Role of exosomes in the development of the immune microenvironment in hepatocellular carcinoma

Article Cell Biology

Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis

Qidi Zhang et al.

Summary: Exosomal miR-222 promotes liver fibrosis by inhibiting TFRC and TFRC-induced ferroptosis in HBV-infected hepatocytes. This study reveals the significance of miR-222 and TFRC in the process of liver fibrosis.

CELL BIOLOGY AND TOXICOLOGY (2023)

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Article Gastroenterology & Hepatology

Disrupted BRCA1-PALB2 interaction induces tumor immunosuppression and T-lymphocyte infiltration in HCC through cGAS-STING pathway

Hui Ma et al.

Summary: This study reveals that persistent DNA damage caused by a defective BRCA pathway induces tumor immunosuppression and T-lymphocyte infiltration in HCC through the cGAS-STING pathway, providing insight into tumor immune microenvironment remodeling that may help improve HCC response to PD-1 antibody treatment.

HEPATOLOGY (2023)

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Article Oncology

Tumor-derived exosomes elicit cancer-associated fibroblasts shaping inflammatory tumor microenvironment in head and neck squamous cell carcinoma

Ikko Mito et al.

Summary: This study investigates the role of exosome-mediated crosstalk between tumor and stromal cells in HNSCC. It demonstrates that exosomes released from HNSCC tumor cells can convert normal fibroblasts into CAF-like cells and influence their gene expression and function. These findings highlight the importance of exosome-based cell-to-cell communication in creating an inflammatory tumor microenvironment.

ORAL ONCOLOGY (2023)

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Article Engineering, Biomedical

Nanodrug enhances post-ablation immunotherapy of hepatocellular carcinoma via promoting dendritic cell maturation and antigen presentation

Zecong Xiao et al.

Summary: Thermal ablation is an effective method for treating hepatocellular carcinoma, but it faces challenges of high recurrence and metastasis. The combination of immune-checkpoint blockade and thermal ablation has shown little progress in treating HCC. However, a study found that using a modified nanoplatform to deliver tumor-associated antigens and a demethylases inhibitor can improve the immune response to tumor growth and metastasis, synergizing with immune-checkpoint blockade treatment.

BIOACTIVE MATERIALS (2023)

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Article Gastroenterology & Hepatology

HBX suppresses PTEN to promote the malignant progression of hepatocellular carcinoma through mi-R155 activation

Lian-Jie Niu et al.

Summary: This study investigated the mechanism of HBx regulation of miR-155 and PTEN in HBV-HCC, revealing that miR-155 promotes hepatocellular carcinoma cell activity, inhibits apoptosis, and promotes invasion and migration. HBx can promote malignant transformation of hepatocellular carcinoma cells by upregulating miR-155.

ANNALS OF HEPATOLOGY (2022)

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Article Environmental Sciences

Exosomal lncRNA HMMR-AS1 mediates macrophage polarization through miR-147a/ARID3A axis under hypoxia and affects the progression of hepatocellular carcinoma

Xu Wang et al.

Summary: This study discovered and verified the role of lncRNA HMMR-AS1 in HCC and elucidated its regulation of ARID3A-mediated macrophage polarization through competitive binding to miR-147a. These findings provide a new direction for the research on the pathogenesis of HCC and the development of targeted therapy.

ENVIRONMENTAL TOXICOLOGY (2022)

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Article Oncology

Global, regional and national burden of primary liver cancer by subtype

Harriet Rumgay et al.

Summary: This study provides worldwide, regional, and national estimates of the incidence of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). The results show that HCC contributes the largest burden of liver cancer globally, with the highest rates in Eastern Asia, Northern Africa, and Southeastern Asia. iCCA rates are highest in Southeastern Asia, Eastern Asia, Northern Europe, the Caribbean and Central America, and Oceania.

EUROPEAN JOURNAL OF CANCER (2022)

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Review Biochemistry & Molecular Biology

Hepatocellular Carcinoma in Chronic Viral Hepatitis: Where Do We Stand?

Francesco Paolo Russo et al.

Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness

Chaoyi Chen et al.

Summary: The study reveals that circRHOBTB3 is upregulated in serum and downregulated in tissue samples of CRC patients, with the downregulation associated with poor prognosis. CircRHOBTB3 acts as a tumor suppressor by repressing metabolic pathways and intracellular ROS production. SNF8 is identified as the protein responsible for sorting circRHOBTB3 into exosomes, and CRC cells secrete more circRHOBTB3 compared to normal cells. Antisense oligonucleotides targeting regulatory elements of circRHOBTB3 can increase its expression and inhibit its exosomal secretion, thereby inhibiting CRC growth and metastasis.

MOLECULAR CANCER (2022)

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Article Cell Biology

Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3

Lei Zhang et al.

Summary: In this study, the researchers found that exosomes derived from macrophages with overexpressed RBPJ can inhibit the progression of hepatocellular carcinoma through the hsa_circ_0004658/miR-499b-5p/JAM3 pathway. The findings suggest that hsa_circ_0004658 could serve as a diagnostic biomarker and potential therapeutic target for HCC.

CELL DEATH & DISEASE (2022)

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Review Physiology

Autophagy and Exosomes: Cross-Regulated Pathways Playing Major Roles in Hepatic Stellate Cells Activation and Liver Fibrosis

Eleftheria M. Mastoridou et al.

Summary: Chronic liver injury leads to altered liver structure and excessive extracellular matrix production, resulting in cirrhosis. Hepatic stellate cells play a crucial role in fibrosis and their activation is regulated by autophagy and exosomes, while they are also influenced by stimuli from neighboring cells.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/nuclear factor -kappa B (NF-κB) pathway

Yun Zhou et al.

Summary: The study found that CAFs-derived exosomes deliver circZFR to HCC cells, promoting HCC development and chemoresistance.

BIOENGINEERED (2022)

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Article Oncology

Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells

Mingyao Huang et al.

Summary: Exosomal circGSE1 derived from hepatocellular carcinoma (HCC) cells promotes HCC progression by inducing expansion of regulatory T cells (Tregs) via the miR-324-5p/TGFBR1/Smad3 axis.

