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Advancement of regulating cellular signaling pathways in NSCLC target therapy via nanodrug

FRONTIERS IN CHEMISTRY (2023)

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Review Immunology

Association of immune-related adverse events and efficacy in advanced non-small-cell lung cancer: a systematic review and meta-analysis

Yu Zhou et al.

Summary: This study aimed to explore the association between immune-related adverse events (irAEs) and efficacy in advanced NSCLC. A total of 35 studies covering 8435 patients with advanced NSCLC were included. The study found that patients with irAEs had significantly longer PFS and OS, and higher objective response rate compared to those without irAEs.

IMMUNOTHERAPY (2023)

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Article Chemistry, Multidisciplinary

Influence of lung cancer model characteristics on tumor targeting behavior of nanodrugs

Weixia Xu et al.

Summary: There is growing evidence that there is a significant difference in the effectiveness of nanodrugs in preclinical mouse tumor models and in clinical human tumors, and this gap is likely due to differences in tumor models. The study found that fast-growing tumors have lower vascular tight junctions, leading to higher vascular paracellular transport activity and nanodrug accumulation. In contrast, orthotopic tumors have low vascular transcellular and paracellular transport activities, making it difficult for nanodrug accumulation.

JOURNAL OF CONTROLLED RELEASE (2023)

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Article Nanoscience & Nanotechnology

Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma

Alexandre Detappe et al.

Summary: Nanomedicine platforms offer solutions for cancer therapies by addressing challenges in drug combination due to differing physical properties. The delivery of multiple drugs in nanocarriers outperforms single-drug combinations, providing design principles for improved multiple myeloma therapies.

NATURE NANOTECHNOLOGY (2023)

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Review Oncology

Thermal immuno-nanomedicine in cancer

Zhe Yang et al.

Summary: Immunotherapy has revolutionized cancer treatment, but promoting antitumour immunity in patients with resistant tumours remains a challenge. Thermal therapies offer a promising approach by reprogramming the tumour microenvironment and promoting immune cell recruitment. This review summarizes the role of thermal therapies in combination with immunotherapies, as well as the development of thermal immuno-nanomedicines for cancer treatment.

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

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Review Chemistry, Multidisciplinary

Advances in Drug Delivery Systems Based on Red Blood Cells and Their Membrane-Derived Nanoparticles e

Phuong Hoang Diem Nguyen et al.

Summary: Red blood cells (RBCs) and RBC membrane derived nanoparticles have been developed as bioinspired drug delivery systems to address the issues of synthetic nanocarriers. RBC-based delivery systems possess characteristics including biocompatibility, biodegradability, and long circulation time, which make them suitable for systemic administration. They have been employed in designing optimal drug formulations in various preclinical models and clinical trials to treat a wide range of diseases.

ACS NANO (2023)

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Article Chemistry, Multidisciplinary

Slimming and Reinvigorating Tumor-Associated Dendritic Cells with Hierarchical Lipid Rewiring Nanoparticles

Chunchen Xu et al.

Summary: A study introduces a novel approach to revitalize tumor-associated dendritic cells (TADCs) and enhance their anti-tumor response. This is achieved by using multilevel lipid rewiring nanoparticles to promote TADC maturation and restore their inflammatory cytokine production, cytotoxic T cell recruitment, and tumor inhibition.

ADVANCED MATERIALS (2023)

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Article Oncology

Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis

Chong Kin Liam et al.

Summary: The final analysis of the INSIGHT phase II study showed that tepotinib plus gefitinib can improve progression-free survival (PFS) and overall survival (OS) compared to chemotherapy in a subgroup of patients with MET-amplified EGFR-mutant NSCLC after progression on EGFR inhibitors.

CLINICAL CANCER RESEARCH (2023)

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Review Oncology

Targeting drugs to tumours using cell membrane-coated nanoparticles

Ronnie H. Fang et al.

Summary: Cell membrane-coated nanoparticles (CNPs) are emerging nanocarriers that have the potential to improve cancer therapy by overcoming limitations of traditional nanoparticles. CNPs, consisting of a synthetic nanoparticulate core surrounded by a layer of naturally derived cell membranes, offer improved biocompatibility, immune evasion, and tumor targeting. They have been used for drug delivery, phototherapy, and immunotherapy.

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

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Review Biochemistry & Molecular Biology

Lung cancer immunotherapy: progress, pitfalls, and promises

Aritraa Lahiri et al.

Summary: Lung cancer is the most common cause of death in the US and worldwide, and current treatment options have limited success. Immunotherapy, however, offers a promising approach by activating the immune system to fight cancer cells. Recent advances in immunotherapy, including tumor-specific vaccines and immune checkpoint inhibitors, have shown encouraging results in lung cancer treatment. Ongoing clinical trials and future research directions in this field are also discussed.

MOLECULAR CANCER (2023)

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Article Biotechnology & Applied Microbiology

An engineered influenza virus to deliver antigens for lung cancer vaccination

Dezhong Ji et al.

Summary: Researchers demonstrate a system for delivering antigenic peptides to the lung using an engineered influenza virus, which leads to increased immune cell infiltration to the tumor and enhanced immune response. They also engineer the virus to express anti-PD1-L1 nanobodies, which further improves tumor regression and survival.

