☆ 4.6 Article

Male infertility

NATURE REVIEWS DISEASE PRIMERS (2023)

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Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries

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Summary: This study reveals a significant decline in sperm count among men from all continents, with a more pronounced decrease observed post-2000. The decline in sperm count is not limited to North America-Europe-Australia, but also seen in South/Central America-Asia-Africa. Urgent research and action are needed to investigate the causes and prevent further disruption of male reproductive health.

HUMAN REPRODUCTION UPDATE (2023)

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Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-analysis

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Summary: This study examined the association between the use of IBD medications (biologics, thiopurine, methotrexate) and semen parameters as well as adverse pregnancy outcomes among male patients with inflammatory bowel disease (IBD). The results showed that there was no significant difference in sperm count, motility, or abnormal morphology between patients exposed to IBD medications and nonexposed patients. The prevalence of adverse pregnancy outcomes was also similar between the two groups. Therefore, the use of IBD medications does not impair male fertility or increase the risk of adverse pregnancy outcomes.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2023)

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Review Endocrinology & Metabolism

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Rossella Cannarella et al.

Summary: This study provides a comprehensive description of the effects of exposure to endocrine-disrupting chemicals (EDCs) on testicular development, spermatogenesis, male genital tract malformations, testicular tumors, and the mechanisms of testicular EDC-mediated damage. Animal studies and human research confirm the deleterious impact of EDCs on the male reproductive system, including hormone receptor binding, dysregulation of receptor expression, disruption of hormonal metabolism, and alteration of epigenetic mechanisms. Increased prenatal and postnatal exposure to EDCs compared to the past may likely contribute to the decline in sperm counts.

ENDOCRINE (2023)

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Review Biology

Impact of nonionizing electromagnetic radiation on male infertility: an assessment of the mechanism and consequences

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Summary: The harmful impact of electromagnetic radiation on the male reproductive system, affecting sperm parameters and genomic stability, is primarily attributed to the generation of reactive oxygen species, leading to oxidative stress and decreased antioxidant capacity. This paper emphasizes the importance of safety measures when using electronic devices and mobile phones.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2022)

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Article Obstetrics & Gynecology

The sixth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen: ensuring quality and standardization in basic examination of human ejaculates

Lars Bjorndahl et al.

Summary: The principles of basic semen investigation are crucial for obtaining reliable and internationally comparable results. However, many studies and practices in reproductive medicine fail to adhere to these principles, leading to a lack of comparable data and accuracy. To address this issue, the sixth edition of the WHO manual introduces revised methods and a complementary formal standard from the International Standards Organization. The new edition also reintroduces the four-category distinction of sperm motility and emphasizes the importance of semen examination for assessing male reproductive functions and overall male health.

FERTILITY AND STERILITY (2022)

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Article Obstetrics & Gynecology

What advances may the future bring to the diagnosis, treatment, and care of male sexual and reproductive health?

Christopher L. R. Barratt et al.

Summary: This article introduces the changes and improvements in laboratory methods for semen evaluation over the past 40 years, as well as the potential advancements in new technologies and diagnostic approaches that may alter routine semen analysis methods in the future. The article also discusses potential advances that could significantly impact the field of andrology in the future.

FERTILITY AND STERILITY (2022)

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Article Obstetrics & Gynecology

Evolution of the WHO Semen processing manual from the first (1980) to the sixth edition (2021)

Christina Wang et al.

Summary: This article highlights the importance and the latest edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen. The manual aims to standardize semen analysis procedures to assess male reproductive function and health, while providing up-to-date information on laboratory procedures.

FERTILITY AND STERILITY (2022)

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Article Obstetrics & Gynecology

The changing tide of human fertility

R. John Aitken

Summary: Over the past few decades, fertility rates have declined significantly in almost every country, mainly due to social factors such as education of women and a shift in life's purpose. Environmental and lifestyle factors also play a role, particularly in male reproductive health. The demographic transition and increased use of assisted reproductive technologies contribute to the exacerbation of infertility.

HUMAN REPRODUCTION (2022)

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Review Endocrinology & Metabolism

Environmental factors in declining human fertility

Niels E. Skakkebaek et al.

Summary: In the past half century, there has been a severe decline in child births, particularly in industrialized regions, leading to considerable population declines. Human reproductive health is deteriorating in these regions, with widespread infertility and increasing need for assisted reproduction. This deterioration is linked to environmental factors.

NATURE REVIEWS ENDOCRINOLOGY (2022)

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Article Obstetrics & Gynecology

Who cares about oligozoospermia when we have ICSI

Sandro C. Esteve

Summary: The value of assessing subfertile males with oligozoospermia is controversial, but offering indiscriminate ICSI is not the best choice. Oligozoospermia is associated with poor male reproductive health, sperm damage, and adverse health consequences for offspring. Many testicular conditions can cause oligozoospermia, and therapeutic interventions can improve sperm quality and male health. Fertility clinics should collaborate with male infertility specialists to diagnose and treat oligozoospermia for better patient health, pregnancy prospects, and offspring well-being.

