4.7 Article

CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons

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Chronic UCN2 treatment desensitizes CRHR2 and improves insulin sensitivity

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Summary: UCN2 acts as a ligand for CRHR2 and acute treatment decreases glucose uptake, while chronic treatment improves glucose uptake. The findings provide mechanistic insights into how UCN2 regulates insulin sensitivity and glucose metabolism, and establish a working model that unifies the contradictory metabolic effects of UCN2.

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