☆ 4.7 Review

FoxO1 as a tissue-specific therapeutic target for type 2 diabetes

FRONTIERS IN ENDOCRINOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies

Maria E. Casado et al.

Summary: Excess body weight is often associated with low-grade inflammation, and evidence suggests a relationship between obesity and various diseases, including cancer and diabetes. Leptin, a hormone mainly produced by adipose tissue, plays a role in energy metabolism, neuroprotection, and regulation of peripheral tissues. Resistance to leptin can be related to neurological disorders and compromise its actions. This review discusses recent advances in understanding the molecular mechanisms of leptin and its potential implications for disease treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Review Clinical Neurology

Type 2 Diabetes and Parkinson's Disease: A Focused Review of Current Concepts

Patrick W. Cullinane et al.

Summary: Highly reproducible epidemiological evidence suggests that type 2 diabetes (T2D) increases the risk and progression of Parkinson's disease (PD) and repurposing certain antidiabetic medications for PD treatment shows promise. The high prevalence of T2D highlights the need for personalized antidiabetic treatment in PD patients. However, understanding the mechanistic relation and molecular pathways affected by T2D in the brain is essential. The review focuses on the evidence of T2D-associated dysregulation in peripheral and brain pathways, its impact on neurodegeneration in PD, and the challenges in unraveling the complex relationship between T2D, insulin resistance, and PD.

MOVEMENT DISORDERS (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Tranilast protects pancreatic beta-cells from palmitic acid-induced lipotoxicity via FoxO-1 inhibition

Hye-Eun Choi et al.

Summary: Tranilast, an anti-allergic drug, was found to inhibit the transcription factor FoxO-1. It demonstrated protective effects against lipotoxic stress by reducing cell death and restoring insulin secretion under high fatty acid exposure. Tranilast also reduced oxidative and ER stress induced by fatty acids. In vivo experiments showed that Tranilast improved glucose tolerance and inactivated FoxO-1 in the pancreas of diabetic mice.

SCIENTIFIC REPORTS (2023)

添加到收藏夹

Article Nutrition & Dietetics

Simiao Wan and its ingredients alleviate type 2 diabetes mellitus via IRS1/AKT2/FOXO1/GLUT2 signaling

Ting Xia et al.

Summary: This study investigated the hypoglycemic effects and mechanisms of Simiao Wan (SMW) and its bioactive ingredients (SMW-BI). The results showed that SMW and SMW-BI could lower fasting blood glucose levels, improve dyslipidemia and insulin resistance in T2DM mice. In addition, the study revealed that SMW and SMW-BI exerted their hypoglycemic effects through regulating the IRS1/AKT2/FOXO1 signaling pathway.

FRONTIERS IN NUTRITION (2023)

添加到收藏夹

Review Endocrinology & Metabolism

Insulin resistance in adipose tissue and metabolic diseases

Yukiko Imi et al.

Summary: Adipose tissue dysfunction, primarily due to insulin resistance, is a key contributor to the pathogenesis of metabolic disorders, including NAFLD and NASH. The concept of MAFLD has recently emerged, highlighting the role of insulin resistance in adipose tissue in the development of liver disease associated with metabolic disorders. This review focuses on the physiological relevance and mechanism of action of PDK1, a key kinase in insulin signaling, and its downstream transcription factor FoxO1 in adipocytes.

DIABETOLOGY INTERNATIONAL (2023)

添加到收藏夹

Article Cell Biology

1,25D/VDR inhibits pancreatic β cell ferroptosis by downregulating FOXO1 expression in diabetes mellitus

Yao Ding et al.

Summary: This study found that 1,25-D/VDR inhibited ferroptosis of pancreatic beta cells in type 2 diabetes mellitus (T2DM) by downregulating the expression of FOXO1. It provides a new theoretical basis for basic research on T2DM and is expected to establish a new idea for the treatment of T2DM.

CELLULAR SIGNALLING (2023)

添加到收藏夹

Article Neurosciences

In silico and in vitro analyses of a novel FoxO1 agonist reducing Aβ levels via downregulation of BACE1

Ming-Ti Lv et al.

Summary: This study aims to identify small molecules that can upregulate FoxO1 activity to alleviate the symptoms of Alzheimer's disease (AD). Through computational screening and molecular dynamics simulation, compound D was found to have the highest affinity for FoxO1. Compound D activates FoxO1 and regulates the expression of its downstream target genes, P21, BIM, and PPAR gamma. In SH-SY5Y cells treated with compound D, the expression levels of BACE1 were downregulated, and the levels of A beta(1-40) and A beta(1-42) were reduced. Therefore, this study presents a novel small-molecule FoxO1 agonist with promising anti-AD effects, offering a potential strategy for new drug discovery.

CNS NEUROSCIENCE & THERAPEUTICS (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Irisin attenuates pyroptosis in high glucose-induced pancreatic fl cells via the miR-133a-3p/FOXO1 axis

Anjun Tan et al.

Summary: Irisin is closely related to type 2 diabetes mellitus (T2DM) and other metabolic diseases. MiR-133a-3p is decreased in the peripheral blood of patients with T2DM. Forkhead box protein O1 (FOXO1) is widely expressed in beta cells and affects the occurrence of diabetes through transcriptional regulation and signalling pathway regulation.

ENDOKRYNOLOGIA POLSKA (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: A Focus on Insulin Resistance

Amaia Ezkurdia et al.

