Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model

Article Pharmacology & Pharmacy

Peiminine inhibits myocardial injury and fibrosis after myocardial infarction in rats by regulating mitogen-activated protein kinase pathway

Peng Chen et al.

Summary: Peiminine has been found to have a cardioprotective effect against myocardial injury and fibrosis induced by myocardial infarction. Its mechanism of action may involve the inhibition of the mitogen-activated protein kinase pathway.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2022)

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Review Biochemistry & Molecular Biology

Inflammatory Bowel Disease Treatments and Predictive Biomarkers of Therapeutic Response

Duaa Ahmed Elhag et al.

Summary: Inflammatory bowel disease is a chronic immune-mediated inflammation of the gastrointestinal tract with a relapsing and remitting clinical course. Continuous disease monitoring and personalized therapy algorithms are crucial for effective treatment. New therapeutic approaches are being evaluated in controlled clinical trials.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pharmacology & Pharmacy

Ulcerative Colitis and Acute Severe Ulcerative Colitis Patients Are Overlooked in Infliximab Population Pharmacokinetic Models: Results from a Comprehensive Review

Alix Demaris et al.

Summary: This review aims to analyze the population PK models of infliximab (IFX) in patients with ulcerative colitis (UC) and acute severe UC (ASUC), and assess the impact of disease activity on IFX PK. The results showed that there are still many gaps in the current research, such as a limited number of models specifically developed for UC patients, a lack of studies on severe UC patients, and a lack of evaluation of predictive performance for the models. Therefore, more comprehensive research and adequate reporting and evaluation of the models are needed for clinical application.

PHARMACEUTICS (2022)

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Article Oncology

Peiminine inhibits the progression of colorectal cancer through up-regulating miR-760 via declining the expression of long noncoding RNA LINC00659

Jianfeng Li et al.

Summary: Peiminine inhibits the progression of colorectal cancer by targeting LINC00659 and miR-760. In vivo experiments confirm that LINC00659 suppresses CRC tumor growth through the LINC00659/miR-760 axis. Peiminine suppresses CRC cell viability, colony formation, and metastasis through the LINC00659/miR-760 axis, suggesting a potential target for CRC therapy.

ANTI-CANCER DRUGS (2021)

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Article Pharmacology & Pharmacy

Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo

Lei Yu et al.

Summary: Peiminine suppressed proliferation and metastasis, induced cell cycle arrest, apoptosis, and autophagy in osteosarcoma cells, depending on intracellular ROS generation and JNK pathway activation. Furthermore, peiminine significantly inhibited xenograft tumor growth in vivo.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Endocrinology & Metabolism

Peiminine Suppresses RANKL-Induced Osteoclastogenesis by Inhibiting the NFATc1, ERK, and NF-κB Signaling Pathways

Mengbo Zhu et al.

Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Chemistry, Medicinal

Anti-inflammatory effect of Perilla frutescens seed oil rich in omega-3 fatty acid on dextran sodium sulfate-induced colitis in mice

Napapan Kangwan et al.

Summary: This study evaluated the anti-inflammatory effect of Perilla seed oil (PSO) on DSS-induced colitis in mice. PSO pretreatment significantly reduced symptoms, improved histopathological changes, and decreased inflammation response. PSO may reduce DSS-induced colitis by suppressing inflammatory markers.

RESEARCH IN PHARMACEUTICAL SCIENCES (2021)

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Article Cell Biology