Serum copper, zinc and copper/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study

Article Oncology

Prediagnostic Levels of Copper and Zinc and Breast Cancer Risk in the ORDET Cohort

Valeria Pala et al.

Summary: The study suggests that increased Cu/Zn ratio in plasma and urine may serve as an early marker and risk factor for breast cancer development, especially within 2 years of diagnosis.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2022)

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Article Multidisciplinary Sciences

Copper induces cell death by targeting lipoylated TCA cycle proteins

Peter Tsvetkov et al.

Summary: Copper is an essential cofactor for all organisms, but excessive copper can lead to cell death. We found that copper-dependent cell death mechanism is different from known mechanisms, and it is related to mitochondrial respiration. Copper directly binds to lipoylated components of the tricarboxylic acid cycle, causing protein aggregation and loss of iron-sulfur cluster proteins, ultimately leading to cell death.

SCIENCE (2022)

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Article Nutrition & Dietetics

Zinc and Breast Cancer Survival: A Prospective Cohort Study of Dietary Intake and Serum Levels

Ylva Bengtsson et al.

Summary: This study investigates the relationship between zinc levels and breast cancer survival. The results suggest that higher zinc intake in women with high phosphorus intake may lead to better breast cancer survival.

NUTRIENTS (2022)

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Article Biochemistry & Molecular Biology

Autoimmunity to selenoprotein P predicts breast cancer recurrence

Kamil Demircan et al.

Summary: The presence of SELENOP autoantibodies in breast cancer patients is associated with poor prognosis, particularly in patients with low selenium levels. These autoantibodies may disrupt the transport function of SELENOP, leading to an increased risk of recurrence and mortality.

REDOX BIOLOGY (2022)

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Article Immunology

A novel cuproptosis-related molecular pattern and its tumor microenvironment characterization in colorectal cancer

Zhonglin Zhu et al.

Summary: This study comprehensively analyzed the molecular patterns of cuproptosis in colorectal cancer and identified three distinct cuproptosis patterns associated with immune infiltration characteristics and clinical prognosis.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Oncology

Connecting copper and cancer: from transition metal signalling to metalloplasia

Eva J. Ge et al.

Summary: Copper is a essential nutrient with both beneficial and toxic properties to cells. Recent progress in transition metal signaling has led to new connections between researchers from different disciplines, with potential for translating basic research into clinical therapies for diseases. The relationship between copper and cancer is particularly important, with opportunities for leveraging disease vulnerabilities through copper-dependent signaling pathways.

NATURE REVIEWS CANCER (2022)

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Review Biochemistry & Molecular Biology

Copper metabolism as a unique vulnerability in cancer

Vinit C. Shanbhag et al.

Summary: Over the past 25 years, significant progress has been made in identifying and characterizing proteins that regulate the uptake, intracellular trafficking and export of copper. While copper is essential for growth and development in humans and other mammals, it is also a limiting nutrient for cancer cell growth and proliferation. Oral copper chelators have been shown to have anti-neoplastic and anti-metastatic effects in animals and humans.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2021)

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Article Biotechnology & Applied Microbiology

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Liyang Cui et al.

Summary: The research developed a mitochondria-targeted copper-depleting nanoparticle that effectively inhibited the growth of triple-negative breast cancer cells and improved survival rates in mouse models. By depriving copper within cancer cells, this approach induced metabolic changes and apoptosis, highlighting its potential clinical relevance.

NATURE BIOTECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study

Kamil Demircan et al.

Summary: Selenium is essential for the synthesis of redox active proteins and its serum status biomarkers SELENOP and GPx3 are associated with overall survival and recurrence in patients with primary invasive breast cancer. An analysis of 1996 patients showed an inverse correlation between these biomarkers and mortality, with the highest quintile associated with significantly lower hazard ratios. Triple deficiency in selenium status biomarkers was linked to the highest mortality risk, and predicting mortality based on these biomarkers outperformed traditional tumour characteristics.

REDOX BIOLOGY (2021)

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Article Oncology

Serum zinc and dietary intake of zinc in relation to risk of different breast cancer subgroups and serum levels as a marker of intake: a prospective nested case-control study

Ylva Bengtsson et al.

Summary: The study found no significant association between zinc levels in serum or pre-diagnostic diet and the risk of breast cancer, as well as no clear associations between zinc and any breast cancer characteristics. Additionally, the results suggest that serum zinc is a poor marker of zinc intake.

BREAST CANCER RESEARCH AND TREATMENT (2021)

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Article Biochemistry & Molecular Biology

Serum copper and zinc levels in breast cancer: A meta-analysis

Yue Feng et al.

JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY (2020)

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Review Oncology

Zinc dysregulation in cancers and its potential as a therapeutic target

Jie Wang et al.

CANCER BIOLOGY & MEDICINE (2020)

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Article Public, Environmental & Occupational Health

Validation of data quality in the Swedish National Register for Breast Cancer

Lars Lofgren et al.

BMC PUBLIC HEALTH (2019)

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Review Nutrition & Dietetics

Role of Zinc in Immune System and Anti-Cancer Defense Mechanisms

Dorota Skrajnowska et al.

NUTRIENTS (2019)

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Article Multidisciplinary Sciences

Cross comparison and prognostic assessment of breast cancer multigene signatures in a large population-based contemporary clinical series

Johan Vallon-Christersson et al.

SCIENTIFIC REPORTS (2019)

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Article Oncology

Serum copper and zinc levels at diagnosis and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort

Ai-Ping Fang et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

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Article Surgery

Minimizing inequality in access to precision medicine in breast cancer by real-time population-based molecular analysis in the SCAN-B initiative

L. Ryden et al.

BRITISH JOURNAL OF SURGERY (2018)

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Article Pharmacology & Pharmacy

Zinc Transporters and the Progression of Breast Cancers

Tomoka Takatani-Nakase

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2018)

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Article Oncology

Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Magdalena Stepien et al.

CARCINOGENESIS (2017)

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Review Oncology

Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals

Sandeo Prasad et al.

CANCER LETTERS (2017)

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Review Nutrition & Dietetics

Biomarkers of Nutrition for Development (BOND)-Zinc Review

Janet C. King et al.

JOURNAL OF NUTRITION (2016)

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Article Health Care Sciences & Services

Appropriate inclusion of interactions was needed to avoid bias in multiple imputation

Kate Tilling et al.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer

Paige Chandler et al.

MOLECULAR CANCER (2016)

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Review Cell Biology

Serum copper to zinc ratio: Relationship with aging and health status

Marco Malavolta et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2015)

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Article Genetics & Heredity

The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine

Lao H. Saal et al.

GENOME MEDICINE (2015)

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Article Biochemistry & Molecular Biology

Epigenetic reprogramming governs EcSOD expression during human mammary epithelial cell differentiation, tumorigenesis and metastasis

M. L. Teoh-Fitzgerald et al.

ONCOGENE (2014)

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Article Biochemistry & Molecular Biology

Copper and Resveratrol Attenuates Serum Catalase, Glutathione Peroxidase, and Element Values in Rats with DMBA-Induced Mammary Carcinogenesis

Dorota Skrajnowska et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2013)

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Review Nutrition & Dietetics

Cellular Mechanisms of Zinc Dysregulation: A Perspective on Zinc Homeostasis as an Etiological Factor in the Development and Progression of Breast Cancer

Samina Alam et al.

NUTRIENTS (2012)

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Article Mathematical & Computational Biology

Multiple imputation using chained equations: Issues and guidance for practice

Ian R. White et al.

STATISTICS IN MEDICINE (2011)

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Article Cell Biology

Effect of Cu supplementation on genomic instability in chemically-induced mammary carcinogenesis in the rat

Barbara Bobrowska et al.

JOURNAL OF BIOMEDICAL SCIENCE (2011)

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Article Nutrition & Dietetics

Methods of assessment of copper status in humans: a systematic review

Linda J. Harvey et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2009)

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Article Biochemistry & Molecular Biology

Relevance of Non-ceruloplasmin Copper to Oxidative Stress in Patients with Hepatocellular Carcinoma

Arumugam Geetha et al.

BIOLOGICAL TRACE ELEMENT RESEARCH (2009)

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Review Pharmacology & Pharmacy

COPPER AND ANGIOGENESIS: UNRAVELLING A RELATIONSHIP KEY TO CANCER PROGRESSION

Lydia Finney et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2009)

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Article Biochemistry & Molecular Biology

Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth

Christine J. Weydert et al.

FREE RADICAL BIOLOGY AND MEDICINE (2006)

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Article Public, Environmental & Occupational Health

Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality

N Leone et al.

EPIDEMIOLOGY (2006)

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Article Biology

Inhibition of iron and copper uptake by iron, copper and zinc

M Arredondo et al.

BIOLOGICAL RESEARCH (2006)

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Article Biology

Survival model predictive accuracy and ROC curves

PJ Heagerty et al.

BIOMETRICS (2005)

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Article Public, Environmental & Occupational Health

Serum iron, copper and zinc concentrations and risk of cancer mortality in US adults

TJ Wu et al.

ANNALS OF EPIDEMIOLOGY (2004)

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Serum copper, zinc and copper/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study

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