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Article
Gastroenterology & Hepatology
Claire Conche et al.
Summary: Investigating the effect of ferroptosis in the tumour microenvironment, specifically focusing on liver cancer, to identify potential combinatory therapies. The study genetically altered GPx4 in mouse models for hepatocellular carcinoma and colorectal cancer to analyze the impact of ferroptosis on tumor cells and the immune response. The findings revealed a context-specific ferroptosis-induced immune response that could be used in the treatment of liver tumors and liver metastases.
Article
Gastroenterology & Hepatology
Yao Liu et al.
Summary: By combining spatial transcriptomics with single-cell RNA sequencing and multiplexed immunofluorescence, we identified a tumor immune barrier (TIB) structure composed of SPP1+ macrophages and cancer-associated fibroblasts (CAFs) that is associated with the efficacy of immunotherapy. Disrupting the TIB structure may be a relevant therapeutic approach to enhance the therapeutic effect of immune checkpoint blockade in HCC.
JOURNAL OF HEPATOLOGY
(2023)
Review
Immunology
Xiangjin Gong et al.
Summary: Ovarian cancer is a highly malignant tumor with a poor prognosis. Current treatments, such as chemotherapy and radiotherapy, yield unsatisfactory results. Exosomes, a type of extracellular vesicle, have shown potential as effective carriers of immunotherapeutic drugs. They play a dual role in inhibiting and promoting tumor development and contain genes that could serve as biomarkers for ovarian cancer diagnosis and prognosis. However, further research is needed to explore the clinical application of exosome-based immunotherapy in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiangyu Zhai et al.
Summary: Accumulating evidence suggests that somatic mutations play a significant role in the occurrence and development of hepatocellular carcinoma (HCC). This study aimed to identify somatic mutations in HCC with important implications and explore their underlying mechanisms. The mutation profiles of HCC patients were analyzed, and 14 genes with a high mutation frequency were identified. In vivo and in vitro experiments demonstrated the effects of these genes on tumor cell behaviors and identified potential therapeutic targets.
Article
Oncology
Hansol Lee et al.
Summary: This study characterized intratumoral macrophage populations in melanoma biopsies and investigated the association between CD16-expressing macrophage densities and treatment outcomes for patients receiving anti-PD-1 monotherapy or a combination with anti-CTLA-4. The results showed that patients who responded to combination therapy had higher CD16 macrophage densities compared to those who did not respond. Additionally, patients with high intratumoral densities of CD16 macrophages had a significantly longer progression-free survival. These findings suggest that CD16 macrophages may serve as a potential biomarker for response to combination immunotherapies in metastatic melanoma patients.
CLINICAL CANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Chenhao Zhou et al.
Summary: This study found that SLFN11, a member of the Schlafen (SLFN) family, plays a critical role in the response to immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) patients. SLFN11 deficiency promotes the infiltration of immunosuppressive macrophages and aggravates HCC progression. SLFN11 regulates the immune microenvironment by suppressing the Notch pathway and C-C motif chemokine ligand 2 transcription, and is associated with the response to ICIs. Inhibition of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 signaling pathway enhances the therapeutic efficacy of ICIs in HCC patients with low SLFN11 levels.
Article
Gastroenterology & Hepatology
Jinghan Wang et al.
Summary: This study reveals that the expression of Frizzled-10 (FZD10) in liver cancer stem cells is regulated by METTL3-mediated N6-methyladenosine methylation of FZD10 mRNA, and FZD10 promotes self-renewal, tumorigenicity, and metastasis of liver CSCs via activating β-catenin and YAP1. The FZD10-β-catenin/YAP1 axis is activated in liver CSCs and indicates poor prognosis. Furthermore, the FZD10/β-catenin/c-Jun/MEK/ERK axis determines the responses of hepatoma cells to lenvatinib treatment.
Article
Immunology
Hao Chi et al.
Summary: This study aimed to establish reliable markers based on biologic clock genes to assess the immunotherapy response and prognosis in HNSCC patients. Through analysis of 502 HNSCC samples and 44 normal samples, 6 circadian rhythm-related genes (CRRGs) strongly associated with HNSCC prognosis were identified and a predictive model was constructed. Patients can evaluate their prognosis and immunotherapy outcome based on the risk score generated by this model.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Qianhe Ren et al.
