期刊
FRONTIERS IN CHEMISTRY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2023.1185669
关键词
heterocycles; saturated; five-membered; transition metals; synthesis; catalysis; green
Drug design and delivery is focused on finding new potent drug candidates and synthetic techniques. Recently, the synthesis of saturated heterocycles has gained significant attention in medicinal chemistry. Transition metal-catalyzed reactions have been the primary method for heterocyclic synthesis, but now they are being combined with other techniques to enhance their effectiveness. This review highlights the recent developments in the transition metal-catalyzed synthesis of five-membered saturated heterocycles.
Drug design and delivery is primarily based on the hunt for new potent drug candidates and novel synthetic techniques. Recently, saturated heterocycles have gained enormous attention in medicinal chemistry as evidenced by the medicinal drugs listed in the FDA Orange Book. Therefore, the demand for novel saturated heterocyclic syntheses has increased tremendously. Transition metal (TM)-catalyzed reactions have remained the prime priority in heterocyclic syntheses for the last three decades. Nowadays, TM catalysis is well adorned by combining it with other techniques such as bio- and/or enzyme-catalyzed reactions, organocatalysis, or using two different metals in a single catalysis. This review highlights the recent developments of the transition metal-catalyzed synthesis of five-membered saturated heterocycles.
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