WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury

Review Biochemistry & Molecular Biology

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

Chen Zhang et al.

Summary: Ferroptosis, an iron-dependent form of cell death, plays a crucial role in tumor suppression and has the potential to reverse cancer therapy resistance.

MOLECULAR CANCER (2022)

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Article Oncology

WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation

Yvonne Xinyi Lim et al.

Summary: WBP2 is an oncogene that promotes breast carcinogenesis by regulating Wnt, ER, and Hippo signaling. It has been found to enhance migration and invasion in TNBC cells under TNF-alpha stimulation, and potentiates NF-kappa B transcriptional activity through degradation of its inhibitor I kappa B alpha. The WBP2-BTRC-I kappa B alpha signaling axis correlates with poorer prognosis in breast cancer patients, revealing a pivotal mechanism of WBP2 in promoting TNBC aggressiveness.

MOLECULAR ONCOLOGY (2022)

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Review Oncology

Targeting ferroptosis as a vulnerability in cancer

Guang Lei et al.

Summary: This article provides an overview of the importance and potential of ferroptosis in cancer research, summarizes the mechanisms of ferroptosis induction and defense, analyzes its roles and mechanisms in tumor suppression and tumor immunity, and explores therapeutic strategies targeting ferroptosis in cancer.

NATURE REVIEWS CANCER (2022)

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Article Biochemistry & Molecular Biology

WBP2 promotes gastric cancer cell migration via novel targeting of LATS2 kinase in the Hippo tumor suppressor pathway

Melissa Hum et al.

Summary: The dysregulation of signaling pathways plays a key role in many human diseases, including gastric cancer (GC). Through mass spectrometry-based phosphoproteomics analysis, WW domain-binding protein 2 (WBP2) was identified as being upregulated in GC cell lines and was found to be essential for GC cell migration by inactivating the Hippo pathway transducer LATS2. This study highlights a novel mechanism by which WBP2 promotes the progression of GC and suggests potential therapeutic targets for the treatment of this disease.

FASEB JOURNAL (2021)

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Article Oncology

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Yahui Ding et al.

Summary: This study identified a novel approach to treat TNBC by inducing ferroptosis through ubiquitination of GPX4 with the compound DMOCPTL, and revealed the role of GPX4 in regulating mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Furthermore, the prodrug Compound 13 showed promising anti-tumor effects in vivo with no apparent toxicity, suggesting its potential as a lead compound for developing effective anti-TNBC drugs.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Urology & Nephrology

Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity

Hirofumi Hamano et al.

Summary: Research suggests that diphenhydramine may serve as a novel treatment for cisplatin-induced kidney toxicity by inhibiting cell death and reducing oxidative stress to alleviate kidney injury, with clinical evidence from patients supporting this finding.

KIDNEY INTERNATIONAL (2021)

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Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Cell Biology

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

Chuan'ai Chen et al.

Summary: The study demonstrates that deficiency of legumain attenuates acute renal tubular injury, inflammation, and ferroptosis in acute kidney injury models induced by ischemia-reperfusion injury or folic acid. Legumain deficiency prevents chaperone-mediated autophagy of GPX4, dampening ferroptosis induced by hypoxia or erastin. The results suggest that legumain promotes tubular ferroptosis in acute kidney injury by promoting chaperone-mediated autophagy of GPX4.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

Seonghun Kim et al.

Summary: The study evaluated the role of ferroptosis in diabetes-induced tubular injury. Results indicated that ferroptosis triggers kidney cell death by affecting glutathione concentration and lipid peroxidation, and the use of ferroptosis inhibitors can alleviate this process.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1

Zhe Zheng et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a common clinical disease without approved drugs due to unclear pathological mechanisms. The newly discovered oncogene WBP2 has been found to decrease in NAFLD and its overexpression can alleviate liver fat deposition and insulin resistance, while knockdown aggravates these symptoms. This suggests a potential new direction for future research on NAFLD.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Yilei Zhang et al.

Summary: Cystine uptake promotes GPX4 synthesis by activating mTORC1, sensitizing cancer cells to ferroptosis. Inhibiting mTORC1 decreases GPX4 protein levels and enhances the effectiveness of ferroptosis inducers in cancer treatment.

NATURE COMMUNICATIONS (2021)

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Review Pharmacology & Pharmacy

Ferroptosis and its potential as a therapeutic target

Hanshu Yuan et al.

Summary: Ferroptosis is a recently defined form of programmed cell death that is distinct due to its iron dependency and accumulation of lipid hydroperoxides. It can be regulated by various cellular variables and is potentially linked to degenerative diseases and acute injury scenarios. Additionally, ferroptosis may have significance in tumor-suppression and cancer therapy as a proposed target.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Medicine, Research & Experimental

DNA damage is overcome by TRIP13 overexpression during cisplatin nephrotoxicity

Taketsugu Hama et al.