Summary: Alzheimer's disease is a disease with a significant socioeconomic burden and a lack of effective treatment. It is highly associated with metabolic syndrome, especially type 2 diabetes mellitus. Insulin resistance is suggested to be the mechanism linking Alzheimer's disease and type 2 diabetes. The role of insulin action on other brain cell types, such as astrocytes, in the onset and/or development of Alzheimer's disease is still unexplored.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

添加到收藏夹

Review Cell Biology

Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review

Kanagavalli Ramasubbu et al.

Summary: Insulin resistance is commonly seen in various diseases and can lead to stress, inflammation, protein misfolding, mitochondrial dysfunction, and metabolic syndrome dysregulation, ultimately contributing to the progression of neurodegenerative diseases.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2023)

添加到收藏夹

Article Neurosciences

Treadmill Exercise Improves PINK1/Parkin-Mediated Mitophagy Activity Against Alzheimer's Disease Pathologies by Upregulated SIRT1-FOXO1/3 Axis in APP/PS1 Mice

Na Zhao et al.

Summary: This study reveals that activating PINK1/Parkin-mediated mitophagy can improve mitochondrial function, reduce beta-amyloid plaques, and ameliorate loss of learning and memory ability in APP/PS1 mice. The SIRT1-FOXO1/3 axis is involved in the rescue of mitophagy by treadmill exercise. These findings have potential implications for the development of treatment strategies and mitophagy enhancers for AD.

MOLECULAR NEUROBIOLOGY (2023)

添加到收藏夹

Article Medicine, General & Internal

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Kanyin Liane Ong et al.

Summary: Diabetes is a major global cause of death and disability, with the total prevalence expected to continue to rise globally by 2050. Type 2 diabetes accounts for the majority of diabetes cases, largely due to obesity caused by multiple factors.

LANCET (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling

Haixia Du et al.

Summary: Skeletal muscle atrophy is commonly observed in patients with type 2 diabetes mellitus (T2DM) due to insulin resistance. Exposure to advanced glycation end products (AGEs) induces reactive oxygen species (ROS) generation, activating the PERK/FOXO1 signaling pathway, resulting in skeletal muscle atrophy and insulin resistance. FOXO1 silencing significantly inhibits skeletal muscle atrophy and insulin resistance without affecting ROS production.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2023)

添加到收藏夹

Article Integrative & Complementary Medicine

Efficacy and safety of Obex® in overweight and obese subjects: a randomised, double-blind, placebo-controlled clinical trial

Eduardo Cabrera-Rode et al.

Summary: This study suggests that Obex(R) may be helpful in reducing body weight and fat. Through a randomized double-blind clinical trial, researchers found that Obex(R) combined with non-pharmacological treatment significantly improved weight, waist circumference, and insulin metabolism in overweight and obese patients. Compared to the placebo group, the Obex(R) group had higher levels of high-density lipoprotein cholesterol.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2023)

添加到收藏夹

Article Chemistry, Applied

Oat β-D-glucan ameliorates type II diabetes through TLR4/PI3K/AKT mediated metabolic axis

Huiqin Guo et al.

International Journal of Biological Macromolecules (2023)

添加到收藏夹

Article Cell Biology

The 15-hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates abnormal hepatic glucose metabolism through PGE2-EP4 receptor-AKT signaling in a type 2 diabetes mellitus mouse model

Mingjie Liang et al.

Summary: SW033291, a small molecule inhibitor of 15-hydroxyprostaglandin dehydrogenase, increases PGE2 levels and exerts a protective effect against T2DM by promoting glycogen synthesis and inhibiting gluconeogenesis.

CELLULAR SIGNALLING (2023)

添加到收藏夹

Review Biochemistry & Molecular Biology

Reversing pancreatic & beta;-cell dedifferentiation in the treatment of type 2 diabetes

Jinsook Son et al.

Summary: Diabetes: Regression of insulin-producing β-cells in the pancreas. Therapies aimed at preventing or reversing the regression of pancreatic insulin-producing cells could restore healthy sugar metabolism in individuals with type 2 diabetes. By understanding the molecular mechanisms and signaling pathways involved, researchers hope to develop targeted therapies to inhibit or reverse the regression of pancreatic β-cells.

EXPERIMENTAL AND MOLECULAR MEDICINE (2023)

添加到收藏夹

Article Cell Biology

L-Methionine prevents β-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats

Umashanker Navik et al.

Summary: In this study, we investigated the effect of L-Methionine (L-Met) on streptozotocin-induced beta-cell damage model of diabetes mellitus in rats. Our results showed that L-Met improved plasma glucose and insulin levels, increased insulin expression, and inhibited the expression of Arx. Furthermore, L-Met regulated the expression of FOXO1 through histone methylation marks H3K27me3 and H3K4me3. These findings suggest that L-Met may be a potential therapeutic approach for preventing beta-cell injury in diabetes.

ACTA HISTOCHEMICA (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The role of FoxO1 and its modulation with small molecules in the development of diabetes mellitus: A review

Joshua Nathanael et al.

Summary: Type 2 diabetes (T2D) is a metabolic disorder influenced by various factors, with FoxO1 playing a key role in its development. While FoxO1 activation is considered detrimental in promoting high blood glucose levels and insulin resistance, it also has a protective role in alleviating oxidative stress and promoting cell survival. Targeting FoxO1 with small molecules presents contrasting approaches in combating diabetes mellitus.

