相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Divergent Mechanistic Routes for the Formation of gem-Dimethyl Groups in the Biosynthesis of Complex Polyketides
Sean Poust et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis
Lihan Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Uncovering the Formation and Selection of Benzylmalonyl-CoA from the Biosynthesis of Splenocin and Enterocin Reveals a Versatile Way to Introduce Amino Acids into Polyketide Carbon Scaffolds
Chenchen Chang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
Reinvigorating natural product combinatorial biosynthesis with synthetic biology
Eunji Kim et al.
NATURE CHEMICAL BIOLOGY (2015)
Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology
Christian Hertweck
TRENDS IN BIOCHEMICAL SCIENCES (2015)
Insights into the Pamamycin Biosynthesis
Yuriy Rebets et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
De novo biosynthesis of terminal alkyne-labeled natural products
Xuejun Zhu et al.
NATURE CHEMICAL BIOLOGY (2015)
An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing α-Ketone in Polyketide Starter Unit Biosynthesis
Hai-Yan He et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)
Predicted Incorporation of Non-native Substrates by a Polyketide Synthase Yields Bioactive Natural Product Derivatives
Kenny Bravo-Rodriguez et al.
CHEMBIOCHEM (2014)
Structure of a modular polyketide synthase
Somnath Dutta et al.
NATURE (2014)
Structural rearrangements of a polyketide synthase module during its catalytic cycle
Jonathan R. Whicher et al.
NATURE (2014)
Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes
Raoul G. Rosenthal et al.
NATURE CHEMICAL BIOLOGY (2014)
Lomaiviticin Biosynthesis Employs a New Strategy for Starter Unit Generation
Abraham J. Waldman et al.
ORGANIC LETTERS (2014)
A Polyketide Synthase Acyltransferase Domain Structure Suggests a Recognition Mechanism for Its Hydroxymalonyl-Acyl Carrier Protein Substrate
Hyunjun Park et al.
PLOS ONE (2014)
Enzyme-Directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase
Uschi Sundermann et al.
ACS CHEMICAL BIOLOGY (2013)
A Common Origin for Guanidinobutanoate Starter Units in Antifungal Natural Products
Hui Hong et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Multiplexing of Combinatorial Chemistry in Antimycin Biosynthesis: Expansion of Molecular Diversity and Utility
Yan Yan et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Mechanism and Specificity of an Acyltransferase Domain from a Modular Polyketide Synthase
Briana J. Dunn et al.
BIOCHEMISTRY (2013)
Bioactivity-Guided Genome Mining Reveals the Lomaiviticin Biosynthetic Gene Cluster in Salinispora tropica
Roland D. Kersten et al.
CHEMBIOCHEM (2013)
Flavin-Linked Oxidase Catalyzes Pyrrolizine Formation of Dichloropyrrole-Containing Polyketide Extender Unit in Chlorizidine A
Simone M. Mantovani et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Engineering the acyltransferase substrate specificity of assembly line polyketide synthases
Briana J. Dunn et al.
JOURNAL OF THE ROYAL SOCIETY INTERFACE (2013)
Chlorizidine, a Cytotoxic 5H-Pyrrolo[2,1-a]isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp.
Xavier Alvarez-Mico et al.
ORGANIC LETTERS (2013)
Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways
Mark C. Walker et al.
SCIENCE (2013)
Structure guided design of improved anti-proliferative rapalogs through biosynthetic medicinal chemistry
Matthew A. Gregory et al.
CHEMICAL SCIENCE (2013)
Enzymatic Synthesis of Dilactone Scaffold of Antimycins
Moriah Sandy et al.
ACS CHEMICAL BIOLOGY (2012)
Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis
Kazuya Yamanaka et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
The structures of type I polyketide synthases
Adrian T. Keatinge-Clay
NATURAL PRODUCT REPORTS (2012)
Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity
Micheal C. Wilson et al.
NATURAL PRODUCT REPORTS (2012)
Microbial engineering for the production of advanced biofuels
Pamela P. Peralta-Yahya et al.