REPRODUCTIVE BIOMEDICINE ONLINE (2022)

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Review Obstetrics & Gynecology

Male fertility as a marker for health

Tony Chen et al.

Summary: Male reproduction is associated with medical diseases, psychological diseases, environmental exposures, dietary habits, and other factors. Diagnosis of male infertility is related to future disease risk. The evaluation of male fertility provides an opportunity to improve male health, requiring a multidisciplinary approach.

REPRODUCTIVE BIOMEDICINE ONLINE (2022)

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Environmental and occupational pesticide exposure and human sperm parameters: A Navigation Guide review

Eric T. Knapke et al.

Summary: The global decline in sperm counts has been associated with the increasing exposure to endocrine-disrupting chemicals, particularly pesticides. A systematic review of 19 studies found consistent associations between pesticide exposure and reduced sperm quality, especially in terms of sperm motility and DNA integrity. Despite some variations in the findings for sperm concentration and morphology, there is sufficient evidence to support the toxicity of pesticides on male reproductive health.

TOXICOLOGY (2022)

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Review Genetics & Heredity

Congenital Bilateral Absence of the Vas Deferens

Zhonglin Cai et al.

Summary: Congenital bilateral absence of the vas deferens (CBAVD) is a common cause of male infertility, often associated with cystic fibrosis. It is primarily caused by gene mutations and carries the risk of genetic transmission. Sperm retrieval surgery and assisted reproductive technology can help CBAVD patients achieve fertility, but the outcome may be affected by gene mutations.

FRONTIERS IN GENETICS (2022)

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Review Biochemistry & Molecular Biology

Toxicity of Antioxidant Supplements in Patients with Male Factor Infertility: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Massimiliano Creta et al.

Summary: Treating oxidative stress through antioxidant therapy is an appealing strategy for managing male infertility. However, there is controversial evidence regarding the toxicity of antioxidant therapy. A systematic review of available clinical evidence found that antioxidant supplementation in infertile males was associated with a significantly increased risk of nausea, headache, and dyspepsia compared to a placebo. However, the rate of treatment discontinuation due to adverse events was not significantly higher in patients taking antioxidants. A more accurate risk/benefit analysis is needed when considering antioxidant supplementation.

ANTIOXIDANTS (2022)

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Article Public, Environmental & Occupational Health

Assisted Reproductive Technology Surveillance - United States, 2018

Saswati Sunderam et al.

Summary: Since the first U.S. infant conceived with assisted reproductive technology (ART) was born in 1981, the use of ART has steadily increased in the United States. While ART treatments have been successful, they also come with increasing risks of multiple births.

MMWR SURVEILLANCE SUMMARIES (2022)

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Article Obstetrics & Gynecology

Automated rare sperm identification from low-magnification microscopy images of dissociated microsurgical testicular sperm extraction samples using deep learning

Ryan Lee et al.

Summary: A machine learning algorithm was developed to detect rare human sperm in semen and microsurgical testicular sperm extraction (microTESE) samples using bright-field (BF) microscopy for nonobstructive azoospermia patients. The algorithm achieved high precision and sensitivity in both validation and testing stages.

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Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment: a randomized controlled trial

Emil Andersen et al.

Summary: This study investigates the effects of diet-induced weight loss on semen parameters in men with obesity. The findings show that an 8-week low-calorie diet resulted in improved sperm concentration and count, which were maintained after 1 year in men who maintained weight loss.

HUMAN REPRODUCTION (2022)

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Article Obstetrics & Gynecology

Actionable secondary findings following exome sequencing of 836 non-obstructive azoospermia cases and their value in patient management

Laura Kasak et al.

Summary: This study analyzed the load, distribution, and clinical value of secondary findings identified in exome sequencing of patients with non-obstructive azoospermia (NOA). The findings showed that 3.6% of NOA cases carried medically actionable secondary findings, and 37% of patients with secondary findings had variants in genes linked to male infertility. Further research is needed to determine the characteristics of these secondary findings in the general population and NOA patients specifically.

HUMAN REPRODUCTION (2022)

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ALDH2 Expression, Alcohol Intake and Semen Parameters among East Asian Men

Daniel R. Greenberg et al.

Summary: This study found an association between alcohol intake and semen parameters among East Asian men carrying the ALDH2*2 allele. Alcohol consumption was associated with significantly lower total and progressive sperm motility in ALDH2*2 carriers. Furthermore, ALDH2 expression in spermatozoa was significantly lower in ALDH2*2 carriers.

