Exploring marine toxins: comparative analysis of chemical reactivity properties and potential for drug discovery

Marine toxins, produced by various marine microorganisms, pose significant risks to both marine ecosystems and human health. Understanding their diverse structures and properties is crucial for effective mitigation and exploration of their potential as therapeutic agents. This study presents a comparative analysis of two hydrophilic and two lipophilic marine toxins, examining their reactivity properties and bioavailability scores. By investigating similarities among these structurally diverse toxins, valuable insights into their potential as precursors for novel drug development can be gained. The exploration of lipophilic and hydrophilic properties in drug design is essential due to their distinct implications on drug distribution, elimination, and target interaction. By elucidating shared molecular properties among toxins, this research aims to identify patterns and trends that may guide future drug discovery efforts and contribute to the field of molecular toxinology. The findings from this study have the potential to expand knowledge on toxins, facilitate a deeper understanding of their bioactivities, and unlock new therapeutic possibilities to address unmet biomedical needs. The results showcased similarities among the studied systems, while also highlighting the exceptional attributes of Domoic Acid (DA) in terms of its interaction capabilities and stability.

Automated summary

Marine toxins pose significant risks to marine ecosystems and human health. Understanding their structures and properties is crucial for mitigating risks and exploring their potential as therapeutic agents. This study compares four marine toxins, examining their reactivity properties and bioavailability. By investigating their similarities, valuable insights for new drug development can be gained. Exploring the lipophilic and hydrophilic properties in drug design is important for drug distribution and interaction. By elucidating shared molecular properties, this research aims to guide future drug discovery efforts and contribute to the field of molecular toxinology. The findings expand knowledge on toxins, deepen understanding of their bioactivities, and unlock new therapeutic possibilities.