NATURE (2012)
Unusual carbon fixation gives rise to diverse polyketide extender units
Nick Quade et al.
NATURE CHEMICAL BIOLOGY (2012)
Characterization of 2-Octenoyl-CoA Carboxylase/Reductase Utilizing pteB from Streptomyce avermitilis
Hye-Gyeong Yoo et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2011)
Enzymatic Extender Unit Generation for In Vitro Polyketide Synthase Reactions: Structural and Functional Showcasing of Streptomyces coelicolor MatB
Amanda J. Hughes et al.
CHEMISTRY & BIOLOGY (2011)
Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues
SangJoon Mo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Cloning and Elucidation of the FR901464 Gene Cluster Revealing a Complex Acyltransferase-less Polyketide Synthase Using Glycerate as Starter Units
Feng Zhang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Protein-Protein Recognition between Acyltransferases and Acyl Carrier Proteins in Multimodular Polyketide Synthases
Fong T. Wong et al.
BIOCHEMISTRY (2010)
Bryostatins: biological context and biotechnological prospects
Amaro E. Trindade-Silva et al.
CURRENT OPINION IN BIOTECHNOLOGY (2010)
Nonactin Biosynthesis: Unexpected Patterns of Label Incorporation from 4,6-Dioxoheptanoate Show Evidence of a Degradation Pathway for Levulinate through Propionate in Streptomyces griseus
Jian Rong et al.
JOURNAL OF NATURAL PRODUCTS (2010)
The Biosynthetic Logic of Polyketide Diversity
Christian Hertweck
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Biosynthesis of polyketide synthase extender units
Yolande A. Chan et al.
NATURAL PRODUCT REPORTS (2009)
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine
Alessandra S. Eustaquio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase
Tobias J. Erb et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Glyceryl-S-acyl carrier protein as an intermediate in the biosynthesis of tetronate antibiotics
Yuhui Sun et al.
CHEMBIOCHEM (2008)
In Vivo and In Vitro Trans-Acylation by BryP, the Putative Bryostatin Pathway Acyltransferase Derived from an Uncultured Marine Symbiont
Nicole B. Lopanik et al.
CHEMISTRY & BIOLOGY (2008)
In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis
Yoo Seong Choi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
GNAT-like strategy for polyketide chain initiation
Liangcai Gu et al.
SCIENCE (2007)
Fluorine in pharmaceuticals:: Looking beyond intuition
Klaus Mueller et al.
SCIENCE (2007)
Synthesis Of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase:: The ethylmalonyl-CoA pathway
Tobias J. Erb et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp strain UC 11065
Xiujun Zhang et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
Christian Hertweck et al.
NATURAL PRODUCT REPORTS (2007)
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units
Yolande A. Chan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis
Pieter C. Dorrestein et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
Michael A. Fischbach et al.
CHEMICAL REVIEWS (2006)
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis
PC Dorrestein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A novel fluorinated erythromycin antibiotic
RJM Goss et al.
CHEMICAL COMMUNICATIONS (2005)
Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiotic aureothin:: Involvement of an unprecedented N-oxygenase
J He et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
J Piel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
bryA:: An unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina
M Hildebrand et al.
CHEMISTRY & BIOLOGY (2004)
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula
DJ Edwards et al.
CHEMISTRY & BIOLOGY (2004)
A novel erythromycin, 6-desmethyl erythromycin D, made by substituting an acyltransferase domain of the erythromycin polyketide synthase
H Petkovic et al.
JOURNAL OF ANTIBIOTICS (2003)
The chalcone synthase superfamily of type III polyketide synthases
MB Austin et al.
NATURAL PRODUCT REPORTS (2003)
Timeline - Metabolic engineering for drug discovery and development
C Khosla et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis
MG Thomas et al.
CHEMISTRY & BIOLOGY (2002)
Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2):: new mechanisms for chain initiation and termination in modular multienzymes
AM Cerdeño et al.
CHEMISTRY & BIOLOGY (2001)
Polyketide biosynthesis: a millennium review
J Staunton et al.
NATURAL PRODUCT REPORTS (2001)
分享论文