JOURNAL OF UROLOGY (2022)

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Evolution of the World Health Organization semen analysis manual: where are we?

Sandro C. Esteves

Summary: This article provides a comprehensive overview and discussion of the newly released sixth edition of the WHO semen analysis manual. It also discusses the limitations of routine semen analysis-based infertility assessment and potential solutions to improve male infertility work-up.

NATURE REVIEWS UROLOGY (2022)

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Editorial Material Obstetrics & Gynecology

WHO 2021 and 2030 reference values for semen assessment: three challenges for andrology in the journey ahead

Ana Vasconcelos et al.

Summary: This article identifies three key challenges in formulating the World Health Organization reference values for semen assessment for 2021, and presents suggested solutions that will have a real-world influence on the next iteration of the reference values for semen assessments and andrology in general.

REPRODUCTIVE BIOMEDICINE ONLINE (2022)

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Article Multidisciplinary Sciences

Achievement of complete in vitro spermatogenesis in testicular tissues from prepubertal mice exposed to mono- or polychemotherapy

Marion Delessard et al.

Summary: This study investigated the effects of chemotherapy on in vitro spermatogenesis in mice and found that combination chemotherapy led to significant changes and apoptosis in testicular tissue, but did not affect the ability of in vitro sperm production.

SCIENTIFIC REPORTS (2022)

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Review Endocrinology & Metabolism

Updates in Sertoli Cell-Mediated Signaling During Spermatogenesis and Advances in Restoring Sertoli Cell Function

Victor A. Ruthig et al.

Summary: Since their discovery, Sertoli cells have fascinated researchers in the field of testis biology. They play a crucial role in regulating germ cell state through endocrine and paracrine signals. Recent advances in understanding these signals have potential implications for treating male infertility, while Sertoli cell transplantation has emerged as a promising breakthrough.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Endocrinology & Metabolism

Spermatogonial Stem Cell-Based Therapies: Taking Preclinical Research to the Next Level

Iris Sanou et al.

Summary: Fertility preservation through biobanking of testicular tissue is recommended for boys undergoing treatment before puberty. However, current fertility therapies using SSCs are still in preclinical phases. Further research and resolution of major issues are needed for optimal clinical implementation.

FRONTIERS IN ENDOCRINOLOGY (2022)

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Review Health Care Sciences & Services

Male Sexual Dysfunction and Infertility in Spinal Cord Injury Patients: State-of-the-Art and Future Perspectives

Francesco Di Bello et al.

Summary: Spinal cord injury (SCI) is a significant medical and social problem that often results in sexual dysfunction and fertility problems for patients. The best management strategies for ejaculatory disorders include penile vibratory stimulation (PVS) and electroejaculation (EEJ), while medical therapies and surgical options are available for treating erectile dysfunction.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article Obstetrics & Gynecology

The statistical foundation of the reference population for semen analysis included in the sixth edition of the WHO manual: a critical reappraisal of the evidence

Alessio Paffoni et al.

Summary: This study evaluated the proposed reference values in the WHO Laboratory Manual for human semen examination and processing. The target population used did not meet the prerequisites for generating consistent reference intervals, and the descriptive reference values from individual studies also failed to accurately describe the populations. Therefore, the use of reference populations to distinguish between fertile and infertile men in the manual is questionable.

HUMAN REPRODUCTION (2022)

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Article Obstetrics & Gynecology

Do studies published in two leading reproduction journals between 2011 and 2020 demonstrate that they followed WHO5 recommendations for basic semen analysis?

A. L. Vasconcelos et al.

Summary: Despite 70% of papers stating that they followed the WHO5 recommendations, there was low evidence of methodological agreement with these recommendations.

HUMAN REPRODUCTION (2022)

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Article Cell Biology

The Molecular Signature of Human Testicular Peritubular Cells Revealed by Single-Cell Analysis

Annika Liebich et al.

Summary: Peritubular cells of the human testis play important roles in sperm transport and spermatogonial stem cell niche. In this study, single-cell RNA sequencing was used to study cultured human testicular peritubular cells (HTPCs) isolated from donors with normal spermatogenesis. The expression profile of HTPCs revealed cell plasticity and identified four cellular states. The findings provide insights into the functions of human testicular peritubular cells and serve as a resource for further understanding male (in)fertility.

CELLS (2022)

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Article Andrology

Effects of recreational cannabis on testicular function in primary infertile men

Federico Belladelli et al.

Summary: The study found that infertile men using cannabis are more likely to have lower testosterone levels and altered sperm morphology compared to nonusers, but not with sperm concentration and sperm motility. This reflects the negative impact of cannabis on the male reproductive system.

ANDROLOGY (2022)

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Review Obstetrics & Gynecology

Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology

Lars Bjorndahl et al.