CHEMICAL BIOLOGY & DRUG DESIGN (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

FOXOs: masters of the equilibrium

Tianshu Gui et al.

Summary: FOXO transcription factors are a subclass of the larger family of forkhead TFs, regulating cellular homeostasis through various pathways to maintain balance.

FEBS JOURNAL (2022)

添加到收藏夹

Article Cell Biology

HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson's disease cell and mouse models

Peng Lun et al.

Summary: The inhibition of HOTTIP can alleviate neuronal apoptosis and microglial activation in Parkinson's disease models by modulating miR-615-3p/FOXO1.

NEURAL REGENERATION RESEARCH (2022)

添加到收藏夹

Article Cell Biology

Cross-Talking Pathways of Forkhead Box O1 (FOXO1) Are Involved in the Pathogenesis of Alzheimer's Disease and Huntington's Disease

Liyang Liu et al.

Summary: Alzheimer's disease (AD) and Huntington's disease (HD) are destructive diseases with global impact. This study investigates the potential role of FOXO1 in the development of AD and HD. Through gene expression analysis and functional enrichment analysis, FOXO1 was found to be associated with various pathways related to neurodegeneration and cellular senescence. FOXO1 also showed predictive capabilities for the onset of AD and HD. These findings provide insights into the molecular function of FOXO1 in AD and HD pathogenesis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling

Qi Yuan et al.

Summary: Vitamin D deficiency is implicated in the development of metabolic diseases. In this study, mice lacking the 1 alpha hydroxylase enzyme, responsible for activating vitamin D, were found to develop glucose overproduction, glucose intolerance, and insulin resistance in the liver. The study revealed that the activated vitamin D receptor directly interacts with a specific element in the Sirt1 gene promoter, resulting in the upregulation of Sirt1 transcription. This triggers a phosphorylation cascade that reduces the expression of genes involved in gluconeogenesis, ultimately attenuating glucose overproduction in the liver. Additionally, a signaling pathway involving Sirt1 and FOXO1 was identified as key regulators of dysregulated gluconeogenesis due to vitamin D deficiency.

JOURNAL OF DIABETES RESEARCH (2022)

添加到收藏夹

Article Public, Environmental & Occupational Health

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease 2019

Emma Nichols et al.

Summary: With projected trends in population ageing and growth, the number of people with dementia is expected to increase. Understanding the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritization, with a focus on potentially modifiable risk factors.

LANCET PUBLIC HEALTH (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

HIF-1α/FOXO1 axis regulated autophagy is protective for β cell survival under hypoxia in human islets

Rui Liang et al.

Summary: Our study revealed that HIF-1 alpha/FOXO1 regulated autophagy benefits beta cell survival under hypoxia and autophagy dysregulation may account for beta cell mass loss in T2DM.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Alzheimer's Disease as Type 3 Diabetes: Common Pathophysiological Mechanisms between Alzheimer's Disease and Type 2 Diabetes

Michalis Michailidis et al.

Summary: This review article discusses the shared pathophysiological connections between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM), emphasizing the role of insulin in the brain and the mechanistic interplay between the two diseases. The findings highlight the need for routine evaluation and treatment of cognitive impairment in T2DM patients and the evaluation of insulin levels or T2DM in AD patients. The hypothesis of AD as a type 3 diabetes is strongly supported.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

GLP-1 and GIP receptor signaling in beta cells - A review of receptor interactions and co-stimulation

Ashok Mayendraraj et al.

Summary: Glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) are two types of G protein-coupled receptors that play important roles in insulin secretion. GLP-1R agonists have been successfully used in the treatment of type 2 diabetes and obesity, while GLP-1R-GIPR co-agonists, particularly tirzepatide, show promise in improving glycemic control and weight reduction. However, the pharmacodynamic mechanisms and downstream signaling pathways of GLP-1R-GIPR co-agonists remain to be fully understood.

PEPTIDES (2022)

添加到收藏夹

Review Physiology

Weighing in on Adipogenesis

Elizabeth R. Nunn et al.

Summary: Obesity has negative effects on health, including metabolic syndrome, type II diabetes, insulin resistance, and various cancers. Understanding the mechanisms of adipose tissue expansion is important for developing therapeutic approaches.

FRONTIERS IN PHYSIOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice

Qinqin Xu et al.

Summary: This study found that exenatide can restore the Th17/Treg balance in obese diabetic mice by regulating the FoxO1 pathway, thereby improving the progression of diabetes and protecting pancreatic beta-cell function.

MOLECULAR MEDICINE (2022)

添加到收藏夹

Article Multidisciplinary Sciences

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

Rucha Patel et al.

Summary: In this study, the researchers identified adipose triglyceride lipase (ATGL) as the first biosynthetic enzyme for the formation of the FAHFA ester bond in mammals. They found that ATGL uses transacylase activity to esterify hydroxy fatty acids (HFAs) with fatty acids (FAs) from triglycerides (TGs) or diglycerides (DGs) to produce FAHFAs. The expression of ATGL and the activity of DGAT were found to be closely associated with FAHFA biosynthesis.

NATURE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The effects of omega-3 fatty acids in type 2 diabetes: A systematic review and meta-analysis

Yanan Xiao et al.