CANCER SCIENCE (2022)

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Article Oncology

Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses

Bingfeng Zuo et al.

Summary: This study demonstrates the feasibility of personalized immunotherapy for hepatocellular carcinoma (HCC) using biological nanovaccines that induce specific tumor immune responses without the need to identify tumor antigens.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Gastroenterology & Hepatology

Blocking CD47 promotes antitumour immunity through CD103+ dendritic cell-NK cell axis in murine hepatocellular carcinoma model

Shuai Wang et al.

Summary: In addition to the classical DC-T cell axis, CD47 blockade significantly enhances the ability of CD103(+) DCs to take up tumor DNA, resulting in the stimulation of the cGAS-STING pathway and the promotion of NK cell infiltration and activation in liver cancer.

JOURNAL OF HEPATOLOGY (2022)

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Article Medicine, Research & Experimental

LncRNA MAPKAPK5_AS1 facilitates cell proliferation in hepatitis B virus -related hepatocellular carcinoma

Lianyuan Tao et al.

Summary: Our study reveals that the hepatitis-B antigen HBeAg found in HBV+HCC upregulates long non-coding RNA MAPKAPK5_AS1 (MAAS) expression in M2 macrophages by affecting its m6A modification. MAAS is transferred to HBV+HCC cells via exosomes, which in turn facilitates their proliferation. This is a novel role for MAAS and further elucidates the mechanism of HBeAg-induced HBV-related HCC development.

LABORATORY INVESTIGATION (2022)

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Review Pharmacology & Pharmacy

The roles of TGF-I3 and VEGF pathways in the suppression of antitumor immunity in melanoma and other solid tumors

Melissa T. Bu et al.

Summary: Immune checkpoint blockade is a well-known approach in cancer therapy, but drug resistance remains a challenge. Gene signatures associated with innate resistance to PD-1 antibody therapy were enriched, with TGF-β and VEGFA pathways identified as dominant drivers. Targeting TGF-β using trap antibodies offers promise for localized therapy within the tumor microenvironment.

PHARMACOLOGY & THERAPEUTICS (2022)

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Article Medicine, Research & Experimental

MicroRNA-10b promotes arthritis development by disrupting CD4+ T cell subtypes

Jiajie Tu et al.

Summary: miR-10b disrupts the balance of CD4(+) T cell subsets and promotes the progression of rheumatoid arthritis (RA). Inhibiting miR-10b can alleviate the severity of arthritis.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

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Review Immunology

Ferroptosis: A Critical Moderator in the Life Cycle of Immune Cells

Ping Wang et al.

Summary: The aim of this review is to explore the relationship between ferroptosis and immune cells, as well as the role of ferroptosis in infection, inflammation, and tumors, in order to identify potential therapeutic targets.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

Exosomal miR-142-3p secreted by hepatitis B virus (HBV)-hepatocellular carcinoma (HCC) cells promotes ferroptosis of M1-type macrophages through SLC3A2 and the mechanism of HCC progression

Zongqiang Hu et al.

Summary: miR-142-3p promotes ferroptosis in HBV-infected M1-type macrophages through SLC3A2, affecting the production of GSH, MDA, and Fe2+, and accelerating the development of HCC.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2022)

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Article Cell Biology

Breast Cancer Exosome-Derived miR-425-5p Induces Cancer-Associated Fibroblast-Like Properties in Human Mammary Fibroblasts by TGFβ1/ROS Signaling Pathway

Yue Zhu et al.

Summary: The microRNA miR-425-5p plays an important role in the interaction between breast cancer cells and fibroblasts. It promotes the conversion of fibroblasts into cancer-associated fibroblasts (CAFs), thereby supporting tumor progression and metastasis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

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Review Immunology

Engineered exosomes for studies in tumor immunology

Ahmet Alptekin et al.

Summary: Exosomes are small extracellular vesicles secreted by cells, capable of altering the microenvironment through interactions with other cells. Engineered and designer exosomes hold great potential for delivering drugs and biologically active molecules to specific sites, opening up new avenues for diagnosis and treatment.

IMMUNOLOGICAL REVIEWS (2022)

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Article Cell & Tissue Engineering

Mesenchymal stem cell-derived exosomes protect against liver fibrosis via delivering miR-148a to target KLF6/STAT3 pathway in macrophages

Siyuan Tian et al.

Summary: This study found that mesenchymal stem cells (MSCs) protect against liver fibrosis by delivering miR-148a through their secreted exosomes (MSC-EXOs) to regulate intrahepatic macrophage functions. This finding provides a potential therapeutic target for liver fibrosis.

STEM CELL RESEARCH & THERAPY (2022)

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Article Oncology

Designer Exosomes for Targeted Delivery of a Novel Therapeutic Cargo to Enhance Sorafenib-Mediated Ferroptosis in Hepatocellular Carcinoma

Xiaoju Li et al.

Summary: Sorafenib is an effective drug for treating hepatocellular carcinoma, but drug resistance is common. This study developed a nanoparticle delivery system that targets hepatocellular carcinoma and enhances the anticancer activity of sorafenib by silencing GPX4 and DHODH genes.

FRONTIERS IN ONCOLOGY (2022)

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Article Oncology

Differentially expressed liver exosome-related genes as candidate prognostic biomarkers for hepatocellular carcinoma

Bangyou Zuo et al.

Summary: This study identified exosome-related genes in hepatocellular carcinoma (HCC) and established a prognostic model based on these genes. Exosome features were found to positively regulate immune response, indicating their potential role in precision treatment for HCC.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Article Pharmacology & Pharmacy

Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models

Ho Yong Kim et al.

Summary: Studies have shown that NK cell-derived exosomes (NK-exo) have strong anti-tumor effects in liver cancer by inhibiting cell proliferation and promoting cell apoptosis.

DRUG DELIVERY (2022)

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Article Oncology

Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis pathway

Minghao Xu et al.

Summary: This study found that tumor-associated macrophages enhance aerobic glycolysis and proliferation in hepatocellular carcinoma cells by transmitting a long non-coding RNA called lncMMPA through exosomes. Furthermore, lncMMPA increases the proliferation of HCC cells by interacting with miR-548s. Clinically, lncMMPA expression is associated with glycolysis in TAMs and reduced survival of HCC patients.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

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Review Medicine, General & Internal

Hepatocellular carcinoma

Arndt Vogel et al.

