期刊
NATURAL PRODUCT RESEARCH
卷 31, 期 6, 页码 676-680出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1180604
关键词
Antimalarial; antitrypanosomal; antileishmanial; cytotoxicity
The bioactive petroleum ether fraction of Verbesina encelioides, previously studied by the authors, was chosen for the isolation of antiprotozoal metabolites. Pseudotaraxasterol-3 beta-acetate (1), benzyl 2,6-dimethoxy benzoate (2), 16 beta-hydroxy-pseudotaraxasterol-3 beta-palmitate (3) and pseudotaraxasterol (4), in addition to beta-sitosterol glucoside (5) and beta-sitosterol galactoside (6) were isolated and identified based on one-dimensional and two-dimensional spectral analysis. This is the first report describing (3) and (6) in genus Verbesina. The isolated compounds were tested in vitro against Plasmodium falciparum, Trypanosoma brucei, Trypanosoma cruzi and Leishmania infantum. Cytotoxicity was evaluated on MRC-5 cells. Compound 1 showed moderate to weak activity against L. infantum T. brucei and P. falciparum and was inactive against T. cruzi. Compound 3 showed moderate activity against L. infantum, compound 4 revealed weak activity against T. cruzi, while 5 and 6 were inactive against all tested protozoa. All compounds were non-cytotoxic. The isolated constituents showed less antiprotozoal activity than the crude fraction. [GRAPHICS] .
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