Summary: Biomedical science is making rapid progress in terms of transparency, openness, and reproducibility of scientific publications, particularly in studies based on human semen examination. Two recent documents, the 6th edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen, and the International Standard ISO 23162:2021, provide guidelines for authors to follow these laboratory methods and use a checklist to ensure the reliability of their studies when publishing in peer-reviewed journals.

HUMAN REPRODUCTION (2022)

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Review Biochemistry & Molecular Biology

Metabolomics of Human Semen: A Review of Different Analytical Methods to Unravel Biomarkers for Male Fertility Disorders

Janet Blaurock et al.

Summary: This review summarizes the attempts made so far to overcome the decreasing fertilizing ability of human spermatozoa using metabolomics-based investigations. Various analytical methods, including liquid chromatography-mass spectrometry (LC-MS), gas chromatography (GC), infrared (IR), Raman, and nuclear magnetic resonance (NMR) spectroscopy, have been discussed. Results show that LC-MS detects the highest number of metabolites and can be considered as the method of choice. However, the reproducibility of some studies is poor, and further improvements of study designs are needed, along with a stronger focus on the biochemical consequences of altered metabolite concentrations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Urology & Nephrology

Genetic Implications of Male-Reproductive-Health-Associated Comorbidities

Nahid Punjani et al.

Summary: Male infertility is a common problem, and infertile men may have significant illnesses. The genetic causes of male infertility also have implications on other systemic diseases. Thorough examinations are important for men seeking fertility assessments.

TURKISH JOURNAL OF UROLOGY (2022)

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Article Reproductive Biology

Male infertility: what on earth is going on? Pilot international questionnaire study regarding clinical evaluation and fertility treatment for men

Nkoyenum Pamela Olisa et al.

Summary: Infertility is a complex process that mainly affects women, but there is little published data on the clinical evaluation of infertile men. This study used a SurveyMonkey questionnaire to assess the current clinical practice of fertility specialists. The results showed that a significant number of clinicians did not consider male medical history in detail and did not routinely examine infertile men. Improvement in clinical care is needed in these areas.

REPRODUCTION AND FERTILITY (2022)

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Review Endocrinology & Metabolism

Environmental disruptors and testicular cancer

Fabiana Faja et al.

Summary: Testicular cancer is the most common malignancy among young adult males. Environmental endocrine disruptors (EEDs) play a crucial role in the origin and development of this tumor. However, limited and heterogeneous human epidemiological studies show conflicting data, highlighting the complexity of the topic.

ENDOCRINE (2022)

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Article Obstetrics & Gynecology

ART in Europe, 2018: results generated from European registries by ESHRE†

C. Wyns et al.

Summary: The 22nd ESHRE report highlights the increasing numbers of ART treatment cycles and livebirths in Europe, a decrease in transfers with more than one embryo, and a reduction in twin delivery rates. Additionally, higher pregnancy rates were observed after frozen embryo transfer compared to fresh IVF or ICSI cycles.

HUMAN REPRODUCTION OPEN (2022)

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Article Obstetrics & Gynecology

Fertility quality of life tool: update on research and practice considerations

Emily Koert et al.

Summary: The 36-item Fertility Quality of Life (FertiQoL) tool is widely used to assess quality of life in fertility patients. Research shows that some FertiQoL subscale scores improved after psychological interventions. Future studies should focus on measurement issues and associations with fertility quality of life.

HUMAN FERTILITY (2021)

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Article Urology & Nephrology

Increased Mortality Among Men Diagnosed With Impaired Fertility: Analysis of US Claims Data

Francesco Del Giudice et al.

Summary: This study found a significant association between male infertility and higher risk of mortality, especially among men with azoospermia. Even after excluding prevalent cardiovascular and malignant diseases, infertile men still had a higher risk of death.

UROLOGY (2021)

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Editorial Material Urology & Nephrology

Re: Canary in the Coal Mine? Male Infertility as a Marker of Overall Health

Craig Niederberger

JOURNAL OF UROLOGY (2021)

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Review Environmental Sciences

Pollutants and sperm quality: a systematic review and meta-analysis

Damiano Pizzol et al.

Summary: Male fertility and semen quality have declined in recent decades, with environmental and occupational pollution potentially impacting sperm quality. It is important to further understand the effects of pollutants on human, animal, and planetary health, as sperm quality is considered a proxy for general health and pollutants have a significant impact on climate change.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

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Article Obstetrics & Gynecology

Top 10 priorities for future infertility research: an international consensus development study

J. M. N. Duffy et al.

Summary: The study identified the top 10 research priorities in male infertility, female and unexplained infertility, medically assisted reproduction, and ethics, access, and organization of care for people with fertility problems. The research priorities highlight the importance of addressing the emotional and psychological impact of infertility, improving access to fertility treatment, and securing appropriate regulation. This diverse range of research priorities will require a variety of research methodologies to tackle the issues effectively.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I

Peter N. Schlegel et al.