NATURE BIOTECHNOLOGY (2023)

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Review Oncology

Rare molecular subtypes of lung cancer

Guilherme Harada et al.

Summary: Lung cancers with rare alterations can be detected in a significant number of patients and are amenable to specific therapies. This review provides an overview of the epidemiology, diagnosis, prognosis, and treatment of lung cancers with rare alterations, emphasizing the importance of expedited drug approval pathways and cooperation between stakeholders.

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

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Review Oncology

Cancer-associated cachexia - understanding the tumour macroenvironment and microenvironment to improve management

Josep M. Argiles et al.

Summary: Cachexia is a devastating syndrome characterized by substantial weight loss mainly in skeletal muscle and adipose tissue, which affects 50-80% of cancer patients. It is associated with systemic inflammation, anorexia, and increased energy expenditure. Understanding the underlying mechanisms and developing therapeutic approaches are essential.

NATURE REVIEWS CLINICAL ONCOLOGY (2023)

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Article Cell Biology

Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties

Huaxin Song et al.

Summary: In this study, the authors evaluated the rescue abilities of 800 common p53 mutants using the compound arsenic trioxide (ATO). They found that the solvent accessibility and temperature sensitivity of mutated residues were key factors in determining if a mutation could be rescued. A total of 390 mutants were successfully rescued and classified into three types. ATO showed preferential inhibition on type 1 and type 2a mutants in both mouse trials and clinical trials. This study provides a valuable resource for the scientific and clinical communities and proposes a new strategy for targeting p53 based on individual mutant alleles.

SCIENCE TRANSLATIONAL MEDICINE (2023)

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Editorial Material Virology

Nanotechnology meets virology

Frank Sainsbury et al.

VIROLOGY (2023)

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Article Multidisciplinary Sciences

Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial

Juliann Chmielecki et al.

Summary: The third-generation EGFR tyrosine kinase inhibitor osimertinib improves progression-free survival compared to platinum-doublet chemotherapy in patients with advanced NSCLC carrying EGFR T790M mutation. In this study, the authors used next-generation sequencing to evaluate the potential mechanisms of acquired resistance to osimertinib in patients from the AURA3 trial. Some patients had undetectable plasma EGFR T790M at disease progression and/or treatment discontinuation.

NATURE COMMUNICATIONS (2023)

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Review Pharmacology & Pharmacy

Approved Nanomedicine against Diseases

Yuanchao Jia et al.

Summary: Nanomedicine is a branch of medicine that uses nanotechnology for disease prevention and treatment. It has revolutionized medicine by improving drug efficacy, reducing toxicity, and targeting drug delivery. Nanomedicine has shown significant potential in treating major diseases like cancer, infections, and cardiovascular diseases. Although clinical implementation is still limited, the use of nanoscale drugs is increasingly being explored to minimize side effects and improve therapeutic outcomes.

PHARMACEUTICS (2023)

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Article Biochemistry & Molecular Biology

Supramolecular Theranostic Nanomedicine for In Situ Self-Boosting Cancer Photochemotherapy

Dan Wu et al.

Summary: A novel supramolecular nanomedicine is ingeniously constructed to achieve in situ self-boosting cancer photochemotherapy, which combines high-efficiency photodynamic therapy (PDT) and chemotherapy through various interactions, prolongs blood circulation time and enhances tumor accumulation.

BIOMACROMOLECULES (2023)

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Review Biochemistry & Molecular Biology

Signaling pathways in cancer metabolism: mechanisms and therapeutic targets

Mengshu You et al.

Summary: A wide range of metabolites can be detected by specific sensors, which then activate signal transduction pathways and regulate gene expression in epigenetics, known as metabolite sensing. Metabolite sensing plays a crucial role in regulating metabolism, immunity, and inflammation, allowing the host to achieve a balance with the external environment. In cancer, metabolic reprogramming leads to phenotypic changes in cancer cells, including cell proliferation, migration, invasion, and angiogenesis, creating a microenvironment favorable for cancer growth. This article discusses the mechanisms of metabolite sensing for the three major nutrients and their derivatives, as well as their abnormalities in cancer development, and explores potential therapeutic targets based on metabolite-sensing signaling pathways to prevent cancer progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

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Article Chemistry, Multidisciplinary

Catalpol improves impaired neurovascular unit in ischemic stroke rats via enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling

Hong-jin Wang et al.

Summary: In this study, it was found that catalpol can protect the NVU in ischemic stroke by activating the PI3K/AKT signaling pathway and increasing VEGF production, which subsequently enhances angiogenesis and neurogenesis. This protective mechanism forms a feed-forward loop to safeguard the NVU from the effects of ischemic stroke.

ACTA PHARMACOLOGICA SINICA (2022)

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Review Oncology

Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy

Michael P. Vincent et al.