Summary: Hepatocellular carcinoma is a common cancer worldwide, with non-alcoholic fatty liver disease becoming a dominant cause. Treatment options are varied, including surgery, radiation, and medication. With the approval of new drugs and the development of immunotherapy, the outlook for hepatocellular carcinoma patients has improved, but the optimal sequencing of drugs and predictive biomarkers still need further research.

LANCET (2022)

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Review Biochemistry & Molecular Biology

Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

Zhengjun Lin et al.

Summary: This article systematically summarizes the roles and detailed molecular mechanisms of mesenchymal stem cell-derived exosomes (MSC-derived exosomes) in mediating cancer therapy resistance, providing novel insights into the clinical applications of MSC-derived exosomes in cancer management.

MOLECULAR CANCER (2022)

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Article Multidisciplinary Sciences

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Aveline Filliol et al.

Summary: The shift in HSC subpopulations during chronic liver disease is associated with a switch from HCC protection to promotion. Quiescent and cytokine-producing HSCs prevent hepatocyte death and HCC development, while activated myofibroblastic HSCs promote proliferation and tumor development through increased stiffness and TAZ and discoidin domain receptor 1 activation.

NATURE (2022)

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Article Immunology

Exosomal miR-452-5p Induce M2 Macrophage Polarization to Accelerate Hepatocellular Carcinoma Progression by Targeting TIMP3

Zongqiang Hu et al.

Summary: This study found that exosomal miR-452-5p secreted by HCC cells can induce polarization of M2 macrophages and stimulate HCC progression by targeting TIMP3.

JOURNAL OF IMMUNOLOGY RESEARCH (2022)

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Review Immunology

H-TEX-mediated signaling between hepatocellular carcinoma cells and macrophages and exosome-targeted therapy for hepatocellular carcinoma

Sihang Yu et al.

Summary: There is increasing evidence showing the crucial role of the immune microenvironment, particularly the polarization state and function of macrophages, in the development of hepatocellular carcinoma. Tumor-derived exosomes in hepatocellular carcinoma act as information carriers and regulate the physiological state of cells in the microenvironment, thus controlling cancer progression. This review focuses on the role of exosome content in disease outcomes at different stages of hepatitis B virus/hepatitis C virus-induced hepatocellular carcinoma, and explores the mechanism by which macrophages contribute to hepatocellular carcinoma formation and the regulation of macrophage functions by the heterogeneity of exosome loading. The application prospects of exosome-based targeted drug delivery in immunotherapy research on hepatocellular carcinoma are also summarized.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases

Tao Wan et al.

Summary: CRISPR-Cas9 gene editing is a powerful therapeutic technology, but the lack of safe and efficient in vivo delivery systems limits its clinical applications. Researchers have developed a novel gene editing delivery system, called exosomeRNP, which loads Cas9 RNPs into purified exosomes derived from hepatic stellate cells. exosomeRNP enables effective cytosolic delivery of RNPs in vitro and specifically accumulates in liver tissue in vivo. By targeting different genes, exosomeRNP demonstrates considerable therapeutic potential in acute liver injury, chronic liver fibrosis, and hepatocellular carcinoma mouse models. This study provides a feasible platform for precise and tissue-specific gene therapies for liver diseases.

SCIENCE ADVANCES (2022)

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Article Biochemistry & Molecular Biology

Exosomal miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression

Liyan Wang et al.

Summary: This study investigated the function of circFUT8 in hepatocellular carcinoma (HCC) and its interaction with exosomes, M1 macrophages, and m6A. The results showed that M1 macrophages-derived exosomal miR-628-5p inhibited the m6A modification of circFUT8, thereby inhibiting HCC development.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2022)

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Article Biochemistry & Molecular Biology

Exosome-depleted MiR-148a-3p derived from Hepatic Stellate Cells Promotes Tumor Progression via ITGA5/PI3K/Akt Axis in Hepatocellular Carcinoma

Xiangyu Zhang et al.

Summary: MiR-148a-3p derived from activated HSCs accelerates HCC progression through ITGA5/PI3K/Akt signaling pathway. These findings contribute to a better understanding of the molecular mechanisms underlying the development of HCC.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

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Article Immunology

Detection of exosomal miR-18a and miR-222 levels in Egyptian patients with hepatic cirrhosis and hepatocellular carcinoma

Eman A. Elghoroury et al.

Summary: This study found that miR-18a and miR-222 could be used as serum markers to differentiate between liver cirrhosis, HCC, and healthy controls. These miRNAs may also be useful in identifying liver injuries, but they have more prognostic value than diagnostic value.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2022)

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Article Multidisciplinary Sciences

Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity

Sushrut Kamerkar et al.

Summary: Researchers have developed an engineered exosome therapeutic candidate that selectively silences the expression of STAT6 gene in tumor-associated macrophages (TAMs). This drug shows high efficacy in inhibiting tumor growth and inducing complete remissions in colorectal cancer and hepatocellular carcinoma models. It also remodels the tumor microenvironment and triggers a specific immune response mediated by CD8 T cells.

SCIENCE ADVANCES (2022)

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Review Biochemistry & Molecular Biology

Exosomes as mediators of immune regulation and immunotherapy in cancer

Fernanda G. Kugeratski et al.

Summary: Exosomes play crucial roles in cancer by either promoting tumor development or inhibiting tumor immune suppression. They deliver signals that affect immune regulation of lymphoid and myeloid cell populations in tumors.

FEBS JOURNAL (2021)

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Article Cell Biology

Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4

Yu-Shui Ma et al.

Summary: Exosomal miR-15a derived from MSCs can inhibit the proliferative, migrating, and invasive abilities of HCC cells by downregulating SALL4 expression. The exosomes successfully deliver miR-15a to HCC cells, leading to decreased tumorigenicity and metastasis of HCC tumors. In vivo experiments in nude mice further confirmed the inhibitory effects of exosomal miR-15a on HCC development.