Summary: This study is Part I of a two-part series on the diagnosis and treatment of male infertility, focusing on the appropriate evaluation of males in infertile couples. The presence of male infertility is crucial to the health of patients and its detection increases the risk of developing other health problems for men.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Diagnosis and treatment of infertility in men: AUA/ASRM guideline part II

Peter N. Schlegel et al.

Summary: This study presents Part II of the Diagnosis and Treatment of Infertility in Men guideline, focusing on the appropriate management of male infertility in infertile couples and various treatment options. The guideline offers evidence-based recommendations for the management of male infertility, which are summarized in an associated algorithm for easier reference and implementation.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Association between preconception paternal health and pregnancy loss in the USA: an analysis of US claims data

Alex M. Kasman et al.

Summary: The study showed a positive correlation between preconception paternal health and the risk of pregnancy loss, especially when fathers had metabolic syndrome and other chronic diseases. Even after adjusting for maternal factors, this association remained significant.

HUMAN REPRODUCTION (2021)

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Article Obstetrics & Gynecology

Fertility evaluation of infertile women: a committee opinion

Group Author Only

Summary: This article provides a critical review of current methods and procedures for evaluating infertility in women, with an emphasis on using the least invasive methods to detect the most common causes.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology, 2014

Georgina M. Chambers et al.

Summary: In 2014, 1.93 million ART cycles were performed in 76 countries, with trends showing increased success rates, frozen embryo transfer cycles, single embryo transfer, and preimplantation genetic testing. Utilization rates and effectiveness of ART continue to improve globally.

HUMAN REPRODUCTION (2021)

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Editorial Material Obstetrics & Gynecology

Electroejaculation in men with spinal cord injury: a step-by-step video demonstration

Emad Ibrahim et al.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Impaired fecundity as a marker of health and survival: a Danish twin cohort study

L. J. Ahrenfeldt et al.

Summary: Long time to first pregnancy (TTP) can be a marker for increased mortality among women and higher hospitalization rates for both women and men, showing that fecundity may be a universal marker of future health and survival.

HUMAN REPRODUCTION (2021)

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Review Urology & Nephrology

The Association between Mortality and Male Infertility: Systematic Review and Meta-analysis

Francesco Del Giudice et al.

Summary: The relationship between impaired male fertility and the risk of early death was explored through systematic review and meta-analysis of population-based retrospective cohort studies. The study found that infertile men have a higher risk of death compared to fertile men, and the risk of death increases with severity of semen quality impairment. However, infertile men have a lower overall risk of death compared to the general population, suggesting the importance of social determinants of health.

UROLOGY (2021)

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Article Multidisciplinary Sciences

A method for utilizing automated machine learning for histopathological classification of testis based on Johnsen scores

Yurika Ito et al.

Summary: The study examined the possibility of using AI to automatically determine Johnsen scores, achieving high levels of precision and recall in evaluation. The Google Cloud AutoML Vision platform was used to assess the accuracy and recall rates for different datasets, showing promising results for potential clinical applications.

SCIENTIFIC REPORTS (2021)

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Article Cell & Tissue Engineering

In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells

Yukiko Ishikura et al.

Summary: This study successfully reconstituted the entire process of male germ-cell development using pluripotent stem cells (PSCs) in vitro, including primordial germ cell development, male germ-cell specification for spermatogonium development, and ensuing spermatogenesis. This creates a foundation for research on in vitro male gametogenesis.

CELL STEM CELL (2021)

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Review Urology & Nephrology

European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2021 Update on Male Infertility

Suks Minhas et al.

Summary: The latest guidelines from the European Association of Urology recommend comprehensive urological evaluation for infertile men to identify and treat modifiable causes of infertility, as well as to monitor their risk for cardiovascular disease and cancer. However, there is still insufficient evidence to support the routine use of some treatments and surgical interventions in clinical practice.

EUROPEAN UROLOGY (2021)

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Article Obstetrics & Gynecology

Semen parameter thresholds and time-to-conception in subfertile couples: how high is high enough?

Sorena Keihani et al.

Summary: This study found that thresholds for total sperm count, sperm concentration, progressive motility, and total progressive motile sperm count (TPMC) well above the WHO references were associated with earlier time-to-conception and higher conception rates in couples undergoing fertility evaluation. Higher values of sperm count, concentration, and progressive motility beyond the WHO references were still associated with better conception rates and time-to-conception.

HUMAN REPRODUCTION (2021)

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Article Obstetrics & Gynecology

Cumulative delivery rate per aspiration IVF/ICSI cycle in POSEIDON patients: a real-world evidence study of 9073 patients

Sandro C. Esteves et al.