Summary: Nanotechnologies applied to cancer immunotherapy focus on self-assembling drug delivery systems composed of lipids and/or polymers, which improve the therapeutic index of drugs and allow for better control of their pharmacokinetics, biodistribution, and bioavailability. This article discusses the fundamental design, suitability, and inherent properties of nanomaterials that induce anti-tumor immune responses and support anti-cancer vaccination. It also presents various targeting strategies and highlights how nanocarrier structure and surface chemistry can be utilized for controlled delivery to the tumor microenvironment while minimizing off-target effects.

CANCER CELL (2022)

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Article Pharmacology & Pharmacy

FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway

Shike Yan et al.

Summary: FGFC1 selectively suppressed the growth of NSCLC cells with EGFR mutation, induced apoptosis of erlotinib-resistant NSCLC cells via mitochondrial dysfunction and ROS accumulation, and inhibited EGFR and its downstream PI3K/Akt/mTOR pathway by directly binding to EGFR. Additionally, FGFC1 inhibited the migration and invasion of NSCLC cells and effectively inhibited tumor growth in a xenograft model, indicating its potential as a candidate for erlotinib-resistant NSCLC therapy.

FRONTIERS IN PHARMACOLOGY (2022)

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Review Immunology

The Role of Long Non-Coding RNAs in the Tumor Immune Microenvironment

Yingli Guo et al.

Summary: This review summarizes the latest research on the functions of long non-coding RNAs (lncRNAs) in the tumor immune microenvironment. These lncRNAs play important roles in tumorigenesis and development by regulating various biological processes. Additionally, the review discusses the current understanding of strategies for targeting lncRNAs.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Polymeric nanocarriers: A promising tool for early diagnosis and efficient treatment of colorectal cancer

Mohamed Haider et al.

Summary: This review highlights the current use of PNCs in the diagnosis and treatment of colorectal cancer (CRC), with a specific focus on targeting strategies, surface modifications, and safety concerns for different types of PNCs in delivering therapeutics to colorectal cancer cells.

JOURNAL OF ADVANCED RESEARCH (2022)

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Article Chemistry, Multidisciplinary

Targeted Drug/Gene/Photodynamic Therapy via a Stimuli-Responsive Dendritic-Polymer-Based Nanococktail for Treatment of EGFR-TKI-Resistant Non-Small-Cell Lung Cancer

Jinxing Huang et al.

Summary: This study proposes a nanococktail therapeutic strategy for treating EGFR-TKI resistant NSCLC by targeted co-delivery of drugs and genes, along with photodynamic therapy. The results show that this nanococktail therapy effectively releases drugs and genes at the tumor site, demonstrating potent antitumor efficacy.

ADVANCED MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Protein-Mimicking Nanoparticles in Biosystems

Xiaoyuan Ji et al.

Summary: Nanoparticles with protein-mimicking capabilities have a wide range of applications in biology and biomedicine, offering innovative strategies to mimic protein functions and provide additional functionalities.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

Mayumi Ikeda-Imafuku et al.

Summary: This review examines the key advances in strategies to enhance the extravasation and retention effect of nanoparticles, as well as analyzes the clinical trials and translation of these strategies.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Oncology

Treatment strategies and outcomes for patients with EGFR-mutant non-small cell lung cancer resistant to EGFR tyrosine kinase inhibitors: Focus on novel therapies

Melissa Johnson et al.

Summary: Tyrosine kinase inhibitors (TKIs) are the standard treatment for patients with EGFR-mutant non-small cell lung cancer (NSCLC). Despite the initial effectiveness of TKIs, almost all patients eventually develop resistance. Current research focuses on developing novel therapies to overcome resistance mechanisms.

LUNG CANCER (2022)

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Review Biotechnology & Applied Microbiology

Nano-based targeted drug delivery for lung cancer: therapeutic avenues and challenges

Devaraj Ezhilarasan et al.

Summary: Most anticancer drugs fail in clinical trials due to various factors, such as poor solubility and bioavailability. Polymeric nanoparticles offer controlled drug release, biocompatibility, and promising anticancer effects. Nano preparations targeting specific receptors on lung cancer cells improve drug bioavailability. However, there are challenges in route of administration, size, pharmacokinetics, and immune clearance. This review explores the potential benefits and challenges of nanoparticle-based drug delivery for lung cancer treatment.

NANOMEDICINE (2022)

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Article Pharmacology & Pharmacy

Therapeutic potential of human serum albumin nanoparticles encapsulated actinonin in murine model of lung adenocarcinoma

Priyanca Ahlawat et al.

Summary: Non-small cell lung cancer is the major type of lung cancer worldwide. Conventional chemotherapeutics have limitations, so the development of new therapeutic agents is needed. This study demonstrated the potential of actinonin encapsulated albumin nanoparticles in inhibiting the proliferation of lung adenocarcinoma.

DRUG DELIVERY (2022)

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Review Biochemistry & Molecular Biology

Targeted Therapy and Immunotherapy in Early-Stage Non-Small Cell Lung Cancer: Current Evidence and Ongoing Trials

Marco de Scordilli et al.

