Automated detection of immune effector cell-associated neurotoxicity syndrome via quantitative EEG

Article Critical Care Medicine

Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S)

Meike van Sleuwen et al.

Summary: The study introduces an automated physiological measure, E-CAM-S, for predicting delirium severity, which performs comparably to traditional interview-based clinical assessments in predicting clinical outcomes.

CRITICAL CARE MEDICINE (2022)

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Article Oncology

EEG findings in CAR T-cell-associated neurotoxicity: Clinical and radiological correlations

Isabelle Beuchat et al.

Summary: In patients experiencing neurotoxicity after CAR T-cell therapy, EEG abnormalities such as diffuse background slowing correlated with severity. Rhythmic/periodic patterns and focal EEG abnormalities were common and often related to clinical symptoms and PET/MRI findings without structural lesions. The etiology of these EEG changes requires further investigation.

NEURO-ONCOLOGY (2022)

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Article Clinical Neurology

Electroencephalographic Abnormalities are Common in COVID-19 and are Associated with Outcomes

Lu Lin et al.

Summary: This study demonstrates that seizures and other epileptiform abnormalities are common in patients with COVID-19 undergoing continuous EEG monitoring and are associated with adverse clinical outcomes.

ANNALS OF NEUROLOGY (2021)

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Article Medicine, General & Internal

Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma

Nikhil C. Munshi et al.

Summary: The phase 2 study confirmed the efficacy and safety of ide-cel in patients with relapsed and refractory myeloma, with a majority of patients achieving responses and 26% achieving MRD-negative status. Despite the high response rate, almost all patients experienced grade 3 or 4 toxic effects, including hematologic toxic effects and cytokine release syndrome.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Clinical Neurology

Neurological complications of cancer immunotherapy (CAR T cells)

Daniel B. Rubin et al.

Summary: CAR T cell therapy is crucial in treating advanced malignancies, but is linked to significant neurologic toxicity. Despite increasing clinical experience, the unpredictability of neurologic symptoms remains a major source of anxiety for both patients and practitioners, presenting a barrier to broader adoption of this treatment modality.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

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Letter Medicine, General & Internal

CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus

Dimitrios Mougiakakos et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Hematology

Modified EASIX predicts severe cytokine release syndrome and neurotoxicity after chimeric antigen receptor T cells

Martina Pennisi et al.

Summary: This study found that EASIX and two modified EASIX formulas can predict severe toxicities related to CAR T-cell therapy, with CRP and PLTs being the most significant variables associated with these toxicities. m-EASIX was identified as a critical predictor of disease response and had high discriminatory ability for diagnosing patients with severe CRS and ICANS.

BLOOD ADVANCES (2021)

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Article Clinical Neurology