Summary: The results of this systematic review indicate that n-3 PUFAs can improve cardiovascular risk factors in patients with type 2 diabetes, including total cholesterol, triglyceride, high-density lipoprotein cholesterol, hemoglobin A1c, and C-reactive protein levels.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2022)

添加到收藏夹

Article

Gaining insight into the role of FoxO1 in the progression of disuse-induced skeletal muscle atrophy

Natalia Vilchinskaya et al.

Advances in Biological Regulation (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Role of Forkhead Box O in Pathogenesis and Therapy of Diabetes Mellitus

Malgorzata Marchelek-Mysliwiec et al.

Summary: FOXO proteins play important roles in various physiological processes and pathological conditions, including diabetes. They regulate pancreatic beta-cell function, glucose metabolism, and have potential value in diabetes therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Medicine, Research & Experimental

The hepatoprotective effects of n3-polyunsaturated fatty acids against non-alcoholic fatty liver disease in diabetic rats through the FOXO1/PPARα/GABARAPL1 signalling pathway

Nehal M. Ramadan et al.

Summary: This study compared the efficacy of n3-PUFAs and metformin in halting the progression of NAFLD. The results showed that n3-PUFAs exerted protective effects on hepatic IR and NAFLD by enhancing PPAR-alpha expression and inhibiting FoxO1/GABARAPL1/MAP1LC3B transcription.

LIFE SCIENCES (2022)

添加到收藏夹

Review Pharmacology & Pharmacy

FOXO transcription factors as therapeutic targets in human diseases

Alba Orea-Soufi et al.

Summary: FOXO proteins are important transcription factors involved in cellular stress adaptation and tumor suppression. Modulating the activity and function of FOXO proteins has potential clinical applications in treating various diseases.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice

Takayoshi Sasako et al.

Summary: This study reveals that suppression of Akt activity in skeletal muscle of mammals associated with insulin resistance and aging could accelerate sarcopenia and reduce lifespan.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Biology

High expression of P4HA3 in obesity: a potential therapeutic target for type 2 diabetes

Langen Zhuang et al.

Summary: The present study evaluated the expression of P4HA3 in adipocytes and adipose tissue and explored its effect on obesity and T2DM. The results showed that P4HA3 was upregulated in the subcutaneous adipose tissue of obesity and T2DM patients. Silencing P4HA3 improved insulin resistance and inhibited adipocyte differentiation. Further analysis revealed that P4HA3 knockdown could improve hepatic glucose homeostasis and reduce steatosis in obese mice.

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH (2022)

添加到收藏夹

Review Geriatrics & Gerontology

Role of Forkhead Box Protein O1 (FoxO1) in Stroke: A Literature Review

Sichao Guo et al.

Summary: Stroke is a prevalent cause of death worldwide, leading to severe cellular dysfunction and long-term disability. FoxO1 plays a role in regulating cellular processes like gluconeogenesis and glycogenolysis. During stroke, FoxO1 modifications are linked to various functions such as inducing cell death and inflammation, affecting BBB, and regulating hepatic gluconeogenesis.

AGING AND DISEASE (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

SREBP-1c and lipogenesis in the liver: an update

Pascal Ferre et al.

Summary: Sterol Regulatory Element Binding Protein-1c is a transcription factor that controls lipid synthesis in the liver from glucose, playing a crucial role in energy storage. Discovered in the early nineties, it has been the subject of over 5000 studies to understand its activation mechanism and physiological and pathological roles.

BIOCHEMICAL JOURNAL (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

FoxO1 signaling as a therapeutic target for type 2 diabetes and obesity

Khaled Benchoula et al.

Summary: This review discusses the importance of maintaining balanced glucose homeostasis in preventing or treating diabetes and obesity, as well as the complexity of activating and inhibiting glucose production. It focuses on the key role of FoxO1 in obesity-induced insulin susceptibility and provides potential therapeutic approaches.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

添加到收藏夹

Article Oncology

Liraglutide protects palmitate-induced INS-1 cell injury by enhancing autophagy mediated via FoxO1

Xiu-Dan Li et al.

Summary: The study demonstrates that liraglutide can ameliorate PA-induced islet beta-cells injury by upregulating autophagy pathway, a protective effect that may be mediated by FoxO1.

MOLECULAR MEDICINE REPORTS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases

Shuqi Du et al.

Summary: With increased lifespan, there is a growing population of elderly individuals facing age-related diseases. FoxO transcription factors play crucial roles in aging and disease, with their dysfunction being implicated in the pathogenesis of many age-related diseases.

CELL AND BIOSCIENCE (2021)

添加到收藏夹

Article Endocrinology & Metabolism

Serum- and glucocorticoid-inducible kinase 1 promotes insulin resistance in adipocytes via degradation of insulin receptor substrate 1

Min Zhang et al.

Summary: Accumulating evidence suggests that SGK1 plays a role in the development of metabolic syndrome through an unclear mechanism. This study found that SGK1 mediates insulin resistance in adipocytes by influencing insulin signaling pathways, indicating it as a potential therapeutic target for metabolic syndrome and its complications.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2021)

添加到收藏夹

Article Plant Sciences

Yunpi Heluo decoction attenuates insulin resistance by regulating SIRT1-FoxO1 autophagy pathway in skeletal muscle of Zucker diabetic fatty rats

Zhu-Jun Mao et al.