CELL DEATH DISCOVERY (2021)

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Editorial Material Cell Biology

M2 macrophage-derived extracellular vesicles facilitate CD8+T cell exhaustion in hepatocellular carcinoma via the miR-21-5p/YOD1/YAP/β-catenin pathway

Jian Pu et al.

Summary: This study revealed that M2 macrophage-derived extracellular vesicles facilitated CD8(+) T cell exhaustion in HCC patients through the miR-21-5p/YOD1/YAP/beta-catenin axis. Inhibition of miR-21-5p or overexpression of YOD1 could annul the promoting effect of EVs on CD8(+) T cell exhaustion.

CELL DEATH DISCOVERY (2021)

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Article Engineering, Biomedical

M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

Gowri Rangaswamy Gunassekaran et al.

Summary: In this study, M1 macrophage-derived exosomes were engineered to reprogram TAMs into M1-like macrophages for inhibiting tumor growth. The results showed that systemic administration of these exosomes increased anti-tumor immunity more efficiently than untargeted and control peptide-labeled exosomes.

BIOMATERIALS (2021)

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Article Gastroenterology & Hepatology

Dual targeting of PD-L1 and PD-L2 by PCED1B-AS1 via sponging hsa-miR-194-5p induces immunosuppression in hepatocellular carcinoma

Fei Fan et al.

Summary: In HCC, PD-L1 and PD-L2 expression are highly correlated, while PCED1B-AS1 and hsa-miR-194-5p expression are up-regulated. PCED1B-AS1 interacts with hsa-miR-194-5p to inhibit PD-Ls expression, promoting immunosuppression in HCC cells. This study suggests a potential role of PCED1B-AS1 in regulating immune response and tumor behavior in HCC.

HEPATOLOGY INTERNATIONAL (2021)

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Article Immunology

Exosomes secreted by M2 macrophages promote cancer stemness of hepatocellular carcinoma via the miR-27a-3p/TXNIP pathways

Wenxiao Li et al.

Summary: The study revealed that miR-27a-3p derived from M2 macrophages promotes cancer stemness of HCC by downregulating TXNIP, leading to increased proliferation, drug resistance, migration, invasion, and in vivo tumorigenicity.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Immunology

miR-660-5p-loaded M2 macrophages-derived exosomes augment hepatocellular carcinoma development through regulating KLF3

BingZhang Tian et al.

Summary: The study revealed higher levels of miR-660-5p and lower levels of KLF3 in HCC tissues. It was found that miR-660-5p targets KLF3. MiR-660-5p-loaded M2-Exo enhance HCC development by downregulating KLF3.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Oncology

Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma

Jia-Cheng Lu et al.

Summary: This study revealed that elevated circTMEM181 in HCC patients contributes to poor response to anti-PD1 therapy and prognosis. High levels of exosomal circTMEM181 facilitate an immunosuppressive microenvironment and resistance to anti-PD1 therapy in HCC by sponging miR-488-3p and upregulating CD39 in macrophages. Targeting CD39 in macrophages to inhibit the ATP-adenosine pathway may overcome anti-PD1 resistance in HCC.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

A dual immune signature of CD8+T cells and MMP9 improves the survival of patients with hepatocellular carcinoma

Huan Ding et al.

Summary: The study utilized the CIBERSORT algorithm to evaluate immune cell infiltration patterns in HCC and identified a dual immune signature of CD8+ T cells and MMP9 as a potential factor in improving patient survival rates.

BIOSCIENCE REPORTS (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Cell Biology

The Power of Plasticity?Metabolic Regulation of Hepatic Stellate Cells

Parth Trivedi et al.

Summary: Hepatic stellate cells play a crucial role in regulating physiological and pathological responses in the liver, particularly in chronic liver injury. They drive hepatic fibrosis and are involved in inflammation and cancer by adapting metabolic pathways to meet increased energy demands.

CELL METABOLISM (2021)

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Article Oncology

Molecular Features of Cancer-associated Fibroblast Subtypes and their Implication on Cancer Pathogenesis, Prognosis, and Immunotherapy Resistance

Phillip M. Galbo et al.

Summary: This study conducted a comprehensive analysis of CAFs from multiple cancer types, identified shared molecular characteristics in CAF subtypes, and revealed the association of different CAF subtypes with clinical outcomes and immunotherapy resistance.

CLINICAL CANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Xiaoqi Mao et al.

Summary: CAFs, as a crucial component of TME, play significant roles in promoting tumor growth, invasion, and metastasis. The interaction between CAFs and tumor cells, as well as immune cells in TIME, is critical for tumor progression.

MOLECULAR CANCER (2021)

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Article Gastroenterology & Hepatology

Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression

Mengjia Song et al.

Summary: This study revealed a cytokine-mediated cellular crosstalk and clinical network involving the CLCF1-CXCL6/TGF-beta axis, which regulates the positive feedback loop among CAFs, tumor stemness, and TANs, HCC progression, and patient prognosis. The up-regulation of the CLCF1-CXCL6/TGF-beta axis in clinical samples showed a correlation with increased cancer stem cells, N2-polarized TANs, tumor stage, and poor prognosis. This suggests the CLCF1 cascade could be a potential prognostic biomarker and targeting CLCF1/ ciliary neurotrophic factor receptor or ERK1/2 signaling could provide an effective therapeutic target for patients with HCC.

HEPATOLOGY (2021)

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Article Chemistry, Multidisciplinary

Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation

GyeungYun Kim et al.

Summary: Exosomes engineered for pulmonary delivery of RAGE-binding peptide (RBP) showed enhanced anti-inflammatory effects, especially when curcumin was loaded into the exosomes. These findings suggest that RBP-exo/Cur may serve as a promising therapy for acute lung injury.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Medicine, Research & Experimental

Treatment for Hepatocellular Carcinoma Is Enhanced When Norcantharidin Is Encapsulated in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells

Leyi Liang et al.

Summary: The study demonstrates that BMSC-Exos-NCTD effectively promotes cellular uptake, induces cell cycle arrest, reduces tumor cell proliferation, increases apoptosis, and shows significant in vitro and in vivo antitumor effects against HCC. Additionally, BMSC-Exos exhibit in situ homing effects on tumor sites in mice and do not show body toxicity, while also repairing damaged liver tissues and promoting cell proliferation. Overall, BMSC-Exos have great potential as drug carriers for HCC treatment in combination with anticancer drugs.