Summary: By analyzing gene data, this study found that cancer-associated fibroblasts (CAFs) in lung adenocarcinoma (LUAD) can predict disease progression and immunotherapy responsiveness, and established a risk signature. This provides new perspectives for the treatment and management of LUAD patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Songyun Zhao et al.
Summary: By analyzing 2601 neurotrophic factor-related genes, we identified 12 genes potentially involved in the pathogenesis of Parkinson's disease and the prognosis of glioblastoma multiforme. Machine learning techniques validated 4 genes as reliable diagnostic markers for Parkinson's disease, and 7 genes were found to be highly associated with the prognosis and diagnosis of glioblastoma multiforme. A prognostic risk scoring system based on these genes was developed, and low-risk patients showed better overall survival and response to immunotherapy. EN1 and LOXL1 were identified as potential therapeutic targets for personalized immunotherapy for Parkinson's disease and glioblastoma multiforme.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jingwen Xiong et al.
Summary: B cells play a crucial role in the immune system by working with T cells to either suppress or promote tumor growth within the tumor microenvironment (TME). Through the release of exosomes, small membrane vesicles, B cells and other cells facilitate intercellular communication in the TME. Exosome research has shown that they carry molecules such as major histocompatibility complex (MHC) molecules and integrins, which regulate the TME. Therefore, targeting substances within the TME has emerged as a promising approach for cancer therapy. This review provides a comprehensive overview of the contributions of B cells and exosomes to the TME, as well as the potential role of B cell-derived exosomes in cancer progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Joselyn Cruz Cruz et al.
Frontiers in Immunology
(2023)
Article
Immunology
Xin Zhang et al.
Summary: This study identified 28 key sphingolipid genes (SPGs) that impact survival and developed a reliable prognostic model for hepatocellular carcinoma (HCC) patients. The model can assist clinicians in choosing personalized treatments. The study also revealed the connection between sphingolipid-related genes and the immune microenvironment, offering a new approach for immunotherapy. By focusing on crucial sphingolipid genes like SMPD2 and CSTA, the efficacy of anti-tumor therapy can be increased in HCC cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Pengpeng Zhang et al.
Summary: In this study, a prognostic model based on glutamine metabolism-related genes (GMRGs) was established using machine learning algorithms. LGALS3 was identified as a potential therapeutic target for lung adenocarcinoma (LUAD), and the effectiveness of immunotherapy was predicted.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jianlan Liu et al.
Summary: This study aimed to investigate the impact of glycosylation-related genes (GRGs) on the prognosis of uveal melanoma (UM). By integrating multiple omics data, a gene signature comprising seven key genes was established as a predictor for UM patient survival. The high gene signature score was associated with poorer prognosis and enhanced immune-related characteristics. In vitro experiments validated the role of one critical gene, AUP1, in UM. The study highlights the importance of exploring GRGs in UM for clinical diagnosis and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Songyun Zhao et al.
Summary: This study investigated the impact of genes associated with copper metabolism on the prognosis of ovarian cancer patients, identified different copper metabolism clusters, and established a risk model to evaluate patient prognosis, immunological features, and therapy response. The results provide valuable insights for individualized treatment of ovarian cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Hao Zhang et al.
Summary: Mitochondrial dysfunction and glycolysis activation are important hallmarks of hepatocellular carcinoma (HCC). In this study, it was found that NOP2, a methyltransferase, is highly expressed in HCC and is associated with unfavorable prognosis. NOP2 promotes HCC progression by promoting aerobic glycolysis through regulating c-Myc expression and the expression of glycolytic genes.
Article
Biochemistry & Molecular Biology
Hao Chi et al.
Summary: This study developed a risk scoring system based on the expression patterns and prognostic relevance of the Familial sequence similarity (FAM) gene family in uterine corpus endometrial carcinoma (UCEC). The FAM family genes (FFGs) were found to be strongly associated with prognosis and immune status in UCEC patients. The identified FFGs can accurately predict prognosis and facilitate personalized treatment with immunotherapy and chemotherapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Oncology
Zhipeng Li et al.
Summary: In this study, it was found that HMGA1 promotes the proliferation, EMT, metastasis, and stemness of iCCA. HMGA1 induces CCND1 expression by promoting CCND1 transcription and activating the PI3K signaling pathway. CDK4/6 inhibitor Palbociclib can suppress iCCA proliferation, migration, and invasion, especially during the first 3 days. Combination therapy of CDK4/6 inhibitor and PI3K/mTOR inhibitor shows more significant inhibition of CCND1, CDK4/6, and PI3K pathway compared to monotherapy.