Summary: This study aimed to investigate the regulatory mechanism of Yunpiheluo (YPHL) on the autophagy pathway in the skeletal muscle of IR Zucker diabetic fatty (ZDF) rats. The results showed that YPHL could increase the autophagy level by regulating the SIRT1-FoxO1 signaling pathway in the skeletal muscle, thereby improving lipid metabolism and attenuating IR.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

添加到收藏夹

Review Medicine, Research & Experimental

Role of FoxO1 in regulating autophagy in type 2 diabetes mellitus (Review)

Xiudan Li et al.

Summary: Type 2 diabetes mellitus is a major chronic disease characterized by pancreatic beta-cell dysfunction and insulin resistance. Autophagy and FoxO1 play important roles in the pathogenesis of T2DM, affecting beta-cell viability, apoptosis, insulin secretion, and peripheral insulin resistance.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Exercise Training-Increased FBXO32 and FOXO1 in a Gender-Dependent Manner in Mild Cognitively Impaired African Americans: GEMS-1 Study

Fikru B. Bedada et al.

Summary: The study investigated the impact of UPS and FOXOs on mild cognitive impairment in African Americans and the effects of exercise on these components. The results showed that exercise can increase the expression levels of FBXO32 and FOXO1 in different genders, which may have a positive effect on enhancing the cellular clearance system in neurodegenerative diseases.

FRONTIERS IN AGING NEUROSCIENCE (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Improving the Dysregulation of FoxO1 Activity Is a Potential Therapy for Alleviating Diabetic Kidney Disease

Yan Wang et al.

Summary: A significant proportion of diabetes patients will develop kidney disease, with Diabetic Kidney Disease (DKD) being a major complication and leading cause of end-stage kidney disease worldwide. FoxO1 transcription factor plays a crucial role in the pathogenesis of DKD and may be a potential clinical target for prevention and treatment.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels

Zoltan Gombos et al.

Summary: The study used an overload model in rats to investigate the molecular signaling pathways involved in skeletal muscle hypertrophy. Results showed an increase in muscle mass and upregulation of anabolic signaling pathways like SIRT1, Akt, mTOR, and S6, while downregulation of FOXO1 and SIRT3 suggested reduced protein breakdown and mitophagy. Additionally, decreased levels of NAD(+), sestrin2, and OGG1 indicated a change in the redox milieu of the skeletal muscle during overload-induced hypertrophy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mutant Huntingtin Impairs Pancreatic beta-cells by Recruiting IRS-2 and Disturbing the PI3K/AKT/FoxO1 Signaling Pathway in Huntington's Disease

Li Li et al.

Summary: In patients with Huntington's disease (HD), there is an increased incidence of diabetes. The activation of the glucose-stimulated PI3K/AKT/FoxO1 signaling pathway in pancreatic beta-cells is significantly blocked, leading to impaired function. However, insulin treatment can alleviate this blockade. These results provide insights into the underlying mechanisms of the high incidence of diabetes and abnormal glucose homeostasis in HD.

JOURNAL OF MOLECULAR NEUROSCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice

Pattawika Lertpatipanpong et al.

Summary: Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) can alleviate diabetes in mice by regulating insulin resistance, lipid accumulation, and pancreatic function. This was observed through various physiological and molecular changes in NAG-1-overexpressing transgenic mice compared to wild-type mice.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metformin Targets Foxo1 to Control Glucose Homeostasis

Xiaoqin Guo et al.

Summary: Metformin primarily lowers hepatic glucose production by inhibiting Foxo1, and it further suppresses glucagon-induced glucose production through inhibiting the PKA -> Foxo1 signaling pathway.

BIOMOLECULES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Differential roles of FOXO transcription factors on insulin action in brown and white adipose tissue

Erica P. Homan et al.

Summary: The research found that FOXO transcription factors play different roles in the action of insulin/IGF-1 in different adipose tissue, with the most significant effect in BAT. While the loss of FOXOs in fat can partially rescue subcutaneous WAT and hepatosteatosis, it cannot rescue systemic insulin resistance and may lead to more severe hyperinsulinemia.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Therapeutic strategies targeting FOXO transcription factors

Giampaolo Calissi et al.

Summary: FOXO proteins are transcription factors that are involved in regulating stress responses to maintain cellular homeostasis. Dysregulation of FOXO protein functions contributes to cardiovascular disease, cancer, diabetes, and neurological diseases. This review summarizes the biology of FOXO proteins, their roles in disease and longevity, and discusses pharmacological approaches to develop FOXO-targeting therapeutics.

NATURE REVIEWS DRUG DISCOVERY (2021)

添加到收藏夹

Article Cell Biology

Photobiomodulation therapy decreases free fatty acid generation and release in adipocytes to ameliorate insulin resistance in type 2 diabetes

Longlong Gong et al.

CELLULAR SIGNALLING (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolic aspects of cardiovascular diseases: Is FoxO1 a player or a target?

Rossella Menghini et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

添加到收藏夹

Article Medicine, Research & Experimental

miRNA-384-5p regulates the progression of Parkinson's disease by targeting SIRT1 in mice and SH-SY5Y cells

Hongli Tao et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

添加到收藏夹

Review Cell Biology

A Review of FoxO1-Regulated Metabolic Diseases and Related Drug Discoveries

Shiming Peng et al.

CELLS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis

Tetsuya Hosooka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion

Fangfang Zhang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Endocrinology & Metabolism

N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation

Jingfan Zhang et al.