MOLECULAR PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis

Min Tang et al.

Summary: Hepatic fibrosis is a wound healing response caused by chronic liver injury, where STAT3 plays a crucial role. Using exosomes as a delivery system, this study showed that iExo(siRNA-STAT3) or iExo(mASO-STAT3) effectively targeted STAT3, leading to suppression of liver fibrosis and improved liver function in mice.

FASEB JOURNAL (2021)

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Article Nanoscience & Nanotechnology

Downregulation of hsa_circ_0074854 Suppresses the Migration and Invasion in Hepatocellular Carcinoma via Interacting with HuR and via Suppressing Exosomes-Mediated Macrophage M2 Polarization

Yong Wang et al.

Summary: The study revealed upregulation of hsa_circ_0074854 in HCC, with its knockdown inhibiting tumor growth. Mechanistically, hsa_circ_0074854 knockdown reduced HCC cell migration and invasion by interacting with HuR. Moreover, hsa_circ_0074854 was transferred from HCC cells to macrophages via exosomes, suppressing macrophage M2 polarization and subsequently inhibiting HCC cell migration and invasion.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Oncology

Norcholic Acid Promotes Tumor Progression and Immune Escape by Regulating Farnesoid X Receptor in Hepatocellular Carcinoma

Yihang Gong et al.

Summary: NorCA promotes HCC progression by negatively regulating FXR and inducing an immunosuppressive microenvironment, which suggests a potential combination therapy of FXR agonist and anti-PD-1 antibody for treating HCC.

FRONTIERS IN ONCOLOGY (2021)

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Article Gastroenterology & Hepatology

Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease

Xin Luo et al.

Summary: miR-1297 is overexpressed in exosomes derived from lipotoxic hepatocytes, promoting the activation and proliferation of hepatic stellate cells through the PTEN/PI3K/AKT signaling pathway, accelerating the progression of MAFLD.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

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Article Cell Biology

MIRLET7BHG promotes hepatocellular carcinoma progression by activating hepatic stellate cells through exosomal SMO to trigger Hedgehog pathway

Yunhong Xia et al.

Summary: This study reveals the significance of SMO in HCC progression by activating HSCs via exosomes, and identifies the involvement of specific miRNAs and signaling pathways in this process.

CELL DEATH & DISEASE (2021)

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Article Oncology

Overexpressed Tumor Suppressor Exosomal miR-15a-5p in Cancer Cells Inhibits PD1 Expression in CD8+T Cells and Suppresses the Hepatocellular Carcinoma Progression

Hong-Yu Zhang et al.

Summary: The study revealed that miR-15a-5p expression was decreased in HCC tissues and cell lines, indicating a poor prognosis. Overexpression of miR-15a-5p inhibited the viability, proliferation, migration, and invasion of HepG2 cells. It was found that exosomes released from cancer cells contained miR-15a-5p, which inhibited PD1 expression in CD8+ T cells through exo-miR-15a-5p. This inhibition ultimately suppressed the development of HCC.

FRONTIERS IN ONCOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Mesenchymal Stem Cells-Derived Exosomes as Dexamethasone Delivery Vehicles for Autoimmune Hepatitis Therapy

Jiawei Zhao et al.

Summary: Exosomes, particularly Exo@DEX, have shown promising potential as a drug carrier for autoimmune hepatitis (AIH) by efficiently improving the accumulation of dexamethasone (DEX) in the liver, suggesting potential applications in other diseases as well.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Oncology

MARCKS on Tumor-Associated Macrophages is Correlated with Immune Infiltrates and Poor Prognosis in Hepatocellular Carcinoma

Xudong Ren et al.

Summary: The study reveals that MARCKS expression on TAMs is associated with poor prognosis and immune cell infiltration in HCC.

CANCER INVESTIGATION (2021)

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Article Medicine, Research & Experimental

A human chorionic gonadotropin (hCG) delivery platform using engineered uterine exosomes to improve endometrial receptivity

Hamed Hajipour et al.

Summary: This study demonstrated the potential of uterine fluid-derived exosomes as a carrier for delivering hCG to endometrial cells, enhancing endometrial receptivity. The effect of hCG-loaded exosomes on endometrial receptivity exceeded that of hCG or exosomes alone. Furthermore, hCG-loaded exosomes showed enhanced regulation of specific gene expression compared to hCG alone.

LIFE SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Delivery of miR-26a Using an Exosomes-Based Nanosystem Inhibited Proliferation of Hepatocellular Carcinoma

Shaya Mahati et al.

Summary: This study designed a delivery nano system using modified exosomes as carriers, successfully delivering miR-26a to hepatocellular carcinoma cells and inhibiting cell proliferation and migration, with favorable anti-tumor effects in vivo. This provided a new perspective for using exosome delivery systems in miRNA-based antitumor therapy.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Biochemistry & Molecular Biology

Extra- and Intra-Cellular Mechanisms of Hepatic Stellate Cell Activation

Yufei Yan et al.

Summary: Hepatic fibrosis is characterized by the accumulation of extracellular matrix in the liver due to persistent injury. Understanding the cellular and molecular mechanisms controlling the fibrotic response is crucial for developing clinical strategies to prevent fibrosis progression. Activation of hepatic stellate cells plays a key role in promoting ECM synthesis, and various external signals contribute to this process.

BIOMEDICINES (2021)

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Article Biochemistry & Molecular Biology

An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+exosomes activity

Yanping Wei et al.

Summary: The study identified potential HMGB1-driven RNA-RNA crosstalk networks in HCC and explored their roles at different stages of the disease, suggesting the potential for RNA-based precision therapy. Interventions against HMGB1 and RICTOR in HCC cells demonstrated the potential to enhance the effectiveness of immunotherapy.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Biochemistry & Molecular Biology

GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages

Jinhong Chen et al.

