期刊
NATURAL PRODUCT RESEARCH
卷 30, 期 22, 页码 2567-2574出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1131984
关键词
Boraginaceae; Solenantus lanatus; pyrrolizidine alkaloids; 7-O-angeloylechinatine N-oxide; anti-AChE activity
资金
- Ministry of Higher Education and Scientific Research of Algeria [F02220120052]
The whole plant ethanolic extract of Solenanthus lanatus was used for the isolation of acetylcholinesterase inhibitors. A new pyrrolizidine alkaloid, 7-O-angeloylechinatine N-oxide, 1, was isolated together with three known compounds of the same class (3-O-acetylheliosupine N-oxide, 2, heliosupine N-oxide, 3, and heliosupine, 4), by bioassay-guided approach. Their structures were elucidated by spectroscopic methods. All the isolated compounds showed inhibition activity against the AChE, with IC50 0.53-0.60mM.
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