☆ 4.6 Article

Case report: Granzyme-B expression by T- and B- cells during severe AQP4-positive Neuromyelitis Optica spectrum disorder with fatal venous thromboembolism outcome

FRONTIERS IN NEUROLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Clinical Neurology

Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex

Anna R. Troscher et al.

Summary: Troscher et al. have found that in patients with GAD65 antibody-associated temporal lobe epilepsy, cytotoxic T cells play a role in the loss of neurons and may cause irreversible hippocampal damage. Early immunological treatment is crucial in preventing this damage.

BRAIN (2023)

添加到收藏夹

Article Immunology

Granzyme B+CD8+T cells with terminal differentiated effector signature determine multiple sclerosis progression

Ziyan Shi et al.

Summary: This study investigated the contribution of peripheral CD8+ T cells during the conversion from RRMS to SPMS and revealed a diagnostic biomarker for distinguishing SPMS from RRMS. Single-cell RNA sequencing and flow cytometry were used to analyze the heterogeneity and dynamic changes of CD8+ T cells. The study found that activated CD8+ T cell subsets were elevated in SPMS patients, and GzmB expression in CD8+ T-EMRA cells played a key role in the progression of MS. The expression of GzmB in CD8+ T cells was correlated with disability and progression of MS, and could effectively distinguish SPMS from RRMS.

JOURNAL OF NEUROINFLAMMATION (2023)

添加到收藏夹

Article Clinical Neurology

Incidence and risk factors for venous thromboembolism during an acute attack in patients with neuromyelitis optica spectrum disorders

Juyuan Pan et al.

Summary: VTE is a common complication in NMOSD patients, especially in those with TM. Advanced age and IVIG treatment are independent risk factors for VTE. Immobilization is also a risk factor for VTE in the total NMOSD cohort.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

添加到收藏夹

Article Clinical Neurology

Inebilizumab for treatment of neuromyelitis optica spectrum disorder in patients with prior rituximab use from the N-MOmentum Study

Eoin P. Flanagan et al.

Summary: This study evaluated the efficacy and tolerability of Inebilizumab in NMOSD patients who had previously been treated with rituximab. The findings suggest that Inebilizumab is effective in these patients, with most infections occurring in those who had prior rituximab exposure. Further research is needed to assess potential safety concerns, including infection risk, in patients with rituximab experience.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2022)

添加到收藏夹

Article Immunology

Cytotoxic B Cells in Relapsing-Remitting Multiple Sclerosis Patients

Vinicius O. Boldrini et al.

Summary: This study found that CD19(+) B cells in the peripheral blood of multiple sclerosis (MS) patients may express serine-protease granzyme-B (GzmB), resembling cytotoxic CD8(+) T lymphocytes. This finding may provide important clues for investigating the pathogenesis of MS and for the development of new therapeutic interventions.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Rasmussen's encephalitis is characterized by relatively lower production of IFN-β and activated cytotoxic T cell upon herpes viruses infection

Yi-Song Wang et al.

Summary: This study compared the HHV infection and immune response in brain tissues of Rasmussen's encephalitis (RE), temporal lobe epilepsy (TLE), and traumatic brain injury (TBI) patients. The results showed that HHV antigens were prevalent in both RE and TLE brain tissues, and CD8+ T cell infiltration was observed in both conditions. However, CD8+ T cells were only activated and showed apoptosis in RE. In comparison to TLE, RE brain tissues had higher levels of inflammatory cytokines but lower levels of interferon-beta, which was negatively correlated with HHV infection. The DNA sensors STING and IFI16 were insufficiently activated in RE.

JOURNAL OF NEUROINFLAMMATION (2022)

添加到收藏夹

Article Immunology

Contact-Dependent Granzyme B-Mediated Cytotoxicity of Th17-Polarized Cells Toward Human Oligodendrocytes

Helene Jamann et al.

Summary: This study reveals that Th17-polarized cells form biologically significant contacts with OLs and exert direct toxicity by releasing granzyme B in multiple sclerosis.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Clinical Neurology

Pathomechanisms in demyelination and astrocytopathy: autoantibodies to AQP4, MOG, GFAP, GRP78 and beyond

Simone Mader et al.

Summary: The purpose of this review is to discuss the emerging pathomechanisms of diseases associated with autoantibodies and explore novel biomarkers and therapeutic approaches. Recent studies have shed light on both complement-dependent and complement-independent effector mechanisms, uncovering potential differences in therapy response.

CURRENT OPINION IN NEUROLOGY (2022)

添加到收藏夹

Article Immunology

Granzyme B in circulating CD8+T cells as a biomarker of immunotherapy effectiveness and disability in neuromyelitis optica spectrum disorders

Ziyan Shi et al.

Summary: This study investigated the CD8+ T cell phenotypes and levels of the cytotoxic protein granzyme B (GzmB) in patients with neuromyelitis optica spectrum disorders (NMOSD). The results showed that GzmB-expressing CD8+ T cells play a role in the inflammatory response in NMOSD and could potentially be used as a biomarker for disease immunotherapy effectiveness and disability progression.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Clinical Neurology

CD8+ T cell subpopulations and pro-inflammatory cytokines in neuromyelitis optica spectrum disorder

Ziyan Shi et al.