BIOMARKER RESEARCH
(2023)
Article
Cell Biology
Ya-Ting Wang et al.
Summary: Research reveals that macrophages exhibit enhanced efferocytosis of apoptotic cells under prolonged physiological hypoxia, characterized by increased internalization and accelerated degradation. This is achieved through the noncanonical pentose phosphate pathway, which promotes NADPH production and ensures phagolysosomal maturation and redox homeostasis. This adaptation supports cell fitness and essential homeostatic functions.
Article
Dentistry, Oral Surgery & Medicine
Jinhao Zhang et al.
Summary: In this study, OLP patients were classified into two subtypes using consensus clustering analysis, which improved our current understanding of the underlying pathogenesis of OLP and provided new insights for future studies.
Article
Gastroenterology & Hepatology
Li-Gong Lu et al.
Summary: In hepatocellular carcinoma (HCC), PD-L1(+) host macrophages are a major cellular source of PD-L1 in tumors, displaying a glycolytic phenotype and producing antitumor IL-12p70. The regulation of these macrophages involves fibronectin 1-induced PKM2, controlling both antitumor properties and inflammation-mediated PD-L1 expression. Modulating the context of glycolytic macrophages in HCC tumors may restore their antitumor properties and offer a precise strategy for anticancer therapy.
Article
Biochemistry & Molecular Biology
Fan Zhang et al.
Summary: This study reveals the oncogenic role of HCG18 in epithelial ovarian cancer. HCG18 serves as a ceRNA for miR-29a/b, derepressing the expression levels of TRAF4/5 and facilitating NF-kappa B pathway-mediated promotion of EOC cell proliferation and migration.
MOLECULAR MEDICINE
(2022)
Review
Oncology
Josep M. Llovet et al.
Summary: Liver cancer, specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related death globally. Traditional treatments involve specific drugs, but the emergence of immune checkpoint inhibitors has revolutionized the management of HCC.
NATURE REVIEWS CLINICAL ONCOLOGY
(2022)
Article
Oncology
Jinti Lin et al.
Summary: In osteosarcoma, efferocytosis promotes tumor progression by increasing PD-L1 expression and M2 polarization of macrophages, which is mediated by MerTK receptor and regulated through the p38/STAT3 pathway. Inhibition of efferocytosis suppresses tumor growth and enhances the cytotoxic function of CD8(+) T cells.
Review
Oncology
Ester Garcia-Pras et al.
Summary: The progression of liver tumors is influenced by the interactions between cancer cells and the surrounding environment. Cell death can promote inflammation, fibrosis, and angiogenesis, but also be targeted as a therapeutic approach. Nonparenchymal hepatic cells play a crucial role in establishing the tumor microenvironment and stimulating tumorigenesis.
Article
Multidisciplinary Sciences
Sophia Maschalidi et al.
Summary: SLC7A11 acts as a negative regulator of efferocytosis, inhibiting its function can accelerate wound healing; it has important implications for wound management in diabetes.
Review
Cell Biology
Yan Yang et al.
Summary: Ferroptosis is a newly discovered iron-dependent cell death pathway characterized by lipid peroxidation and GSH depletion, participating in the development of various diseases. Macrophages, as immune cells, play crucial roles in regulating iron, lipid, and amino acid metabolisms, and recent studies target their polarization to induce ferroptosis in cancer cells for treatment.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Sui Peng et al.
Summary: This study demonstrates that personalized neoantigen-loaded immunotherapy as adjuvant treatment has the potential to reduce hepatocellular carcinoma recurrence after curative therapy, is feasible, and has a good safety profile.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Wenyi Jin et al.
Summary: This study proposes a reliable approach to predict individual responses to immunotherapies using ensemble learning and self-attention mechanism. The proposed model, ELISE, demonstrated high accuracy in predicting responses to different immunotherapeutic agents in various cancer types.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Gangcheng Liu et al.
Summary: This study elucidated the complex regulatory mechanisms and molecular characteristics involved in the interaction between clear cell renal cell carcinoma (ccRCC) and inflammation. This has important implications for identifying high-risk ccRCC patients and designing clinical treatment strategies.
Article
Immunology
Wenchang Lv et al.