Summary: Patients classified under the POSEIDON criteria generally have a lower cumulative delivery rate (CDR) in IVF/ICSI treatment compared to normal responders, with differences primarily influenced by female age and the number of oocytes retrieved.

HUMAN REPRODUCTION (2021)

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Review Medicine, General & Internal

Differential Diagnosis of Azoospermia in Men with Infertility

Danilo L. Andrade et al.

Summary: The differential diagnosis between obstructive and nonobstructive azoospermia involves a comprehensive evaluation including medical history, physical examination, semen analysis, hormonal assessment, genetic tests, and imaging studies. Testicular biopsy may be necessary in cases of doubt, and should be combined with sperm extraction for sperm cryopreservation. A multidisciplinary approach involving reproductive urologists/andrologists, geneticists, pathologists, and embryologists is crucial for the best diagnostic path for men with azoospermia.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Andrology

Viral infections and implications for male reproductive health

Thiago A. Teixeira et al.

Summary: Viral infections can have adverse effects on male reproductive health and impact offspring health through sexual transmission. Diagnosis and treatment strategies are important for addressing these issues.

ASIAN JOURNAL OF ANDROLOGY (2021)

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Review Andrology

Cycles, waves, and pulses: Retinoic acid and the organization of spermatogenesis

Artur Mayerhofer

ANDROLOGY (2020)

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Article Andrology

Clinical and molecular characterization of Y microdeletions and X-linked CNV67 implications in male fertility: a 20-year experience

A. Pinho et al.

ANDROLOGY (2020)

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Review Pediatrics

Cystic fibrosis in the year 2020: A disease with a new face

Kris De Boeck

ACTA PAEDIATRICA (2020)

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Article Medicine, General & Internal

Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment A Randomized Clinical Trial

Enrique F. Schisterman et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Andrology

Role of genetics and epigenetics in male infertility

Sezgin Gunes et al.

ANDROLOGIA (2020)

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Article Endocrinology & Metabolism

Burdens and awareness of adverse self-reported lifestyle factors in men with sub-fertility: A cross-sectional study in 1149 men

Channa N. Jayasena et al.

CLINICAL ENDOCRINOLOGY (2020)

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Review Andrology

An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men

Sandro C. Esteves et al.

ANDROLOGY (2020)

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Review Urology & Nephrology

Genetic testing in male infertility - reassessing screening thresholds

James L. Liu et al.

CURRENT OPINION IN UROLOGY (2020)

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Review Urology & Nephrology

The role of leptin and obesity on male infertility

Kajal Khodamoradi et al.

CURRENT OPINION IN UROLOGY (2020)

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Article Obstetrics & Gynecology

Assessment of SARS-CoV-2 in human semen-a cohort study

Nora Holtmann et al.

FERTILITY AND STERILITY (2020)

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Article Nutrition & Dietetics

Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition

Andrea Garolla et al.

NUTRIENTS (2020)

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The transcription factor Maz is essential for normal eye development

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FERTILITY AND STERILITY (2020)

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Normal sperm parameters per se do not reliably account for fertility: A case-control study in the real-life setting

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Obesity and Baseline Estradiol Levels Are Independent Predictors for Initiation of Anastrozole in Hypogonadal Men on Clom phene Citrate

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Cannabis and Male Fertility: A Systematic Review

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The Prevalence of Y-chromosome Microdeletions in Oligozoospermic Men: A Systematic Review and Meta-analysis of European and North American Studies

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Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years

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Men With Severe Oligospermia Appear to Benefit From Varicocele Repair: A Cost-effectiveness Analysis of Assisted Reproductive Technology

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FERTILITY AND STERILITY (2013)

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HUMAN REPRODUCTION (2013)

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ANDROLOGIA (2012)

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HUMAN REPRODUCTION (2012)

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The Impact of Varicocelectomy on Sperm Parameters: A Meta-Analysis

Ingrid Schauer et al.

JOURNAL OF UROLOGY (2012)

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Article Multidisciplinary Sciences

Rate of de novo mutations and the importance of father's age to disease risk

Augustine Kong et al.

NATURE (2012)

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Article Obstetrics & Gynecology

Sperm parameters and male fertility after bariatric surgery: three case series

Nathalie Sermondade et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2012)

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Article Immunology

Sirolimus-Associated Testicular Toxicity: Detrimental But Reversible

Jordi Rovira et al.

TRANSPLANTATION (2012)

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Review Urology & Nephrology

Critical Appraisal of World Health Organization's New Reference Values for Human Semen Characteristics and Effect on Diagnosis and Treatment of Subfertile Men

Sandro C. Esteves et al.

UROLOGY (2012)

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Article Medicine, General & Internal

National, Regional, and Global Trends in Infertility Prevalence Since 1990: A Systematic Analysis of 277 Health Surveys

Maya N. Mascarenhas et al.

