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注意:仅列出部分参考文献,下载原文获取全部文献信息。Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma
Scott X. Atwood et al.
CANCER CELL (2015)
Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma
Hayley J. Sharpe et al.
CANCER CELL (2015)
MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor
Lucile Hoch et al.
FASEB JOURNAL (2015)
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Uwe Weierstall et al.
NATURE COMMUNICATIONS (2014)
Structure of the human smoothened receptor bound to an antitumour agent
Chong Wang et al.
NATURE (2013)
The mechanisms of Hedgehog signalling and its roles in development and disease
James Briscoe et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Loss of SUFU Function in Familial Multiple Meningioma
Mervi Aavikko et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2012)
Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
Raffaele Teperino et al.
CELL (2012)
The molecular basis of T cell acute lymphoblastic leukemia
Pieter Van Vlierberghe et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
Aleksandar Sekulic et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor
Hans Skvara et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)
Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified
Steven Ray Wilson et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2010)
Identification of a SUFU Germline Mutation in a Family With Gorlin Syndrome
L. Pastorino et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2009)
Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
Martin R. Tremblay et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Brief Report: Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449.
Charles M. Rudin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma.
Daniel D. Von Hoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
A paracrine requirement for hedgehog signalling in cancer
Robert L. Yauch et al.
NATURE (2008)
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
JK Chen et al.
GENES & DEVELOPMENT (2002)
Small molecule modulation of Smoothened activity
JK Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Medulloblastoma growth inhibition by Hedgehog pathway blockade
DM Berman et al.
SCIENCE (2002)
Mutations in SUFU predispose to medulloblastoma
MD Taylor et al.
NATURE GENETICS (2002)
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
J Taipale et al.
NATURE (2000)