Summary: The study reveals that GOLM1 induces CD8(+) T cell suppression in HCC by promoting PD-L1 stabilization and transporting PD-L1 into TAMs via exosomes. Targeting PD-L1(+) TAMs could be a novel strategy to enhance the efficacy of anti-PD-L1 therapy in HCC.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Medicine, Research & Experimental

An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment

Chih-Hsiung Hsieh et al.

Summary: This study demonstrates the dual properties of zero-valent-iron nanoparticles (ZVI-NP) in inducing cancer-specific cytotoxicity and anti-cancer immunity, highlighting their potential as an advanced integrated anti-cancer strategy. ZVI-NP not only induces cancer cell death but also enhances the anti-tumor immune response in animal models.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy

Jianbing Du et al.

Summary: This study successfully designed an exosome-based platform to deliver ferroptosis inducer and photosensitizer into liver cancer cells, inducing cell death significantly while minimizing toxicity to the liver and kidney.

THERANOSTICS (2021)

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Review Oncology

The immunological and metabolic landscape in primary and metastatic liver cancer

Xin Li et al.

Summary: This review discusses the unique immunological and metabolic features of the liver during cancer development, and how these factors can impact the development of primary liver cancer and liver metastases. The liver is often influenced by chronic inflammation and metabolic alterations, which may affect cancer metastasis.

NATURE REVIEWS CANCER (2021)

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Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

THERANOSTICS (2021)

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Article Oncology

MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway

Guohua Lou et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

The significance of exosomes in the development and treatment of hepatocellular carcinoma

Xin Li et al.

MOLECULAR CANCER (2020)

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Article Oncology

Long noncoding RNA LINC00662 promotes M2 macrophage polarization and hepatocellular carcinoma progression via activating Wnt/β-catenin signaling

Xiaohui Tian et al.

MOLECULAR ONCOLOGY (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Melanoma cell-derived exosomes in plasma of melanoma patients suppress functions of immune effector cells

Priyanka Sharma et al.

SCIENTIFIC REPORTS (2020)

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Article Medicine, Research & Experimental

PTEN inhibitor VO-OHpic suppresses TSC2-/- MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway

Wenda Wang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

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Article Multidisciplinary Sciences

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice

Bingfeng Zuo et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer

Yann Kieffer et al.

CANCER DISCOVERY (2020)

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Review Cell Biology

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Natascha Roehlen et al.

CELLS (2020)

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Review Oncology

Designer Exosomes: A New Platform for Biotechnology Therapeutics

Davod Jafari et al.

BIODRUGS (2020)

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Article Biochemistry & Molecular Biology

The miR-92a-2-5p in exosomes from macrophages increases liver cancer cells invasion via altering the AR/PHLPP/p-AKT/β-catenin signaling

Guodong Liu et al.

CELL DEATH AND DIFFERENTIATION (2020)

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Article Biochemistry & Molecular Biology

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

Peng-Fei Zhang et al.

MOLECULAR CANCER (2020)

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Review Immunology

Fibroblast heterogeneity in tumor micro-environment: Role in immunosuppression and new therapies

Rana Mhaidly et al.

SEMINARS IN IMMUNOLOGY (2020)

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Article Cell Biology

PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

Xiaozhe Yin et al.

CELL REPORTS (2020)

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Article Immunology

Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer via the miR-92/PD-L1 Pathway

Dongwei Dou et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Oncology

Roles of IFN-γ in tumor progression and regression: a review

Dragica Jorgovanovic et al.

BIOMARKER RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Exosome-based immunotherapy: a promising approach for cancer treatment

Zhijie Xu et al.

MOLECULAR CANCER (2020)

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Article Oncology

Enhanced antitumor efficacy through microwave ablation combined with a dendritic cell-derived exosome vaccine in hepatocellular carcinoma

Xinyu Zhong et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2020)

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Article Cell Biology

A combined eat me/don't eat me strategy based on extracellular vesicles for anticancer nanomedicine

Zakia Belhadj et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Gastroenterology & Hepatology

Endoplasmic Reticulum Stress Causes Liver Cancer Cells to Release Exosomal miR-23a-3p and Up-regulate Programmed Death Ligand 1 Expression in Macrophages

Jiatao Liu et al.

HEPATOLOGY (2019)

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Article Biochemistry & Molecular Biology

TIMP-3 suppression induces choroidal neovascularization by moderating the polarization of macrophages in age-related macular degeneration

Ying Cheng et al.

MOLECULAR IMMUNOLOGY (2019)

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Article Multidisciplinary Sciences

Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs

Betul Gokyavuz et al.

SCIENTIFIC REPORTS (2019)

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Article Biotechnology & Applied Microbiology

Exosome origin determines cell targeting and the transfer of therapeutic nanoparticles towards target cells

Maria Sancho-Albero et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Exosomes in cancer development, metastasis, and immunity

Lin Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Review Immunology

Transforming Growth Factor-β Signaling in Immunity and Cancer

Eduard Batlle et al.

IMMUNITY (2019)

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Review Biochemistry & Molecular Biology

The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

Jacopo Baglieri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Nanoscience & Nanotechnology

Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy

Faezeh Vakhshiteh et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Oncology

SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC

Chunlai Yin et al.

ONCOIMMUNOLOGY (2019)

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Article Surgery

Circulating exosomal miR-92b: Its role for cancer immunoediting and clinical value for prediction of posttransplant hepatocellular carcinoma recurrence

Toshiaki Nakano et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

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Article Oncology

NOTCH Signaling via WNT Regulates the Proliferation of Alternative, CCR2-Independent Tumor-Associated Macrophages in Hepatocellular Carcinoma

Yu-Chen Ye et al.

CANCER RESEARCH (2019)

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Article Oncology

Circulating exosomes from esophageal squamous cell carcinoma mediate the generation of B10 and PD-1high Breg cells

Yu Mao et al.

CANCER SCIENCE (2019)

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Article Hematology

Human acute myeloid leukemia blast-derived exosomes in patient-derived xenograft mice mediate immune suppression

Chang-Sook Hong et al.

EXPERIMENTAL HEMATOLOGY (2019)

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Article Chemistry, Multidisciplinary

Friend or Foe? Evidence Indicates Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein

Ran Chen et al.