Summary: The scenario of neoadjuvant and adjuvant settings in non-small cell lung cancer (NSCLC) is rapidly evolving. Molecular analysis and PD-L1 evaluation have become routine assessments. New treatment options have been approved, including osimertinib for EGFRm patients and ICIs in both adjuvant and neoadjuvant settings. However, mature data on overall survival benefits are not yet available.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Oncology

Advanced diagnostic and therapeutic strategies in nanotechnology for lung cancer

Yujuan Duan et al.

Summary: Nanotechnology has emerged as a promising approach for the diagnosis and treatment of lung cancer, providing more effective and specific detection of cancer biomarkers and cells, as well as targeted drug delivery systems to overcome resistance and reduce side effects.

FRONTIERS IN ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

Natalie Boehnke et al.

Summary: This study used an integrated genomic approach to investigate the association between cancer cells and nanoparticles, identifying both materials properties and cell-intrinsic features that mediate nanoparticle-cell association. The study also identified nanoparticle-specific biomarkers and validated one biomarker for lipid-based nanoparticle uptake. The findings contribute to the rational design of nanoformulations.

SCIENCE (2022)

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Article Engineering, Biomedical

Precisely Targeted Nano-Controller of PD-L1 Level for Non-Small Cell Lung Cancer Spinal Metastasis Immunotherapy

Lei Zhou et al.

Summary: This study reveals the potential use of RGDyK as a new PD-L1 inhibitor and a targeting peptide for NSCLC-SM treatment. By fabricating ZnPP@MSN-RGDyK nanoparticles, efficient photodynamic therapy and immunotherapeutic effects are achieved in an NSCLC SM mouse model.

ADVANCED HEALTHCARE MATERIALS (2022)

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Editorial Material Multidisciplinary Sciences

Bioavailability of nanomaterials: bridging the gap between nanostructures and their bioactivity

Mingjing Cao et al.

NATIONAL SCIENCE REVIEW (2022)

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Article Chemistry, Multidisciplinary

HSP70-Promoter-Driven CRISPR/Cas9 System Activated by Reactive Oxygen Species for Multifaceted Anticancer Immune Response and Potentiated Immunotherapy

Liang Zhao et al.

Summary: This study proposes a specific promoter-driven CRISPR/Cas9 system that can permanently disrupt the PD-L1 gene and elicit a multifaceted anticancer immune response. Furthermore, it also enhances cancer immunotherapy by inducing immunogenic cell death and reprogramming the tumor microenvironment. This system shows great anticancer efficacy and stimulates an immune memory response to inhibit distant tumor growth and metastasis.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Engineering Poly(ethylene glycol) Nanoparticles for Accelerated Blood Clearance Inhibition and Targeted Drug Delivery

Yuan Tian et al.

Summary: Surface modification with poly(ethylene glycol) (PEGylation) improves the stability of nanoparticles (NPs) and reduces their uptake and clearance by the immune system. However, PEGylation can also trigger the accelerated blood clearance (ABC) phenomenon. This study presents a new type of stealth PEG NPs that can avoid the ABC effect and can be functionalized for targeted drug delivery to cancer cells.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Review Oncology

The current state of the art and future trends in RAS-targeted cancer therapies

Salman R. Punekar et al.

Summary: Despite being historically considered 'undruggable', improvements in drug design have led to the development of inhibitors that target KRAS mutations in solid tumors. Some of these inhibitors have shown efficacy in patients with KRAS (G12C)-mutant cancers, but drug resistance limits their effectiveness. However, there is potential for novel combination therapies, which are currently being explored in clinical trials, to overcome resistance mechanisms. This article provides an overview of the RAS pathway and reviews the current strategies for targeting oncogenic RAS, as well as the challenges presented by drug resistance mechanisms.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Oncology

Anlotinib exerts potent antileukemic activities in Ph chromosome negative and positive B-cell acute lymphoblastic leukemia via perturbation of PI3K/ AKT/mTOR pathway

Qiuling Chen et al.

Summary: This study provides impressive preclinical evidence of anlotinib against Ph- and Ph+ B-ALL, showing its potential therapeutic effect through the inhibition of VEGFR and PI3K/AKT/mTOR signaling pathways. It raises a rationale for future clinical evaluation of anlotinib in managing Ph- and Ph+ B-ALL.

TRANSLATIONAL ONCOLOGY (2022)

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Article Oncology

Afatinib and Dacomitinib Efficacy, Safety, Progression Patterns, and Resistance Mechanisms in Patients with Non-Small Cell Lung Cancer Carrying Uncommon EGFR Mutations: A Comparative Cohort Study in China (AFANDA Study)

Hong-Shuai Li et al.

Summary: The study found that dacomitinib demonstrated a more favorable activity with manageable toxicity compared with afatinib in patients with non-small cell lung cancer carrying uncommon EGFR mutations. This study provides further evidence for the application of dacomitinib in this setting.

CANCERS (2022)

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Article Cell Biology

A Novel P53 Nanomedicine Reduces Immunosuppression and Augments Anti-PD-1 Therapy for Non-Small Cell Lung Cancer in Syngeneic Mouse Models

Sang-Soo Kim et al.

Summary: This article introduces a novel therapeutic approach for lung cancer, combining p53 gene therapy with immune checkpoint inhibitors (ICIs) to enhance treatment efficacy. The study demonstrates that this combination can inhibit tumor growth, prolong survival, and improve immune responses against lung cancer cells.