JOURNAL OF DIABETES RESEARCH (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Cyb5r3 links FoxO1-dependent mitochondrial dysfunction with β-cell failure

Jason Fan et al.

MOLECULAR METABOLISM (2020)

添加到收藏夹

Review Cell Biology

Adipose Tissue and FoxO1: Bridging Physiology and Mechanisms

Laura Ioannilli et al.

CELLS (2020)

添加到收藏夹

Review Medicine, General & Internal

Photobiomodulation-Underlying Mechanism and Clinical Applications

Claudia Dompe et al.

JOURNAL OF CLINICAL MEDICINE (2020)

添加到收藏夹

Article Pharmacology & Pharmacy

Neuroprotective effects of vildagliptin on drug induced Alzheimer's disease in rats with metabolic syndrome: Role of hippocampal klotho and AKT signaling pathways

Rasha R. Yossef et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sirt1/FoxO1-Associated MAO-A Upregulation Promotes Depressive-Like Behavior in Transgenic Mice Expressing Human A53T α-Synuclein

Yong Li et al.

ACS CHEMICAL NEUROSCIENCE (2020)

添加到收藏夹

Article Neurosciences

FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro

Wei Zhang et al.

NEUROSCIENCE LETTERS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling

F. Bartoli-Leonard et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Agriculture, Multidisciplinary

Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle

Yan Li et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

MicroRNA-223 is essential for maintaining functional β-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways

Yutian Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins

Maria Saline et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

FoxO1 localizes to mitochondria of adipose tissue and is affected by nutrient stress

Daniele Lettieri-Barbato et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2019)

添加到收藏夹

Review Neurosciences

Roles of forkhead box O (FoxO) transcription factors in neurodegenerative diseases: A panoramic view

Wei Hu et al.

PROGRESS IN NEUROBIOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

Omar Al-Massadi et al.

DIABETES (2019)

添加到收藏夹

Editorial Material Endocrinology & Metabolism

Editorial: Transcriptional Regulation of Glucose Metabolism: Gaps and Controversies

Antonio Brunetti et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

添加到收藏夹

Article Endocrinology & Metabolism

Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle

Leonidas S. Lundell et al.

MOLECULAR METABOLISM (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Lentivirus-mediated klotho up-regulation improves aging-related memory deficits and oxidative stress in senescence-accelerated mouse prone-8 mice

Hong-Jing Zhou et al.

LIFE SCIENCES (2018)

添加到收藏夹

Article Cell Biology

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

Valentina Celestini et al.

CELL DEATH & DISEASE (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis

Yuxin Wu et al.

DIABETES (2018)

添加到收藏夹

Article Cell Biology

eIF2 kinases PERK and GCN2 act on FOXO to potentiate FOXO activity

Shiqiu You et al.

GENES TO CELLS (2018)

添加到收藏夹

Article Endocrinology & Metabolism

The PI3K/Akt1-FoxO1 Translocation Pathway Mediates EXf Effects on NIT-1 Cell Survival

Guo-jiang Hou et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2017)

添加到收藏夹

Review Oncology

FOXO transcription factors at the interface of metabolism and cancer

Wolfgang Link et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated Cell Aging in Pancreas-specific SMAD7 Mutant Mice

Xiangwei Xiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

添加到收藏夹

Article Neurosciences

SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle

Erika Koltai et al.

JOURNAL OF PHYSIOLOGY-LONDON (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

Fanny Langlet et al.

CELL (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis

Jiangying Kuang et al.

DIABETES (2017)

添加到收藏夹

Article Endocrinology & Metabolism

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development

Mini Sajan et al.

DIABETES (2016)

添加到收藏夹

Article Endocrinology & Metabolism

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

Ting Zhang et al.

ENDOCRINOLOGY (2016)

添加到收藏夹

Article Medicine, Research & Experimental

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Brian T. O'Neill et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling

Lei Yang et al.

MOLECULAR ENDOCRINOLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice

Ja Young Kim-Muller et al.

NATURE COMMUNICATIONS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Oxidative Stress Induces Mouse Follicular Granulosa Cells Apoptosis via JNK/FoxO1 Pathway

Qiannan Weng et al.

PLOS ONE (2016)

添加到收藏夹

Article Cell Biology

FoxO1 interacts with transcription factor EB and differentially regulates mitochondrial uncoupling proteins via autophagy in adipocytes

Longhua Liu et al.

CELL DEATH DISCOVERY (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Central Sirt1 Regulates Body Weight and Energy Expenditure Along With the POMC-Derived Peptide α-MSH and the Processing Enzyme CPE Production in Diet-Induced Obese Male Rats

Nicole E. Cyr et al.

ENDOCRINOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

Insug O-Sullivan et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

Giulia Milan et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Cell Biology

Targeting FoxO1 with AS1842856 Suppresses Adipogenesis

Peng Zou et al.

CELL CYCLE (2014)

添加到收藏夹

Article Geriatrics & Gerontology

Type 2 diabetes is associated with low muscle mass in older adults

Kyung-Soo Kim et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2014)

添加到收藏夹

Review Endocrinology & Metabolism

Minireview: Central Sirt1 Regulates Energy Balance via the Melanocortin System and Alternate Pathways

Anika M. Toorie et al.

