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TRENDS IN PHARMACOLOGICAL SCIENCES (2023)
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REDOX BIOLOGY (2023)
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REDOX BIOLOGY (2023)
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Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug
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Targeting of Nrf2 improves antitumoral responses by human NK cells, TIL and CAR T cells during oxidative stress
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JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)
NRF2 and Mitochondrial Function in Cancer and Cancer Stem Cells
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CELLS (2022)
A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase
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Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition
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SCIENCE ADVANCES (2021)
Molecular basis for the disruption of Keap1-Nrf2 interaction via Hinge & Latch mechanism
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COMMUNICATIONS BIOLOGY (2021)
Cullin Deneddylation Suppresses the Necroptotic Pathway in Cardiomyocytes
Megan T. Lewno et al.
FRONTIERS IN PHYSIOLOGY (2021)
NRF2-Dependent Bioactivation of Mitomycin C as a Novel Strategy To Target KEAP1-NRF2 Pathway Activation in Human Cancer
Liam Baird et al.
MOLECULAR AND CELLULAR BIOLOGY (2021)
Redox regulation of immunometabolism
Jonathan Muri et al.
NATURE REVIEWS IMMUNOLOGY (2021)
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway
Jonathan M. Ghergurovich et al.
NATURE CHEMICAL BIOLOGY (2020)
Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors
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CANCER RESEARCH (2020)
Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1
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NRF2 Activation in Cancer: From DNA to Protein
Erica W. Cloer et al.
CANCER RESEARCH (2019)
LKB1 and KEAP1/NRF2 Pathways Cooperatively Promote Metabolic Reprogramming with Enhanced Glutamine Dependence in KRAS-Mutant Lung Adenocarcinoma
Ana Galan-Cobo et al.
CANCER RESEARCH (2019)
BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis
Clotilde Wiel et al.
CELL (2019)
Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1
Takafumi Suzuki et al.
CELL REPORTS (2019)
Nrf2 and SQSTM1/p62 jointly contribute to mesenchymal transition and invasion in glioblastoma
Petri Polonen et al.
ONCOGENE (2019)
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
Robert D. Leone et al.
SCIENCE (2019)
Therapeutic targeting of the NRF2 and KEAP 1 partnership in chronic diseases
Antonio Cuadrado et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
NRF2 and the Hallmarks of Cancer
Montserrat Rojo de la Vega et al.
CANCER CELL (2018)
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega et al.
CELL (2018)
Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment
Sarah A. Best et al.
CELL METABOLISM (2018)
Non-covalent Small-Molecule Kelch-like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Inhibitors and Their Potential for Targeting Central Nervous System Diseases
Jakob S. Pallesen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Prediction of Binding Energy of Keap1 Interaction Motifs in the Nrf2 Antioxidant Pathway and Design of Potential High-Affinity Peptides
Mikko Karttunen et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2018)
Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy
Bo Zhu et al.
ONCOGENE (2018)
THE KEAP1-NRF2 SYSTEM: A THIOL-BASED SENSOR-EFFECTOR APPARATUS FOR MAINTAINING REDOX HOMEOSTASIS
Masayuki Yamamoto et al.
PHYSIOLOGICAL REVIEWS (2018)
High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance
In-geun Ryoo et al.
REDOX BIOLOGY (2018)
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
David Olagnier et al.
NATURE COMMUNICATIONS (2018)
A catalogue of somatic NRF2 gain-of-function mutations in cancer
Michael John Kerins et al.
SCIENTIFIC REPORTS (2018)
Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation
Kouhei Tsuchida et al.
FREE RADICAL BIOLOGY AND MEDICINE (2017)
Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress
Takafumi Suzuki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Brusatol overcomes chemoresistance through inhibition of protein translation
Bryan Harder et al.
MOLECULAR CARCINOGENESIS (2017)
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Rodrigo Romero et al.
NATURE MEDICINE (2017)
A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation
Haibin Zhou et al.
NATURE COMMUNICATIONS (2017)
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
Volkan I. Sayin et al.
ELIFE (2017)
Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis
Steffan Vartanian et al.
MOLECULAR & CELLULAR PROTEOMICS (2016)
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
Ryota Saito et al.