CELLS (2022)

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Review Biochemistry & Molecular Biology

Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trials

Zhenyi Niu et al.

Summary: Lung cancer is a major cause of cancer-related death worldwide, with patients with lung squamous cell carcinoma (LSCC) not benefiting from targeted therapies. Immunotherapy has improved outcomes in cancer patients, but its clinical application in LSCC is hindered by low response rates and adverse events. Understanding the mechanisms of LSCC pathogenesis and the connections between signaling pathways is important for developing more effective treatments. This review discusses classical signaling pathways, potential therapeutic targets, epigenetic and immune checkpoint therapies, and combination strategies for LSCC.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Biochemistry & Molecular Biology

VEGF/VEGFR-Targeted Therapy and Immunotherapy in Non-small Cell Lung Cancer: Targeting the Tumor Microenvironment

Yueshui Zhao et al.

Summary: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide, with poor prognosis. Vascular endothelial growth factor (VEGF) plays a crucial role in tumor angiogenesis and immunomodulation in NSCLC. Current research focuses on understanding the functions of VEGF in NSCLC and its interaction with the tumor microenvironment, as well as exploring novel treatment approaches targeting VEGF/VEGFR and immunotherapy.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Oncology

Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer

Baolin Liu et al.

Summary: In lung cancer patients treated with anti-PD-1, precursor exhausted T cells were found in responders, accumulating through local expansion and clonal revival from peripheral T cells.

NATURE CANCER (2022)

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Article Oncology

Nanomaterials multifunctional behavior for enlightened cancer therapeutics

Ganji Seeta Rama Raju et al.

Summary: Cancer is a deadly disease with limitations in traditional therapies. Nanotechnology, as an emerging science, provides more effective cancer treatments by overcoming biomedical and biophysical barriers.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Nanoscale drug delivery systems for controllable drug behaviors by multi-stage barrier penetration

Jinjin Wang et al.

Summary: The inadequate concentration of drugs at the site of action due to poor physicochemical properties and multi-stage biological barriers can lead to side effects. The rapid development of nanoscale drug delivery systems offers a way to overcome multi-stage biological barriers. However, poor understanding of biological barriers remains a bottleneck for the development of NDDS.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Oncology

Moving beyond epidermal growth factor receptor resistance in metastatic non-small cell lung cancer- a drug development perspective

Julia Lai-Kwon et al.

Summary: EGFR mutations are the most common targetable oncogenic driver mutation in metastatic non-small lung cancer. The development of third-generation inhibitor osimertinib has shown improved outcomes compared to first and second generation agents. Despite excellent initial response rates, responses may not be durable due to the development of acquired resistance, highlighting the importance of understanding resistance mechanisms and exploring drug combinations.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Nanoscience & Nanotechnology

The ancillary effects of nanoparticles and their implications for nanomedicine

Evan P. Stater et al.

Summary: Nanoparticles, beyond their engineered functions, can induce specific biological effects, which may have implications for the development and clinical application of nanomedicine.

NATURE NANOTECHNOLOGY (2021)

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Article Oncology

Association Between Sex and Immune-Related Adverse Events During Immune Checkpoint Inhibitor Therapy

Ying Jing et al.

Summary: Analysis of clinical study data, pharmacovigilance data, and genomic data revealed minimal sex-associated differences in immune-related adverse events (irAEs) among cancer patients treated with immune checkpoint inhibitors. Therefore, considering sex effects for irAE management in clinical practice may be unnecessary.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

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Article Biochemistry & Molecular Biology

Non-Small-Cell Lung Cancer Regression by siRNA Delivered Through Exosomes That Display EGFR RNA Aptamer

Zhefeng Li et al.

Summary: This study utilized RNA nanotechnology to display ligands on exosomes loaded with siRNA for NSCLC regression. Cholesterol was used to target the epidermal growth factor receptor on exosomes loaded with survivin-silencing siRNA. Cytosolic delivery of siRNA overcame endosome trapping, leading to potent gene knockdown, chemotherapy sensitization, and tumor regression, achieving a favorable IC50 in in vivo gene knockdown assessment.

NUCLEIC ACID THERAPEUTICS (2021)

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Article Biochemistry & Molecular Biology

MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking

Fei Wang et al.

Summary: MICAL2PV is a novel TNT regulator that suppresses formation and modulates mitochondrial distribution, with its MO domain playing a key role in activity. Down-regulation of MICAL2PV enhances cell survival to chemotherapeutic drugs.

EMBO REPORTS (2021)

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Article Medicine, Research & Experimental

Myeloid-derived suppressor cells in cancer immunotherapy-clinical perspectives

Keywan Mortezaee

Summary: Myeloid-derived suppressor cells (MDSCs) are a group of immature immune cells that significantly increase in cancer patients, releasing factors that impact tumor-related events such as metastasis and immune evasion, and can serve as an indicator of tumor prognosis. They can be targeted in combination with current immunotherapies to enhance the immune system's response against tumors.

LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer

Zhenchuan Liu et al.