MOLECULAR ENDOCRINOLOGY (2014)

添加到收藏夹

Article Geriatrics & Gerontology

Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model

Xi Kuang et al.

NEUROBIOLOGY OF AGING (2014)

添加到收藏夹

Article Physiology

Energy Metabolism in the Liver

Liangyou Rui

COMPREHENSIVE PHYSIOLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Extracellular Signal-regulated Kinase (ERK) Phosphorylates Histone Deacetylase 6 (HDAC6) at Serine 1035 to Stimulate Cell Migration

Kendra A. Williams et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth

Donghoon Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mitochondrial localization of the Forkhead box class O transcription factor FOXO3a in brain

Aurelien Caballero-Caballero et al.

JOURNAL OF NEUROCHEMISTRY (2013)

添加到收藏夹

Article Geriatrics & Gerontology

Patients With Type 2 Diabetes Show a Greater Decline in Muscle Mass, Muscle Strength, and Functional Capacity With Aging

Marika Leenders et al.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2013)

添加到收藏夹

Article Multidisciplinary Sciences

High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

Rokhsana Mortuza et al.

PLOS ONE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Deletion of Hepatic FoxO1/3/4 Genes in Mice Significantly Impacts on Glucose Metabolism through Downregulation of Gluconeogenesis and Upregulation of Glycolysis

Xiwen Xiong et al.

PLOS ONE (2013)

添加到收藏夹

Article Endocrinology & Metabolism

FoxO1 as a double-edged sword in the pancreas: analysis of pancreas-and β-cell-specific FoxO1 knockout mice

Masaki Kobayashi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

Chutima Talchai et al.

CELL (2012)

添加到收藏夹

Article Nutrition & Dietetics

Vitamin D and incidence of diabetes: A prospective cohort study

Inmaculada Gonzalez-Molero et al.

CLINICAL NUTRITION (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Plasma 25-Hydroxyvitamin D and Progression to Diabetes in Patients at Risk for Diabetes An ancillary analysis in the Diabetes Prevention Program

Anastassios G. Pittas et al.

DIABETES CARE (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Hepatic Suppression of Foxo1 and Foxo3 Causes Hypoglycemia and Hyperlipidemia in Mice

Kebin Zhang et al.

ENDOCRINOLOGY (2012)

添加到收藏夹

Article Endocrinology & Metabolism

Overexpression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance

Hye-Jin Kim et al.

ENDOCRINOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

Sarah A. Reed et al.

FASEB JOURNAL (2012)

添加到收藏夹

Article Cell Biology

FoxO6 regulates memory consolidation and synaptic function

Dervis A. M. Salih et al.

GENES & DEVELOPMENT (2012)

添加到收藏夹

Article Geriatrics & Gerontology

Effect of vitamin D on insulin sensitivity in elderly patients with impaired fasting glucose

Ilkin Naharci et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

Rene L. Vidal et al.

HUMAN MOLECULAR GENETICS (2012)

添加到收藏夹

Article Oncology

The Akt/FoxO1/p27 pathway mediates the proliferative action of liraglutide in β cells

Donghong Fang et al.

MOLECULAR MEDICINE REPORTS (2012)

添加到收藏夹

Article Genetics & Heredity

Gene Expression Profiles in Parkinson Disease Prefrontal Cortex Implicate FOXO1 and Genes under Its Transcriptional Regulation

Alexandra Dumitriu et al.

PLOS GENETICS (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Bimodal regulation of FoxO3 by AKT and 14-3-3

Melissa Dobson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

添加到收藏夹

Article Endocrinology & Metabolism

Glucagon-Like Peptide 1 Inhibits the Sirtuin Deacetylase SirT1 to Stimulate Pancreatic β-Cell Mass Expansion

Pierre-Olivier Bastien-Dionne et al.

DIABETES (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

Yu Li et al.

FASEB JOURNAL (2011)

添加到收藏夹

Article Medicine, Research & Experimental

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

Rui-Hong Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL

Partha Chakrabarti et al.

JOURNAL OF LIPID RESEARCH (2011)

添加到收藏夹

Article Cell Biology

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

Sara Froejdoe et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

Nagalingam R. Sundaresan et al.

SCIENCE SIGNALING (2011)

添加到收藏夹

Article Medical Laboratory Technology

Vitamin D3 supplementation improves insulin sensitivity in subjects with impaired fasting glucose

Shaban Nazarian et al.

TRANSLATIONAL RESEARCH (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

The cathepsin L gene is a direct target of FOXO1 in skeletal muscle

Yoshihiro Yamazaki et al.

BIOCHEMICAL JOURNAL (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization

Li Qiang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

添加到收藏夹

Article Cell Biology

Protein Phosphatase 2A Reactivates FOXO3a through a Dynamic Interplay with 14-3-3 and AKT

Amrik Singh et al.

MOLECULAR BIOLOGY OF THE CELL (2010)

添加到收藏夹

Article Pharmacology & Pharmacy

Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice

Takeyuki Nagashima et al.

MOLECULAR PHARMACOLOGY (2010)

添加到收藏夹

Article Gastroenterology & Hepatology

FoxO4 Inhibits NF-κ3 and Protects Mice Against Colonic Injury and Inflammation

Wen Zhou et al.

