4.8 Article

Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

The differential effects of tumor burdens on predicting the net benefits of ssCART-19 cell treatment on r/r B-ALL patients

Minghao Li et al.

Summary: This study found that tumor burden (TB) is related to the safety and efficacy of CAR-T cell treatment for r/r B-ALL. Patients with low tumor burden had better safety profiles and higher complete remission rates. Tumor burden did not significantly affect long-term therapeutic efficacy. Severe cytokine release syndrome (CRS) was significantly correlated with tumor burden.

SCIENTIFIC REPORTS (2022)

Article Cell Biology

Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine

Mathieu Gigoux et al.

Summary: CALR(MUT)-specific T cells are rare in patients with CALR(MUT) MPN, possibly due to MHC-I allele restriction and immune-mediated tumor rejection. A modified CALR(MUT) heteroclitic peptide vaccine can effectively induce a CALR(MUT) cross-reactive CD8(+) T cell response.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Biochemistry & Molecular Biology

The distribution of cellular turnover in the human body

Ron Sender et al.

Summary: The research integrated ubiquity, mass, and lifespan of major cell types to quantitatively describe cellular turnover, finding a total cellular mass turnover of 80+/-20 grams per day, primarily from blood cells and gut epithelial cells. The study also revealed that close to 90% of the daily cell turnover was from blood cells, providing an estimation of the distribution of cellular turnover in the human body.

NATURE MEDICINE (2021)

Article Oncology

Therapeutic Cancer Vaccination With a Peptide Derived From the Calreticulin Exon 9 Mutations Induces Strong Cellular Immune Responses in Patients With CALR-Mutant Chronic Myeloproliferative Neoplasms

Jacob Handlos Grauslund et al.

Summary: In a phase I clinical vaccination trial of CALRLong36 peptide vaccines for CALR-mutant MPN patients, the vaccines were found to be safe and tolerable, and were able to induce T-cell responses. However, the vaccines did not lead to clinical responses, but the study indicates that vaccines targeting mutant CALR may have potential in enhancing anti-tumor immune responses.

FRONTIERS IN ONCOLOGY (2021)

Article Hematology

PD-1 inhibition in advanced myeloproliferative neoplasms

Gabriela Hobbs et al.

Summary: Myelofibrosis is a rare clonal stem cell neoplasm characterized by immune suppression. While immunotherapy with pembrolizumab did not lead to significant clinical responses, changes in immune profiles suggest potential therapeutic benefits that may require combination approaches to reverse immune suppression in myeloproliferative neoplasms.

BLOOD ADVANCES (2021)

Review Oncology

Evidence of immune elimination, immuno-editing and immune escape in patients with hematological cancer

Morten Orebo Holmstrom et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

Article Oncology

Healthy Donors Harbor Memory T Cell Responses to RAS Neo-Antigens

Morten Orebo Holmstrom et al.

CANCERS (2020)

Article Biochemistry & Molecular Biology

Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I

Najla Arshad et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Review Oncology

Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment

James L. Gulley et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Medicine, Research & Experimental

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

Robert Sackstein et al.

LABORATORY INVESTIGATION (2017)

Review Immunology

Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity In Vivo

Stephan Halle et al.

TRENDS IN IMMUNOLOGY (2017)

Review Oncology

Role of Antigen Spread and Distinctive Characteristics of Immunotherapy in Cancer Treatment

James L. Gulley et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Oncology

An Immune Dysregulation in MPN

Giovanni Barosi

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2014)

Article Medicine, General & Internal

Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2

J. Nangalia et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medicine, General & Internal

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

Thorsten Klampfl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Oncology

Response definition criteria for ELISPOT assays revisited

Z. Moodie et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2010)

Review Medicine, General & Internal

Mechanisms of disease: The myeloproliferative disorders

Peter J. Campbell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Medicine, General & Internal

A gain-of-function mutation of JAK2 in myeloproliferative disorders

R Kralovics et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)