Summary: In this study, it was found that circIGF2BP3 contributes to immune escape in NSCLC by upregulating PKP3 expression and stabilizing OTUB1 mRNA to increase PD-L1 abundance. The impact on the CD8(+) T cell response was observed, shedding light on a novel mechanism of PD-L1 regulation in NSCLC and providing insight on enhancing the efficacy of anti-PD-1 treatment.

MOLECULAR CANCER (2021)

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Article Biotechnology & Applied Microbiology

Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells

Hua-Zhen Xu et al.

Summary: The combination of Nano-DOX and BMS-1 can activate TAMs' M1-type response, inhibit tumor cell growth, and achieve synergistic therapeutic efficacy against tumors.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Oncology

Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer

Heidie Frisco Cabanos et al.

Summary: Drug-resistant persister cells, which play a critical role in the development of drug resistance, maintain viability under therapy but their partial resistance is transient and reversible; they may originate from minimal residual disease and can lead to relapse if treatment is discontinued or if drug resistance develops in response to continued therapy.

CANCERS (2021)

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Article Nanoscience & Nanotechnology

CoFe2O4-Quantum Dots for Synergistic Photothermal/Photodynamic Therapy of Non-small-Cell Lung Cancer Via Triggering Apoptosis by Regulating PI3K/AKT Pathway

Jingfeng Liu et al.

Summary: In this study, novel CoFe2O4-quantum dots with outstanding synergistic photothermal/photodynamic property were constructed to efficiently suppress non-small-cell lung cancer. The combination of CoFe2O4-QDs + NIR treatment induced apoptosis of NSCLC cells and promoted reactive oxygen species generation to trigger cell death through regulating PI3K/AKT pathway. Moreover, the CoFe2O4-QDs + NIR treatment successfully eliminated tumor xenografts in vivo without toxicity.

NANOSCALE RESEARCH LETTERS (2021)

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Review Oncology

Overcoming therapy resistance in EGFR-mutant lung cancer

Antonio Passaro et al.

Summary: Tyrosine kinase inhibitors have greatly improved the clinical outcomes for non-small cell lung cancer patients with EGFR-activating mutations, but resistance eventually develops. Recent advances in detecting and overcoming EGFR TKI resistance mechanisms are discussed by Passaro and colleagues.

NATURE CANCER (2021)

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Review Allergy

A Review of the Contribution of Mast Cells in Wound Healing: Involved Molecular and Cellular Mechanisms

Daniel Elieh Ali Komi et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2020)

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Review Medicine, Research & Experimental

Precision Management of Advanced Non-Small Cell Lung Cancer

Ching-Yao Yang et al.

ANNUAL REVIEW OF MEDICINE, VOL 71, 2020 (2020)

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Review Oncology

Novel molecular targets for the treatment of lung cancer

Rafael Rosell et al.

CURRENT OPINION IN ONCOLOGY (2020)

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Article Nanoscience & Nanotechnology

Folate receptor-targeted RNAi nanoparticles for silencing STAT3 in tumor-associated macrophages and tumor cells

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

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Article Nanoscience & Nanotechnology

Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy

Gayathri Kandasamy et al.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2020)

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Review Pharmacology & Pharmacy

Delivery strategies for macromolecular drugs in cancer therapy

Qin Guo et al.

ACTA PHARMACEUTICA SINICA B (2020)

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Review Oncology

Targeting the PI3K/Akt/mTOR pathway in non-small cell lung cancer (NSCLC)

Aaron C. Tan

THORACIC CANCER (2020)

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Article Chemistry, Inorganic & Nuclear

Nano-manganese oxide-functionalized-oleyl amine as a simple and low cost nanosorbent for remediation of ZnII/CoII and their radioactive nuclides 65Zn and 60Co from water

Mohamed E. Mahmoud et al.

APPLIED RADIATION AND ISOTOPES (2020)

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Review Cell Biology

Memory T cells: strategies for optimizing tumor immunotherapy

Qingjun Liu et al.

PROTEIN & CELL (2020)

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Review Pharmacology & Pharmacy

Nanostructured Lipid Carriers for Delivery of Chemotherapeutics: A Review

Mohamed Haider et al.

PHARMACEUTICS (2020)

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Article Medicine, General & Internal

Correlation Between Tumor-Associated Macrophage and Immune Checkpoint Molecule Expression and Its Prognostic Significance in Cutaneous Melanoma

Young Jae Kim et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Six Birds with One Stone: Versatile Nanoporphyrin for Single-Laser-Triggered Synergistic Phototheranostics and Robust Immune Activation

Yue Sun et al.

ADVANCED MATERIALS (2020)

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Article Medicine, Research & Experimental

Biomimetic nanoparticle loading obatoclax mesylate for the treatment of non-small-cell lung cancer (NSCLC) through suppressing Bcl-2 signaling

Song Chen et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Chemistry, Multidisciplinary

Manipulating the function of tumor-associated macrophages by siRNA-loaded lipid nanoparticles for cancer immunotherapy

Nour Shobaki et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Biology

Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy

Xin Cui et al.