PLOS MEDICINE (2012)

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Article Urology & Nephrology

Novel methods for the diagnosis and treatment of ejaculatory duct obstruction

Bin Xu et al.

BJU INTERNATIONAL (2011)

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Article Obstetrics & Gynecology

Interpretation of the Semen Analysis and Initial Male Factor Management

Peter J. Stahl et al.

CLINICAL OBSTETRICS AND GYNECOLOGY (2011)

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Review Medicine, General & Internal

An update on the clinical assessment of the infertile male

Sandro C. Esteves et al.

CLINICS (2011)

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Review Urology & Nephrology

Male reproductive health and prostate cancer risk

Thomas J. Walsh

CURRENT OPINION IN UROLOGY (2011)

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Article Obstetrics & Gynecology

The Fertility Quality of Life (FertiQoL) tool: development and general psychometric properties

Jacky Boivin et al.

FERTILITY AND STERILITY (2011)

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Article Obstetrics & Gynecology

The fertility quality of life (FertiQoL) tool: development and general psychometric properties

Jacky Boivin et al.

HUMAN REPRODUCTION (2011)

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Article Andrology

Semen analysis in 21st century medicine: the need for sperm function testing

Dolores J. Lamb

ASIAN JOURNAL OF ANDROLOGY (2010)

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Article Oncology

Increased Risk of High-Grade Prostate Cancer Among Infertile Men

Thomas J. Walsh et al.

CANCER (2010)

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Article Obstetrics & Gynecology

Adverse effect of paroxetine on sperm

Cigdem Tanrikut et al.

FERTILITY AND STERILITY (2010)

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Review Urology & Nephrology

Male infertility in cancer patients: Review of the literature

Gert R. Dohle

INTERNATIONAL JOURNAL OF UROLOGY (2010)

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Article Psychology, Clinical

Investigating quality of life and health-related quality of life in infertility: a systematic review

Juliana Rigol Chachamovich et al.

JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY (2010)

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Article Multidisciplinary Sciences

Identification of De Novo Copy Number Variants Associated with Human Disorders of Sexual Development

Mounia Tannour-Louet et al.

PLOS ONE (2010)

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Article Urology & Nephrology

Cut-off Value of Testes Volume in Young Adults and Correlation Among Testes Volume, Body Mass Index, Hormonal Level, and Seminal Profiles

Jong Y. Bahk et al.

UROLOGY (2010)

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Article Medicine, General & Internal

Increased Risk of Testicular Germ Cell Cancer Among Infertile Men

Thomas J. Walsh et al.

ARCHIVES OF INTERNAL MEDICINE (2009)

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Review Anesthesiology

The Impact of Opioids on the Endocrine System

Nathaniel Katz et al.

CLINICAL JOURNAL OF PAIN (2009)

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Article Endocrinology & Metabolism

The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System

J. Roa et al.

ENDOCRINOLOGY (2009)

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Article Obstetrics & Gynecology

Comparison of transrectal ultrasonography and transrectal ultrasonography-guided seminal vesicle aspiration in the diagnosis of the ejaculatory duct obstruction

Gulgun Engin et al.

FERTILITY AND STERILITY (2009)

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Article Obstetrics & Gynecology

When and why do subfertile couples discontinue their fertility care? A longitudinal cohort study in a secondary care subfertility population

M. Brandes et al.

HUMAN REPRODUCTION (2009)

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Article Obstetrics & Gynecology

The longitudinal impact of partner coping in couples following 5 years of unsuccessful fertility treatments

B. D. Peterson et al.

HUMAN REPRODUCTION (2009)

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Article Endocrinology & Metabolism

Effect of Roux-en-Y Gastric Bypass Surgery on the Sex Steroids and Quality of Life in Obese Men

Ahmad Hammoud et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

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Article Endocrinology & Metabolism

Multicenter Contraceptive Efficacy Trial of Injectable Testosterone Undecanoate in Chinese Men

Yiqun Gu et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

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Review Endocrinology & Metabolism

The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism

Suzy D. C. Bianco et al.

NATURE REVIEWS ENDOCRINOLOGY (2009)

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Review Urology & Nephrology

Male infertility: a risk factor for testicular cancer

James M. Hotaling et al.

NATURE REVIEWS UROLOGY (2009)

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Review Urology & Nephrology

Ejaculatory Dysfunction and Its Association With Lower Urinary Tract Symptoms of Benign Prostatic Hyperplasia and BPH Treatment

Wayne J. G. Hellstrom et al.

UROLOGY (2009)

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Review Urology & Nephrology

Fertility potential after unilateral and bilateral orchidopexy for cryptorchidism

Bojan Trsinar et al.

WORLD JOURNAL OF UROLOGY (2009)

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Article Obstetrics & Gynecology

Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles

John L. Frattarelli et al.

