期刊
NATURAL PRODUCT RESEARCH
卷 30, 期 20, 页码 2274-2277出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1163695
关键词
Penicillium chrysogenum; gorgonian Carijoa sp; flavone; cytotoxicity
资金
- Program of National Natural Science Foundation of China [41322037]
- Program of Natural Science Foundation of Shandong Province of China [JQ201510]
- Marine Special Public Welfare Scientific Research, State Oceanic Administration of China [201405038]
A novel flavone, penimethavone A (1), possessing a rare unique methyl group at ring-B, was isolated from the fungus Penicillium chrysogenum cultured from a gorgonian Carijoa sp. collected from the South China Sea. The structure was elucidated by extensive spectroscopic analysis and by comparison with related known compound. Compound 1 showed selective and moderate cytotoxicity against cervical cancer (HeLa) and rhabdomyosarcoma cell lines with IC50 values of 8.41 and 8.18M, respectively. [GRAPHICS]
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