SMALL (2019)

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Article Medicine, Research & Experimental

Exosomes Derived From T Regulatory Cells Suppress CD8+ Cytotoxic T Lymphocyte Proliferation and Prolong Liver Allograft Survival

Liang Chen et al.

MEDICAL SCIENCE MONITOR (2019)

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Article Biochemistry & Molecular Biology

KLF3 is a crucial regulator of metastasis by controlling STAT3 expression in lung cancer

Wei Sun et al.

MOLECULAR CARCINOGENESIS (2019)

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Review Gastroenterology & Hepatology

A global view of hepatocellular carcinoma: trends, risk, prevention and management

Ju Dong Yang et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

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Review Genetics & Heredity

The biogenesis, biology and characterization of circular RNAs

Lasse S. Kristensen et al.

NATURE REVIEWS GENETICS (2019)

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Article Oncology

PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

Jiaqiang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Oncology

Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms

Paolo Neviani et al.

CANCER RESEARCH (2019)

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Review Cell Biology

Exosomes in hepatocellular carcinoma: a new horizon

Rui Chen et al.

CELL COMMUNICATION AND SIGNALING (2019)

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Article Gastroenterology & Hepatology

Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer

Delphine Goehrig et al.

GUT (2019)

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Review Biotechnology & Applied Microbiology

Turning foes to friends: targeting cancer-associated fibroblasts

Xueman Chen et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Medicine, Research & Experimental

Exosome-Mediated MiR-155 Transfer Contributes to Hepatocellular Carcinoma Cell Proliferation by Targeting PTEN

Jing-Feng Sun et al.

MEDICAL SCIENCE MONITOR BASIC RESEARCH (2019)

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Article Medicine, Research & Experimental

Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis

Xiao-Peng Tian et al.

THERANOSTICS (2019)

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Review Medicine, Research & Experimental

Design strategies and application progress of therapeutic exosomes

Chunying Liu et al.

THERANOSTICS (2019)

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Article Oncology

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

Ana Costa et al.

CANCER CELL (2018)

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Letter Cell Biology

Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth

Yi Yang et al.

CELL RESEARCH (2018)

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Article Oncology

Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment

Takuya Kato et al.

CLINICAL CANCER RESEARCH (2018)

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Review Immunology

NKG2D and its ligands in cancer

Payal Dhar et al.

CURRENT OPINION IN IMMUNOLOGY (2018)

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Article Gastroenterology & Hepatology

Exosome miR-335 as a novel therapeutic strategy in hepatocellular carcinoma

Fang Wang et al.

HEPATOLOGY (2018)

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Article Nanoscience & Nanotechnology

Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

Gaofeng Liang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Cell Biology

LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway

Xiaoyu Liao et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)

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Article Biochemistry & Molecular Biology

Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379

K. P. O'Brien et al.

ONCOGENE (2018)

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Article Biochemistry & Molecular Biology

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

Meng-Xi Liu et al.

ONCOGENE (2018)

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Article Multidisciplinary Sciences

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity

Lucas Ferrari de Andrade et al.

SCIENCE (2018)

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Review Immunology

Tumor-derived exosomes, microRNAs, and cancer immune suppression

Michael W. Graner et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

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Article Oncology

Dendritic Cells Pulsed with Exosomes in Combination with PD-1 Antibody Increase the Efficacy of Sorafenib in Hepatocellular Carcinoma Model

Shengbin Shi et al.

TRANSLATIONAL ONCOLOGY (2018)

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Article Cell Biology

14-3-3 zeta delivered by hepatocellular carcinoma-derived exosomes impaired anti-tumor function of tumor-infiltrating T lymphocytes

Xiaochen Wang et al.

CELL DEATH & DISEASE (2018)

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Article Multidisciplinary Sciences

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

Tian Fang et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Regulatory T cell-derived extracellular vesicles modify dendritic cell function

Sim L. Tung et al.

SCIENTIFIC REPORTS (2018)

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Review Oncology

The Origin and Functions of Exosomes in Cancer

Chitra Rajagopal et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Biochemistry & Molecular Biology

Regulation of Macrophage Activation and Polarization by HCC-Derived Exosomal lncRNA TUC339

Xue Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Multidisciplinary Sciences

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Gang Chen et al.

NATURE (2018)

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Article Cell & Tissue Engineering

Potential Effect of Exosomes Derived from Cancer Stem Cells and MSCs on Progression of DEN-Induced HCC in Rats

Faisal A. Alzahrani et al.

STEM CELLS INTERNATIONAL (2018)

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Article Oncology

FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors

Viviana Cremasco et al.

CANCER IMMUNOLOGY RESEARCH (2018)

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Article Immunology

Altered NKp30, NKp46, NKG2D, and DNAM-1 Expression on Circulating NK Cells Is Associated with Tumor Progression in Human Gastric Cancer

Bin Han et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2018)

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Review Immunology

Natural Killer Cells: Development, Maturation, and Clinical Utilization

Alex M. Abel et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

NKG2D Ligands-Critical Targets for Cancer Immune Escape and Therapy

Dominik Schmiedel et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Oncology

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Yuan Zhou et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Review Medicine, General & Internal

Prognostic value of tumor-infiltrating lymphocytes in hepatocellular carcinoma A meta-analysis

Wei Ding et al.

MEDICINE (2018)

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Article Biotechnology & Applied Microbiology

Exosomes derived from siRNA against GRP78 modified bone-marrow-derived mesenchymal stem cells suppress Sorafenib resistance in hepatocellular carcinoma

Hongdan Li et al.

JOURNAL OF NANOBIOTECHNOLOGY (2018)

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Article Oncology

Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1(+) regulatory B cell expansion

Linsen Ye et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Article Medicine, Research & Experimental

Generation and testing of clinical-grade exosomes for pancreatic cancer

Mayela Mendt et al.

JCI INSIGHT (2018)

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Review Cell Biology

Extracellular vesicles as a platform for membrane-associated therapeutic protein delivery

Yoosoo Yang et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Gastroenterology & Hepatology

SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop

Chun-Ping Cui et al.

GUT (2017)

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Article Cell Biology

BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells

Ming-Xin An et al.

JOURNAL OF CELL BIOLOGY (2017)

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Article Immunology

PTEN drives Th17 cell differentiation by preventing IL-2 production

Hyeong Su Kim et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Gastroenterology & Hepatology

Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models

Zhen Lu et al.

