Plasma & beta;-synuclein, GFAP, and neurofilaments in patients with malignant gliomas undergoing surgical and adjuvant therapy

We analyzed the longitudinal concentrations and prognostic roles of plasma & beta;-synuclein (& beta;-syn), glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) in 33 patients with malignant gliomas, who underwent surgical and adjuvant therapy. GFAP and NfL levels were increased in patients with glioblastoma compared to cases with other tumors. & beta;-syn, NfL and NfH increased after surgery, whereas GFAP decreased at long-term follow-up. & beta;-syn and neurofilament concentrations were influenced by surgery and/or radiotherapy regimens. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and displayed distinct trajectories after surgical and adjuvant therapy.

Automated summary

The concentrations and prognostic roles of plasma β-synuclein, glial fibrillary acidic protein (GFAP), and neurofilament proteins (NfL and NfH) were analyzed in 33 patients with malignant gliomas. GFAP and NfL levels were higher in glioblastoma patients compared to other tumor cases. Post-surgery, β-syn, NfL, and NfH increased, while GFAP decreased in long-term follow-up. Surgery and/or radiotherapy regimens influenced β-syn and neurofilament concentrations. GFAP and neurofilament levels were significantly associated with survival. Plasma neuronal and astrocytic biomarkers are differentially altered in malignant glioma types and have distinct trajectories after surgical and adjuvant therapy.