Proteome changes of fibroblasts and endothelial cells upon incubation with human cytomegalovirus subviral Dense Bodies

Human cytomegalovirus (HCMV) is a pathogen of high medical relevance. Subviral Dense Bodies (DB) were developed as a vaccine candidate to ameliorate the severe consequences of HCMV infection. Development of such a candidate vaccine for human application requires detailed knowledge of its interaction with the host. A comprehensive mass spectrometry (MS)- based analysis was performed regarding the changes in the proteome of cell culture cells, exposed to DB.

Automated summary

Human cytomegalovirus (HCMV) is a highly medically relevant pathogen, and Subviral Dense Bodies (DB) have been developed as a vaccine candidate to mitigate the severe consequences of HCMV infection. To develop a candidate vaccine for human application, a comprehensive mass spectrometry (MS)-based analysis was performed to study the proteome changes in cell culture cells exposed to DB.