JOURNAL OF HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

JOURNAL OF HEPATOLOGY (2017)

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Article Medicine, General & Internal

Change in the Treg/Th17 cell imbalance in hepatocellular carcinoma patients and its clinical value

Yong-Ting Lan et al.

MEDICINE (2017)

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Article Medicine, General & Internal

Serum microRNA panel for early diagnosis of the onset of hepatocellular carcinoma

Ying Zhang et al.

MEDICINE (2017)

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Review Multidisciplinary Sciences

Elements of cancer immunity and the cancer-immune set point

Daniel S. Chen et al.

NATURE (2017)

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Review Microbiology

Viral effects on the content and function of extracellular vesicles

Nancy Raab-Traub et al.

NATURE REVIEWS MICROBIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

N. Cohen et al.

ONCOGENE (2017)

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Review Pharmacology & Pharmacy

Exosomes: Therapy delivery tools and biomarkers of diseases

Lucio Barile et al.

PHARMACOLOGY & THERAPEUTICS (2017)

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Review Oncology

Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy

Ruan F. V. Medrano et al.

ONCOTARGET (2017)

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Article Cell & Tissue Engineering

Extracellular Vesicles from Bone Marrow-Derived Mesenchymal Stem Cells Improve Survival from Lethal Hepatic Failure in Mice

Hiroaki Haga et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells

Alfonso Eirin et al.

PLOS ONE (2017)

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Article Oncology

Suppression of Lymphocyte Functions by Plasma Exosomes Correlates with Disease Activity in Patients with Head and Neck Cancer

Sonja Ludwig et al.

CLINICAL CANCER RESEARCH (2017)

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Review Chemistry, Multidisciplinary

Engineering exosomes as refined biological nanoplatforms for drug delivery

Xin Luan et al.

ACTA PHARMACOLOGICA SINICA (2017)

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Article Medicine, General & Internal

Exosomes as nanocarriers for siRNA delivery: paradigms and challenges

Fahimeh Shahabipour et al.

ARCHIVES OF MEDICAL SCIENCE (2016)

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Article Oncology

Cancer Statistics in China, 2015

Wanqing Chen et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

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Review Oncology

The Emerging Role of B Cells in Tumor Immunity

Peiling Tsou et al.

CANCER RESEARCH (2016)

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Review Immunology

Adaptive immunity in the liver

Zongwen Shuai et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2016)

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Article Cell & Tissue Engineering

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

Tek N. Lamichhane et al.

CELLULAR AND MOLECULAR BIOENGINEERING (2016)

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Article Biochemistry & Molecular Biology

miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis

Xuemin Niu et al.

FEBS LETTERS (2016)

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Article Gastroenterology & Hepatology

Tumor-Derived Exosomes Elicit Tumor Suppression in Murine Hepatocellular Carcinoma Models and Humans In Vitro

Quan Rao et al.

HEPATOLOGY (2016)

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Review Medicine, Research & Experimental

Dendritic cell-derived exosomes for cancer therapy

Jonathan M. Pitt et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Immunology

CD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells

Ben C. King et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Nanoscience & Nanotechnology

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2016)

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Article Oncology

Expression and inhibitory role of TIMP-3 in hepatocellular carcinoma

Bo Shen et al.

ONCOLOGY REPORTS (2016)

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Article Oncology

PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression

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Hepatic carcinoma-associated fibroblasts induce IDO-producing regulatory dendritic cells through IL-6-mediated STAT3 activation

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miR-27a-3p suppresses tumor metastasis and VM by down-regulating VE-cadherin expression and inhibiting EMT: an essential role for Twist-1 in HCC

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SCIENTIFIC REPORTS (2016)

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Engineering hybrid exosomes by membrane fusion with liposomes

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SCIENTIFIC REPORTS (2016)

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miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells

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SCIENTIFIC REPORTS (2016)

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High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

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JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Review Oncology

NK cells and cancer: you can teach innate cells new tricks

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NATURE REVIEWS CANCER (2016)

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Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma

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CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)

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Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

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The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients with Liver Cancer and their Significance

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INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2015)

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Article Oncology

Combination of exosomes and circulating microRNAs may serve as a promising tumor marker complementary to alpha-fetoprotein for early-stage hepatocellular carcinoma diagnosis in rats

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Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

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Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2015)

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Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature

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Correlation between microRNA-21 and expression of Th17 and Treg cells in microenvironment of rats with hepatocellular carcinoma

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ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2015)

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Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma

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Regulatory B cells accelerate hepatocellular carcinoma progression via CD40/CD154 signaling pathway

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Epigenetic Regulation of Connective Tissue Growth Factor by MicroRNA-214 Delivery in Exosomes From Mouse or Human Hepatic Stellate Cells

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Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

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Involvement of Extracellular Vesicle Long Noncoding RNA (linc-VLDLR) in Tumor Cell Responses to Chemotherapy

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Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

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Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

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Impairment of CD4+ Cytotoxic T Cells Predicts Poor Survival and High Recurrence Rates in Patients With Hepatocellular Carcinoma

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15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation

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Tumor microenviroment and hepatocellular carcinoma metastasis

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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013)

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Review Immunology

Epigenetic regulation of macrophage polarization and function

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Effects of the epigenetic drug MS-275 on the release and function of exosome-related immune molecules in hepatocellular carcinoma cells

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EUROPEAN JOURNAL OF MEDICAL RESEARCH (2013)

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Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

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Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer

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Hepatic androgen receptor suppresses hepatocellular carcinoma metastasis through modulation of cell migration and anoikis

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Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

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Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

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A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

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Review Immunology

IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation

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CURRENT OPINION IN IMMUNOLOGY (2011)

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Inflammatory signaling in macrophages: Transitions from acute to tolerant and alternative activation states

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Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling

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Alternative Activation of Macrophages: Mechanism and Functions

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Kupffer Cell Suppression of CD8+ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

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HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

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PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity

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Tumor exosomes inhibit differentiation of bone marrow dendritic cells

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Role of exosomes in the development of the immune microenvironment in hepatocellular carcinoma

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