis in atherosclerosis

Ming Chang et al.

Summary: This study revealed the regulatory function of LINC00299/miR-135a-5p/XBP1 axis in AS development and proposed a potential therapeutic strategy for AS treatment.

PANMINERVA MEDICA (2022)

Article Chemistry, Multidisciplinary

Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats

Chao Ye et al.

Summary: The study demonstrated that miR-135a-5p promotes vascular smooth muscle cell (VSMC) proliferation in spontaneously hypertensive rats (SHRs), while FNDC5 inhibits it. Silencing miR-135a-5p or upregulating FNDC5 could attenuate VSMC proliferation and vascular remodeling in SHRs. These findings suggest that manipulating miR-135a-5p or FNDC5 levels may be a therapeutic strategy for reducing vascular remodeling and hypertension.

ACTA PHARMACOLOGICA SINICA (2021)

Review Medicine, General & Internal

The role of exosomes derived miRNAs in cancer

Shahid Hussain et al.

Summary: Exosomes are cell-secreting nano-bodies that help transport various biomolecules, including miRNA, in the human body. miRNA plays a dynamic role in cancer, gene regulation, interfering in biological pathways, gene silencing or amplification, and cancer resistance. Further investigation is needed for clinical applications of miRNA in cancer research.

JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION (2021)

Article Cell Biology

Extracellular-vesicle containing miRNA-503-5p released by macrophages contributes to atherosclerosis

Yuquan Wang et al.

Summary: The study identified miR-503-5p as a pro-atherosclerotic factor in atherosclerosis, mediating communication between macrophages, HCAECs, and HCASMCs via EVs. MiR-503-5p reduced the proliferative and angiogenic abilities of HCAECs while enhancing the proliferative and migrating abilities of HCASMCs. It also upregulated inflammatory cytokines and adhesion molecules by downregulating Smad family members 1, 2, and 7 in HCAECs and HCASMCs. Inhibition of miR-503-5p reduced atherosclerotic lesion formation in aortic tissue of atherosclerotic mice.

AGING-US (2021)

Article Multidisciplinary Sciences

MicroRNA-212-5p and its target PAFAH1B2 suppress vascular proliferation and contraction via the downregulation of RhoA

Gwi Ran Kim et al.

Summary: miR-212-5p and PAFAH1B2 are novel negative regulators of VSMC proliferation, migration, and contraction in hypertension.

PLOS ONE (2021)

Article Pharmacology & Pharmacy

Extracellular vesicle-mediated miR135a-5p transfer in hypertensive rat contributes to vascular smooth muscle cell proliferation via targeting FNDC5

Ying Tong et al.

Summary: The study demonstrated that increased levels of miR135a-5p in SHR-EVs promoted VSMC proliferation by inhibiting FNDC5 expression. This indicates that miR135a-5p plays a crucial role in the proliferation of VSMCs in hypertension and could be a potential target for intervention.

VASCULAR PHARMACOLOGY (2021)

Review Medicine, Research & Experimental

Fatty acids and their role in type-2 diabetes (Review)

Shilpa S. Shetty et al.

Summary: Age, lifestyle, and diet are major risk factors for type 2 diabetes, and lipid changes may not only be a consequence of impaired glucose metabolism, but also a causative factor. Fatty acids play a crucial role in the development of insulin resistance (IR) and type 2 diabetes.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

Article Multidisciplinary Sciences

ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells

Celina Uhlemeyer et al.

PLOS ONE (2020)

Article Pharmacology & Pharmacy

Type 1 diabetes upregulates metastasis-associated protein 1-phosphorylated histone 2AX signaling in the testis

Narayana Kilarkaje et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

Correction Medicine, Research & Experimental

Human peripheral blood-derived exosomes for microRNA delivery (vol 43, pg 2319, 2019)

Ji-Young Kang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Review Endocrinology & Metabolism

Biomarkers for type 2 diabetes

Markku Laakso

MOLECULAR METABOLISM (2019)

Article Integrative & Complementary Medicine

Research Progress on Non-Drug Treatment for Blood Glucose Control of Type 2 Diabetes Mellitus

Wei Jun-ping et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2018)

Review Cardiac & Cardiovascular Systems

ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease

Yolandi Espach et al.

CARDIOVASCULAR DRUGS AND THERAPY (2015)

Review Biochemistry & Molecular Biology

Molecular Pathways Regulating Macrovascular Pathology and Vascular Smooth Muscle Cells Phenotype in Type 2 Diabetes

Sara Casella et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Medicine, General & Internal

Type 2 diabetes mellitus

Ralph A. DeFronzo et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Chemistry, Analytical

Determination of Exosome Concentration in Solution Using Surface Plasmon Resonance Spectroscopy

Deborah L. M. Rupert et al.

ANALYTICAL CHEMISTRY (2014)

Review Medicine, Research & Experimental

The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes?

Karen E. Porter et al.

CLINICAL SCIENCE (2013)

Article Endocrinology & Metabolism

EGF Receptor (ERBB1) Abundance in Adipose Tissue Is Reduced in Insulin-Resistant and Type 2 Diabetic Women

Carlyle Rogers et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)

Article Medical Laboratory Technology

Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus

Saba Khan et al.

TRANSLATIONAL RESEARCH (2011)

Article Pharmacology & Pharmacy

ErbB Targeted Drugs and Angiogenesis

Erika Iivanainen et al.

CURRENT VASCULAR PHARMACOLOGY (2010)

Article Multidisciplinary Sciences

Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation

Jay P. Reddy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Biochemistry & Molecular Biology

Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

William W. Chen et al.

MOLECULAR SYSTEMS BIOLOGY (2009)