MOLECULAR AND CELLULAR BIOLOGY (2016)
The Mediator Subunit MED16 Transduces NRF2-Activating Signals into Antioxidant Gene Expression
Hiroki Sekine et al.
MOLECULAR AND CELLULAR BIOLOGY (2016)
Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
Anju Singh et al.
ACS CHEMICAL BIOLOGY (2016)
NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth
Hironori Satoh et al.
CANCER RESEARCH (2016)
Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer
Evan C. Lien et al.
NATURE CELL BIOLOGY (2016)
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
Joshua D. Campbell et al.
NATURE GENETICS (2016)
NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis
Hui Wang et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Eri H. Kobayashi et al.
NATURE COMMUNICATIONS (2016)
Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
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CELL REPORTS (2016)
NAD(P)H: Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG
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PLOS ONE (2016)
A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer
Michael J. Bollong et al.
ACS CHEMICAL BIOLOGY (2015)
Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation
Dapeng Wang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
Kornelius Schulze et al.
NATURE GENETICS (2015)
Protein neddylation: beyond cullin-RING ligases
Radoslav I. Enchev et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination
Bridgid E. Hast et al.
CANCER RESEARCH (2014)
Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Shasha Tao et al.
CANCER RESEARCH (2014)
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
Anne Cleasby et al.
PLOS ONE (2014)
RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
Hongyan Wang et al.
CANCER RESEARCH (2013)
Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases
Peter Canning et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis
Anju Singh et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
Yoshinobu Ichimura et al.
MOLECULAR CELL (2013)
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
S. Chowdhry et al.
ONCOGENE (2013)
Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
Liam Baird et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
Emilia Kansanen et al.
REDOX BIOLOGY (2013)
Analysis of dimerization of BTB-IVR domains of Keap1 and its interaction with Cul3, by molecular modeling
Nandini Chauhan et al.
BIOINFORMATION (2013)
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Yoichiro Mitsuishi et al.
CANCER CELL (2012)
Oxidative Stress-Regulated Lentiviral TK/GCV Gene Therapy for Lung Cancer Treatment
Hanna M. Leinonen et al.
CANCER RESEARCH (2012)
An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis
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CANCER RESEARCH (2012)
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis
Patricia Rada et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Increased NRF2 gene (NFE2L2) copy number correlates with mutations in lung squamous cell carcinomas
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MOLECULAR MEDICINE REPORTS (2012)
Keap1 degradation by autophagy for the maintenance of redox homeostasis
Keiko Taguchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
NRF2 and cancer: the good, the bad and the importance of context
Michael B. Sporn et al.
NATURE REVIEWS CANCER (2012)
An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
Aikseng Ooi et al.
CANCER CELL (2011)
Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
Julie Adam et al.
CANCER CELL (2011)
Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer
Lucia Anna Muscarella et al.
EPIGENETICS (2011)
Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism
Emilia Kansanen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
Patricia Rada et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
Gina M. De Nicola et al.
NATURE (2011)
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
Dongmei Ren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Regulation of the Nrf2-Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases
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ANTIOXIDANTS & REDOX SIGNALING (2010)
The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3
Christopher P. Guise et al.
CANCER RESEARCH (2010)
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
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CARCINOGENESIS (2010)
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
Alexandria Lau et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Masaaki Komatsu et al.
NATURE CELL BIOLOGY (2010)
Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
Weimin Chen et al.
MOLECULAR CELL (2009)
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Teresa A. Soucy et al.
NATURE (2009)
Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues
Rui Wang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Regulatory potential for concerted modulation of Nrf2-and Nfkb1-mediated gene expression in inflammation and carcinogenesis
S. Nair et al.
BRITISH JOURNAL OF CANCER (2008)
Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
Tsutonm Ohta et al.
CANCER RESEARCH (2008)
The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer
Wananit Wimuttisuk et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
KI Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
B Padmanabhan et al.
MOLECULAR CELL (2006)
CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1
SC Lo et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
BTB protein keap1 targets antioxidant transcription factor nrf2 for ubiquitination by the cullin 3-Roc1 ligase
M Furukawa et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases
R Geyer et al.
MOLECULAR CELL (2003)
Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression
H Sasaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors
H Motohashi et al.
GENE (2002)
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Y Katoh et al.
GENES TO CELLS (2001)
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