Summary: This study establishes a predictive signature based on glycosyltransferase-related lncRNAs (GT-lncRNAs) in breast cancer prognosis and response to immune checkpoint inhibitors (ICIs) treatment. The risk score calculated from the coefficients of 8 GT-lncRNAs can divide breast cancer patients into high- and low-risk groups, with the high-risk group showing shorter survival and the risk score being an independent predictor of breast cancer prognosis. The risk score can also stratify patients with distinct immune infiltration and patients in the high-risk group might benefit more from ICIs treatment. The well-constructed prognostic signature with GT-lncRNAs provides reliable tools for predicting breast cancer outcomes and making rational follow-up strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hao Chi et al.
Summary: This study established a reliable signature based on genes related to NK cells in HNSCC, providing a new perspective for assessing immunotherapy response and prognosis. The 17-NRGs signature demonstrated excellent predictive performance and offered new perspectives for evaluating pre-immune efficacy, facilitating future precision immuno-oncology research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yue Zhao et al.
Summary: Cancer vaccines have shown specificity, effectiveness, and safety as an alternative immunotherapeutic strategy. However, maintaining long-term immune memory, especially T cell memory, after vaccination is still a challenge. IL-7, as an adjuvant, has potential in the development of cancer vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Hao Chi et al.
Summary: This study constructed a prognostic model for HNSCC using anoikis-related genes (ANRGs) and found differential immune status and drug sensitivity between high-risk and low-risk groups. In addition, through DCA analysis, the researchers demonstrated the potential clinical benefit of the model in the clinical practice.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Xiaojing Wang et al.
Summary: This study found that microRNAs related to fatty acid metabolism are strongly linked to the prognosis of HNSCC patients. Reprogramming of fatty acid metabolism in tumor tissues may play an important role in HNSCC cancer.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Yujian Zhong et al.
Summary: Sphingolipid metabolism plays a crucial role in the tumorigenesis and malignant progression of osteosarcoma. This study identified key genes related to sphingolipid metabolism in osteosarcoma and developed a prognostic signature based on these genes. The signature showed excellent predictive ability for the prognosis of osteosarcoma patients. Additionally, the study revealed a dysregulated immune microenvironment in high-risk osteosarcoma patients, which may be attributed to the dysregulated sphingolipid metabolism of glycolipids. A nomogram integrating the prognostic signature and clinical parameters was constructed for clinical application, providing accurate prognosis prediction for osteosarcoma patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mingyu Lee et al.
Summary: Neutrophils, as the most abundant innate immune cells, play crucial roles in the immune response, including detecting pathogens, initiating immune cascades, and regulating adaptive immunity.
Article
Cell Biology
Wenyi Jin et al.
Summary: This study systematically investigated the immune interaction in neuroblastoma (NBL) and identified immune-related genes with prognostic potential. The immune signature combining nine immunity genes was found to be more effective for individual risk stratification and survival outcome prediction than common clinical characteristics. A constructed nomogram based on the immune signature and clinical characteristics showed high potential for prognosis prediction.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Philippe Icard et al.
Summary: Hepatocellular carcinoma is the third leading cause of cancer death in men globally, with poor prognosis and limited sensitivity to conventional treatments. Targeting the Warburg effect to increase drug delivery into tumors may improve treatment effectiveness.
DRUG RESISTANCE UPDATES
(2021)
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Oncology
Mojdeh Soltani et al.
Summary: Metabolic alterations and bioenergetic pathways play crucial roles in leukemia, and targeting leukemic cell vulnerabilities is essential for treatment, especially in nonresponsive patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Amir Tajbakhsh et al.
Summary: Efferocytosis plays a role in clearing apoptotic tumor cells but can be controversial in treatment-induced scenarios. Tumor cells can exploit efferocytosis to escape the immune response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
Valentina Leone et al.
Summary: Immune regulation plays a crucial role in cancer development, especially in organs like the liver and gastrointestinal tract that are constantly exposed to environmental pathogens. Chronic liver inflammation can lead to hepatobiliary cancers, including HCC, iCCA, and cHCC-CCA. This review discusses the relationship between oxidative stress, immune response in the liver, hepatocyte damage, proliferation, and the initiation and sustainment of cancer, as well as new anticancer therapies based on immunomodulation.
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GYNECOLOGIC ONCOLOGY
(2016)
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Fabiana N. Soki et al.
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(2014)
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