ELIFE (2020)

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Review Environmental Sciences

Smart nanocarriers for cancer treatment: Clinical impact and safety

Zehuan Liao et al.

NANOIMPACT (2020)

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Article Medicine, Research & Experimental

Tumor-associated macrophage, angiogenesis and lymphangiogenesis markers predict prognosis of non-small cell lung cancer patients

Ilseon Hwang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells

Silke Eisinger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer

Man Zhang et al.

NATURE COMMUNICATIONS (2020)

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Article Immunology

PD-L1-Mediated Immunosuppression in Glioblastoma Is Associated With the Infiltration and M2-Polarization of Tumor-Associated Macrophages

Zhiyuan Zhu et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer

Dong Ha Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Review Chemistry, Medicinal

Graphene quantum dots (GQDs)-based nanomaterials for improving photodynamic therapy in cancer treatment

Hua-yang Fan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

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Article Nanoscience & Nanotechnology

Smart cancer nanomedicine

Roy van der Meel et al.

NATURE NANOTECHNOLOGY (2019)

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Article Oncology

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

J. Ferlay et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Review Materials Science, Biomaterials

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

Dnyaneshwar Kalyane et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Review Biochemistry & Molecular Biology

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Xianjie Jiang et al.

MOLECULAR CANCER (2019)

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Article Multidisciplinary Sciences

AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells

Hirokazu Taniguchi et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition

Na Kong et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Nanoscience & Nanotechnology

Antimicrobial Amino-Functionalized Nitrogen-Doped Graphene Quantum Dots for Eliminating Multidrug-Resistant Species in Dual-Modality Photodynamic Therapy and Bioimaging under Two-Photon Excitation

Wen-Shuo Kuo et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Chemistry, Multidisciplinary

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents

Kevin J. McHugh et al.

ADVANCED MATERIALS (2018)

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Review Chemistry, Multidisciplinary

Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates

Hadeer M. Abdelaziz et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Medicine, Research & Experimental

Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-κB signaling

Mohammad Rasheduzzaman et al.

LIFE SCIENCES (2018)

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Review Oncology

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

Daniel E. Johnson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Review Pharmacology & Pharmacy

Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment

Ruixiang Li et al.

ACTA PHARMACEUTICA SINICA B (2018)

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Review Oncology

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

J. Ferlay et al.

EUROPEAN JOURNAL OF CANCER (2018)

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Editorial Material Multidisciplinary Sciences

TECHNOLOGY FEATURE MOUSE MODELS WITH A HUMAN TOUCH

Mike May

NATURE (2018)

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Review Biotechnology & Applied Microbiology

Nano based drug delivery systems: recent developments and future prospects

Jayanta Kumar Patra et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Chemistry, Multidisciplinary

Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy

S. -Ja Tseng et al.

ACS NANO (2018)

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Review Biochemistry & Molecular Biology

The Clinical Translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes

Stefano Palazzoloa et al.

CURRENT MEDICINAL CHEMISTRY (2018)

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Article Pharmacology & Pharmacy

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Tony Eight Lin et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

Biodegradable Nanoparticles Mediated Co-delivery of Erlotinib (ELTN) and Fedratinib (FDTN) Toward the Treatment of ELTN-Resistant Non-small Cell Lung Cancer (NSCLC) via Suppression of the JAK2/STAT3 Signaling Pathway

Donglai Chen et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

A nanomedicine approach enables co-delivery of cyclosporin A and gefitinib to potentiate the therapeutic efficacy in drug-resistant lung cancer

Weidong Han et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2018)

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Article Oncology

Programmed cell death ligand-1 (PD-L1) as a biomarker for non-small cell lung cancer (NSCLC) treatment-are we barking up the wrong tree?

Wolfram C. M. Dempke et al.

TRANSLATIONAL LUNG CANCER RESEARCH (2018)

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Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

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Article Pharmacology & Pharmacy

Preparation and characterization of lipid nanoparticle/pDNA complexes for STAT3 downregulation and overcoming chemotherapy resistance in lung cancer cells

Mustafa Kotmakci et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Chemistry, Multidisciplinary

Synergistic antitumor effects of combination treatment with metronomic doxorubicin and VEGF-targeting RNAi nanoparticles

Gijung Kwak et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Biochemistry & Molecular Biology

CRH promotes human colon cancer cell proliferation via IL-6/JAK2/STAT3 signaling pathway and VEGF-induced tumor angiogenesis

Xianjun Fang et al.

MOLECULAR CARCINOGENESIS (2017)

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Article Multidisciplinary Sciences

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Sydney R. Gordon et al.

NATURE (2017)

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Article Materials Science, Biomaterials

Combined bortezomib-based chemotherapy and p53 gene therapy using hollow mesoporous silica nanospheres for p53 mutant non-small cell lung cancer treatment

Chun Li et al.

BIOMATERIALS SCIENCE (2017)

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Article Biochemistry & Molecular Biology

Synergistic anti-tumor effects of bevacizumab and tumor targeted polymerized VEGF siRNA nanoparticles

Myung Goo Kim et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Pharmacology & Pharmacy

Aptamer-Conjugated Chitosan-Anchored Liposomal Complexes for Targeted Delivery of Erlotinib to EGFR-Mutated Lung Cancer Cells

Fengqiao Li et al.