Summary: The study demonstrates that thyroid receptor interacting protein 13 (TRIP13) may play a crucial role in protecting proximal tubules from DNA damage caused by cisplatin. Restoring TRIP13 activity could effectively reduce nephrotoxic damage and protect the kidney.

JCI INSIGHT (2021)

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Review Urology & Nephrology

Potential Therapeutic Targets for Cisplatin-Induced Kidney Injury: Lessons from Other Models of AKI and Fibrosis

Sophia M. Sears et al.

Summary: The effectiveness of cisplatin, a common drug in treating solid organ cancers, is hindered by its dose-limiting nephrotoxicity. AKI and CKD are closely related, with renal fibrosis being a key feature of CKD development. Understanding the mechanisms behind cisplatin-induced kidney pathologies is crucial for developing effective preventative measures.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Biochemistry & Molecular Biology

Role of ferroptosis in cisplatin-induced acute nephrotoxicity in mice

Yasumasa Ikeda et al.

Summary: The study investigated the role of ferroptosis in cisplatin-induced nephrotoxicity (CIN) and found that ferroptosis is involved in the pathogenesis of CIN, suggesting it as a new preventive target. Inhibition of ferroptosis alleviated kidney injury and inflammation caused by cisplatin, while also preventing cell apoptosis and necrosis induced by cisplatin.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2021)

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Article Immunology

Selenium-GPX4 axis protects follicular helper T cells from ferroptosis

Yin Yao et al.

Summary: Researchers found that T follicular helper (T-FH) cells are highly sensitive to ferroptosis, and this process is regulated by the activity of the selenoenzyme GPX4. Selenium supplementation can increase GPX4 expression, leading to an increase in T-FH cell numbers and antibody responses.

NATURE IMMUNOLOGY (2021)

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Review Physiology

Regulated cell death in cisplatin-induced AKI: relevance of myo-inositol metabolism

Fei Deng et al.

Summary: Regulated cell death (RCD), which is distinct from accidental cell death, is a well-controlled programmed cell death process with defined pathological mechanisms. The term RCD encompasses various types of cell death, some of which have been implicated in the pathogenesis of acute kidney injury (AKI), such as cisplatin-induced AKI.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2021)

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Article Urology & Nephrology

Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers

Eikan Mishima et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2020)

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Article Cell Biology

microRNA-485-5p inhibits the progression of hepatocellular carcinoma through blocking the WBP2/Wnt signaling pathway

Jun Gao et al.

CELLULAR SIGNALLING (2020)

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Article Cell Biology

VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis

Zhaoxin Hu et al.

CELL DEATH & DISEASE (2020)

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Review Biochemistry & Molecular Biology

The emerging roles of WBP2 oncogene in human cancers

Hossein Tabatabaeian et al.

ONCOGENE (2020)

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Article Cell Biology

Hippo/MST blocks breast cancer by downregulating WBP2 oncogene expression via miRNA processor Dicer

Shen Kiat Lim et al.

CELL DEATH & DISEASE (2020)

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Article Biochemistry & Molecular Biology

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Yang Li et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Review Oncology

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Yanhua Mou et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Multidisciplinary Sciences

Chaperone-mediated autophagy is involved in the execution of ferroptosis

Zheming Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Biochemistry & Molecular Biology

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death

Melania Guerrero-Hue et al.

FASEB JOURNAL (2019)

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Review Biochemistry & Molecular Biology

Cisplatin: The first metal based anticancer drug

Sumit Ghosh

BIOORGANIC CHEMISTRY (2019)

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Article Medicine, Research & Experimental

Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

Fei Deng et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Review Cell Biology

Emerging Role of Ferroptosis in Acute Kidney Injury

Zhaoxin Hu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Cell Biology

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

Hiroshi Maekawa et al.

CELL REPORTS (2019)

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Article Physiology

Renal tubular injury exacerbated by vasohibin-1 deficiency in a murine cisplatin-induced acute kidney injury model

Satoshi Tanimura et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

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Article Urology & Nephrology

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI

Diego Martin-Sanchez et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

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Review Biochemistry & Molecular Biology

WW domain-binding protein 2: an adaptor protein closely linked to the development of breast cancer

Shuai Chen et al.

MOLECULAR CANCER (2017)

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Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

CELL (2017)

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Article Cell Biology

Ferroptosis is an autophagic cell death process

Minghui Gao et al.

CELL RESEARCH (2016)

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Article Medicine, Research & Experimental

Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing

Annalisa Buniello et al.

EMBO MOLECULAR MEDICINE (2016)

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Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

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Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

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Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

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Article Multidisciplinary Sciences

Synchronized renal tubular cell death involves ferroptosis

Andreas Linkermann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

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Article Biotechnology & Applied Microbiology

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Guangchuang Yu et al.

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway

X. Zhang et al.

CELL DEATH AND DIFFERENTIATION (2011)

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Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

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Article Multidisciplinary Sciences

A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells

Sergey V. Novoselov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

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WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury

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