Summary: The study found that circulating CD8(+) T cell subpopulations were significantly altered in NMOSD and MS patients. Patients treated with immunotherapy showed improvements in CD8(+) T cell subpopulations in NMOSD. Furthermore, NMOSD patients exhibited higher levels of pro-inflammatory cytokines compared to healthy controls and MS patients, but these levels decreased in NMOSD patients receiving immunotherapy.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2021)

添加到收藏夹

Article Oncology

Long-term Follow-up and Correlative Analysis of Two Phase II Trials of Rituximab and Lenalidomide Followed by Continuous Lenalidomide in Untreated and Relapsed/Refractory Indolent Lymphoma

Joseph M. Tuscano et al.

Summary: Rituximab plus lenalidomide followed by continuous lenalidomide is effective with manageable toxicity in patients with previously untreated and R/R iNHL. This regimen produces durable remissions, even in heavily pretreated patients, with some lasting greater than 10 years. GranB(+) CD8(+) T cells and B cell levels may allow prediction of treatment response.

CLINICAL CANCER RESEARCH (2021)

添加到收藏夹

Article Immunology

Massive activity of cytotoxic cells during refractory Neuromyelitis Optica spectrum disorder

Vinicius O. Boldrini et al.

JOURNAL OF NEUROIMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

A Tridimensional Model for NK Cell-Mediated ADCC of Follicular Lymphoma

Emilie Decaup et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome

Catharina C. Gross et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Article Immunology

Epstein-Barr virus-associated immune reconstitution inflammatory syndrome as possible cause of fulminant multiple sclerosis relapse after natalizumab interruption

Barbara Serafini et al.

JOURNAL OF NEUROIMMUNOLOGY (2018)

添加到收藏夹

Article Clinical Neurology

Differences in T cell cytotoxicity and cell death mechanisms between progressive multifocal leukoencephalopathy, herpes simplex virus encephalitis and cytomegalovirus encephalitis

Susanne Laukoter et al.

ACTA NEUROPATHOLOGICA (2017)

添加到收藏夹

Review Clinical Neurology

Neurodegeneration in multiple sclerosis and neuromyelitis optica

Izumi Kawachi et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)

添加到收藏夹

Article Clinical Neurology

Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal

Catherine Larochelle et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

添加到收藏夹

Article Clinical Neurology

Risk of venous thromboembolism in neuromyelitis optica patients hospitalized for acute relapse

Rebecca Straus Farber et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

添加到收藏夹

Article Clinical Neurology

Immunological and pathological characterization of fatal rebound MS activity following natalizumab withdrawal

Catherine Larochelle et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

添加到收藏夹

Article Clinical Neurology

Risk of venous thromboembolism in neuromyelitis optica patients hospitalized for acute relapse

Rebecca Straus Farber et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

添加到收藏夹

Article Immunology

Programmed death 1 is highly expressed on CD8+ CD57+ T cells in patients with stable multiple sclerosis and inhibits their cytotoxic response to Epstein-Barr virus

Maria T. Cencioni et al.

IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

Massive intracerebral Epstein-Barr virus reactivation in lethal multiple sclerosis relapse after natalizumab withdrawal

Barbara Serafini et al.

JOURNAL OF NEUROIMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

Cytotoxic CD4+T Cells Drive Multiple Sclerosis Progression

Liesbet M. Peeters et al.

FRONTIERS IN IMMUNOLOGY (2017)

添加到收藏夹

Article Oncology

Peripheral blood T cell alterations in newly diagnosed diffuse large B cell lymphoma patients and their long-term dynamics upon rituximab-based chemoimmunotherapy

Simone Battella et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

添加到收藏夹

Review Immunology

Involvement of CD8+ T Cells in Multiple Sclerosis

Marion Salou et al.

FRONTIERS IN IMMUNOLOGY (2015)

添加到收藏夹

Review Immunology

B cells in MS and NMO: pathogenesis and therapy

Markus Krumbholz et al.

SEMINARS IN IMMUNOPATHOLOGY (2014)

添加到收藏夹

Article Clinical Neurology

Neuromyelitis Optica: Pathogenicity of Patient Immunoglobulin In Vivo

Monika Bradl et al.

ANNALS OF NEUROLOGY (2009)

添加到收藏夹

Article Clinical Neurology

Preferential Recruitment of Interferon-γ-Expressing TH17 Cells in Multiple Sclerosis

Hania Kebir et al.

ANNALS OF NEUROLOGY (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Hania Kebir et al.

NATURE MEDICINE (2007)

添加到收藏夹

Article Immunology

Phenotypic characterization of autoreactive T cells in multiple sclerosis

Robert B. Ratts et al.

JOURNAL OF NEUROIMMUNOLOGY (2006)

添加到收藏夹

Article Medicine, General & Internal

A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis

VA Lennon et al.

LANCET (2004)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.