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Review
Immunology
Seiichiro Sakai et al.
Summary: Severe loss of cerebral blood flow leads to hypoxia and glucose deprivation, causing cell death in the ischemic brain. Dead cells release alarmins to activate immune cells, resulting in inflammation and neuronal cell death. Poststroke inflammation resolves within several days, and neural repair restores neurological functions. Clearance of damaged brain molecules is crucial for resolving inflammation. This review describes the molecular dynamics, signaling pathways, and functions of alarmins in poststroke inflammation and resolution.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Article
Clinical Neurology
Yuyan Yang et al.
Summary: This study aimed to construct a valuable prognostic nomogram model incorporating hemoglobin levels for adult patients with intracerebral hemorrhage (ICH). Independent prognostic factors were identified and a new nomogram model was developed and validated. The model showed high accuracy in predicting early functional prognosis.
Article
Medicine, General & Internal
Wen-Jun Tu et al.
Summary: This study investigated the prevalence, incidence, and mortality rate of stroke in China in 2020 using a nationally representative sample. The results showed that the overall burden of stroke in mainland China was 2.6%, with higher prevalence in urban areas and higher incidence and mortality rates in rural areas. These findings highlight the need for an improved stroke prevention strategy in China.
Article
Immunology
Mian Zhou et al.
Summary: In this study, we identified a novel mechanism by which eCIRP impairs macrophage bacterial phagocytosis in sepsis. Increased eCIRP levels were associated with decreased bacterial clearance in infected mice. eCIRP inhibited actin remodeling in macrophages through the formation of a STAT3-beta PIX complex, resulting in phagocytic dysfunction. Inhibition of STAT3 rescued the macrophage phagocytic dysfunction induced by eCIRP.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Cell Biology
Peng Zhong et al.
Summary: CIRP, a stress-response protein, plays a role in various inflammatory-related diseases by modulating the expression of inflammatory genes and triggering inflammatory responses, such as acute lung injury and chronic obstructive pulmonary diseases. Its mechanism of action mainly involves its function as an RNA chaperone and its ability to induce inflammatory phenotypes in different cell types.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Mayowa O. Owolabi et al.
Summary: Stroke is a major global threat to life and disability, particularly in low- and middle-income countries that struggle to address its challenges. This article provides an overview of primary stroke prevention, estimating the cost and identifying deficiencies in guidelines and primary prevention approaches. Pragmatic solutions are offered, emphasizing the role of governments and population-wide strategies. Implementation of primary stroke prevention involves various stakeholders across the lifespan.
LANCET PUBLIC HEALTH
(2022)
Article
Biotechnology & Applied Microbiology
Xiaomin Ren et al.
Summary: This study found that plasma CIRP has independent prognostic value and it can improve the predictive value of the GRACE score for ACS patients.
Article
Medicine, General & Internal
Kristin Walter
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Immunology
Peng Zhong et al.
Summary: CIRP is a crucial stress-response protein that can adapt to various stress conditions intracellularly and act as a pro-inflammatory factor extracellularly in inflammatory settings. Genetic studies have highlighted the key role of eCIRP in inflammatory diseases, emphasizing the importance of targeting eCIRP in these conditions.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Clinical Neurology
Valery L. Feigin et al.
Summary: Regularly updated data on stroke including incidence, prevalence, mortality, disability, risk factors, and trends are crucial for evidence-based care planning. The Global Burden of Diseases Study provides comprehensive measurement of these metrics. From 1990 to 2019, while age-standardized rates improved, the number of strokes and deaths increased. Low-income countries had the highest stroke-related mortality and DALY rates, with high body-mass index being the fastest-growing risk factor.
Review
Pharmacology & Pharmacy
Peng Zhong et al.
Summary: CIRP is an intracellular stress-response protein that plays a significant role in cardiac physiology and diseases by regulating cardiac electrophysiological properties and protecting cardiomyocytes from apoptosis. These functions of CIRP are important for maintaining heart health under various stress conditions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Natsumi Maehara et al.
Summary: Sterile inflammation caused by DAMPs aggravates the prognosis of primary injury such as ischemic stroke. The AIM protein can reduce sterile inflammation by attenuating DAMPs and administration of AIM can ameliorate the deleterious effects of ischemic stroke. AIM binds to DAMPs through charge-based interactions and disulfide bond formation, promoting their phagocytic removal and neutralizing their inflammatory effects.AIM-deficient mice in experimental stroke show severe damage and higher mortality, while administration of recombinant AIM reduces sterile inflammation in the infarcted region, leading to a significant reduction in animal mortality. Targeting DAMPs may improve therapies for ischemic stroke.
Article
Cell Biology
Samantha M. Logan et al.
CELL STRESS & CHAPERONES
(2020)
Review
Neurosciences
Archna Sharma et al.
MOLECULAR NEUROBIOLOGY
(2020)
Article
Medicine, Research & Experimental
Naomi-Liza Denning et al.
Article
Medicine, Research & Experimental
Lifang Chen et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Review
Immunology
Naomi-Liza Denning et al.
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Cell Biology
Monowar Aziz et al.
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Cell Biology
Daniel A. Lujan et al.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2018)
Review
Oncology
Yi Liao et al.
INTERNATIONAL JOURNAL OF CANCER
(2017)
Article
Biochemistry & Molecular Biology
Mian Zhou et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2014)
Article
Clinical Neurology
Yang Wang et al.
Article
Clinical Neurology
Jamie L. Banks et al.