GASTROENTEROLOGY (2009)

添加到收藏夹

Article Cell Biology

Forkhead transcription factor Foxo1 is essential for adipocyte differentiation

Keisuke Munekata et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling

Zengqiang Yuan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

FOXO1 Transrepresses Peroxisome Proliferator-activated Receptor γ Transactivation, Coordinating an Insulin-induced Feed-forward Response in Adipocytes

WuQiang Fan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

添加到收藏夹

Article Neurosciences

Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats (Publication with Expression of Concern. See vol. 594, pg. 5025, 2016) (Publication with Expression of Concern. See vol. 594, pg. 5025, 2016) (Publication with Expression of Concern. See vol. 594, pg. 5025, 2016)

Eduardo R. Ropelle et al.

JOURNAL OF PHYSIOLOGY-LONDON (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tissue expression of porcine FoxO1 and its negative regulation during primary preadipocyte differentiation

Wei-Jun Pang et al.

MOLECULAR BIOLOGY REPORTS (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

Leona Plum et al.

NATURE MEDICINE (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Foxo1 integrates insulin signaling with mitochondrial function in the liver

Zhiyong Cheng et al.

NATURE MEDICINE (2009)

添加到收藏夹

Article Endocrinology & Metabolism

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

David S. Waddell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

Kazuhiro Hasegawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

添加到收藏夹

Editorial Material Cell Biology

Selective versus total insulin resistance: A pathogenic paradox

Michael S. Brown et al.

CELL METABOLISM (2008)

添加到收藏夹

Review Endocrinology & Metabolism

The role of advanced glycation end products in progression and complications of diabetes

Su-Yen Goh et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2008)

添加到收藏夹

Article Medicine, Research & Experimental

FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice

Adama Kamagate et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

添加到收藏夹

Review Biochemistry & Molecular Biology

Lysine acetylation: Codified crosstalk with other posttranslational modifications

Xiang-Jiao Yang et al.

MOLECULAR CELL (2008)

添加到收藏夹

Review Biochemistry & Molecular Biology

Structure/function relationships underlying regulation of FOXO transcription factors

T. Obsil et al.

ONCOGENE (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor

P. Liu et al.

ONCOGENE (2008)

添加到收藏夹

Article Endocrinology & Metabolism

Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure

Jun Nakae et al.

DIABETES (2008)

添加到收藏夹

Article Endocrinology & Metabolism

Regulation of pancreatic β-cell function by the forkhead protein FoxO1

J. Buteau et al.

DIABETES OBESITY & METABOLISM (2007)

添加到收藏夹

Article Cell Biology

Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1

Sachie Asada et al.

CELLULAR SIGNALLING (2007)

添加到收藏夹

Article Cell Biology

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver

Michihiro Matsumoto et al.

CELL METABOLISM (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein α transcriptional complex

Liping Qiao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

添加到收藏夹

Article Multidisciplinary Sciences

CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage

Haojie Huang et al.

SCIENCE (2006)

添加到收藏夹

Article Medicine, Research & Experimental

The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity

Jun Nakae et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

添加到收藏夹

Review Medicine, Research & Experimental

Central insulin action in energy and glucose homeostasis

Leona Plum et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

FoxO1 regulates multiple metabolic pathways in the liver - Effects on gluconeogenic, glycolytic, and lipogenic gene expression

WW Zhang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

The forkhead transcription factor foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

D Kawamori et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

添加到收藏夹

Article Developmental Biology

Spatial and temporal expression of FoxO transcription factors in the developing and adult murine brain

MFM Hoekman et al.

GENE EXPRESSION PATTERNS (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

FoxO6 transcriptional activity is regulated by Thr26 and Ser184, independent of nucleo-cytoplasmic shuttling

LP Van der Heide et al.

BIOCHEMICAL JOURNAL (2005)

添加到收藏夹

Article Nutrition & Dietetics

Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with β-glucans from oats or barley:: a randomised dose-controlled trial

M Biörklund et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2005)

添加到收藏夹

Article Cell Biology

FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

YI Kitamura et al.

CELL METABOLISM (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

H Matsuzaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms

CC Bastie et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

JT Rodgers et al.

NATURE (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

M Sandri et al.

CELL (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

T Hosaka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch/red muscle) fiber genes, and impaired glycemic control

Y Kamei et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK

MAG Essers et al.

EMBO JOURNAL (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1

A van der Horst et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

添加到收藏夹

Article Endocrinology & Metabolism

Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA

FN Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

F Picard et al.

NATURE (2004)

添加到收藏夹

Article Endocrinology & Metabolism

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice

J Altomonte et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics

FMJ Jacobs et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle

Y Kamei et al.

FEBS LETTERS (2003)

添加到收藏夹

Article Medicine, Research & Experimental

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

T Kitamura et al.

JOURNAL OF CLINICAL INVESTIGATION (2002)

添加到收藏夹

Article Anatomy & Morphology

Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles

T Furuyama et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2002)

添加到收藏夹

Article Genetics & Heredity

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

J Nakai et al.

NATURE GENETICS (2002)

添加到收藏夹

Article Multidisciplinary Sciences

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

S Nemoto et al.

SCIENCE (2002)

添加到收藏夹

Article Cell Biology

14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

A Brunet et al.

JOURNAL OF CELL BIOLOGY (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulation of the forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451

ND De Ruiter et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX

AM Brownawell et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

G Rena et al.

BIOCHEMICAL JOURNAL (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

T Furuyama et al.

BIOCHEMICAL JOURNAL (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.