Functional Microgel Enables Effective Delivery and Colonization of Probiotics for Treating Colitis

Article Chemistry, Multidisciplinary

Calcium Tungstate Microgel Enhances the Delivery and Colonization of Probiotics during Colitis via Intestinal Ecological Niche Occupancy

Jiali Yang et al.

Summary: Calcium tungstate microgel selectively disrupts the ecological niche occupied by abnormally expanded Enterobacteriaceae during colitis, promoting probiotic colonization. The use of a calcium tungste microgel-based oral probiotic delivery system improves the delivery and colonization of probiotics. The synergistic reduction of Enterobacteriaceae and increase in probiotic colonization results in effective treatment for colitis.

ACS CENTRAL SCIENCE (2023)

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Article Multidisciplinary Sciences

Chemical reaction-mediated covalent localization of bacteria

Huilong Luo et al.

Summary: This article describes a strategy for controlling bacterial colonization by using chemical reactions. The researchers demonstrate that transforming bacteria with a reactive surface can enhance their attachment to the mucous layer in the jejunum, leading to improved colonization. This finding has important implications for developing next-generation bacterial living bioagents.

NATURE COMMUNICATIONS (2022)

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Review Multidisciplinary Sciences

GUT PHYSIOLOGY The microbiome and gut homeostasis

Jee-Yon Lee et al.

Summary: Changes in gut microbiota composition are linked to various human diseases. However, defining homeostasis or dysbiosis based on the presence or absence of specific microbial species has been unsuccessful. The adult gut microbiota is regulated by diet and host factors, with oxygen and nitrate availability shaping the bacterial community in different parts of the gut. Poor diet weakens host control mechanisms, potentially leading to dysbiosis. Therefore, quantifying host parameters that control microbial growth could offer alternative approaches to define and remediate dysbiosis.

SCIENCE (2022)

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Article Engineering, Biomedical

Hydrogels as promising platforms for engineered living bacteria-mediated therapeutic systems

Shuangjiang Yu et al.

Summary: The idea of using engineered bacteria as living therapeutic agents for treating various diseases has been proposed, with a focus on the importance of developing safe and effective treatment strategies. Hydrogels are seen as promising vehicles for delivering living bacterial therapeutics due to their adjustable properties, bioactivities, and ability to protect labile payloads. Current challenges and future prospects in the field are discussed, indicating that the significance of hydrogel-based living bacteria-mediated therapy is expected to increase with advancements in synthetic biology and biomaterials science.

MATERIALS TODAY BIO (2022)

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Review Gastroenterology & Hepatology