期刊
NATURAL PRODUCT RESEARCH
卷 31, 期 5, 页码 604-609出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1207076
关键词
Sponge-derived fungus; Phakellia fusca Thiele; meroterpenoid; roquefortine; cytotoxic activity; antitubercular activity; anti-enterovirus 71 activity
资金
- National Natural Science Foundation of China [21502204, 31270402, 21172230, 41476135]
- Chinese Academy of Sciences [XDA11030403]
- Guangzhou Science and Technology Project [201604010081]
Fifteen compounds, including six quinone/hydroquinone meroter-penoids, purpurogemutantin (1), macrophorin A (2), 4'-oxomacrophorin (3), 7-deacetoxyyanuthone A (4), 2,3-hydro-deacetoxyyanuthone A (5), 22-deacetylyanuthone A (6), anicequol (7), three roquefortine derivatives, roquefortine C (8), (16S)-hydroxyroquefortine C (9), (16R)-hydroxyroquefortine C (10), dihydroresorcylide (11), nectriapyrone (12), together with three fatty acid derivatives, methyl linoleate (13), phospholipase A 2 (14), methyl elaidate (15), were isolated from the sponge-derived fungus Gliomastix sp. ZSDS1-F7 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analyses. Among these compounds, compounds 1-3 and 5-7 showed significant in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4 and HL60 cell lines, with IC50 values ranging from 0.19 to 35.4 mu M. And compounds 2-4 exhibited antitubercular activity with IC 50 values of 22.1, 2.44 and 17.5 mu M, respectively. Furthermore, compound 7 had anti-enterovirus 71 activity with MIC value of 17.8 mu M. To the best of our knowledge, this is the first report to product two quinone/hydroquinone meroterpenoids skeletons (linear skeleton and drimane skeleton) from the same fungal strain. [GRAPHICS] .
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