FERTILITY AND STERILITY (2008)

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Review Obstetrics & Gynecology

Impact of male obesity on infertility: a critical review of the current literature

Ahmad O. Hammoud et al.

FERTILITY AND STERILITY (2008)

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Article Obstetrics & Gynecology

Why do couples drop-out from IVF treatment? A prospective cohort study

M. F. G. Verberg et al.

HUMAN REPRODUCTION (2008)

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Article Andrology

Prediction of spontaneous conception based on semen parameters

Piotr Jedrzejczak et al.

INTERNATIONAL JOURNAL OF ANDROLOGY (2008)

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Article Urology & Nephrology

Sexual function and quality of life in the male partner of infertile couples: Prevalence and correlates of dysfunction

Alan W. Shindel et al.

JOURNAL OF UROLOGY (2008)

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Article Endocrinology & Metabolism

Treatment of male infertility secondary to morbid obesity

Mara Y. Roth et al.

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM (2008)

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Article Obstetrics & Gynecology

International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care

Jacky Boivin et al.

HUMAN REPRODUCTION (2007)

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Article Endocrinology & Metabolism

The effect of 5α reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy men

John K. Amory et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

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Article Endocrinology & Metabolism

Molecular and clinical characterization of Y chromosome microdeletions in infertile men: A 10-year experience in Italy

Alberto Ferlin et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

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Article Obstetrics & Gynecology

Sperm DNA integrity in testicular cancer patients

O. Stahl et al.

HUMAN REPRODUCTION (2006)

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Review Clinical Neurology

Male erectile dysfunction following spinal cord injury: a systematic review

D. DeForge et al.

SPINAL CORD (2006)

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Article Multidisciplinary Sciences

Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm

A. J. Wyrobek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Article Medicine, General & Internal

Rate, extent, and modifiers of spermatogenic recovery after hormonal male contraception: an integrated analysis

PY Liu et al.

LANCET (2006)

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Article Multidisciplinary Sciences

Pluripotency of spermatogonial stem cells from adult mouse testis

K Guan et al.

NATURE (2006)

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Article Urology & Nephrology

Surgery or assisted reproduction? A decision analysis of treatment costs in male infertility

MV Meng et al.

JOURNAL OF UROLOGY (2005)

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Article Obstetrics & Gynecology

Rates of suppression and recovery of human sperm output in testosterone-based hormonal contraceptive regimens

LP Ly et al.

HUMAN REPRODUCTION (2005)

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Article Endocrinology & Metabolism

Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression

AD Coviello et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)

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Review Nursing

Men and health help-seeking behaviour: literature review

PM Galdas et al.

JOURNAL OF ADVANCED NURSING (2005)

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Article Obstetrics & Gynecology

Increase in scrotal temperature in laptop computer users

Y Sheynkin et al.

HUMAN REPRODUCTION (2005)

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Article Obstetrics & Gynecology

Prevalence of chromosomal abnormalities in 2078 infertile couples referred for assisted reproductive techniques

E Clementini et al.

HUMAN REPRODUCTION (2005)

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Article Urology & Nephrology

Androgens and male fertility

GR Dohle et al.

WORLD JOURNAL OF UROLOGY (2003)

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Article Pharmacology & Pharmacy

Bladder, bowel and sexual dysfunction in multiple sclerosis - Management strategies

R DasGupta et al.

DRUGS (2003)

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Article Urology & Nephrology

Clinical and genetic features of patients with congenital unilateral absence of the vas deferens

PN Kolettis et al.

UROLOGY (2002)

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Review Medicine, General & Internal

Primer on medical genomics part I: History of genetics and sequencing of the human genome

CP Lorentz et al.

MAYO CLINIC PROCEEDINGS (2002)

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Review Multidisciplinary Sciences

Germline stem cell transplantation and transgenesis

RL Brinster

SCIENCE (2002)

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Article Obstetrics & Gynecology

Best practice policies for male infertility

ID Sharlip et al.

FERTILITY AND STERILITY (2002)

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Review Andrology

Cytogenetic investigations of infertile men with low sperm counts: A 25-year experience

MC Vincent et al.

JOURNAL OF ANDROLOGY (2002)

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Article Medicine, General & Internal

Sperm morphology, motility, and concentration in fertile and infertile men.

DS Guzick et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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Review Endocrinology & Metabolism

Inhibin B in male reproduction: pathophysiology and clinical relevance

SJ Meachem et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2001)

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Article Urology & Nephrology

Significant medical pathology discovered during a male infertility evaluation

PN Kolettis et al.

JOURNAL OF UROLOGY (2001)

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Article Urology & Nephrology

Modified vasoepididymostomy with simultaneous double needle placement, tubulotomy and tubular invagination

JL Marmar

JOURNAL OF UROLOGY (2000)

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