AAPS JOURNAL (2017)

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Review Pharmacology & Pharmacy

Tumor-associated macrophages: Potential therapeutic targets for anti-cancer therapy

Yoshihiro Komohara et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Biotechnology & Applied Microbiology

Tumor-associated GM-CSF overexpression induces immunoinhibitory molecules via STAT3 in myeloid-suppressor cells infiltrating liver metastases

M. Thorn et al.

CANCER GENE THERAPY (2016)

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Review Chemistry, Medicinal

PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

Vivek Asati et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

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Review Biochemistry & Molecular Biology

Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment

Yan Cui et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Oncology

Comprehensive Characterization of Oncogenic Drivers in Asian Lung Adenocarcinoma

Shiyong Li et al.

JOURNAL OF THORACIC ONCOLOGY (2016)

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Article Oncology

Targeted Therapy and Immunotherapy for Lung Cancer

Evan C. Naylor et al.

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (2016)

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Article Biochemistry & Molecular Biology

MnSOD overexpression confers cisplatin resistance in lung adenocarcinoma via the NF-κB/Snail/Bcl-2 pathway

Po-Ming Chen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

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Article Chemistry, Multidisciplinary

Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles

Corey J. Bishop et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Review Oncology

The Evolution of Therapies in Non-Small Cell Lung Cancer

Vishal Boolell et al.

CANCERS (2015)

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Review Pharmacology & Pharmacy

The PD-1/PD-L1 pathway: biological background and clinical relevance of an emerging treatment target in immunotherapy

Simone Muenst et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2015)

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Article Pharmacology & Pharmacy

Signaling Intermediates (MAPK and PI3K) as Therapeutic Targets in NSCLC

Ludovica Ciuffreda et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

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Article Chemistry, Multidisciplinary

Self-Assembly of Poly-Adenine-Tailed CpG Oligonucleotide-Gold Nanoparticle Nanoconjugates with Immunostimulatory Activity

Nan Chen et al.

SMALL (2014)

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Article Nanoscience & Nanotechnology

A novel small peptide as an epidermal growth factor receptor targeting ligand for nanodelivery in vitro

Cui-yan Han et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2013)

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Review Chemistry, Multidisciplinary

Progress in microRNA delivery

Yu Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Review Critical Care Medicine

Personalizing Therapy in Advanced Non-Small Cell Lung Cancer

Liza C. Villaruz et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

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Article Oncology

First-line chemotherapy with liposomal doxorubicin plus cisplatin for patients with advanced malignant pleural mesothelioma: phase II trial

O. Arrieta et al.

BRITISH JOURNAL OF CANCER (2012)

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Review Oncology

Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non-Small-Cell Lung Cancer

Vassiliki Papadimitrakopoulou

JOURNAL OF THORACIC ONCOLOGY (2012)

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Article Biochemistry & Molecular Biology

EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

Michela Garofalo et al.

NATURE MEDICINE (2012)

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Article Oncology

STAT3 Knockdown in B16 Melanoma by siRNA Lipopolyplexes Induces Bystander Immune Response In Vitro and In Vivo

Aws Alshamsan et al.

TRANSLATIONAL ONCOLOGY (2011)

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Article Oncology

A phase I study of obatoclax mesylate, a Bcl-2 antagonist, plus topotecan in solid tumor malignancies

Paul K. Paik et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)

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Article Biochemistry & Molecular Biology

MicroRNAs reduce tumor growth and contribute to enhance cytotoxicity induced by gefitinib in non-small cell lung cancer

Miao Zhong et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2010)

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Review Pharmacology & Pharmacy

Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches

Stephen Y. Lai et al.

DRUG RESISTANCE UPDATES (2010)

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Article Biochemistry & Molecular Biology

Novel peptide ligand directs liposomes toward EGF-R high-expressing cancer cells in vitro and in vivo

Shuxian Song et al.

FASEB JOURNAL (2009)

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Article Biotechnology & Applied Microbiology

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

Marcin Kortylewski et al.

NATURE BIOTECHNOLOGY (2009)

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Article Pharmacology & Pharmacy

Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo

Shuxian Song et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Review Oncology

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy

J. A. McCubrey et al.

LEUKEMIA (2008)

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Review Medicine, General & Internal

Non-small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship

Julian R. Molina et al.

MAYO CLINIC PROCEEDINGS (2008)

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Review Genetics & Heredity

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Jeffrey A. Engelman et al.

NATURE REVIEWS GENETICS (2006)

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Letter Oncology

Absence of JAK2 V617F mutation in gastric cancers

JW Lee et al.

ACTA ONCOLOGICA (2006)

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Review Oncology

Cancer nanotechnology: Opportunities and challenges

M Ferrari

NATURE REVIEWS CANCER (2005)

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Article Biochemistry & Molecular Biology

Pyk2 amplifies epidermal growth factor and c-Src-induced Stat3 activation

CS Shi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells

A Aicher et al.

NATURE MEDICINE (2003)

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